SG144736A1 - Synthesis of temozolomide and analogs - Google Patents

Synthesis of temozolomide and analogs

Info

Publication number
SG144736A1
SG144736A1 SG200504445-8A SG2005044458A SG144736A1 SG 144736 A1 SG144736 A1 SG 144736A1 SG 2005044458 A SG2005044458 A SG 2005044458A SG 144736 A1 SG144736 A1 SG 144736A1
Authority
SG
Singapore
Prior art keywords
temozolomide
analogs
synthesis
relates
novel process
Prior art date
Application number
SG200504445-8A
Other languages
English (en)
Inventor
Shen-Chun Kuo
Janet L Mas
Donald Hou
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of SG144736A1 publication Critical patent/SG144736A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/28—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG200504445-8A 2001-01-18 2002-01-16 Synthesis of temozolomide and analogs SG144736A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26246501P 2001-01-18 2001-01-18

Publications (1)

Publication Number Publication Date
SG144736A1 true SG144736A1 (en) 2008-08-28

Family

ID=22997631

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200504445-8A SG144736A1 (en) 2001-01-18 2002-01-16 Synthesis of temozolomide and analogs

Country Status (9)

Country Link
US (4) US7087751B2 (ja)
EP (1) EP1353924A1 (ja)
JP (2) JP4358510B2 (ja)
CN (4) CN101220033A (ja)
AR (1) AR035419A1 (ja)
CA (1) CA2434308C (ja)
MX (1) MXPA03006403A (ja)
SG (1) SG144736A1 (ja)
WO (1) WO2002057269A1 (ja)

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EP2275425A1 (en) * 2003-12-30 2011-01-19 Chemagis Ltd. Novel crystalline forms of temozolomide
US7612202B2 (en) * 2005-02-17 2009-11-03 Chemagis, Ltd. Process for preparing temozolomide
CN1300143C (zh) * 2005-04-08 2007-02-14 江苏天士力帝益药业有限公司 替莫唑胺的精制方法
US20060222792A1 (en) * 2006-04-21 2006-10-05 Chemagis Ltd. Temozolomide storage system
EP2374807B1 (en) 2006-09-29 2013-12-18 Cipla Limited An improved process for the isolation of temozolomide
PE20091101A1 (es) 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
EP2151442A3 (en) 2008-08-07 2011-04-06 Chemi SPA Process for preparing temozolomide
CN102405044A (zh) 2009-02-06 2012-04-04 南加利福尼亚大学 含有单萜的治疗组合物
WO2010140168A1 (en) * 2009-06-03 2010-12-09 Ind-Swift Laboratories Limited Improved process for preparing temozolomide
ES2583006T3 (es) 2009-06-23 2016-09-16 Pharminox Limited Compuestos de 3-sustituido-8-sustituido-3H-imidazo[5,1-d][1,2,3,5-tetrazin-4-ona y su uso
WO2011036676A2 (en) 2009-09-23 2011-03-31 Ashwini Nangia Stable cocrystals of temozolomide
WO2011107726A1 (en) 2010-03-01 2011-09-09 Pharminox Ltd Methods and intermediates for the synthesis of 4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazines
CN102070639B (zh) * 2010-12-21 2012-10-10 中南大学 一种替莫唑胺的合成方法
CN102659789B (zh) * 2011-04-27 2014-10-15 四川科瑞德凯华制药有限公司 一锅法制备替莫唑胺的方法及替莫唑胺的精制方法
PL3532059T3 (pl) 2016-10-27 2022-05-09 Celgene Quanticel Research, Inc. Terapia skojarzona z zastosowaniem inhibitora białka bet
WO2020194168A1 (en) * 2019-03-25 2020-10-01 Shivalik Rasayan Limited Process for preparing highly pure temozolomide
CN111233871B (zh) * 2020-03-17 2021-11-12 江苏美迪克化学品有限公司 一种替莫唑胺的制备方法
US11597731B2 (en) 2021-07-17 2023-03-07 Shivalik Rasayan Limited Process for preparing highly pure temozolomide
JP2023043987A (ja) 2021-09-17 2023-03-30 キオクシア株式会社 基板処理装置及び基板処理方法

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JPS5441830A (en) 1977-09-07 1979-04-03 Seitetsu Kagaku Co Ltd Production of p-hydroxybenzaldehyde
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Title
A NEW ROUTE TO THE ANTITUMOR DRUG TEMOZOLOMIDE, BUT NOT THIOTEMOZOLOMIDE *
ANTITUMOR IMIDAZOTETRAZINES. 35. NEW SYNTHETIC ROUTES TO THE ANTITUMOR DRUG TEMOZOLOMIDE *
ANTITUMOR IMIDAZOTETRAZINES. PART 33 *
ANTITUMOR IMIDAZOTETRAZINES. PART 36 ..... *

Also Published As

Publication number Publication date
CA2434308C (en) 2010-09-21
CN1800184A (zh) 2006-07-12
JP4358510B2 (ja) 2009-11-04
JP2004518673A (ja) 2004-06-24
US20060229456A1 (en) 2006-10-12
EP1353924A1 (en) 2003-10-22
WO2002057269A1 (en) 2002-07-25
CN101195589A (zh) 2008-06-11
US20090023919A1 (en) 2009-01-22
CN1487941A (zh) 2004-04-07
CN101220033A (zh) 2008-07-16
AR035419A1 (es) 2004-05-26
MXPA03006403A (es) 2003-10-15
US7087751B2 (en) 2006-08-08
CN100372852C (zh) 2008-03-05
US20050131227A1 (en) 2005-06-16
US7737284B2 (en) 2010-06-15
US20020095036A1 (en) 2002-07-18
US7446209B2 (en) 2008-11-04
CA2434308A1 (en) 2002-07-25
CN1269819C (zh) 2006-08-16
JP2009024025A (ja) 2009-02-05

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