HK1080088A1 - 製備c-7取代的5-雄甾烯的方法 - Google Patents

製備c-7取代的5-雄甾烯的方法

Info

Publication number
HK1080088A1
HK1080088A1 HK05112224.8A HK05112224A HK1080088A1 HK 1080088 A1 HK1080088 A1 HK 1080088A1 HK 05112224 A HK05112224 A HK 05112224A HK 1080088 A1 HK1080088 A1 HK 1080088A1
Authority
HK
Hong Kong
Prior art keywords
processes
androstenes
substituted
preparing
novel
Prior art date
Application number
HK05112224.8A
Other languages
English (en)
Inventor
Peter Gm Wuts
Original Assignee
法馬西亞和厄普喬恩公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 法馬西亞和厄普喬恩公司 filed Critical 法馬西亞和厄普喬恩公司
Publication of HK1080088A1 publication Critical patent/HK1080088A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
HK05112224.8A 2002-11-07 2005-12-31 製備c-7取代的5-雄甾烯的方法 HK1080088A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42448802P 2002-11-07 2002-11-07
PCT/US2003/007284 WO2004043986A1 (en) 2002-11-07 2003-03-21 Processes for preparing c-7 substituted 5-androstenes

Publications (1)

Publication Number Publication Date
HK1080088A1 true HK1080088A1 (zh) 2006-04-21

Family

ID=32312815

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05112224.8A HK1080088A1 (zh) 2002-11-07 2005-12-31 製備c-7取代的5-雄甾烯的方法

Country Status (19)

Country Link
US (1) US20040097475A1 (zh)
EP (1) EP1562974B1 (zh)
JP (1) JP2006508962A (zh)
KR (1) KR100667123B1 (zh)
CN (1) CN1694896A (zh)
AT (1) ATE354583T1 (zh)
AU (1) AU2003220139A1 (zh)
BR (1) BR0316052A (zh)
CA (1) CA2500580A1 (zh)
DE (1) DE60312029T2 (zh)
ES (1) ES2280739T3 (zh)
HK (1) HK1080088A1 (zh)
MX (1) MXPA05004024A (zh)
PL (1) PL376896A1 (zh)
RS (1) RS20050339A (zh)
RU (1) RU2289586C2 (zh)
TW (1) TWI280133B (zh)
WO (1) WO2004043986A1 (zh)
ZA (1) ZA200502698B (zh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
CN1321128C (zh) * 2005-07-15 2007-06-13 浙江医药股份有限公司新昌制药厂 孕甾－4－烯－7，21－二甲酸，9，11－环氧－17－羟基－3－氧代，γ－内酯，甲酯，(7α,11α,17α)－的制备方法
CA2774197A1 (en) * 2006-04-22 2008-04-03 Harbor Biosciences, Inc. Drugs and uses to modulate inflammation, metabolic disorders and other conditions
CA2649940C (en) * 2006-04-22 2012-08-07 Hollis-Eden Pharmaceuticals, Inc. Drugs and uses to modulate inflammation, metabolic disorders and other conditions
US8486926B2 (en) * 2006-11-17 2013-07-16 Harbor Therapeutics, Inc. Steroid tetrol solid state forms
US20080221074A1 (en) * 2006-11-17 2008-09-11 Jaime Flores-Riveros Drug Screen and Treatment Method
US8217025B2 (en) * 2006-11-17 2012-07-10 Harbor Therapeutics, Inc. Drug screening and treatment methods
US20080153792A1 (en) * 2006-11-17 2008-06-26 Frincke James M Drug Identification and Treatment Method
US8354396B2 (en) * 2006-11-17 2013-01-15 Harbor Therapeutics, Inc. Drug identification and treatment method
US8309746B2 (en) * 2008-06-06 2012-11-13 Harbor Therapeutics, Inc Methods for preparing 17-alkynyl-7-hydroxy steroids and related compounds
US20100227841A1 (en) * 2008-09-24 2010-09-09 Harbor BioSciencs, Inc. Patient populations and treatment methods
WO2010036822A1 (en) * 2008-09-24 2010-04-01 Hollis-Eden Pharmaceuticals, Inc. Patient populations and treatment methods
US20100222315A1 (en) * 2008-09-24 2010-09-02 Harbor BioSciencs, Inc. Patient populations and treatment methods
CN103087139B (zh) * 2011-11-08 2016-08-03 中国科学院上海药物研究所 一种坎利酮衍生物类甾体化合物、其制备方法及其在制备依普利酮中的用途
CN105753930A (zh) * 2016-03-30 2016-07-13 北京万全德众医药生物技术有限公司 依普利酮的一种合成方法
CN110698529A (zh) * 2019-11-19 2020-01-17 湖南新合新生物医药有限公司 一种依普利酮中间体△9,11烯酯的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069219A (en) * 1976-12-27 1978-01-17 G. D. Searle & Co. 7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters
FI77669C (fi) * 1983-04-13 1989-04-10 Ciba Geigy Ag 20-spiroxaner och analoger, som innehaoller en oeppen ring e, foerfarande foer deras framstaellning samt dessa innehaollande farmaceutiska preparat.
US5227375A (en) * 1990-02-08 1993-07-13 Endorecherche, Inc. Aromatase inhibitors
US5237064A (en) * 1992-05-20 1993-08-17 Merck & Co., Inc. Process for producing 7β-substituted-aza-5αandrostan-3-ones
ATE365171T1 (de) * 1995-12-11 2007-07-15 Searle Llc Verfahren zur herstellung einer epoxyverbindung
CA2273343C (en) * 1996-12-11 2006-10-10 G.D. Searle & Co. Processes for preparation of 9,11-epoxy steroids and intermediates useful therein
US6887991B1 (en) * 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
US6716829B2 (en) * 2000-07-27 2004-04-06 Pharmacia Corporation Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders

Also Published As

Publication number Publication date
RU2289586C2 (ru) 2006-12-20
WO2004043986A1 (en) 2004-05-27
ZA200502698B (en) 2006-07-26
RU2005117372A (ru) 2006-01-20
DE60312029D1 (de) 2007-04-05
CN1694896A (zh) 2005-11-09
JP2006508962A (ja) 2006-03-16
TW200407151A (en) 2004-05-16
KR20050084953A (ko) 2005-08-29
KR100667123B1 (ko) 2007-01-12
BR0316052A (pt) 2005-09-20
ATE354583T1 (de) 2007-03-15
US20040097475A1 (en) 2004-05-20
EP1562974A1 (en) 2005-08-17
TWI280133B (en) 2007-05-01
AU2003220139A1 (en) 2004-06-03
ES2280739T3 (es) 2007-09-16
MXPA05004024A (es) 2005-06-08
EP1562974B1 (en) 2007-02-21
PL376896A1 (pl) 2006-01-09
DE60312029T2 (de) 2007-06-21
CA2500580A1 (en) 2004-05-27
RS20050339A (sr) 2007-08-03

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