PL1888541T3 - Związki benzo[d]izoksazol-3-iloaminy i ich zastosowanie jako ligandów receptora waniloidowego - Google Patents
Związki benzo[d]izoksazol-3-iloaminy i ich zastosowanie jako ligandów receptora waniloidowegoInfo
- Publication number
- PL1888541T3 PL1888541T3 PL06742972T PL06742972T PL1888541T3 PL 1888541 T3 PL1888541 T3 PL 1888541T3 PL 06742972 T PL06742972 T PL 06742972T PL 06742972 T PL06742972 T PL 06742972T PL 1888541 T3 PL1888541 T3 PL 1888541T3
- Authority
- PL
- Poland
- Prior art keywords
- isoxazol
- benzo
- amine compounds
- receptor ligands
- vanilloid receptor
- Prior art date
Links
- NLMVYUBGWZWUGB-UHFFFAOYSA-N 1,2-benzoxazol-3-amine Chemical class C1=CC=C2C(N)=NOC2=C1 NLMVYUBGWZWUGB-UHFFFAOYSA-N 0.000 title abstract 2
- 102000011040 TRPV Cation Channels Human genes 0.000 title 1
- 108010062740 TRPV Cation Channels Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/12—Antidiarrhoeals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005023589 | 2005-05-18 | ||
| DE102005038947A DE102005038947A1 (de) | 2005-05-18 | 2005-08-16 | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
| EP06742972A EP1888541B1 (de) | 2005-05-18 | 2006-05-18 | Benzo (d) isoxazol-3-yl-amin- verbindungen und deren verwendung als vanilloid-rezeptor liganden |
| PCT/EP2006/004698 WO2006122799A1 (de) | 2005-05-18 | 2006-05-18 | Benzo (d) isoxazol-3-yl-amin- verbindungen und deren verwendung als vanilloid-rezeptor liganden |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1888541T3 true PL1888541T3 (pl) | 2010-01-29 |
Family
ID=36699120
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06753695T PL1881967T3 (pl) | 2005-05-18 | 2006-05-18 | Podstawione benzo[d]izoksazol-3-iloaminy jako środki przeciwbólowe |
| PL06742972T PL1888541T3 (pl) | 2005-05-18 | 2006-05-18 | Związki benzo[d]izoksazol-3-iloaminy i ich zastosowanie jako ligandów receptora waniloidowego |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06753695T PL1881967T3 (pl) | 2005-05-18 | 2006-05-18 | Podstawione benzo[d]izoksazol-3-iloaminy jako środki przeciwbólowe |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7977360B2 (pl) |
| EP (2) | EP1881967B1 (pl) |
| JP (2) | JP2008540597A (pl) |
| AT (2) | ATE466002T1 (pl) |
| AU (1) | AU2006249065B2 (pl) |
| CA (2) | CA2608386A1 (pl) |
| CY (2) | CY1109568T1 (pl) |
| DE (3) | DE102005038947A1 (pl) |
| DK (2) | DK1881967T3 (pl) |
| ES (2) | ES2344272T3 (pl) |
| PL (2) | PL1881967T3 (pl) |
| PT (2) | PT1888541E (pl) |
| RU (1) | RU2416607C2 (pl) |
| SI (2) | SI1881967T1 (pl) |
| WO (2) | WO2006122800A1 (pl) |
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| US8933236B2 (en) | 2012-05-22 | 2015-01-13 | Xenon Pharmaceuticals Inc. | N-substituted benzamides and methods of use thereof |
| DE102005038947A1 (de) * | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
| US20100080773A1 (en) | 2008-09-26 | 2010-04-01 | Sdg, Inc. | Orally Bioavailable Lipid-Based Constructs |
| CN101925575B (zh) | 2008-01-28 | 2014-06-18 | 株式会社爱茉莉太平洋 | 作为香草酸受体拮抗剂的化合物、其异构体或其药物学可接受的盐、及包含这些化合物的药物组合物 |
| WO2010002209A2 (en) | 2008-07-02 | 2010-01-07 | Amorepacific Corporation | Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist and pharmaceutical compositions containing the same |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| TWI504395B (zh) | 2009-03-10 | 2015-10-21 | Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier | |
| WO2010102778A2 (de) * | 2009-03-10 | 2010-09-16 | Grünenthal GmbH | Substituierte 3-aminoisoxazolopyridine als kcnq2/3 modulatoren |
| TW201038565A (en) | 2009-03-12 | 2010-11-01 | Gruenenthal Gmbh | Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators |
| TWI461197B (zh) | 2009-03-12 | 2014-11-21 | 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier | |
| CN102762572A (zh) | 2010-02-01 | 2012-10-31 | 诺瓦提斯公司 | 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物 |
| WO2011092293A2 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
| CN102753527B (zh) | 2010-02-02 | 2014-12-24 | 诺华股份有限公司 | 用作crf受体拮抗剂的环己基酰胺衍生物 |
| AU2011215645A1 (en) | 2010-02-11 | 2012-09-20 | Vanderbilt University | Benzisoxazoles and azabenzisoxazoles as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| AR082733A1 (es) | 2010-08-27 | 2012-12-26 | Gruenenthal Gmbh | 2-amino-quinolina-3-carboxamidas sustituidas como moduladores de kcnq2/3 |
| PE20140214A1 (es) | 2010-08-27 | 2014-02-19 | Gruenenthal Chemie | 2-oxo- y 2-tioxo-dihidroquinolina-3-carboxamidas sustituidos como moduladores kcnq2/3 |
| BR112013004562A2 (pt) | 2010-08-27 | 2016-09-06 | Gruenenthal Gmbh | 2-óxi-quinolina-3-carboxamidas substituídas como moduladores kcnq2/3 |
| AU2011297937B2 (en) | 2010-09-01 | 2015-10-01 | Grunenthal Gmbh | Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as KCNQ2/3 modulators |
| WO2013064984A1 (en) | 2011-10-31 | 2013-05-10 | Xenon Pharmaceuticals Inc. | Biaryl ether sulfonamides and their use as therapeutic agents |
| JP6014154B2 (ja) | 2011-10-31 | 2016-10-25 | ゼノン・ファーマシューティカルズ・インコーポレイテッドXenon Pharmaceuticals Inc. | ベンゼンスルホンアミド化合物および治療剤としてのそれらの使用 |
| BR112015000187A2 (pt) | 2012-07-06 | 2017-06-27 | Genentech Inc | benzamidas substituídas com n e métodos de uso das mesmas |
| KR20150131233A (ko) | 2013-03-14 | 2015-11-24 | 제넨테크, 인크. | 치환된 트리아졸로피리딘 및 이의 사용 방법 |
| US9493429B2 (en) | 2013-03-15 | 2016-11-15 | Genentech, Inc. | Substituted benzoxazoles and methods of use thereof |
| CR20160296A (es) | 2013-11-27 | 2016-09-20 | Genentech Inc | Benzamidas sustituidas y métodos para usarlas |
| HK1223358A1 (zh) * | 2013-12-20 | 2017-07-28 | 吉利德科学公司 | 作為離子通道調節劑的稠合雜環化合物 |
| WO2016007534A1 (en) | 2014-07-07 | 2016-01-14 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| AU2015302908B2 (en) | 2014-08-13 | 2020-02-13 | Auckland Uniservices Limited | Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy |
| US10183938B2 (en) | 2014-12-16 | 2019-01-22 | Axovant Sciences Gmbh | Geminal substituted quinuclidine amide compounds as agonists of α-7 nicotonic acetylcholine receptors |
| WO2016096709A1 (en) * | 2014-12-16 | 2016-06-23 | Eudendron S.R.L. | Heterocyclic derivatives modulating activity of certain protein kinases |
| EP3297989A1 (en) | 2015-05-22 | 2018-03-28 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| JP2018516973A (ja) | 2015-06-10 | 2018-06-28 | フォーラム・ファーマシューティカルズ・インコーポレイテッドForum Pharmaceuticals Inc. | α7−ニコチン性アセチルコリン受容体のアゴニストとしてのアミノベンゾイソオキサゾール化合物 |
| EP3334740A4 (en) * | 2015-08-12 | 2019-02-06 | Axovant Sciences GmbH | GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF ALPHA 7-NICOTINIC ACETYLCHOLINE RECEPTORS |
| CN108137477A (zh) | 2015-08-27 | 2018-06-08 | 基因泰克公司 | 治疗化合物及其使用方法 |
| AU2016312848A1 (en) | 2015-08-27 | 2018-03-29 | Auckland Uniservices Limited | Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy |
| CN108290881B (zh) | 2015-09-28 | 2021-12-07 | 健泰科生物技术公司 | 治疗性化合物和其使用方法 |
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| US10766858B2 (en) | 2016-03-30 | 2020-09-08 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| MX388175B (es) | 2016-10-17 | 2025-03-19 | Genentech Inc | Compuestos terapéuticos y métodos para utilizarlos |
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| CN112041313A (zh) | 2018-02-26 | 2020-12-04 | 基因泰克公司 | 吡啶-磺酰胺化合物及其针对疼痛和相关疾患的用途 |
| JP2021519788A (ja) | 2018-03-30 | 2021-08-12 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ナトリウムチャネル阻害剤としての縮合環ヒドロピリド化合物 |
| TW202003490A (zh) | 2018-05-22 | 2020-01-16 | 瑞士商赫孚孟拉羅股份公司 | 治療性化合物及其使用方法 |
| GB201810092D0 (en) | 2018-06-20 | 2018-08-08 | Ctxt Pty Ltd | Compounds |
| GB201810581D0 (en) | 2018-06-28 | 2018-08-15 | Ctxt Pty Ltd | Compounds |
| IL288802B2 (en) | 2019-06-18 | 2025-08-01 | Pfizer | Benzisoxazole sulfonamide derivatives |
| JP7788377B2 (ja) | 2019-12-04 | 2025-12-18 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 殺有害生物的に活性な縮合二環式芳香族複素環式アミノ化合物 |
| TW202136239A (zh) * | 2019-12-31 | 2021-10-01 | 美商Ifm Due有限公司 | 用於治療與sting活性相關之病狀的化合物及組合物 |
| JP2023513047A (ja) | 2020-01-30 | 2023-03-30 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 殺有害生物的に有効な縮合二環式芳香族複素環式アミノ化合物 |
| CN112142683B (zh) * | 2020-09-01 | 2022-05-24 | 成都大学 | 一种氮杂十一元环化合物及其制备方法、用途以及包含该化合物的药物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE126512T1 (de) * | 1989-05-19 | 1995-09-15 | Hoechst Roussel Pharma | N-(aryloxyalkyl)heteroarylpiperidine und - heteroarylpiperazine, verfahren zu ihrer herstellung und ihre verwendung als medikamente. |
| FI934223L (fi) * | 1991-03-28 | 1993-09-27 | Pfizer | Heterocykliscykliska aminderivat |
| US5328920A (en) * | 1991-04-17 | 1994-07-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted (pyridinylamino)-indoles |
| ES2187518T3 (es) * | 1992-11-23 | 2003-06-16 | Aventis Pharma Inc | 3-(aminoalquilamino)-1-2-benzisoxazoles sustituidos y compuestos relacionados. |
| US5494908A (en) * | 1992-11-23 | 1996-02-27 | Hoechst-Roussel Pharmaceutical Incorporated | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds |
| ES2157442T3 (es) * | 1995-06-06 | 2001-08-16 | Aventis Pharma Inc | Derivados de benzoisoxazol y de indazol, utilizados como agentes neurolepticos. |
| EP1119570B1 (en) * | 1998-10-06 | 2004-06-16 | Janssen Pharmaceutica N.V. | Tricyclic delta3-piperidines as pharmaceuticals |
| WO2000027627A1 (en) * | 1998-11-12 | 2000-05-18 | Eli Lilly And Company | Aryloxime linkers in the solid-phase synthesis of 3-aminobenzisoxazoles |
| WO2000027199A1 (en) * | 1998-11-12 | 2000-05-18 | Eli Lilly And Company | Aminobenzisoxazole compounds and libraries thereof |
| ATE268766T1 (de) * | 1999-07-16 | 2004-06-15 | Bristol Myers Squibb Pharma Co | Stickstoff enthaltende heterobicyclen als factor xa inhibitoren |
| WO2001087845A2 (en) * | 2000-05-15 | 2001-11-22 | Fujisawa Pharmaceutical Co., Ltd. | N-containing heterocyclic compounds and their use as 5-ht antagonists |
| HUP0303841A2 (hu) * | 2001-02-20 | 2004-03-01 | Bristol-Myers Squibb Company | 2,4-Diszubsztituált-5-pirimidinkarboxamid-származékok mint KCNQ káliumcsatorna modulátorok és ezeket tartalmazó gyógyszerkészítmények és előállításuk |
| US6469042B1 (en) * | 2001-02-20 | 2002-10-22 | Bristol-Myers Squibb Company | Fluoro oxindole derivatives as modulators if KCNQ potassium channels |
| MXPA03007397A (es) | 2001-02-20 | 2003-12-04 | Bristol Myers Squibb Co | Moduladores de canales de potasio kcnq y uso de los mismos en tratamiento de migrana y enfermedades mecanicamente relacionadas. |
| US6593349B2 (en) * | 2001-03-19 | 2003-07-15 | Icagen, Inc. | Bisarylamines as potassium channel openers |
| KR100789567B1 (ko) * | 2001-11-06 | 2007-12-28 | 동화약품공업주식회사 | 3-아미도-1,2-벤조이소옥사졸 유도체, 그 염, 제조방법 및 용도 |
| DE10229070A1 (de) * | 2002-06-28 | 2004-01-15 | Merck Patent Gmbh | Phenylderivate 5 |
| GB0217757D0 (en) * | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
| JO2696B1 (en) * | 2002-12-23 | 2013-03-03 | شركة جانسين فارماسوتيكا ان. في | Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists |
| PL1638941T3 (pl) * | 2003-05-22 | 2010-11-30 | Abbvie Bahamas Ltd | Indazolowe, benzizoksazolowe i benzizotiazolowe inhibitory kinaz |
| GB0319150D0 (en) | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Novel compounds |
| EP1746991A2 (en) * | 2004-03-16 | 2007-01-31 | Janssen Pharmaceutica N.V. | Daao inhibiting benzisoxazoles for treating mental disorders |
| US7759337B2 (en) * | 2005-03-03 | 2010-07-20 | Amgen Inc. | Phthalazine compounds and methods of use |
| DE102005038947A1 (de) * | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
| DE102005026194A1 (de) * | 2005-06-06 | 2006-12-07 | Grünenthal GmbH | Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln |
| US7989461B2 (en) * | 2005-12-23 | 2011-08-02 | Amgen Inc. | Substituted quinazolinamine compounds for the treatment of cancer |
-
2005
- 2005-08-16 DE DE102005038947A patent/DE102005038947A1/de not_active Withdrawn
-
2006
- 2006-05-18 US US11/914,636 patent/US7977360B2/en not_active Expired - Fee Related
- 2006-05-18 AT AT06753695T patent/ATE466002T1/de active
- 2006-05-18 CA CA002608386A patent/CA2608386A1/en not_active Abandoned
- 2006-05-18 ES ES06753695T patent/ES2344272T3/es active Active
- 2006-05-18 PL PL06753695T patent/PL1881967T3/pl unknown
- 2006-05-18 AT AT06742972T patent/ATE438633T1/de active
- 2006-05-18 JP JP2008511637A patent/JP2008540597A/ja not_active Ceased
- 2006-05-18 PT PT06742972T patent/PT1888541E/pt unknown
- 2006-05-18 AU AU2006249065A patent/AU2006249065B2/en not_active Ceased
- 2006-05-18 JP JP2008511638A patent/JP2008540598A/ja not_active Ceased
- 2006-05-18 DE DE502006004453T patent/DE502006004453D1/de active Active
- 2006-05-18 CA CA002608773A patent/CA2608773A1/en not_active Abandoned
- 2006-05-18 RU RU2007146385/04A patent/RU2416607C2/ru not_active IP Right Cessation
- 2006-05-18 DE DE502006006854T patent/DE502006006854D1/de active Active
- 2006-05-18 EP EP06753695A patent/EP1881967B1/de not_active Not-in-force
- 2006-05-18 DK DK06753695.3T patent/DK1881967T3/da active
- 2006-05-18 DK DK06742972T patent/DK1888541T3/da active
- 2006-05-18 WO PCT/EP2006/004700 patent/WO2006122800A1/de not_active Ceased
- 2006-05-18 PL PL06742972T patent/PL1888541T3/pl unknown
- 2006-05-18 ES ES06742972T patent/ES2331259T3/es active Active
- 2006-05-18 PT PT06753695T patent/PT1881967E/pt unknown
- 2006-05-18 SI SI200630725T patent/SI1881967T1/sl unknown
- 2006-05-18 WO PCT/EP2006/004698 patent/WO2006122799A1/de not_active Ceased
- 2006-05-18 SI SI200630455T patent/SI1888541T1/sl unknown
- 2006-05-18 EP EP06742972A patent/EP1888541B1/de not_active Not-in-force
-
2007
- 2007-11-16 US US11/941,331 patent/US7696238B2/en not_active Expired - Fee Related
-
2009
- 2009-11-05 CY CY20091101144T patent/CY1109568T1/el unknown
-
2010
- 2010-07-15 CY CY20101100664T patent/CY1110209T1/el unknown
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