JPS5517349A - Production of diterpene derivative - Google Patents
Production of diterpene derivativeInfo
- Publication number
- JPS5517349A JPS5517349A JP9021078A JP9021078A JPS5517349A JP S5517349 A JPS5517349 A JP S5517349A JP 9021078 A JP9021078 A JP 9021078A JP 9021078 A JP9021078 A JP 9021078A JP S5517349 A JPS5517349 A JP S5517349A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- methanol
- nitration
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: Title compound useful as a synthetic intermediate of various kinds of sesquiterpene is readily and inexpensively obtained by the diazotization of 7-oxo-13- amino-derivative in methanol.
CONSTITUTION: A compound of formula (2) is dissolved in a large amount of methanol and the solution is acidified by adding sulfuric acid or the like. Then, sodium nitrite is added and the reaction is effected at room temperature. The methanol is distilled off to 1/4 volume. Water is added to the residue and the mixture is extracted with benzene to give compounds of formula I, II and III. The starting compound of formula (2) is produced by the reduction of l-abietic acid (1) with lithium-aluminum hydride, then nitration with fuming nitric acid-conc. sulfuric acid, and further reduction. Or the nitration of a compound of formula III gives a compound of formula (3), which is subsequently reduced to give the compound of formula (2).
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9021078A JPS5517349A (en) | 1978-07-24 | 1978-07-24 | Production of diterpene derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9021078A JPS5517349A (en) | 1978-07-24 | 1978-07-24 | Production of diterpene derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5517349A true JPS5517349A (en) | 1980-02-06 |
JPS5653295B2 JPS5653295B2 (en) | 1981-12-17 |
Family
ID=13992113
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9021078A Granted JPS5517349A (en) | 1978-07-24 | 1978-07-24 | Production of diterpene derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5517349A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7087751B2 (en) | 2001-01-18 | 2006-08-08 | Schering Corporation | Synthesis of temozolomide and analogs |
CN103613490A (en) * | 2013-12-11 | 2014-03-05 | 中国科学院烟台海岸带研究所 | Drop diterpenoid type compound as well as preparation method and application thereof |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58174794U (en) * | 1982-05-18 | 1983-11-22 | ホーチキ株式会社 | photoelectric smoke detector |
JPS6010393U (en) * | 1983-07-01 | 1985-01-24 | ホーチキ株式会社 | Structure of smoke detection part of scattered light smoke detector |
JPS60148688U (en) * | 1984-03-09 | 1985-10-02 | ホーチキ株式会社 | Scattered light smoke detector |
JPS6155787U (en) * | 1984-09-19 | 1986-04-15 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS49116051A (en) * | 1973-03-12 | 1974-11-06 | ||
JPS5324069A (en) * | 1976-08-18 | 1978-03-06 | Okura Kikai Kk | Peeling apparatus for food material |
-
1978
- 1978-07-24 JP JP9021078A patent/JPS5517349A/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS49116051A (en) * | 1973-03-12 | 1974-11-06 | ||
JPS5324069A (en) * | 1976-08-18 | 1978-03-06 | Okura Kikai Kk | Peeling apparatus for food material |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7087751B2 (en) | 2001-01-18 | 2006-08-08 | Schering Corporation | Synthesis of temozolomide and analogs |
US7446209B2 (en) | 2001-01-18 | 2008-11-04 | Schering Corporation | Synthesis of temozolomide and analogs |
CN103613490A (en) * | 2013-12-11 | 2014-03-05 | 中国科学院烟台海岸带研究所 | Drop diterpenoid type compound as well as preparation method and application thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS5653295B2 (en) | 1981-12-17 |
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