JPS54130598A - Preparation of 1,2-dihydro-3h-pyrrolo3,2-eindole derivative - Google Patents

Preparation of 1,2-dihydro-3h-pyrrolo3,2-eindole derivative

Info

Publication number
JPS54130598A
JPS54130598A JP3675378A JP3675378A JPS54130598A JP S54130598 A JPS54130598 A JP S54130598A JP 3675378 A JP3675378 A JP 3675378A JP 3675378 A JP3675378 A JP 3675378A JP S54130598 A JPS54130598 A JP S54130598A
Authority
JP
Japan
Prior art keywords
compound
dihydro
derivative
converting
eindole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3675378A
Other languages
Japanese (ja)
Other versions
JPS6259703B2 (en
Inventor
Kiyoaki Niuchi
Nobuo Kawamoto
Yoshinori Tanaka
Hideo Yamazaki
Kazuo Akihiro
Hamao Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP3675378A priority Critical patent/JPS54130598A/en
Publication of JPS54130598A publication Critical patent/JPS54130598A/en
Publication of JPS6259703B2 publication Critical patent/JPS6259703B2/ja
Granted legal-status Critical Current

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  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PURPOSE: To prepare 3-carbamoly-1,2-dihydro-4-hydroxy-5-methoxy-3H-[3,2-e] indole-7-carboxylic acid useful as an enzyme inhibitor, by chemical synthesis.
CONSTITUTION: The objective compound VIII is prepared by (1) protecting the 7- position OH group of compound I to obtain compound II; (2) converting the compound II to compound III by alkali hydrolysis; (3) converting the 1-position of the compound III to afford compound IV; (4) hydrogenating the compound IV; (5) converting the resulting compound V to compound VI by diazotization and reaction with ethyl-2-acetylpropionate; (6) cyclizing the compound VI to compound VII which is a derivative of 1,2-dihydro-3H-pyrrolo[3,2-e]indole; and finally (7) hydrolyzing the compound VII.
COPYRIGHT: (C)1979,JPO&Japio
JP3675378A 1978-03-31 1978-03-31 Preparation of 1,2-dihydro-3h-pyrrolo3,2-eindole derivative Granted JPS54130598A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3675378A JPS54130598A (en) 1978-03-31 1978-03-31 Preparation of 1,2-dihydro-3h-pyrrolo3,2-eindole derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3675378A JPS54130598A (en) 1978-03-31 1978-03-31 Preparation of 1,2-dihydro-3h-pyrrolo3,2-eindole derivative

Publications (2)

Publication Number Publication Date
JPS54130598A true JPS54130598A (en) 1979-10-09
JPS6259703B2 JPS6259703B2 (en) 1987-12-12

Family

ID=12478488

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3675378A Granted JPS54130598A (en) 1978-03-31 1978-03-31 Preparation of 1,2-dihydro-3h-pyrrolo3,2-eindole derivative

Country Status (1)

Country Link
JP (1) JPS54130598A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087751B2 (en) 2001-01-18 2006-08-08 Schering Corporation Synthesis of temozolomide and analogs

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087751B2 (en) 2001-01-18 2006-08-08 Schering Corporation Synthesis of temozolomide and analogs
US7446209B2 (en) 2001-01-18 2008-11-04 Schering Corporation Synthesis of temozolomide and analogs

Also Published As

Publication number Publication date
JPS6259703B2 (en) 1987-12-12

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