JPS54130597A - Preparation of 1,2-dihydro-3h-pyrrolo3,2-eindole derivative - Google Patents

Preparation of 1,2-dihydro-3h-pyrrolo3,2-eindole derivative

Info

Publication number
JPS54130597A
JPS54130597A JP3675278A JP3675278A JPS54130597A JP S54130597 A JPS54130597 A JP S54130597A JP 3675278 A JP3675278 A JP 3675278A JP 3675278 A JP3675278 A JP 3675278A JP S54130597 A JPS54130597 A JP S54130597A
Authority
JP
Japan
Prior art keywords
compound
dihydro
pyrrolo
methoxy
eindole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3675278A
Other languages
Japanese (ja)
Other versions
JPS6259108B2 (en
Inventor
Kiyoaki Niuchi
Nobuo Kawamoto
Yoshinori Tanaka
Hideo Yamazaki
Kazuo Akihiro
Hamao Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP3675278A priority Critical patent/JPS54130597A/en
Publication of JPS54130597A publication Critical patent/JPS54130597A/en
Publication of JPS6259108B2 publication Critical patent/JPS6259108B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PURPOSE: To prepare 3-acetyl-1,2-dihydro-4-hydroxy-5-methoxy-3H-pyrrolo[3,2-e] indole-7-carboxylic acid having phosphodiesterase-inhibiting activity, by chemical process.
CONSTITUTION: The objective compound is prepared by (1) reducing 6-methoxy- 1H-indol-7-ole (compound I) to compound II in the presence of a catalyst; (2) subjecting the compound II to acetylation reaction; (3) converting the resulting compound III to compound IV by nitration; (4) partially hydrolyzing the compound IV to afford compound V; (5) reducing the compund V to an amino compound VI; (6) reacting the compound VI with ethyl-2-acetyl propionate; (7) cyclizing the side chain of the resulting compound VII to obtain 1, 2-dihydro-3H-pyrrolo[3,2-e] indole derivative VIII; and finally (8) hydrolyzing the compound VIII.
COPYRIGHT: (C)1979,JPO&Japio
JP3675278A 1978-03-31 1978-03-31 Preparation of 1,2-dihydro-3h-pyrrolo3,2-eindole derivative Granted JPS54130597A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3675278A JPS54130597A (en) 1978-03-31 1978-03-31 Preparation of 1,2-dihydro-3h-pyrrolo3,2-eindole derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3675278A JPS54130597A (en) 1978-03-31 1978-03-31 Preparation of 1,2-dihydro-3h-pyrrolo3,2-eindole derivative

Publications (2)

Publication Number Publication Date
JPS54130597A true JPS54130597A (en) 1979-10-09
JPS6259108B2 JPS6259108B2 (en) 1987-12-09

Family

ID=12478458

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3675278A Granted JPS54130597A (en) 1978-03-31 1978-03-31 Preparation of 1,2-dihydro-3h-pyrrolo3,2-eindole derivative

Country Status (1)

Country Link
JP (1) JPS54130597A (en)

Also Published As

Publication number Publication date
JPS6259108B2 (en) 1987-12-09

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