JPS54130597A - Preparation of 1,2-dihydro-3h-pyrrolo3,2-eindole derivative - Google Patents
Preparation of 1,2-dihydro-3h-pyrrolo3,2-eindole derivativeInfo
- Publication number
- JPS54130597A JPS54130597A JP3675278A JP3675278A JPS54130597A JP S54130597 A JPS54130597 A JP S54130597A JP 3675278 A JP3675278 A JP 3675278A JP 3675278 A JP3675278 A JP 3675278A JP S54130597 A JPS54130597 A JP S54130597A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- dihydro
- pyrrolo
- methoxy
- eindole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PURPOSE: To prepare 3-acetyl-1,2-dihydro-4-hydroxy-5-methoxy-3H-pyrrolo[3,2-e] indole-7-carboxylic acid having phosphodiesterase-inhibiting activity, by chemical process.
CONSTITUTION: The objective compound is prepared by (1) reducing 6-methoxy- 1H-indol-7-ole (compound I) to compound II in the presence of a catalyst; (2) subjecting the compound II to acetylation reaction; (3) converting the resulting compound III to compound IV by nitration; (4) partially hydrolyzing the compound IV to afford compound V; (5) reducing the compund V to an amino compound VI; (6) reacting the compound VI with ethyl-2-acetyl propionate; (7) cyclizing the side chain of the resulting compound VII to obtain 1, 2-dihydro-3H-pyrrolo[3,2-e] indole derivative VIII; and finally (8) hydrolyzing the compound VIII.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3675278A JPS54130597A (en) | 1978-03-31 | 1978-03-31 | Preparation of 1,2-dihydro-3h-pyrrolo3,2-eindole derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3675278A JPS54130597A (en) | 1978-03-31 | 1978-03-31 | Preparation of 1,2-dihydro-3h-pyrrolo3,2-eindole derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54130597A true JPS54130597A (en) | 1979-10-09 |
JPS6259108B2 JPS6259108B2 (en) | 1987-12-09 |
Family
ID=12478458
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3675278A Granted JPS54130597A (en) | 1978-03-31 | 1978-03-31 | Preparation of 1,2-dihydro-3h-pyrrolo3,2-eindole derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54130597A (en) |
-
1978
- 1978-03-31 JP JP3675278A patent/JPS54130597A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6259108B2 (en) | 1987-12-09 |
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