AR035419A1 - Un proceso para preparar compuestos imidazo-tetrazin-4-ona, compuestos intermediarios, sales de adicion de acidos, un proceso para preparar la temozolomida, un proceso para preparar intermediarios - Google Patents

Un proceso para preparar compuestos imidazo-tetrazin-4-ona, compuestos intermediarios, sales de adicion de acidos, un proceso para preparar la temozolomida, un proceso para preparar intermediarios

Info

Publication number
AR035419A1
AR035419A1 ARP020100140A ARP020100140A AR035419A1 AR 035419 A1 AR035419 A1 AR 035419A1 AR P020100140 A ARP020100140 A AR P020100140A AR P020100140 A ARP020100140 A AR P020100140A AR 035419 A1 AR035419 A1 AR 035419A1
Authority
AR
Argentina
Prior art keywords
prepare
temozolomide
compounds
tetrazin
imidazo
Prior art date
Application number
ARP020100140A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AR035419A1 publication Critical patent/AR035419A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/28—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un proceso para la preparación de un compuesto imidazo-tetrazin-4-ona de la fórmula (1) en la cual R es un grupo alquilo C1-6, que comprende: (a) diazotar un compuesto de la fórmula (2) en la cual R es como se lo definiera anteriormente; y Pg'' es un grupo protector divalente que puede ser fácilmente separado por hidrólisis o hidrogenólisis, o bien dos grupos protectores Pg monovalentes que pueden ser fácilmente separados por hidrólisis o hidrogenólisis, o un grupo protector monovalente voluminoso Pg que puede ser fácilmente separado por hidrólisis o hidrogenólisis, junto con un átomo de hidrógeno; y luego (b) someter al compuesto así obtenido, de la fórmula (3); compuestos intermediarios, sales de adición de ácidos, un proceso para preparar la temozolomida, proceso para preparar intermediarios, la síntesis de la Temozolomida, un compuesto antitumoral, así como sus análogos, e intermediarios útiles en este proceso.
ARP020100140A 2001-01-18 2002-01-16 Un proceso para preparar compuestos imidazo-tetrazin-4-ona, compuestos intermediarios, sales de adicion de acidos, un proceso para preparar la temozolomida, un proceso para preparar intermediarios AR035419A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26246501P 2001-01-18 2001-01-18

Publications (1)

Publication Number Publication Date
AR035419A1 true AR035419A1 (es) 2004-05-26

Family

ID=22997631

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020100140A AR035419A1 (es) 2001-01-18 2002-01-16 Un proceso para preparar compuestos imidazo-tetrazin-4-ona, compuestos intermediarios, sales de adicion de acidos, un proceso para preparar la temozolomida, un proceso para preparar intermediarios

Country Status (9)

Country Link
US (4) US7087751B2 (es)
EP (1) EP1353924A1 (es)
JP (2) JP4358510B2 (es)
CN (4) CN101220033A (es)
AR (1) AR035419A1 (es)
CA (1) CA2434308C (es)
MX (1) MXPA03006403A (es)
SG (1) SG144736A1 (es)
WO (1) WO2002057269A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005063757A2 (en) 2003-12-30 2005-07-14 Chemagis Ltd. Novel crystalline forms of temozolomide
DE102006007309B4 (de) * 2005-02-17 2012-11-29 Chemagis Ltd. Verbessertes Verfahren zur Herstellung von Temozolomid
CN1300143C (zh) * 2005-04-08 2007-02-14 江苏天士力帝益药业有限公司 替莫唑胺的精制方法
US20060222792A1 (en) * 2006-04-21 2006-10-05 Chemagis Ltd. Temozolomide storage system
ZA200901970B (en) 2006-09-29 2010-01-27 Cipla Ltd An improved process for the preparation of temozolomide and analogs
PE20091101A1 (es) 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
EP2151442A3 (en) * 2008-08-07 2011-04-06 Chemi SPA Process for preparing temozolomide
WO2010091198A1 (en) 2009-02-06 2010-08-12 University Of Southern California Therapeutic compositions comprising monoterpenes
WO2010140168A1 (en) * 2009-06-03 2010-12-09 Ind-Swift Laboratories Limited Improved process for preparing temozolomide
PL2445915T3 (pl) 2009-06-23 2016-10-31 Związki 3-podstawionego-8-podstawionego-3H imidazo[5,1-d][1,2,3,5 tetrazyn]-4-onu i ich zastosowanie
WO2011036676A2 (en) 2009-09-23 2011-03-31 Ashwini Nangia Stable cocrystals of temozolomide
EP2542553A1 (en) 2010-03-01 2013-01-09 Pharminox Ltd Methods and intermediates for the synthesis of 4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazines
CN102070639B (zh) * 2010-12-21 2012-10-10 中南大学 一种替莫唑胺的合成方法
CN102659789B (zh) * 2011-04-27 2014-10-15 四川科瑞德凯华制药有限公司 一锅法制备替莫唑胺的方法及替莫唑胺的精制方法
SI3532059T1 (sl) 2016-10-27 2022-06-30 Celgene Quanticel Research, Inc. Kombinacijska terapija z bromodomeno in ekstra terminalnim inhibitorskim proteinom
WO2020194168A1 (en) * 2019-03-25 2020-10-01 Shivalik Rasayan Limited Process for preparing highly pure temozolomide
CN111233871B (zh) * 2020-03-17 2021-11-12 江苏美迪克化学品有限公司 一种替莫唑胺的制备方法
US11597731B2 (en) 2021-07-17 2023-03-07 Shivalik Rasayan Limited Process for preparing highly pure temozolomide
JP2023043987A (ja) 2021-09-17 2023-03-30 キオクシア株式会社 基板処理装置及び基板処理方法

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JPS582229B2 (ja) 1977-04-11 1983-01-14 住友化学工業株式会社 グリシンエステルの製法
JPS5920665B2 (ja) 1977-07-06 1984-05-15 住友化学工業株式会社 フエニルヒドラジンの精製方法
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Also Published As

Publication number Publication date
US20060229456A1 (en) 2006-10-12
US7087751B2 (en) 2006-08-08
SG144736A1 (en) 2008-08-28
MXPA03006403A (es) 2003-10-15
US20050131227A1 (en) 2005-06-16
CN101195589A (zh) 2008-06-11
US7446209B2 (en) 2008-11-04
CN1269819C (zh) 2006-08-16
CN100372852C (zh) 2008-03-05
CN1487941A (zh) 2004-04-07
JP2004518673A (ja) 2004-06-24
EP1353924A1 (en) 2003-10-22
CA2434308C (en) 2010-09-21
CA2434308A1 (en) 2002-07-25
US20020095036A1 (en) 2002-07-18
US20090023919A1 (en) 2009-01-22
WO2002057269A1 (en) 2002-07-25
US7737284B2 (en) 2010-06-15
JP4358510B2 (ja) 2009-11-04
CN1800184A (zh) 2006-07-12
JP2009024025A (ja) 2009-02-05
CN101220033A (zh) 2008-07-16

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