EP2151442A3 - Process for preparing temozolomide - Google Patents

Process for preparing temozolomide Download PDF

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Publication number
EP2151442A3
EP2151442A3 EP09166077A EP09166077A EP2151442A3 EP 2151442 A3 EP2151442 A3 EP 2151442A3 EP 09166077 A EP09166077 A EP 09166077A EP 09166077 A EP09166077 A EP 09166077A EP 2151442 A3 EP2151442 A3 EP 2151442A3
Authority
EP
European Patent Office
Prior art keywords
temozolomide
aminoimidazole
carboxamide
reaction
preparing temozolomide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09166077A
Other languages
German (de)
French (fr)
Other versions
EP2151442A2 (en
Inventor
Stefano Turchetta
Lorenzo De Ferra
Maurizio Zenoni
Mauro Anibaldi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemi SpA
Original Assignee
Chemi SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemi SpA filed Critical Chemi SpA
Priority to EP09166077A priority Critical patent/EP2151442A3/en
Publication of EP2151442A2 publication Critical patent/EP2151442A2/en
Publication of EP2151442A3 publication Critical patent/EP2151442A3/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Described is a new process for producing temozolomide, comprising the reaction between 5-aminoimidazole-4-carboxamide and N-succinimidyl-N'-methyl carbamate and the subsequent reaction of the thus obtained carbamoyl 5-aminoimidazole-4-carboxamide with sodium nitrite. Temozolomide is then purified by chromatography on adsorbent polymeric resin and subsequent crystallization from water and acetone.
EP09166077A 2008-08-07 2009-07-22 Process for preparing temozolomide Withdrawn EP2151442A3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09166077A EP2151442A3 (en) 2008-08-07 2009-07-22 Process for preparing temozolomide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08425547 2008-08-07
EP09166077A EP2151442A3 (en) 2008-08-07 2009-07-22 Process for preparing temozolomide

Publications (2)

Publication Number Publication Date
EP2151442A2 EP2151442A2 (en) 2010-02-10
EP2151442A3 true EP2151442A3 (en) 2011-04-06

Family

ID=41278211

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09166077A Withdrawn EP2151442A3 (en) 2008-08-07 2009-07-22 Process for preparing temozolomide

Country Status (2)

Country Link
US (1) US8232392B2 (en)
EP (1) EP2151442A3 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102285991A (en) * 2011-07-20 2011-12-21 江苏奥赛康药业股份有限公司 Method for refining temozolomide
CN103626772B (en) * 2012-08-24 2016-08-17 国药一心制药有限公司 A kind of Temozolomide and the synthetic method of intermediate
RU2669777C2 (en) 2013-10-29 2018-10-16 Цзянсу Тасли Дии Фармасьютикал Ко., Лтд. Crystalline forms of temozolomide and method for preparing same
GB201401198D0 (en) 2014-01-24 2014-03-12 Bial Portela & Ca Sa Process for the syntheis of substituted urea compounds
CN110177792B (en) * 2016-12-20 2022-03-04 克里斯泰利亚化学药物产品有限公司 Process for preparing temozolomide and intermediates
WO2018122724A1 (en) * 2016-12-27 2018-07-05 Granules India Limited Temozolomide process
CN109467534A (en) * 2017-09-07 2019-03-15 湖北半天制药有限公司 A kind of synthetic method of Temozolomide intermediate
US11597731B2 (en) 2021-07-17 2023-03-07 Shivalik Rasayan Limited Process for preparing highly pure temozolomide
AR127856A1 (en) * 2021-12-06 2024-03-06 Cristalia Produtos Quim Farmaceuticos Ltda PROCESS FOR THE PREPARATION OF TEMOZOLOMIDE

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008038031A1 (en) * 2006-09-29 2008-04-03 Cipla Limited An improved process for the preparation of temozolomide and analogs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260291A (en) 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
MXPA03006402A (en) 2001-01-18 2003-10-15 Schering Corp Synthesis of temozolomide and analogs.
MXPA03006403A (en) * 2001-01-18 2003-10-15 Schering Corp Synthesis of temozolomide and analogs.
DE102006007309B4 (en) 2005-02-17 2012-11-29 Chemagis Ltd. Improved process for the preparation of temozolomide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008038031A1 (en) * 2006-09-29 2008-04-03 Cipla Limited An improved process for the preparation of temozolomide and analogs

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GALLANT, G. ET AL, ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, vol. 2, no. 5, 1991, pages 313 - 319, XP008127357 *
WANG Y ET AL: "ANTITUMOR IMIDAZOTETRAZINES. 35. NEW SYNTHETIC ROUTES TO THE ANTITUMOR DRUG TEMOZOLOMIDE", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON.; US LNKD- DOI:10.1021/JO970802L, vol. 62, 1997, pages 7288 - 7294, XP001069488, ISSN: 0022-3263 *
WANG Y ET AL: "Synthesis and antibacterial activity of dual-action agents of a beta-lactam antibiotic with cytotoxic agent mitozolomide or temozolomide", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR LNKD- DOI:10.1016/S0223-5234(01)01331-9, vol. 37, no. 4, 1 April 2002 (2002-04-01), pages 323 - 332, XP004372947, ISSN: 0223-5234 *

Also Published As

Publication number Publication date
US8232392B2 (en) 2012-07-31
US20100036121A1 (en) 2010-02-11
EP2151442A2 (en) 2010-02-10

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