WO2008136394A1 - Method for production of lactam compound, and intermediate for the production method - Google Patents

Method for production of lactam compound, and intermediate for the production method Download PDF

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Publication number
WO2008136394A1
WO2008136394A1 PCT/JP2008/058038 JP2008058038W WO2008136394A1 WO 2008136394 A1 WO2008136394 A1 WO 2008136394A1 JP 2008058038 W JP2008058038 W JP 2008058038W WO 2008136394 A1 WO2008136394 A1 WO 2008136394A1
Authority
WO
WIPO (PCT)
Prior art keywords
production
lactam compound
producing
therapeutic agent
production method
Prior art date
Application number
PCT/JP2008/058038
Other languages
French (fr)
Japanese (ja)
Inventor
Kouji Haga
Nobuhiro Yamanaka
Tsuyoshi Mita
Shigeo Hirasawa
Akinori Tatara
Junko Yamanaka
Kotaro Okado
Seiji Niwa
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2007/059545 external-priority patent/WO2008139576A1/en
Priority claimed from PCT/JP2007/059540 external-priority patent/WO2008139574A1/en
Priority claimed from PCT/JP2007/059544 external-priority patent/WO2008139575A1/en
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Publication of WO2008136394A1 publication Critical patent/WO2008136394A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Disclosed are: a novel method for producing a lactam compound; and an intermediate for use in the production method. Specifically disclosed are: a simple method for producing a lactam compound that can be used as a therapeutic agent for diabetes or as an intermediate for the production of the therapeutic agent, which can be conducted under mild and safe conditions; and an intermediate which is useful for the production method.
PCT/JP2008/058038 2007-04-27 2008-04-25 Method for production of lactam compound, and intermediate for the production method WO2008136394A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JPPCT/JP2007/059545 2007-04-27
PCT/JP2007/059545 WO2008139576A1 (en) 2007-04-27 2007-04-27 Method for producing lactam compound and production intermediate thereof
PCT/JP2007/059540 WO2008139574A1 (en) 2007-04-27 2007-04-27 Crystalline form of lactam compound and process for producing the same
JPPCT/JP2007/059540 2007-04-27
JPPCT/JP2007/059544 2007-04-27
PCT/JP2007/059544 WO2008139575A1 (en) 2007-04-27 2007-04-27 Preparation for oral administration

Publications (1)

Publication Number Publication Date
WO2008136394A1 true WO2008136394A1 (en) 2008-11-13

Family

ID=39943501

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/JP2008/058037 WO2008136393A1 (en) 2007-04-27 2008-04-25 Crystal of lactam compound, and method for production thereof
PCT/JP2008/058036 WO2008136392A1 (en) 2007-04-27 2008-04-25 Preparation for oral administration
PCT/JP2008/058038 WO2008136394A1 (en) 2007-04-27 2008-04-25 Method for production of lactam compound, and intermediate for the production method

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/JP2008/058037 WO2008136393A1 (en) 2007-04-27 2008-04-25 Crystal of lactam compound, and method for production thereof
PCT/JP2008/058036 WO2008136392A1 (en) 2007-04-27 2008-04-25 Preparation for oral administration

Country Status (1)

Country Link
WO (3) WO2008136393A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011002075A1 (en) * 2009-07-02 2011-01-06 味の素株式会社 Method for producing lactam compound and production intermediate thereof
WO2011002076A1 (en) * 2009-07-02 2011-01-06 味の素株式会社 Method for producing lactam compound and production intermediate thereof

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
WO2011107494A1 (en) 2010-03-03 2011-09-09 Sanofi Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof
MY187718A (en) * 2010-05-11 2021-10-14 Janssen Pharmaceutica Nv Pharmaceutical formulations
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
KR20170095850A (en) * 2014-12-22 2017-08-23 이에이 파마 가부시키가이샤 Drug for treating disorders of corneal epithelium
JP6498158B2 (en) * 2016-07-11 2019-04-10 ニプロ株式会社 Orally disintegrating tablets

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044180A1 (en) * 2000-12-01 2002-06-06 Ajinomoto Co.,Inc. Lactam compounds and medicinal use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL136460A0 (en) * 1997-12-22 2001-06-14 Schering Corp Molecular dispersion composition with enhanced bioavailability
JP4327424B2 (en) * 2000-05-15 2009-09-09 武田薬品工業株式会社 Crystal production method
ITMI20011727A1 (en) * 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma LERCANIDIPINE HYDROCHLORIDE SOLVATES AND NEW CRYSTALLINE FORMS OF LERCANIDIPINE HYDROCHLORIDE OBTAINED FROM THEM
CN101822834A (en) * 2003-02-07 2010-09-08 味之素株式会社 Medicine for treating diabetes
WO2005013964A1 (en) * 2003-08-08 2005-02-17 Ajinomoto Co., Inc. Pharmaceutical preparation containing nateglinide
EP1683798B1 (en) * 2003-10-31 2016-04-20 Ajinomoto Co., Inc. Fused polycyclic compounds having heterocycle and medicinal use thereof
TW200616634A (en) * 2004-10-01 2006-06-01 Bristol Myers Squibb Co Crystalline forms and process for preparing spiro-hydantoin compounds
CN101166742B (en) * 2005-04-28 2011-07-13 味之素株式会社 Novel lactam compound
US20090208584A1 (en) * 2005-06-09 2009-08-20 Tomohiro Yoshinari Solid preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044180A1 (en) * 2000-12-01 2002-06-06 Ajinomoto Co.,Inc. Lactam compounds and medicinal use thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011002075A1 (en) * 2009-07-02 2011-01-06 味の素株式会社 Method for producing lactam compound and production intermediate thereof
WO2011002076A1 (en) * 2009-07-02 2011-01-06 味の素株式会社 Method for producing lactam compound and production intermediate thereof

Also Published As

Publication number Publication date
WO2008136393A1 (en) 2008-11-13
WO2008136392A1 (en) 2008-11-13

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