MXPA03008946A - Metodos para sintetizar compuestos que contienen fenol. - Google Patents

Metodos para sintetizar compuestos que contienen fenol.

Info

Publication number
MXPA03008946A
MXPA03008946A MXPA03008946A MXPA03008946A MXPA03008946A MX PA03008946 A MXPA03008946 A MX PA03008946A MX PA03008946 A MXPA03008946 A MX PA03008946A MX PA03008946 A MXPA03008946 A MX PA03008946A MX PA03008946 A MXPA03008946 A MX PA03008946A
Authority
MX
Mexico
Prior art keywords
methods
containing compounds
synthesizing phenol
synthesizing
phenol
Prior art date
Application number
MXPA03008946A
Other languages
English (en)
Inventor
L Widdowson Katherine
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of MXPA03008946A publication Critical patent/MXPA03008946A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/47—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/43—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Abstract

Esta invencion describe un metodo para colocar un grupo sulfona o sulfonamida que es orto con respecto a un fenol en una sustancia de farmaco a fin de incrementar la estabilidad metabolica y la vida media del compuesto, mientras se mantiene la acidez del fenol; tambien se describen metodos para sintetizar compuestos que contienen fenol.
MXPA03008946A 2001-03-30 2002-03-27 Metodos para sintetizar compuestos que contienen fenol. MXPA03008946A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28041101P 2001-03-30 2001-03-30
PCT/US2002/010038 WO2002079122A2 (en) 2001-03-30 2002-03-27 Methods of synthesizing phenol-containing compounds

Publications (1)

Publication Number Publication Date
MXPA03008946A true MXPA03008946A (es) 2004-05-21

Family

ID=23072962

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03008946A MXPA03008946A (es) 2001-03-30 2002-03-27 Metodos para sintetizar compuestos que contienen fenol.

Country Status (16)

Country Link
US (1) US20040110954A1 (es)
EP (1) EP1383488A2 (es)
JP (1) JP2005507366A (es)
KR (1) KR20030088044A (es)
CN (1) CN1529591A (es)
AR (1) AR034299A1 (es)
BR (1) BR0208510A (es)
CA (1) CA2442480A1 (es)
CZ (1) CZ20032639A3 (es)
HU (1) HUP0500644A3 (es)
IL (1) IL158014A0 (es)
MX (1) MXPA03008946A (es)
NO (1) NO20034288L (es)
PL (1) PL373510A1 (es)
WO (1) WO2002079122A2 (es)
ZA (1) ZA200307443B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2287284T3 (es) * 2001-04-16 2007-12-16 Schering Corporation Ciclobuteno-1,2-dionas disustituidas en las posiciones 3,4 como ligandos de receptores de quimiocinas cxc.
TW200418812A (en) * 2002-10-29 2004-10-01 Smithkline Beecham Corp IL-8 receptor antagonists
US20070249625A1 (en) * 2004-10-20 2007-10-25 Jakob Busch-Petersen Il-8 Receptor Antagonists
RU2008145871A (ru) * 2006-04-21 2010-05-27 Смитклайн Бичам Корпорейшн (US) Антагонисты рецептора il-8
PT2009992E (pt) * 2006-04-21 2012-09-06 Glaxosmithkline Llc Antagonistas de receptores da il-8
PE20080943A1 (es) * 2006-06-23 2008-09-27 Smithkline Beecham Corp Sal toluenosulfonato de 4-{[6-cloro-3-({[(2-cloro-3-fluorofenil)amino]carbonil}amino)-2-hidroxifenil]sulfonil}-1-piperazinacarboxilato de 1,1-dimetiletilo como antagonista del receptor de il-8
UA103198C2 (en) 2008-08-04 2013-09-25 Новартис Аг Squaramide derivatives as cxcr2 antagonists
JP2013514313A (ja) 2009-12-17 2013-04-25 ガルデルマ・リサーチ・アンド・デヴェロップメント 皮膚障害の治療又は予防における化合物の使用
EA201490552A1 (ru) 2011-09-02 2014-11-28 Новартис Аг Холиновая соль замещенного циклобутендиона, обладающая противовоспалительной способностью
WO2019036374A1 (en) 2017-08-14 2019-02-21 Allergan, Inc. 3,4-DISUBSTITUTED 3-CYCLOBUTENE-1,2-DIONES AND THEIR USE

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714232A (en) * 1969-06-25 1973-01-30 Merck & Co Inc 5-arylphenyl sulfonic acids
US3691185A (en) * 1970-04-20 1972-09-12 Lewis H Sarett 5-aryl and arylphenyl sulfonic acids in treating inflammation
DE3208189A1 (de) * 1982-03-06 1983-09-08 Hoechst Ag, 6230 Frankfurt 2-aminomethyl-6-sulfamoylphenolderivate, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
UY25842A1 (es) * 1998-12-16 2001-04-30 Smithkline Beecham Corp Antagonistas de receptores de il-8

Also Published As

Publication number Publication date
KR20030088044A (ko) 2003-11-15
BR0208510A (pt) 2005-04-19
IL158014A0 (en) 2004-03-28
PL373510A1 (en) 2005-09-05
AR034299A1 (es) 2004-02-18
HUP0500644A3 (en) 2005-11-28
CA2442480A1 (en) 2002-10-10
NO20034288L (no) 2003-12-01
CZ20032639A3 (cs) 2004-04-14
US20040110954A1 (en) 2004-06-10
EP1383488A2 (en) 2004-01-28
JP2005507366A (ja) 2005-03-17
WO2002079122A2 (en) 2002-10-10
NO20034288D0 (no) 2003-09-25
HUP0500644A2 (hu) 2005-09-28
WO2002079122A3 (en) 2002-11-28
CN1529591A (zh) 2004-09-15
ZA200307443B (en) 2004-10-29

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