SG11202004090YA - Polycyclic compounds as allosteric shp2 inhibitors - Google Patents
Polycyclic compounds as allosteric shp2 inhibitorsInfo
- Publication number
- SG11202004090YA SG11202004090YA SG11202004090YA SG11202004090YA SG11202004090YA SG 11202004090Y A SG11202004090Y A SG 11202004090YA SG 11202004090Y A SG11202004090Y A SG 11202004090YA SG 11202004090Y A SG11202004090Y A SG 11202004090YA SG 11202004090Y A SG11202004090Y A SG 11202004090YA
- Authority
- SG
- Singapore
- Prior art keywords
- polycyclic compounds
- shp2 inhibitors
- allosteric shp2
- allosteric
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762599583P | 2017-12-15 | 2017-12-15 | |
US201862678891P | 2018-05-31 | 2018-05-31 | |
PCT/US2018/065817 WO2019118909A1 (en) | 2017-12-15 | 2018-12-14 | Polycyclic compounds as allosteric shp2 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202004090YA true SG11202004090YA (en) | 2020-05-28 |
Family
ID=65003535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202004090YA SG11202004090YA (en) | 2017-12-15 | 2018-12-14 | Polycyclic compounds as allosteric shp2 inhibitors |
Country Status (16)
Country | Link |
---|---|
US (2) | US11673901B2 (es) |
EP (1) | EP3724189B1 (es) |
JP (1) | JP7361693B2 (es) |
KR (1) | KR20200099530A (es) |
CN (1) | CN111433205B (es) |
AU (1) | AU2018385713A1 (es) |
BR (1) | BR112020009757A2 (es) |
CA (1) | CA3084058A1 (es) |
CO (1) | CO2020005887A2 (es) |
IL (1) | IL275089A (es) |
MX (1) | MX2020006273A (es) |
PH (1) | PH12020550857A1 (es) |
RU (1) | RU2020123241A (es) |
SG (1) | SG11202004090YA (es) |
TW (1) | TW201927791A (es) |
WO (1) | WO2019118909A1 (es) |
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JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
CA3024706A1 (en) | 2016-05-31 | 2017-12-07 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of ptpn11 |
ES2810852T3 (es) | 2016-06-14 | 2021-03-09 | Novartis Ag | Compuestos y composiciones para inhibir la actividad de shp2 |
TN2019000010A1 (en) | 2016-07-12 | 2020-07-15 | Revolution Medicines Inc | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors |
EP3515916B1 (en) | 2016-09-22 | 2023-06-07 | Relay Therapeutics, Inc. | Shp2 phosphatase inhibitors and methods of use thereof |
TW201819386A (zh) | 2016-10-24 | 2018-06-01 | 美商傳達治療有限公司 | Shp2磷酸酶抑制劑及其使用方法 |
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CO2020005887A2 (es) | 2020-08-10 |
JP7361693B2 (ja) | 2023-10-16 |
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PH12020550857A1 (en) | 2021-05-17 |
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US11673901B2 (en) | 2023-06-13 |
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BR112020009757A2 (pt) | 2020-11-03 |
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WO2019118909A1 (en) | 2019-06-20 |
US20200407372A1 (en) | 2020-12-31 |
AU2018385713A1 (en) | 2020-06-18 |
EP3724189A1 (en) | 2020-10-21 |
US20240101577A1 (en) | 2024-03-28 |
TW201927791A (zh) | 2019-07-16 |
CN111433205A (zh) | 2020-07-17 |
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