SG11201907299XA - Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer - Google Patents

Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer

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Publication number
SG11201907299XA
SG11201907299XA SG11201907299XA SG11201907299XA SG11201907299XA SG 11201907299X A SG11201907299X A SG 11201907299XA SG 11201907299X A SG11201907299X A SG 11201907299XA SG 11201907299X A SG11201907299X A SG 11201907299XA SG 11201907299X A SG11201907299X A SG 11201907299XA
Authority
SG
Singapore
Prior art keywords
international
specific binding
binding proteins
pct
activation
Prior art date
Application number
SG11201907299XA
Other languages
English (en)
Inventor
Gregory Chang
Ann Cheung
William Haney
Asya Grinberg
Original Assignee
Dragonfly Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dragonfly Therapeutics Inc filed Critical Dragonfly Therapeutics Inc
Publication of SG11201907299XA publication Critical patent/SG11201907299XA/en

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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/75—Agonist effect on antigen
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
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  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Biophysics (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG11201907299XA 2017-02-08 2018-02-08 Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer SG11201907299XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762456535P 2017-02-08 2017-02-08
PCT/US2018/017470 WO2018148445A1 (fr) 2017-02-08 2018-02-08 Protéines de fixation multi-spécifiques destinées à l'activation de cellules tueuses naturelles et leurs utilisations thérapeutiques pour traiter le cancer

Publications (1)

Publication Number Publication Date
SG11201907299XA true SG11201907299XA (en) 2019-09-27

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ID=63107062

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201907299XA SG11201907299XA (en) 2017-02-08 2018-02-08 Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer

Country Status (12)

Country Link
US (2) US11834506B2 (fr)
EP (1) EP3579848A4 (fr)
JP (2) JP2020506971A (fr)
KR (2) KR20240023449A (fr)
CN (1) CN110944651A (fr)
AU (1) AU2018219887A1 (fr)
BR (1) BR112019016315A2 (fr)
CA (2) CA3221995C (fr)
IL (1) IL268554A (fr)
MX (1) MX2019009468A (fr)
SG (1) SG11201907299XA (fr)
WO (1) WO2018148445A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201907299XA (en) 2017-02-08 2019-09-27 Dragonfly Therapeutics Inc Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
EP3579876A4 (fr) * 2017-02-10 2020-11-18 Dragonfly Therapeutics, Inc. Protéines fixant le bcma, le nkg2d et le cd16
CA3054078A1 (fr) * 2017-02-20 2018-08-23 Dragonfly Therapeutics, Inc. Proteines de liaison a cd33, nkg2d et cd16
ES2955074T3 (es) * 2017-02-20 2023-11-28 Dragonfly Therapeutics Inc Proteínas que se unen a HER2, NKG2D Y CD16
CN110891976A (zh) * 2017-02-20 2020-03-17 蜻蜓疗法股份有限公司 结合gd2、nkg2d和cd16的蛋白质
CA3064567A1 (fr) * 2017-05-23 2018-11-29 Dragonfly Therapeutics, Inc. Proteine de liaison nkg2d, cd16 et antigene associe a une tumeur
CA3064714A1 (fr) * 2017-05-23 2018-11-29 Dragonfly Therapeutics, Inc. Proteine se liant au nkg2d, cd16 et antigene associe a une tumeur
MX2020008333A (es) * 2018-02-08 2020-09-21 Dragonfly Therapeutics Inc Terapia de combinacion del cancer que incluye proteinas de union multiespecificas que activan a las celulas asesinas naturales.
WO2019157366A1 (fr) 2018-02-08 2019-08-15 Dragonfly Therapeutics, Inc. Domaines variables d'anticorps ciblant le récepteur nkg2d
TW201942134A (zh) * 2018-02-20 2019-11-01 美商蜻蜓醫療公司 結合cd33、nkg2d及cd16之多特異性結合蛋白及使用方法
CA3100234A1 (fr) * 2018-05-16 2019-11-21 Dragonfly Therapeutics, Inc. Proteine de liaison au nkg2d, cd16 et proteine d'activation des fibroblastes
EA202091977A1 (ru) * 2018-05-28 2021-02-09 Драгонфлай Терапьютикс, Инк. Мультиспецифические связывающие белки, которые связывают cd33, nkg2d и cd16, и способы применения
CA3108915A1 (fr) * 2018-08-08 2020-02-13 Dragonfly Therapeutics, Inc. Proteines de liaison a nkg2d, a cd16 et antigene associe a une tumeur
CA3130582A1 (fr) * 2019-02-18 2020-08-27 Courier Therapeutics, Inc. Proteine de fusion bispecifique utilisant une proteine de type l du complexe majeur d'histocompatibilite (omcp) d'orthopoxvirus et partenaire de liaison specifique a une tumeur
AR119393A1 (es) 2019-07-15 2021-12-15 Hoffmann La Roche Anticuerpos que se unen a nkg2d
AU2021301788A1 (en) 2020-06-30 2023-01-19 Gaia Biomedicine Inc. Method for stabilizing binding of NK cell and antibody, and use thereof
US20230257467A1 (en) 2020-08-05 2023-08-17 Dragonfly Therapeutics, Inc. Proteins binding nkg2d, cd16 and egfr
WO2022148853A1 (fr) 2021-01-11 2022-07-14 F. Hoffmann-La Roche Ag Immunoconjugués
WO2023107956A1 (fr) 2021-12-08 2023-06-15 Dragonfly Therapeutics, Inc. Protéines se liant à nkg2d, cd16 et 5t4
CN116948029A (zh) * 2022-04-20 2023-10-27 南京融捷康生物科技有限公司 一种包含IgG类Fc区变体的抗体及其用途
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