SG10201402267VA - Mtor Kinase Inhibitors For Oncology Indications And Diseases Associated With The MTOR/P13K/AKT Pathway - Google Patents
Mtor Kinase Inhibitors For Oncology Indications And Diseases Associated With The MTOR/P13K/AKT PathwayInfo
- Publication number
- SG10201402267VA SG10201402267VA SG10201402267VA SG10201402267VA SG10201402267VA SG 10201402267V A SG10201402267V A SG 10201402267VA SG 10201402267V A SG10201402267V A SG 10201402267VA SG 10201402267V A SG10201402267V A SG 10201402267VA SG 10201402267V A SG10201402267V A SG 10201402267VA
- Authority
- SG
- Singapore
- Prior art keywords
- mtor
- kinase inhibitors
- diseases associated
- akt pathway
- oncology indications
- Prior art date
Links
- 101150097381 Mtor gene Proteins 0.000 title 1
- 102100023085 Serine/threonine-protein kinase mTOR Human genes 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 title 1
- 230000037361 pathway Effects 0.000 title 1
Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- C07D241/20—Nitrogen atoms
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D471/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D498/14—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
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- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Otolaryngology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10862708P | 2008-10-27 | 2008-10-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201402267VA true SG10201402267VA (en) | 2014-07-30 |
Family
ID=41490345
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2014006852A SG2014006852A (en) | 2008-10-27 | 2009-10-27 | Mtor kinase inhibitors for oncology indications and diseases associated with the mtor/p13k/akt pathway |
SG10201402267VA SG10201402267VA (en) | 2008-10-27 | 2009-10-27 | Mtor Kinase Inhibitors For Oncology Indications And Diseases Associated With The MTOR/P13K/AKT Pathway |
SG10201402273RA SG10201402273RA (en) | 2008-10-27 | 2009-10-27 | Mtor Kinase Inhibitors For Oncology Indications And Diseases Associated With The MTOR/P13K/AKT Pathway |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2014006852A SG2014006852A (en) | 2008-10-27 | 2009-10-27 | Mtor kinase inhibitors for oncology indications and diseases associated with the mtor/p13k/akt pathway |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201402273RA SG10201402273RA (en) | 2008-10-27 | 2009-10-27 | Mtor Kinase Inhibitors For Oncology Indications And Diseases Associated With The MTOR/P13K/AKT Pathway |
Country Status (35)
Country | Link |
---|---|
US (10) | US8110578B2 (he) |
EP (5) | EP2358718B1 (he) |
JP (3) | JP5689420B2 (he) |
KR (2) | KR101815604B1 (he) |
CN (3) | CN104725384B (he) |
AR (2) | AR073995A1 (he) |
AU (1) | AU2009320137C1 (he) |
BR (1) | BRPI0920254A2 (he) |
CA (1) | CA2740975C (he) |
CO (1) | CO6501147A2 (he) |
CR (1) | CR20110223A (he) |
CY (2) | CY1117272T1 (he) |
DK (2) | DK2740733T3 (he) |
EC (1) | ECSP11011084A (he) |
ES (4) | ES2620774T3 (he) |
HK (3) | HK1154858A1 (he) |
HR (2) | HRP20160084T1 (he) |
HU (1) | HUE026834T2 (he) |
IL (1) | IL212440A (he) |
LT (1) | LT2740732T (he) |
MX (2) | MX361916B (he) |
MY (1) | MY159235A (he) |
NI (1) | NI201100080A (he) |
NZ (4) | NZ708183A (he) |
PE (3) | PE20130457A1 (he) |
PL (2) | PL2740733T3 (he) |
PT (1) | PT2740732T (he) |
RU (2) | RU2692796C2 (he) |
SG (3) | SG2014006852A (he) |
SI (2) | SI2740732T1 (he) |
SM (1) | SMT201600089B (he) |
TW (3) | TWI605047B (he) |
UA (1) | UA108601C2 (he) |
WO (1) | WO2010062571A1 (he) |
ZA (1) | ZA201102813B (he) |
Families Citing this family (119)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2645689T3 (es) | 2008-05-21 | 2017-12-07 | Ariad Pharmaceuticals, Inc. | Derivados de fósforo como inhibidores de quinasas |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
US8110578B2 (en) | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
CA2743449C (en) | 2008-11-12 | 2016-10-18 | Ariad Pharmaceuticals, Inc. | Pyrazinopyrazines and derivatives as kinase inhibitors |
DE102009043260A1 (de) | 2009-09-28 | 2011-04-28 | Merck Patent Gmbh | Pyridinyl-imidazolonderivate |
CN102686225A (zh) | 2009-10-26 | 2012-09-19 | 西格诺药品有限公司 | 杂芳基化合物的合成和纯化方法 |
UA110697C2 (uk) | 2010-02-03 | 2016-02-10 | Сігнал Фармасьютікалз, Елелсі | ЗАСТОСУВАННЯ ІНГІБІТОРІВ TOR-КІНАЗИ ДЛЯ ЛІКУВАННЯ ПУХЛИННИХ ЗАХВОРЮВАНЬ У ПАЦІЄНТА ЗІ ЗНИЖЕНИМ РІВНЕМ БІЛКА pAMPK ТА/АБО АКТИВНОСТІ AMPK |
US20110275699A1 (en) * | 2010-03-16 | 2011-11-10 | University Of California | Treatment For Obesity And Diabetes |
US20120028972A1 (en) * | 2010-07-30 | 2012-02-02 | Lilly Wong | Biomarker assays for detecting or measuring inhibition of tor kinase activity |
KR102024948B1 (ko) * | 2011-02-18 | 2019-11-04 | 노파르티스 파르마 아게 | mTOR/JAK 저해제 병용 요법 |
WO2012122405A2 (en) * | 2011-03-08 | 2012-09-13 | The Trustees Of Columbia University In The City Of New York | Screening assays using stem cells and stem cell-derived neurons from mouse models of alzheimer's disease |
CN103501612B (zh) | 2011-05-04 | 2017-03-29 | 阿里亚德医药股份有限公司 | 抑制表皮生长因子受体导致的癌症中细胞增殖的化合物 |
CN105039520A (zh) * | 2011-08-03 | 2015-11-11 | 西格诺药品有限公司 | 作为lkb1状态的预测性生物标志物的基因表达谱的鉴定 |
EP3466423B1 (en) | 2011-10-19 | 2021-07-28 | Signal Pharmaceuticals, LLC | Treatment of cancer with tor kinase inhibitors |
AU2015200318B2 (en) * | 2011-10-19 | 2016-10-20 | Signal Pharmaceuticals, Llc | Treatment of cancer with TOR kinase inhibitors |
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