SE8201015L - Forfarande for framstellning av nya, optiskt aktiva daunosaminylderivat av antracyklinoner - Google Patents
Forfarande for framstellning av nya, optiskt aktiva daunosaminylderivat av antracyklinonerInfo
- Publication number
- SE8201015L SE8201015L SE8201015A SE8201015A SE8201015L SE 8201015 L SE8201015 L SE 8201015L SE 8201015 A SE8201015 A SE 8201015A SE 8201015 A SE8201015 A SE 8201015A SE 8201015 L SE8201015 L SE 8201015L
- Authority
- SE
- Sweden
- Prior art keywords
- optically active
- vate
- coch
- methoxy
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Claims (1)
1. ...011 R2 Oat OR (VEMIF:(S) R3 0 011 COCH, t 1 N. BI 112 0 OH .011 (VIII")) (7S : (R) SVERIGE (A)Allmant tillganglig Ans dat82-02-18 Lbpdag76 Avdelad fr 76005636 Off dat82-02-18 (21)Ans nr 8201015-8 Rotel 8134 (51)Klass C 07 H 15/24 .(74)0mbud Branns 122 24 62 41 (XIIP) Sr vate, metyl, OK) R, 0 OH R,I/0001,3 1"ranC OH IIII R, 0 OH 0, 0 OH B'/C°CH' / I iiI 1 R,0 OH van i Ri, R2 och 03 hay den ovan angivna betydelsen, kondenseras med 2,3,6-trideoxi-3-trifluoracetamido-4-0-trifluoracetyl-n-L-lyxopyrahosylklorid eller med 1,2,3,6-tetradeoxi-4-0- —trifluoracety1-3-trifluoraceramido-L-lyxo-hex-1-enpyranos i Ott vattenfritt lOsningsmedel, sasom bensen eller nitrometan, och i narvaro av p-toluensulfonsyra under bildning ay de skyddade mellanprodukterna, av vilka genom behandling med metanol och efterfaljande avlagsnande av skyddsgruppen Old sockerresten med hjalp av 0,1 N Na00 de onskade optiskt aktiva foreningarna med de allmanna formlerna (X), (XI), (XII) och (XIII) erhalles tillsammans med deras motsvarande R-anomerer (X'), (xi.), (xII') och (xIII'). (XI') B 0, 0 OH L, IIIr „ 0 „S;), 0„ COCH, OH 11, 0 011 B,IIII lo) yyiR, 0 OH (x)P) -OH
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2691/75A GB1500421A (en) | 1975-01-22 | 1975-01-22 | Optically active anthracyclinones |
Publications (2)
Publication Number | Publication Date |
---|---|
SE8201015L true SE8201015L (sv) | 1982-02-18 |
SE461529B SE461529B (sv) | 1990-02-26 |
Family
ID=9744103
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7600563A SE435498B (sv) | 1975-01-22 | 1976-01-20 | Forfarande for optisk isomer-uppdelning av racemisk 1,4-dimetoxi-6-hydroxi-6-acetyl-tetrahydronaftalen |
SE8201014A SE461525B (sv) | 1975-01-22 | 1982-02-18 | Foerfarande foer framstaellning av nya, optiskt aktiva antracyklinoner |
SE8201013A SE453185B (sv) | 1975-01-22 | 1982-02-18 | Forfarande for framstellning av optiskt aktiva antracyklinoner |
SE8201015A SE461529B (sv) | 1975-01-22 | 1982-02-18 | Foerfarande foer framstaellning av nya, optiskt aktiva daunos-aminylderivat av antracyklinoner |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7600563A SE435498B (sv) | 1975-01-22 | 1976-01-20 | Forfarande for optisk isomer-uppdelning av racemisk 1,4-dimetoxi-6-hydroxi-6-acetyl-tetrahydronaftalen |
SE8201014A SE461525B (sv) | 1975-01-22 | 1982-02-18 | Foerfarande foer framstaellning av nya, optiskt aktiva antracyklinoner |
SE8201013A SE453185B (sv) | 1975-01-22 | 1982-02-18 | Forfarande for framstellning av optiskt aktiva antracyklinoner |
Country Status (18)
Country | Link |
---|---|
US (1) | US4077988A (sv) |
JP (4) | JPS6033819B2 (sv) |
AT (1) | AT342035B (sv) |
AU (1) | AU500067B2 (sv) |
BE (1) | BE837756A (sv) |
CA (1) | CA1064920A (sv) |
CH (3) | CH622486A5 (sv) |
DE (2) | DE2660848C2 (sv) |
DK (1) | DK155518C (sv) |
ES (1) | ES444494A1 (sv) |
FR (4) | FR2320105A1 (sv) |
GB (1) | GB1500421A (sv) |
HK (1) | HK1082A (sv) |
MX (1) | MX4278E (sv) |
NL (1) | NL179724C (sv) |
SE (4) | SE435498B (sv) |
SU (5) | SU683613A3 (sv) |
ZA (1) | ZA76292B (sv) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4070382A (en) * | 1975-11-18 | 1978-01-24 | Research Corporation | Intermediates for polycyclic quinoid antibiotics |
GB1527050A (en) * | 1976-06-19 | 1978-10-04 | Farmaceutici Italia | Optically active anthracyclinones |
US4134903A (en) * | 1976-08-07 | 1979-01-16 | Societa Farmaceutici Italia S.P.A. | Anthracycline ethers and their preparation |
GB1573037A (en) * | 1977-05-05 | 1980-08-13 | Farmaceutici Italia | Anthracyclines |
GB1573036A (en) * | 1977-05-05 | 1980-08-13 | Farmaceutici Italia | Anthracyclines |
US4296105A (en) * | 1978-08-03 | 1981-10-20 | Institut International De Pathologie Cellulaire Et Moleculaire | Derivatives of doxorubicine, their preparation and use |
NL8001417A (nl) * | 1979-03-17 | 1980-09-19 | Erba Farmitalia | Antitumorglycosiden. |
US4259476A (en) * | 1979-04-02 | 1981-03-31 | Kende Andrew S | Novel heterocyclic anthracycline compounds |
JPS5673039A (en) * | 1979-08-20 | 1981-06-17 | Hoffmann La Roche | Naphthacene derivative |
GB2056443B (en) * | 1979-08-20 | 1984-01-18 | Hoffmann La Roche | Cyclic compounds |
GB2071084B (en) * | 1980-01-22 | 1984-02-29 | Hoffmann La Roche | Polycylic compounds |
JPS5756494A (en) * | 1980-09-22 | 1982-04-05 | Microbial Chem Res Found | New anthracyclin derivative |
ES8308301A1 (es) * | 1981-07-29 | 1983-08-16 | Sumitomo Chemical Co | Un procedimiento para la preparacion de derivados de aminonaftaceno. |
BE896743A (fr) * | 1982-08-13 | 1983-09-16 | Erba Farmitalia | Synthese de naphtacenequinone. |
US4489206A (en) * | 1983-05-13 | 1984-12-18 | Adria Laboratories, Inc. | Synthesis of (+)-4-demethoxydaunomycinone |
US4831019A (en) * | 1983-10-31 | 1989-05-16 | Adria Laboratories, Inc. | Pharmaceutical preparations of 4-demethoxy-n-trifluoroacetyl anthracyclines |
US4496485A (en) * | 1983-11-25 | 1985-01-29 | G. D. Searle & Co. | Asymmetric 7-O-(substituted acetyl)-4-demethoxydaunomycinones |
GB8519452D0 (en) * | 1985-08-02 | 1985-09-11 | Erba Farmitalia | Injectable solutions |
AU622105B2 (en) * | 1987-03-11 | 1992-04-02 | Austin Research Institute, The | Immunoglobulin conjugates |
NZ224252A (en) * | 1987-04-21 | 1991-09-25 | Erba Carlo Spa | An anthracycline glycoside and its preparation |
GB8803301D0 (en) * | 1988-02-12 | 1988-03-09 | Erba Carlo Spa | Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin |
GB8824947D0 (en) * | 1988-10-25 | 1988-11-30 | Erba Carlo Spa | New 4-substituted anthracyclinones & process for preparing them |
NL9001834A (nl) * | 1990-08-16 | 1992-03-16 | Pharmachemie Bv | Nieuwe antracyclineverbindingen met anti-tumorwerkzaamheid, nieuwe tussenverbindingen voor de bereiding van deze antracyclineverbindingen, alsmede preparaten die de aktieve antracyclineverbindingen bevatten. |
GB9418260D0 (en) * | 1994-09-09 | 1994-10-26 | Erba Carlo Spa | Anthracycline derivatives |
IT1317106B1 (it) * | 2000-11-16 | 2003-05-26 | Menarini Ricerche Spa | Processo per la sintesi di antracicline otticamente attive. |
DE10155016A1 (de) * | 2001-11-07 | 2003-05-15 | Knoell Hans Forschung Ev | Neue Chinon-Verbindung, Verfahren zur Herstellung und deren Verwendung |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3904632A (en) * | 1972-05-08 | 1975-09-09 | Hoffmann La Roche | (')-di-o-isopropylidene-2-keto-l-gulonates |
JPS5840556A (ja) * | 1981-09-04 | 1983-03-09 | Ricoh Co Ltd | 電子写真圧力定着転写紙及びその転写紙用原紙の製造法 |
-
1975
- 1975-01-22 GB GB2691/75A patent/GB1500421A/en not_active Expired
-
1976
- 1976-01-06 NL NLAANVRAGE7600075,A patent/NL179724C/xx not_active IP Right Cessation
- 1976-01-16 US US05/649,825 patent/US4077988A/en not_active Expired - Lifetime
- 1976-01-19 AT AT30676A patent/AT342035B/de not_active IP Right Cessation
- 1976-01-19 ZA ZA292A patent/ZA76292B/xx unknown
- 1976-01-19 MX MX763633U patent/MX4278E/es unknown
- 1976-01-20 DK DK020376A patent/DK155518C/da not_active IP Right Cessation
- 1976-01-20 JP JP51005803A patent/JPS6033819B2/ja not_active Expired
- 1976-01-20 CA CA243,860A patent/CA1064920A/en not_active Expired
- 1976-01-20 AU AU10432/76A patent/AU500067B2/en not_active Expired
- 1976-01-20 DE DE2660848A patent/DE2660848C2/de not_active Expired
- 1976-01-20 DE DE2601785A patent/DE2601785C2/de not_active Expired
- 1976-01-20 SE SE7600563A patent/SE435498B/sv not_active IP Right Cessation
- 1976-01-21 ES ES444494A patent/ES444494A1/es not_active Expired
- 1976-01-21 CH CH74276A patent/CH622486A5/de not_active IP Right Cessation
- 1976-01-21 FR FR7601535A patent/FR2320105A1/fr active Granted
- 1976-01-21 BE BE163665A patent/BE837756A/xx not_active IP Right Cessation
- 1976-01-21 SU SU762311601A patent/SU683613A3/ru active
- 1976-09-24 FR FR7628763A patent/FR2320085A1/fr active Granted
- 1976-09-24 FR FR7628762A patent/FR2333769A1/fr active Granted
- 1976-09-24 FR FR7628764A patent/FR2320086A1/fr active Granted
- 1976-12-03 SU SU762425700A patent/SU646914A3/ru active
-
1977
- 1977-10-11 SU SU772532447A patent/SU650498A3/ru active
- 1977-10-11 SU SU772530649A patent/SU724087A3/ru active
- 1977-10-11 SU SU772532450A patent/SU776557A3/ru active
-
1980
- 1980-01-07 CH CH7880A patent/CH622530A5/de not_active IP Right Cessation
- 1980-01-07 CH CH7780A patent/CH624085A5/de not_active IP Right Cessation
-
1982
- 1982-01-14 HK HK10/82A patent/HK1082A/xx unknown
- 1982-02-18 SE SE8201014A patent/SE461525B/sv not_active IP Right Cessation
- 1982-02-18 SE SE8201013A patent/SE453185B/sv not_active IP Right Cessation
- 1982-02-18 SE SE8201015A patent/SE461529B/sv not_active IP Right Cessation
-
1984
- 1984-04-13 JP JP59073132A patent/JPS59231037A/ja active Pending
- 1984-04-13 JP JP59073134A patent/JPS59231098A/ja active Granted
- 1984-04-13 JP JP59073133A patent/JPS59231038A/ja active Pending
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