SE8201014L - Forfarande for framstellning av nya, optiskt aktiva antracyklinoner - Google Patents

Forfarande for framstellning av nya, optiskt aktiva antracyklinoner

Info

Publication number
SE8201014L
SE8201014L SE8201014A SE8201014A SE8201014L SE 8201014 L SE8201014 L SE 8201014L SE 8201014 A SE8201014 A SE 8201014A SE 8201014 A SE8201014 A SE 8201014A SE 8201014 L SE8201014 L SE 8201014L
Authority
SE
Sweden
Prior art keywords
optically active
viii
vate
mixture
treatment
Prior art date
Application number
SE8201014A
Other languages
English (en)
Other versions
SE461525B (sv
Inventor
F Arcamone
A Dimarco
L Benardi
B Patelli
Original Assignee
Farmaceutici Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia filed Critical Farmaceutici Italia
Publication of SE8201014L publication Critical patent/SE8201014L/sv
Publication of SE461525B publication Critical patent/SE461525B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Claims (1)

PATENTKRAV Rirfarande fdr framstAllning av nya optiskt noner med de allmAnna formlerna 113 0 011 R's, 1 11 1 1011011\011 11/-1n( Y'r R, o W R1111r CCC"' CL 101 1\0,1 1. IrY W N 0 m It COCH 101 LOH 2. N 0 m 01-1' COCII, aktiva antracykli- 0,11P) (75:99) (VIII") (711:9H) (vino.) (78199) och 22. 0io pi- LiC)7 fc.:2.13cor_V313 113 0 OH IIIel CCC"' 61'Y° vani193 0 OH a. 1. RI Ar vAte och R2 och ft, Ar like och betecknar Wit°, metyl, metoxi, klor eller brom, 2. R2 och 813 an bAda vate och 11, an metyl, metoxi, klor eller brom eller 3. RI och 813 dr bAda vAte och R2 An metoxi k Annetecknat &tray, att en optiskt aktiv f5rening med formlerna 812 och R3 her den oven angivna betydelsen, I nArvaro av p-toluensulfonsyra omsattes med etylenglykol till de optiskt aktiva ketalerna, vilka genom behandling i koltetraklorid f8rst med N-bromsuccinimid och dArefter med metanol ger en blandning av 7(S)- och 7(R)-metyletrar, or vilka efter demetylering I stAllning 6 och 11 med hjAlp av vattenfri aluminiumklorid I bensen vid °C erhAlles en blandning av optiskt aktiva 7(5)- och 7(R)-metoxiantracyklinoner, ur vilken efter behandling med trifluorAttiksyra och genom efterf8ljande be-handling med natriumbikarbonat erhAlles en blandning av de motsvarande 7(0)- och 7(R)-hydroxiderivaten, corn separeras genom kristallisation eller genom kromatografi pi silikagel i de motsvarande optiskt aktiva rena f8reningarna (VIII.), (VIII"), (VIII.") och FI„ 0 OCH3 811I1COCII3 01 IC 1 .,/ 11, o ocn,
1. 0 OCH, 11'III pi 101 T.cccH' /13 0 OCH3 vari OHMW") (79:91I) OH (v') och OW1
SE8201014A 1975-01-22 1982-02-18 Foerfarande foer framstaellning av nya, optiskt aktiva antracyklinoner SE461525B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2691/75A GB1500421A (en) 1975-01-22 1975-01-22 Optically active anthracyclinones

Publications (2)

Publication Number Publication Date
SE8201014L true SE8201014L (sv) 1982-02-18
SE461525B SE461525B (sv) 1990-02-26

Family

ID=9744103

Family Applications (4)

Application Number Title Priority Date Filing Date
SE7600563A SE435498B (sv) 1975-01-22 1976-01-20 Forfarande for optisk isomer-uppdelning av racemisk 1,4-dimetoxi-6-hydroxi-6-acetyl-tetrahydronaftalen
SE8201014A SE461525B (sv) 1975-01-22 1982-02-18 Foerfarande foer framstaellning av nya, optiskt aktiva antracyklinoner
SE8201013A SE453185B (sv) 1975-01-22 1982-02-18 Forfarande for framstellning av optiskt aktiva antracyklinoner
SE8201015A SE461529B (sv) 1975-01-22 1982-02-18 Foerfarande foer framstaellning av nya, optiskt aktiva daunos-aminylderivat av antracyklinoner

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7600563A SE435498B (sv) 1975-01-22 1976-01-20 Forfarande for optisk isomer-uppdelning av racemisk 1,4-dimetoxi-6-hydroxi-6-acetyl-tetrahydronaftalen

Family Applications After (2)

Application Number Title Priority Date Filing Date
SE8201013A SE453185B (sv) 1975-01-22 1982-02-18 Forfarande for framstellning av optiskt aktiva antracyklinoner
SE8201015A SE461529B (sv) 1975-01-22 1982-02-18 Foerfarande foer framstaellning av nya, optiskt aktiva daunos-aminylderivat av antracyklinoner

Country Status (18)

Country Link
US (1) US4077988A (sv)
JP (4) JPS6033819B2 (sv)
AT (1) AT342035B (sv)
AU (1) AU500067B2 (sv)
BE (1) BE837756A (sv)
CA (1) CA1064920A (sv)
CH (3) CH622486A5 (sv)
DE (2) DE2660848C2 (sv)
DK (1) DK155518C (sv)
ES (1) ES444494A1 (sv)
FR (4) FR2320105A1 (sv)
GB (1) GB1500421A (sv)
HK (1) HK1082A (sv)
MX (1) MX4278E (sv)
NL (1) NL179724C (sv)
SE (4) SE435498B (sv)
SU (5) SU683613A3 (sv)
ZA (1) ZA76292B (sv)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4070382A (en) * 1975-11-18 1978-01-24 Research Corporation Intermediates for polycyclic quinoid antibiotics
GB1527050A (en) * 1976-06-19 1978-10-04 Farmaceutici Italia Optically active anthracyclinones
US4134903A (en) * 1976-08-07 1979-01-16 Societa Farmaceutici Italia S.P.A. Anthracycline ethers and their preparation
GB1573036A (en) * 1977-05-05 1980-08-13 Farmaceutici Italia Anthracyclines
GB1573037A (en) * 1977-05-05 1980-08-13 Farmaceutici Italia Anthracyclines
US4296105A (en) * 1978-08-03 1981-10-20 Institut International De Pathologie Cellulaire Et Moleculaire Derivatives of doxorubicine, their preparation and use
NL8001417A (nl) * 1979-03-17 1980-09-19 Erba Farmitalia Antitumorglycosiden.
US4259476A (en) * 1979-04-02 1981-03-31 Kende Andrew S Novel heterocyclic anthracycline compounds
GB2056443B (en) * 1979-08-20 1984-01-18 Hoffmann La Roche Cyclic compounds
JPS5673039A (en) * 1979-08-20 1981-06-17 Hoffmann La Roche Naphthacene derivative
GB2071084B (en) * 1980-01-22 1984-02-29 Hoffmann La Roche Polycylic compounds
JPS5756494A (en) * 1980-09-22 1982-04-05 Microbial Chem Res Found New anthracyclin derivative
ES514486A0 (es) * 1981-07-29 1983-08-16 Sumitomo Chemical Co Un procedimiento para la preparacion de derivados de aminonaftaceno.
BE896743A (fr) * 1982-08-13 1983-09-16 Erba Farmitalia Synthese de naphtacenequinone.
US4489206A (en) * 1983-05-13 1984-12-18 Adria Laboratories, Inc. Synthesis of (+)-4-demethoxydaunomycinone
US4831019A (en) * 1983-10-31 1989-05-16 Adria Laboratories, Inc. Pharmaceutical preparations of 4-demethoxy-n-trifluoroacetyl anthracyclines
US4496485A (en) * 1983-11-25 1985-01-29 G. D. Searle & Co. Asymmetric 7-O-(substituted acetyl)-4-demethoxydaunomycinones
GB8519452D0 (en) * 1985-08-02 1985-09-11 Erba Farmitalia Injectable solutions
BE1001051A4 (fr) * 1987-03-11 1989-06-20 Erba Carlo Spa Conjugue d'immunoglobuline contenant de l'idarubicine, medicament le contenant et procede de depletion in vitro d'un sous-groupe de lymphocytes t d'une population cellulaire utilisant ce conjugue.
NZ224252A (en) * 1987-04-21 1991-09-25 Erba Carlo Spa An anthracycline glycoside and its preparation
GB8803301D0 (en) * 1988-02-12 1988-03-09 Erba Carlo Spa Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB8824947D0 (en) * 1988-10-25 1988-11-30 Erba Carlo Spa New 4-substituted anthracyclinones & process for preparing them
NL9001834A (nl) * 1990-08-16 1992-03-16 Pharmachemie Bv Nieuwe antracyclineverbindingen met anti-tumorwerkzaamheid, nieuwe tussenverbindingen voor de bereiding van deze antracyclineverbindingen, alsmede preparaten die de aktieve antracyclineverbindingen bevatten.
GB9418260D0 (en) * 1994-09-09 1994-10-26 Erba Carlo Spa Anthracycline derivatives
IT1317106B1 (it) * 2000-11-16 2003-05-26 Menarini Ricerche Spa Processo per la sintesi di antracicline otticamente attive.
DE10155016A1 (de) * 2001-11-07 2003-05-15 Knoell Hans Forschung Ev Neue Chinon-Verbindung, Verfahren zur Herstellung und deren Verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904632A (en) * 1972-05-08 1975-09-09 Hoffmann La Roche (')-di-o-isopropylidene-2-keto-l-gulonates
JPS5840556A (ja) * 1981-09-04 1983-03-09 Ricoh Co Ltd 電子写真圧力定着転写紙及びその転写紙用原紙の製造法

Also Published As

Publication number Publication date
FR2320085B1 (sv) 1978-11-03
CH624085A5 (sv) 1981-07-15
JPS59231038A (ja) 1984-12-25
SU683613A3 (ru) 1979-08-30
DK155518C (da) 1989-08-28
CA1064920A (en) 1979-10-23
CH622486A5 (sv) 1981-04-15
NL179724B (nl) 1986-06-02
DE2660848C2 (de) 1986-02-06
SE7600563L (sv) 1976-07-23
SU776557A3 (ru) 1980-10-30
BE837756A (fr) 1976-07-22
JPS5198264A (en) 1976-08-30
SE461529B (sv) 1990-02-26
AU500067B2 (en) 1979-05-10
DK20376A (da) 1976-08-02
NL7600075A (nl) 1976-07-26
SU650498A3 (ru) 1979-02-28
SE435498B (sv) 1984-10-01
CH622530A5 (sv) 1981-04-15
ATA30676A (de) 1977-07-15
SE453185B (sv) 1988-01-18
DE2601785A1 (de) 1976-07-29
FR2333769A1 (fr) 1977-07-01
JPH036157B2 (sv) 1991-01-29
JPS59231037A (ja) 1984-12-25
FR2320105A1 (fr) 1977-03-04
SU646914A3 (ru) 1979-02-05
SE8201013L (sv) 1982-02-18
FR2320086A1 (fr) 1977-03-04
JPS6033819B2 (ja) 1985-08-05
ES444494A1 (es) 1977-05-16
FR2320086B1 (sv) 1978-11-03
NL179724C (nl) 1986-11-03
FR2320105B1 (sv) 1982-07-23
MX4278E (es) 1982-03-11
FR2320085A1 (fr) 1977-03-04
AT342035B (de) 1978-03-10
HK1082A (en) 1982-01-22
DE2601785C2 (de) 1985-10-03
AU1043276A (en) 1977-07-28
SU724087A3 (ru) 1980-03-25
SE8201015L (sv) 1982-02-18
SE461525B (sv) 1990-02-26
DK155518B (da) 1989-04-17
US4077988A (en) 1978-03-07
GB1500421A (en) 1978-02-08
FR2333769B1 (sv) 1979-07-06
JPS59231098A (ja) 1984-12-25
ZA76292B (en) 1977-01-26

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