SE516690C2 - Förfarande för framställning av citalopram - Google Patents

Förfarande för framställning av citalopram

Info

Publication number
SE516690C2
SE516690C2 SE0100193A SE0100193A SE516690C2 SE 516690 C2 SE516690 C2 SE 516690C2 SE 0100193 A SE0100193 A SE 0100193A SE 0100193 A SE0100193 A SE 0100193A SE 516690 C2 SE516690 C2 SE 516690C2
Authority
SE
Sweden
Prior art keywords
formula
compound
citalopram
process according
palladium catalyst
Prior art date
Application number
SE0100193A
Other languages
English (en)
Swedish (sv)
Other versions
SE0100193D0 (sv
SE0100193L (sv
Inventor
Hans Petersen
Michael Harold Rock
Henrik Svane
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of SE0100193D0 publication Critical patent/SE0100193D0/xx
Publication of SE0100193L publication Critical patent/SE0100193L/xx
Publication of SE516690C2 publication Critical patent/SE516690C2/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SE0100193A 1999-06-25 2001-01-24 Förfarande för framställning av citalopram SE516690C2 (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199900920 1999-06-25
PCT/DK1999/000640 WO2000013648A2 (en) 1999-06-25 1999-11-22 Method for the preparation of citalopram

Publications (3)

Publication Number Publication Date
SE0100193D0 SE0100193D0 (sv) 2001-01-24
SE0100193L SE0100193L (sv) 2001-04-25
SE516690C2 true SE516690C2 (sv) 2002-02-12

Family

ID=8099035

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0100193A SE516690C2 (sv) 1999-06-25 2001-01-24 Förfarande för framställning av citalopram

Country Status (36)

Country Link
US (2) US20020077353A1 (sk)
EP (1) EP1159274B1 (sk)
JP (1) JP3447267B2 (sk)
KR (1) KR100491368B1 (sk)
CN (2) CN1502616A (sk)
AR (1) AR020863A1 (sk)
AT (3) AT409961B (sk)
AU (2) AU1374500A (sk)
BG (1) BG65574B1 (sk)
BR (1) BR9917368B1 (sk)
CA (2) CA2475401A1 (sk)
CH (1) CH691305A5 (sk)
CZ (1) CZ292198B6 (sk)
DE (2) DE19983487C1 (sk)
DK (2) DK1159274T3 (sk)
EA (1) EA002560B1 (sk)
ES (2) ES2189699A1 (sk)
FI (1) FI108641B (sk)
GB (2) GB2354239B (sk)
HK (1) HK1049002B (sk)
HU (1) HUP0103235A3 (sk)
IL (2) IL145959A0 (sk)
IS (1) IS2343B (sk)
IT (1) ITMI991581A1 (sk)
MX (1) MXPA01010989A (sk)
NO (1) NO328542B1 (sk)
NZ (1) NZ514979A (sk)
PL (1) PL205579B1 (sk)
PT (1) PT1159274E (sk)
SE (1) SE516690C2 (sk)
SI (1) SI1159274T1 (sk)
SK (1) SK285813B6 (sk)
TR (1) TR200103702T2 (sk)
UA (1) UA63034C2 (sk)
WO (1) WO2000013648A2 (sk)
ZA (1) ZA200108854B (sk)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2195644T3 (es) 1998-12-23 2003-12-01 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida.
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ES2195554T5 (es) 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
CH692421A5 (de) 1999-10-25 2002-06-14 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram.
TR200401456T1 (tr) 1999-10-25 2005-04-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem.
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
NZ519739A (en) 1999-12-28 2004-03-26 H Method for the preparation of citalopram
IL150367A0 (en) 1999-12-30 2002-12-01 Lundbeck & Co As H Method for the preparation of citalopram
EA005134B1 (ru) 2000-01-14 2004-12-30 Х.Лундбекк А/С Способ получения 5-цианофталида
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
CA2402553A1 (en) * 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
GB2357762B (en) 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
HUP0300274A2 (hu) 2000-03-13 2003-06-28 H. Lundbeck A/S Eljárás citalopram előállítására
CN1418205A (zh) 2000-03-14 2003-05-14 H·隆德贝克有限公司 制备西酞普兰的方法
HUP0300134A2 (en) * 2000-03-16 2003-05-28 Lundbeck & Co As H Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
BR0106976A (pt) * 2000-07-06 2002-07-23 Lundbeck & Co As H Método para a preparação de citalopram
FI20011621A (fi) * 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
PT1181713E (pt) 2000-12-22 2005-02-28 Lundbeck & Co As H Metodo para preparacao de citalopram puro
PT1181272E (pt) * 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro
EP1355897A1 (en) 2001-01-30 2003-10-29 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
EP1370545A4 (en) * 2001-03-09 2005-03-16 Ranbaxy Lab Ltd PROCESS FOR THE PREPARATION OF CITALOPRAM
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
US7148364B2 (en) * 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
US7019153B2 (en) 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
EP2141156A1 (en) 2004-08-23 2010-01-06 Sun Pharma Global FZE Process for Preparation of Citalopram and Enantiomers
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI347942B (en) * 2005-06-22 2011-09-01 Lundbeck & Co As H Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
EP2017271A1 (en) 2007-07-06 2009-01-21 Aurobindo Pharma Limited Process for the preparation of escitalopram

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (sk) * 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) * 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) * 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) * 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) * 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
PT1015416E (pt) * 1997-07-08 2002-03-28 Lundbeck & Co As H Metodo para a producao de citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
JP3813820B2 (ja) * 1997-11-11 2006-08-23 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
EP1123284B1 (en) * 1998-10-20 2003-01-08 H. Lundbeck A/S Method for the preparation of citalopram
ES2195644T3 (es) * 1998-12-23 2003-12-01 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida.
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ES2195554T5 (es) * 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
CH692421A5 (de) * 1999-10-25 2002-06-14 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram.
AR026063A1 (es) * 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
FR2805812A1 (fr) * 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
FI20011621A (fi) * 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
PT1181713E (pt) * 2000-12-22 2005-02-28 Lundbeck & Co As H Metodo para preparacao de citalopram puro
PT1181272E (pt) * 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro

Also Published As

Publication number Publication date
SK18402001A3 (sk) 2002-06-04
CA2475401A1 (en) 2000-12-25
GB2354239A (en) 2001-03-21
SI1159274T1 (en) 2003-10-31
BR9917368B1 (pt) 2010-02-09
HUP0103235A2 (hu) 2002-01-28
WO2000013648A8 (en) 2000-05-11
FI108641B (fi) 2002-02-28
US20090088469A1 (en) 2009-04-02
GB0105182D0 (en) 2001-04-18
NO328542B1 (no) 2010-03-15
WO2000013648A3 (en) 2000-07-13
PL346237A1 (en) 2002-01-28
AT409961B (de) 2002-12-27
EA002560B1 (ru) 2002-06-27
DE69906389T2 (de) 2003-10-30
ATE235478T1 (de) 2003-04-15
PL205579B1 (pl) 2010-05-31
AU2001100440A4 (en) 2001-11-01
ES2189699A1 (es) 2003-07-01
KR100491368B1 (ko) 2005-05-24
AU2001100440B4 (en) 2002-01-24
SE0100193D0 (sv) 2001-01-24
CZ292198B6 (cs) 2003-08-13
FI20010155A (fi) 2001-02-09
CA2290127C (en) 2005-01-25
CA2290127A1 (en) 2000-12-25
WO2000013648B1 (en) 2001-03-15
ATA904199A (de) 2002-05-15
AU1374500A (en) 2000-03-27
AR020863A1 (es) 2002-05-29
IS2343B (is) 2008-02-15
NZ514979A (en) 2004-01-30
US20020077353A1 (en) 2002-06-20
HK1049002A1 (en) 2003-04-25
BG106191A (en) 2002-08-30
NO20010319D0 (no) 2001-01-19
ZA200108854B (en) 2002-08-28
HK1049002B (zh) 2004-12-31
CZ2001320A3 (en) 2001-05-16
HUP0103235A3 (en) 2003-01-28
GB2357761B (en) 2001-09-05
EA200101072A1 (ru) 2002-02-28
IL145959A0 (en) 2002-07-25
JP2002526386A (ja) 2002-08-20
IL145959A (en) 2007-07-24
DK1159274T3 (da) 2003-07-21
AT4365U1 (de) 2001-06-25
NO20010319L (no) 2001-02-23
CH691305A5 (de) 2001-06-29
EP1159274A2 (en) 2001-12-05
TR200103702T2 (tr) 2002-06-21
CN1502616A (zh) 2004-06-09
GB0101504D0 (en) 2001-03-07
WO2000013648A2 (en) 2000-03-16
PT1159274E (pt) 2003-08-29
BG65574B1 (bg) 2009-01-30
CN1140521C (zh) 2004-03-03
KR20020012204A (ko) 2002-02-15
MXPA01010989A (es) 2002-06-04
CN1367786A (zh) 2002-09-04
ITMI991581A0 (it) 1999-07-15
SK285813B6 (sk) 2007-08-02
IS5861A (is) 2001-02-23
DE19983487C1 (de) 2002-07-25
ITMI991581A1 (it) 2001-01-15
GB2357761A (en) 2001-07-04
UA63034C2 (en) 2004-01-15
DE69906389D1 (de) 2003-04-30
JP3447267B2 (ja) 2003-09-16
BR9917368A (pt) 2002-03-05
SE0100193L (sv) 2001-04-25
GB2354239B (en) 2001-06-06
ES2194545T3 (es) 2003-11-16
DK200100060A (da) 2001-04-10
EP1159274B1 (en) 2003-03-26

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