BR9917368A - Método para preparação de citalopram e preparação farmacêutica obtida - Google Patents

Método para preparação de citalopram e preparação farmacêutica obtida

Info

Publication number
BR9917368A
BR9917368A BR9917368-9A BR9917368A BR9917368A BR 9917368 A BR9917368 A BR 9917368A BR 9917368 A BR9917368 A BR 9917368A BR 9917368 A BR9917368 A BR 9917368A
Authority
BR
Brazil
Prior art keywords
preparation
citalopram
pharmaceutical
pharmaceutical preparation
palladium catalyst
Prior art date
Application number
BR9917368-9A
Other languages
English (en)
Other versions
BR9917368B1 (pt
Inventor
Hans Petersen
Michael Harold Rock
Henrik Svane
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of BR9917368A publication Critical patent/BR9917368A/pt
Publication of BR9917368B1 publication Critical patent/BR9917368B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Abstract

"MéTODO PARA PREPARAçãO DE CITALOPRAM E PREPARAçãO FARMACêUTICA OBTIDA". Método para a preparação de citalopram compreendendo reação de um composto de Fórmula IV onde R é halogênio ou CF~ 3~-(CF~ 2~)~ n~-SO~ 2~-, n sendo 0-8, com uma fonte de cianeto na presença de um catalisador de paládio e uma quantidade catalítica de Cu^ +^ ou Zn^ 2+^, ou com Zn(CN)~ 2~ na presença de um catalisador de paládio.
BRPI9917368-9A 1999-06-25 1999-11-22 mÉtodo para preparaÇço de citalopram. BR9917368B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA199900920 1999-06-25
DKPA199900920 1999-06-25
PCT/DK1999/000640 WO2000013648A2 (en) 1999-06-25 1999-11-22 Method for the preparation of citalopram

Publications (2)

Publication Number Publication Date
BR9917368A true BR9917368A (pt) 2002-03-05
BR9917368B1 BR9917368B1 (pt) 2010-02-09

Family

ID=8099035

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9917368-9A BR9917368B1 (pt) 1999-06-25 1999-11-22 mÉtodo para preparaÇço de citalopram.

Country Status (36)

Country Link
US (2) US20020077353A1 (pt)
EP (1) EP1159274B1 (pt)
JP (1) JP3447267B2 (pt)
KR (1) KR100491368B1 (pt)
CN (2) CN1140521C (pt)
AR (1) AR020863A1 (pt)
AT (3) AT409961B (pt)
AU (2) AU2001100440B4 (pt)
BG (1) BG65574B1 (pt)
BR (1) BR9917368B1 (pt)
CA (2) CA2475401A1 (pt)
CH (1) CH691305A5 (pt)
CZ (1) CZ292198B6 (pt)
DE (2) DE19983487C1 (pt)
DK (2) DK1159274T3 (pt)
EA (1) EA002560B1 (pt)
ES (2) ES2194545T3 (pt)
FI (1) FI108641B (pt)
GB (2) GB2354239B (pt)
HK (1) HK1049002B (pt)
HU (1) HUP0103235A3 (pt)
IL (2) IL145959A0 (pt)
IS (1) IS2343B (pt)
IT (1) ITMI991581A1 (pt)
MX (1) MXPA01010989A (pt)
NO (1) NO328542B1 (pt)
NZ (1) NZ514979A (pt)
PL (1) PL205579B1 (pt)
PT (1) PT1159274E (pt)
SE (1) SE516690C2 (pt)
SI (1) SI1159274T1 (pt)
SK (1) SK285813B6 (pt)
TR (1) TR200103702T2 (pt)
UA (1) UA63034C2 (pt)
WO (1) WO2000013648A2 (pt)
ZA (1) ZA200108854B (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2195644T3 (es) 1998-12-23 2003-12-01 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida.
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ES2195554T5 (es) 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
AU742554B2 (en) 1999-10-25 2002-01-03 H. Lundbeck A/S Method for the preparation of citalopram
DE69935355T2 (de) 1999-10-25 2007-11-08 H. Lundbeck A/S, Valby Verfahren zur Herstellung von Citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
MXPA02006503A (es) 1999-12-28 2002-12-09 Lundbeck & Co As H Metodo para la preparacion de citalopram.
EA004055B1 (ru) 1999-12-30 2003-12-25 Х.Лундбекк А/С Способ получения циталопрама
ATE252570T1 (de) 2000-01-14 2003-11-15 Lundbeck & Co As H Verfahren zur herstellung von 5-cyanophthalid
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
AU2001242298A1 (en) 2000-03-13 2001-09-24 H Lunbeck A/S Method for the preparation of citalopram
GB2357762B (en) 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
WO2001068629A1 (en) * 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
MXPA02008653A (es) 2000-03-14 2003-02-24 Lundbeck & Co As H Metodo para la preparacion de citalopram.
CN1418206A (zh) * 2000-03-16 2003-05-14 H·隆德贝克有限公司 5－氰基－1－(4－氟苯基)－1,3－二氢异苯并呋喃的制备方法
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
AU2001272368A1 (en) * 2000-07-06 2002-01-21 H. Lundbeck, A/S Method for the preparation of citalopram
FI20011622A (fi) * 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
SI1181713T1 (en) 2000-12-22 2005-02-28 H. Lundbeck A/S Method for the preparation of pure citalopram
TR200200018T1 (tr) * 2000-12-28 2002-06-21 H. Lundbeck A/S Saf sitalopram hazırlanması için yöntem.
EP1355897A1 (en) 2001-01-30 2003-10-29 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
CN1221541C (zh) * 2001-03-09 2005-10-05 兰贝克塞实验室有限公司 制备西酞普兰的方法
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
US7148364B2 (en) * 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
TWI306846B (en) 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
WO2004085416A1 (en) * 2003-03-24 2004-10-07 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
EP1486492A3 (en) 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. A process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran.
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
WO2006021971A2 (en) 2004-08-23 2006-03-02 Sun Pharmaceutical Industries Limited 'process for preparation of citalopram and enantiomers'
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI358407B (en) 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
EP2017271A1 (en) 2007-07-06 2009-01-21 Aurobindo Pharma Limited Process for the preparation of escitalopram

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (pt) * 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) * 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) * 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) * 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) * 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ATE205824T1 (de) * 1997-07-08 2001-10-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
TR200001341T2 (tr) * 1997-11-11 2000-11-21 H. Lundbeck A/S Sitalopramın hazırlandığı metot
WO2000023431A1 (en) * 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
ES2195644T3 (es) * 1998-12-23 2003-12-01 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida.
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ES2195554T5 (es) * 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
AU742554B2 (en) * 1999-10-25 2002-01-03 H. Lundbeck A/S Method for the preparation of citalopram
AR026063A1 (es) * 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) * 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
FI20011622A (fi) * 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
SI1181713T1 (en) * 2000-12-22 2005-02-28 H. Lundbeck A/S Method for the preparation of pure citalopram
TR200200018T1 (tr) * 2000-12-28 2002-06-21 H. Lundbeck A/S Saf sitalopram hazırlanması için yöntem.

Also Published As

Publication number Publication date
NO328542B1 (no) 2010-03-15
NO20010319L (no) 2001-02-23
AR020863A1 (es) 2002-05-29
JP3447267B2 (ja) 2003-09-16
AT4365U1 (de) 2001-06-25
US20020077353A1 (en) 2002-06-20
FI108641B (fi) 2002-02-28
GB2357761B (en) 2001-09-05
PT1159274E (pt) 2003-08-29
SK18402001A3 (sk) 2002-06-04
AU1374500A (en) 2000-03-27
GB0101504D0 (en) 2001-03-07
WO2000013648A8 (en) 2000-05-11
GB0105182D0 (en) 2001-04-18
CZ292198B6 (cs) 2003-08-13
WO2000013648A2 (en) 2000-03-16
ES2189699A1 (es) 2003-07-01
WO2000013648A3 (en) 2000-07-13
BG65574B1 (bg) 2009-01-30
FI20010155A (fi) 2001-02-09
MXPA01010989A (es) 2002-06-04
BG106191A (en) 2002-08-30
NO20010319D0 (no) 2001-01-19
CA2290127A1 (en) 2000-12-25
UA63034C2 (en) 2004-01-15
EA002560B1 (ru) 2002-06-27
GB2354239B (en) 2001-06-06
HUP0103235A2 (hu) 2002-01-28
US20090088469A1 (en) 2009-04-02
CA2290127C (en) 2005-01-25
DK1159274T3 (da) 2003-07-21
CZ2001320A3 (en) 2001-05-16
GB2354239A (en) 2001-03-21
AT409961B (de) 2002-12-27
DE19983487C1 (de) 2002-07-25
DK200100060A (da) 2001-04-10
EP1159274A2 (en) 2001-12-05
WO2000013648B1 (en) 2001-03-15
SI1159274T1 (en) 2003-10-31
EA200101072A1 (ru) 2002-02-28
ES2194545T3 (es) 2003-11-16
CH691305A5 (de) 2001-06-29
PL205579B1 (pl) 2010-05-31
EP1159274B1 (en) 2003-03-26
BR9917368B1 (pt) 2010-02-09
IL145959A0 (en) 2002-07-25
GB2357761A (en) 2001-07-04
KR20020012204A (ko) 2002-02-15
HUP0103235A3 (en) 2003-01-28
AU2001100440A4 (en) 2001-11-01
SE516690C2 (sv) 2002-02-12
NZ514979A (en) 2004-01-30
ATA904199A (de) 2002-05-15
ITMI991581A0 (it) 1999-07-15
SE0100193L (sv) 2001-04-25
ITMI991581A1 (it) 2001-01-15
CN1367786A (zh) 2002-09-04
DE69906389T2 (de) 2003-10-30
IS5861A (is) 2001-02-23
IL145959A (en) 2007-07-24
IS2343B (is) 2008-02-15
KR100491368B1 (ko) 2005-05-24
HK1049002B (zh) 2004-12-31
CN1140521C (zh) 2004-03-03
SE0100193D0 (sv) 2001-01-24
ZA200108854B (en) 2002-08-28
CA2475401A1 (en) 2000-12-25
JP2002526386A (ja) 2002-08-20
CN1502616A (zh) 2004-06-09
AU2001100440B4 (en) 2002-01-24
ATE235478T1 (de) 2003-04-15
TR200103702T2 (tr) 2002-06-21
DE69906389D1 (de) 2003-04-30
PL346237A1 (en) 2002-01-28
HK1049002A1 (en) 2003-04-25
SK285813B6 (sk) 2007-08-02

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