BR0106976A - Método para a preparação de citalopram - Google Patents

Método para a preparação de citalopram

Info

Publication number
BR0106976A
BR0106976A BR0106976-4A BR0106976A BR0106976A BR 0106976 A BR0106976 A BR 0106976A BR 0106976 A BR0106976 A BR 0106976A BR 0106976 A BR0106976 A BR 0106976A
Authority
BR
Brazil
Prior art keywords
citalopram
fluorophenyl
magnesium
preparation
isobenzofuran
Prior art date
Application number
BR0106976-4A
Other languages
English (en)
Inventor
Eva Bolzonella
Andrea Castellin
Andrea Nicole
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2000/006426 external-priority patent/WO2001002383A2/en
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of BR0106976A publication Critical patent/BR0106976A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans

Abstract

"MéTODO PARA PREPARAçãO DE CITALOPRAM". Um método de fabricação de citalopram caracterizado por na reação (i) de 1-(4-fluorophenil)-1-(3-dimetilaminopropil)-5-haloftalano com magnésio ativado para formar o reagente Grignard [3-[1-(4-fluorofenil)-1,3 díidro-isobenzofurano-1-yl]propil]dimetil amina 5-haleto de magnésio seguido pela reação (iii) de [3-[1-(4-fluorofenil)-1,3 díidro-isobenzofurano-1-yl]propil]dimetil amina 5-haleto de magnésio com um composto contendo grupo CN unido para um grupo de saída, para formar o citalopram.
BR0106976-4A 2000-07-06 2001-07-06 Método para a preparação de citalopram BR0106976A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2000/006426 WO2001002383A2 (en) 1999-07-06 2000-07-06 Process for the synthesis of citalopram
PCT/DK2001/000481 WO2002004435A1 (en) 2000-07-06 2001-07-06 Method for the preparation of citalopram

Publications (1)

Publication Number Publication Date
BR0106976A true BR0106976A (pt) 2002-07-23

Family

ID=8164018

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0106976-4A BR0106976A (pt) 2000-07-06 2001-07-06 Método para a preparação de citalopram

Country Status (11)

Country Link
US (1) US20020128497A1 (pt)
AU (1) AU2001272368A1 (pt)
BR (1) BR0106976A (pt)
CA (1) CA2383963A1 (pt)
CZ (1) CZ2002832A3 (pt)
EA (1) EA200200332A1 (pt)
IL (1) IL148525A0 (pt)
IS (1) IS6293A (pt)
NO (1) NO20021118L (pt)
SK (1) SK3362002A3 (pt)
WO (1) WO2002004435A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1173431E (pt) 1999-04-14 2003-09-30 Lundbeck & Co As H Metodo de preparacao do citalopram
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
KR20020080485A (ko) * 2000-03-13 2002-10-23 하. 룬트벡 아크티에 셀스카브 5-치환 1-(4-플루오로페닐)-1,3-디히드로이소벤조푸란의단계적 알킬화
TR200202166T2 (tr) 2000-03-13 2002-12-23 H. Lndbeck A/S Sitalopramın preparasyon metodu
TR200202155T2 (tr) 2000-03-14 2002-12-23 H. Lundbeck A/S Sitalopramin preparasyon metodu
WO2001068632A1 (en) * 2000-03-16 2001-09-20 H. Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) * 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram

Also Published As

Publication number Publication date
CA2383963A1 (en) 2002-01-17
EA200200332A1 (ru) 2002-06-27
NO20021118D0 (no) 2002-03-06
WO2002004435A1 (en) 2002-01-17
AU2001272368A1 (en) 2002-01-21
SK3362002A3 (en) 2002-08-06
NO20021118L (no) 2002-04-24
IL148525A0 (en) 2002-09-12
CZ2002832A3 (cs) 2002-05-15
US20020128497A1 (en) 2002-09-12
IS6293A (is) 2002-03-05

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]