ATE234837T1 - 3-bicycloindole als liganden des 5-ht 1d rezeptors - Google Patents

3-bicycloindole als liganden des 5-ht 1d rezeptors

Info

Publication number
ATE234837T1
ATE234837T1 AT99942679T AT99942679T ATE234837T1 AT E234837 T1 ATE234837 T1 AT E234837T1 AT 99942679 T AT99942679 T AT 99942679T AT 99942679 T AT99942679 T AT 99942679T AT E234837 T1 ATE234837 T1 AT E234837T1
Authority
AT
Austria
Prior art keywords
receptor
bicycloindole
ligands
general formula
ht1d receptor
Prior art date
Application number
AT99942679T
Other languages
English (en)
Inventor
Louise Edwards
Abdelmalik Slassi
Ashok Tehim
Tao Xin
Original Assignee
Nps Allelix Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nps Allelix Corp filed Critical Nps Allelix Corp
Application granted granted Critical
Publication of ATE234837T1 publication Critical patent/ATE234837T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Conductive Materials (AREA)
  • Electric Double-Layer Capacitors Or The Like (AREA)
AT99942679T 1998-09-18 1999-09-13 3-bicycloindole als liganden des 5-ht 1d rezeptors ATE234837T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/156,496 US6562809B1 (en) 1998-09-18 1998-09-18 3-bicycloindole compounds
PCT/CA1999/000833 WO2000017198A1 (en) 1998-09-18 1999-09-13 3-bicycloindole compounds as 5-ht1d ligands

Publications (1)

Publication Number Publication Date
ATE234837T1 true ATE234837T1 (de) 2003-04-15

Family

ID=22559821

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99942679T ATE234837T1 (de) 1998-09-18 1999-09-13 3-bicycloindole als liganden des 5-ht 1d rezeptors

Country Status (8)

Country Link
US (1) US6562809B1 (de)
EP (1) EP1114049B1 (de)
JP (1) JP2002526497A (de)
AT (1) ATE234837T1 (de)
AU (1) AU772960C (de)
CA (1) CA2343391A1 (de)
DE (1) DE69906101D1 (de)
WO (1) WO2000017198A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686374B1 (en) 1999-08-12 2004-02-03 Nps Allelix Corp. Azaindoles having serotonin receptor affinity
DE60011269T2 (de) * 1999-08-12 2005-06-23 Nps Allelix Corp., Mississauga Azaidole mit serotonin rezeptor affinität
GB9926303D0 (en) * 1999-11-05 2000-01-12 Smithkline Beecham Plc Novel compounds
KR20130136010A (ko) 2005-04-13 2013-12-11 네우렉슨 인코포레이티드 Ｎｏｓ 저해 활성을 갖는 치환된 인돌 화합물
WO2007098418A1 (en) 2006-02-17 2007-08-30 Memory Pharmaceuticals Corporation Compounds having 5-ht6 receptor affinity
JP5350219B2 (ja) 2006-04-13 2013-11-27 ニューラクソン，インコーポレーテッド Ｎｏｓ阻害活性を有する１，５および３，６−置換インドール化合物
NZ586082A (en) 2007-11-16 2013-03-28 Neuraxon Inc Indole compounds and methods for treating visceral pain

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9519558D0 (en) * 1995-09-26 1995-11-29 Merck Sharp & Dohme Therapeutic agents
GB9601786D0 (en) * 1996-01-30 1996-04-03 Merck Sharp & Dohme Therapeutic agents
CA2253941A1 (en) * 1996-05-16 1997-11-20 Sumanas Rakhit Thiophene- and furan-tryptamine derivatives
AU738668B2 (en) * 1996-11-26 2001-09-20 Nps Allelix Corp. 5-cyclo indole compounds as 5-HT1D receptor ligands
EP0875513A1 (de) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituierte heteroaromatische 5-HT1F Agoniste
US6251893B1 (en) * 1998-06-15 2001-06-26 Nps Allelix Corp. Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity

Also Published As

Publication number Publication date
EP1114049B1 (de) 2003-03-19
US6562809B1 (en) 2003-05-13
EP1114049A1 (de) 2001-07-11
WO2000017198A1 (en) 2000-03-30
CA2343391A1 (en) 2000-03-30
AU5613599A (en) 2000-04-10
AU772960C (en) 2005-04-07
AU772960B2 (en) 2004-05-13
JP2002526497A (ja) 2002-08-20
DE69906101D1 (de) 2003-04-24

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties