SE468988B - Substituerade androsta-1,4-dien-3,17-dioner, foerfarande foer deras framstaellning samt farmaceutiska kompositioner - Google Patents

Substituerade androsta-1,4-dien-3,17-dioner, foerfarande foer deras framstaellning samt farmaceutiska kompositioner

Info

Publication number
SE468988B
SE468988B SE8603046A SE8603046A SE468988B SE 468988 B SE468988 B SE 468988B SE 8603046 A SE8603046 A SE 8603046A SE 8603046 A SE8603046 A SE 8603046A SE 468988 B SE468988 B SE 468988B
Authority
SE
Sweden
Prior art keywords
dione
compound
diene
hydrogen
formula
Prior art date
Application number
SE8603046A
Other languages
English (en)
Swedish (sv)
Other versions
SE8603046D0 (sv
SE8603046L (sv
Inventor
F Buzetti
N Barbugian
P Lombardi
Salle E Di
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10582036&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE468988(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of SE8603046D0 publication Critical patent/SE8603046D0/xx
Publication of SE8603046L publication Critical patent/SE8603046L/
Publication of SE468988B publication Critical patent/SE468988B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE8603046A 1985-07-09 1986-07-08 Substituerade androsta-1,4-dien-3,17-dioner, foerfarande foer deras framstaellning samt farmaceutiska kompositioner SE468988B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858517360A GB8517360D0 (en) 1985-07-09 1985-07-09 Substituted androsta-1,4-diene-3,17-diones

Publications (3)

Publication Number Publication Date
SE8603046D0 SE8603046D0 (sv) 1986-07-08
SE8603046L SE8603046L (sv) 1987-01-10
SE468988B true SE468988B (sv) 1993-04-26

Family

ID=10582036

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8603046A SE468988B (sv) 1985-07-09 1986-07-08 Substituerade androsta-1,4-dien-3,17-dioner, foerfarande foer deras framstaellning samt farmaceutiska kompositioner

Country Status (38)

Country Link
US (2) US4808616A (ru)
JP (1) JPS6212797A (ru)
KR (1) KR950003614B1 (ru)
CN (1) CN86104664B (ru)
AT (1) AT395157B (ru)
AU (1) AU578840B2 (ru)
BE (1) BE905067A (ru)
BG (1) BG61370B2 (ru)
BR (1) BR1100240A (ru)
CA (1) CA1277656C (ru)
CH (1) CH668599A5 (ru)
CS (2) CS257794B2 (ru)
CZ (1) CZ413591A3 (ru)
DE (1) DE10199030I1 (ru)
DK (1) DK163520C (ru)
ES (2) ES8801304A1 (ru)
FI (1) FI83424C (ru)
FR (1) FR2584725B1 (ru)
GB (2) GB8517360D0 (ru)
GR (1) GR861780B (ru)
HK (1) HK94190A (ru)
HU (1) HU194274B (ru)
IE (1) IE58949B1 (ru)
IL (1) IL79336A (ru)
IT (1) IT1196436B (ru)
MY (1) MY102294A (ru)
NL (2) NL193616C (ru)
NO (2) NO165547C (ru)
NZ (1) NZ216763A (ru)
PH (1) PH21785A (ru)
PT (1) PT82944B (ru)
SE (1) SE468988B (ru)
SG (1) SG80490G (ru)
SK (1) SK413591A3 (ru)
SU (2) SU1442077A3 (ru)
UA (1) UA6046A1 (ru)
YU (2) YU44585B (ru)
ZA (1) ZA865079B (ru)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones
GB8617107D0 (en) * 1986-07-14 1986-08-20 Erba Farmitalia 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives
GB8622330D0 (en) * 1986-09-17 1986-10-22 Erba Farmitalia 4-substituted 6-alkylidenandrostene-3,17-dione derivatives
DE3715869A1 (de) * 1987-05-07 1988-11-17 Schering Ag Verfahren zur herstellung von 1-methyl-androsta-1,4-dien-3,17-dion und die neuen zwischenprodukte fuer dieses verfahren
GB8721383D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia Preparation of methylene derivatives
GB8721384D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia 17-substituted andro-sta-1 4-dien-3-one derivatives
GB8801697D0 (en) * 1988-01-26 1988-02-24 Erba Farmitalia Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione
AU652038B2 (en) * 1991-03-28 1994-08-11 Teikoku Hormone Mfg. Co., Ltd. Novel oxa- or azasteroid derivative
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
JP3293629B2 (ja) * 1992-09-30 2002-06-17 帝国臓器製薬株式会社 新規なオキサ又はアザステロイド７位置換化合物
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
GB9313420D0 (en) * 1993-06-29 1993-08-11 Erba Carlo Spa Fluorinated 6-methylenandrosta-1,4-dien-3-one-derivatives and process for their preparations
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
WO2001004342A1 (en) * 1999-07-07 2001-01-18 Pharmacia & Upjohn Company Process to prepare exemestane
GB9930839D0 (en) * 1999-12-30 2000-02-16 Pharmacia & Upjohn Spa Process for treating gynecomastia
GB0005257D0 (en) * 2000-03-03 2000-04-26 Pharmacia & Upjohn Spa Breast cancer hormonal therapy
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
GB0017635D0 (en) * 2000-07-18 2000-09-06 Pharmacia & Upjohn Spa Antitumor combined therapy
AU2001283964A1 (en) * 2000-08-09 2002-02-18 Pharmacia And Upjohn Company Composition for combined use of aromatase inhibitors
JP2004508334A (ja) * 2000-09-08 2004-03-18 フアルマシア・イタリア・エツセ・ピー・アー 化学予防剤としてのエクセメスタン
WO2002072106A2 (en) * 2001-01-26 2002-09-19 Pharmacia Italia Spa Combined method for treating hormono-dependent disorders with exemestane
US20040082557A1 (en) * 2001-01-26 2004-04-29 Wajszczuk Charles Paul Methods for treating estrogen-dependent disorders
SK288834B6 (sk) 2001-02-19 2021-03-10 Novartis Pharma Ag 40-O-(2-hydroxyetyl)-rapamycín na použitie ako jediná účinná zložka pri liečení pevného nádoru iného ako lymfatická rakovina
CN1700917B (zh) 2001-05-16 2010-04-28 诺瓦提斯公司 含n-(5-{4-[4-甲基-(1-哌嗪基)甲基]-苯甲酰氨基}-2-甲基苯基)-4-(3-吡啶基)-2-嘧啶-胺和化疗药的联合形式
GB0120147D0 (en) * 2001-08-17 2001-10-10 Metris Therapeutics Ltd Treatment method
US20040043938A1 (en) * 2001-11-06 2004-03-04 Dinesh Purandare Combination therapy for estrogen-dependent disorders
GB0128510D0 (en) * 2001-11-28 2002-01-23 Novartis Ag Organic compounds
CA2483594C (en) 2002-05-16 2011-02-15 Novartis Ag Use of edg receptor binding agents in cancer
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
US20040186160A1 (en) * 2002-12-13 2004-09-23 Sugen, Inc. Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
WO2005027916A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
US20050101579A1 (en) * 2003-11-06 2005-05-12 Shippen Eugene R. Endometriosis treatment protocol
ES2382609T3 (es) * 2004-01-16 2012-06-11 Cedarburg Pharmaceuticals, Inc. Exemestano y sus productos intermedios y métodos de preparación de los mismos
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
WO2007041564A2 (en) 2005-09-30 2007-04-12 Endece, Llc (s)-6-methyloxaalkyl exemestane compounds and related methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
US10174070B2 (en) * 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
DE102006008074B4 (de) * 2006-02-22 2013-08-14 RUHR-UNIVERSITäT BOCHUM Behandlung von Krebs mit Geruchsrezeptor-Liganden
WO2007128820A1 (en) 2006-05-09 2007-11-15 Novartis Ag Combination comprising an iron chelator and an anti-neoplastic agent and use thereof
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
BRPI0818637A2 (pt) 2007-10-16 2015-04-07 Repros Therapeutics Inc Métodos de tratamento de sintoma da síndrome metabólica, de glicose em jejum prejudicada, da síndrome metabólica e de redução de níveis de glicose em, jejum em sujeito com hipogonadismo hipogonadotrófico secundário ou idiopático
EP2070943A1 (en) * 2007-12-14 2009-06-17 Crystal Pharma, S.A. Process for obtaining 6-Alkylidenandrost-1,4-diene-3one
CN101468023B (zh) * 2007-12-26 2011-02-02 上海复星医药（集团）股份有限公司 依西美坦片及其制备工艺
ES2461092T3 (es) * 2008-01-21 2014-05-16 Cadila Healthcare Limited Procedimiento para preparar el inhibidor de aromatasa Exemestano
GB0813628D0 (en) * 2008-07-25 2008-09-03 Arrow Int Ltd Stable coated anti-cancer agent
WO2010076811A2 (en) * 2008-12-30 2010-07-08 Ind-Swift Laboratories Limited Process for the preparation of exemestane
ES2587977T3 (es) 2009-05-01 2016-10-28 Celloxess Llc Tratamiento de la infertilidad masculina secundaria al estrés oxidativo de esperma
DE102010003494A1 (de) * 2010-03-31 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
AU2011237592B2 (en) 2010-04-08 2016-10-27 Emory University Substituted androst-4-ene diones
EP2558098A2 (en) 2010-04-16 2013-02-20 Novartis AG Treatment of endocrine resistant breast cancer
EP2616477B1 (en) 2010-09-14 2016-11-09 Endece, LLC 6-substituted demethyl-estradiol derivatives as er-beta agonists
MX2014009322A (es) 2012-02-29 2014-11-10 Repros Therapeutics Inc Terapia de combinacion para el tratamiento de la deficiencia androgenica.
CN106061505A (zh) 2014-02-11 2016-10-26 诺华股份有限公司 用于治疗癌症的含pi3k抑制剂的药物组合
JP7048505B2 (ja) 2015-11-10 2022-04-05 パラクリン セラピューティクス エービー Ｐｄｇｆ－ｃｃ阻害剤および抗エストロゲン剤によるｅｒ陰性乳癌の処置
CN112409432B (zh) * 2020-11-16 2023-07-07 陕西理工大学 一种依西美坦的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB929985A (ru) *
US2744120A (en) * 1953-01-14 1956-05-01 Olin Mathieson 1-dehydrotestololactone
US3112305A (en) * 1960-11-07 1963-11-26 British Drug Houses Ltd 6-methylene-3-oxo-delta4-steroids and process for their preparation
GB1042291A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd í¸-6ª‡-amino steroids and the preparation thereof
DK120154B (da) * 1968-02-29 1971-04-19 Schering Ag Fremgangsmåde til fremstilling af N-substituerede 4-amino-3-oxosteroid-4,6-diener af androstan- eller pregnanrækken eller deres ammoniumsalte.
BE759143A (fr) * 1969-11-19 1971-05-19 Upjohn Co Procede de preparation d'un nouveau compose steroide
US4235893A (en) * 1978-05-08 1980-11-25 Brodie Angela M Ester derivatives of 4-hydroxy-4-androstene-3,17-dione and a method for inhibiting estrogen biosynthesis
DE3004508C2 (de) * 1980-02-05 1981-12-10 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von 6-Methylensteroiden
DE3322285A1 (de) * 1983-06-18 1984-12-20 Schering AG, 1000 Berlin und 4709 Bergkamen 1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US4512986A (en) * 1983-07-26 1985-04-23 Research Triangle Institute Progrestationally active steroids
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones

Also Published As

Publication number Publication date
NO165547C (no) 1991-02-27
GB2177700B (en) 1988-12-07
DE10199030I1 (de) 2001-10-04
NO2000009I1 (no) 2000-10-05
GB2177700A (en) 1987-01-28
NO862753L (no) 1987-01-12
YU103687A (en) 1988-08-31
CS258498B2 (en) 1988-08-16
ZA865079B (en) 1987-03-25
FR2584725A1 (fr) 1987-01-16
SU1501923A3 (ru) 1989-08-15
HK94190A (en) 1990-11-23
IT8621004A0 (it) 1986-07-02
CS521486A2 (en) 1987-09-17
DK163520B (da) 1992-03-09
SU1442077A3 (ru) 1988-11-30
YU44628B (en) 1990-10-31
FI862871A0 (fi) 1986-07-07
PT82944B (pt) 1989-01-30
US4904650A (en) 1990-02-27
PT82944A (en) 1986-08-01
NL300017I2 (nl) 2001-01-02
FI83424B (fi) 1991-03-28
CN86104664B (zh) 1988-06-29
GB8616585D0 (en) 1986-08-13
CH668599A5 (de) 1989-01-13
IL79336A (en) 1991-06-10
HUT42780A (en) 1987-08-28
ES8801304A1 (es) 1987-12-16
JPS6212797A (ja) 1987-01-21
SE8603046D0 (sv) 1986-07-08
BE905067A (fr) 1987-01-08
CZ413591A3 (en) 1994-03-16
ES557466A0 (es) 1988-06-01
IL79336A0 (en) 1986-10-31
CS257794B2 (en) 1988-06-15
GR861780B (en) 1986-11-11
NO165547B (no) 1990-11-19
SG80490G (en) 1990-11-23
ATA181986A (de) 1992-02-15
SK413591A3 (en) 1995-07-11
BR1100240A (pt) 1999-12-28
NZ216763A (en) 1988-05-30
NO862753D0 (no) 1986-07-08
DK324386A (da) 1987-01-10
HU194274B (en) 1988-01-28
DK163520C (da) 1992-07-27
US4808616A (en) 1989-02-28
CA1277656C (en) 1990-12-11
NL300017I1 (nl) 2000-11-01
GB8517360D0 (en) 1985-08-14
MY102294A (en) 1992-05-15
KR950003614B1 (ko) 1995-04-17
IT1196436B (it) 1988-11-16
DK324386D0 (da) 1986-07-08
YU120186A (en) 1988-02-29
UA6046A1 (ru) 1994-12-29
NL193616C (nl) 2000-04-04
AU5979986A (en) 1987-01-15
PH21785A (en) 1988-02-24
BG61370B2 (bg) 1997-06-30
ES8802429A1 (es) 1988-06-01
ES556550A0 (es) 1987-12-16
YU44585B (en) 1990-10-31
JPH0443919B2 (ru) 1992-07-20
SE8603046L (sv) 1987-01-10
FI862871A (fi) 1987-01-10
IE861821L (en) 1987-01-09
NL193616B (nl) 1999-12-01
NL8601785A (nl) 1987-02-02
FR2584725B1 (fr) 1988-05-13
AU578840B2 (en) 1988-11-03
IE58949B1 (en) 1993-12-01
CN86104664A (zh) 1987-02-18
FI83424C (fi) 1991-07-10
AT395157B (de) 1992-10-12
KR870001140A (ko) 1987-03-11

Similar Documents

Publication Publication Date Title
SE468988B (sv) Substituerade androsta-1,4-dien-3,17-dioner, foerfarande foer deras framstaellning samt farmaceutiska kompositioner
CA1319362C (en) 4-substituted androstendione derivatives and process for their preparation
EP0260975B1 (en) 4-substituted 6- alkylidenandrostene-3,17-dione derivatives and process for their preparation
KR970007948B1 (ko) 17-치환된 안드로스타-1,4-디엔-3-온 유도체, 이의 제조방법 및 이를 포함하는 약제학적 조성물
EP0253591A1 (en) New 6- or 7-methylenandrosta-1, 4-diene-3,17-dione derivatives and process for their preparation
US4840943A (en) Androst-4-ene-3,17-diones and process for their preparation
US4771043A (en) Steroidic aromatase inhibitors
NO166039B (no) Analogifremgangsmaate for fremstilling av steroido(3,2-c)pyrazoler med antiandrogen virkning.
US4810423A (en) 1,2-beta-methylene-4-substituted androstene-3,17-dione derivatives and process for their preparation
HU197925B (en) Process for producing 11 beta-(aminophenyl)-steroids and pharmaceutical compositions comprising same
DE3622841C2 (de) Substituierte Androsta-1,4-dien-3,17-dione und Verfahren zu deren Herstellung
DE69302007T2 (de) Androst-4-en[4,5-b]-pyrrol-derivate und ein verfahren zu ihrer herstellung
US3937697A (en) 12-Dehydro digoxin-4'"-and 3'"-alkyl ethers
US3872081A (en) Digitoxigenin rhamnoside cyclocarbonates
GB2166742A (en) Novel 4-thioandrostene derivatives useful as aromatase inhibitors
HU199157B (en) Process for producing 17-substituted androsta-1,4-dien-3-one derivatives and pharmaceutical compositions comprising same as active ingredient
SI8611201A8 (sl) Postopek za pridobivanje substituiranih androsta -1,4-dien-3,17-dionov

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 8603046-7

Format of ref document f/p: F

SPCF Application for supplementary protection certificate filed

Free format text: 0090009, 991104

SPCG Supplementary protection certificate granted

Free format text: 0090009, 20060709, EXPIRES: 20110708

NUG Patent has lapsed