SE444562B - Nya karbostyrilderivat - Google Patents

Nya karbostyrilderivat

Info

Publication number
SE444562B
SE444562B SE7806710A SE7806710A SE444562B SE 444562 B SE444562 B SE 444562B SE 7806710 A SE7806710 A SE 7806710A SE 7806710 A SE7806710 A SE 7806710A SE 444562 B SE444562 B SE 444562B
Authority
SE
Sweden
Prior art keywords
group
carbon atoms
compound according
carbostyril
propoxy
Prior art date
Application number
SE7806710A
Other languages
English (en)
Swedish (sv)
Other versions
SE7806710L (sv
Inventor
T Nishi
H Ueda
K Nakagawa
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6931977A external-priority patent/JPS545981A/ja
Priority claimed from JP7586377A external-priority patent/JPS5412385A/ja
Priority claimed from JP53023012A external-priority patent/JPS6059912B2/ja
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of SE7806710L publication Critical patent/SE7806710L/xx
Publication of SE444562B publication Critical patent/SE444562B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
SE7806710A 1977-06-10 1978-06-09 Nya karbostyrilderivat SE444562B (sv)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP6931977A JPS545981A (en) 1977-06-10 1977-06-10 Carbostyryl derivatives
JP7586377A JPS5412385A (en) 1977-06-24 1977-06-24 Carbostyril derivative
JP53023012A JPS6059912B2 (ja) 1978-02-28 1978-02-28 カルボスチリル誘導体

Publications (2)

Publication Number Publication Date
SE7806710L SE7806710L (sv) 1978-12-11
SE444562B true SE444562B (sv) 1986-04-21

Family

ID=27284068

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7806710A SE444562B (sv) 1977-06-10 1978-06-09 Nya karbostyrilderivat

Country Status (21)

Country Link
US (1) US4298739A (fi)
AR (2) AR224345A1 (fi)
AT (1) AT367038B (fi)
AU (1) AU510138B2 (fi)
CA (1) CA1098907A (fi)
CH (1) CH636087A5 (fi)
DE (1) DE2825048A1 (fi)
DK (1) DK149449C (fi)
ES (2) ES470690A1 (fi)
FI (1) FI69300C (fi)
FR (1) FR2393795B1 (fi)
GB (1) GB2002745B (fi)
IE (1) IE46852B1 (fi)
IT (1) IT1108326B (fi)
MX (1) MX5527E (fi)
NL (1) NL178074C (fi)
NO (1) NO148813C (fi)
NZ (1) NZ187452A (fi)
PH (1) PH14670A (fi)
PT (1) PT68157A (fi)
SE (1) SE444562B (fi)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU843739A3 (ru) * 1978-02-17 1981-06-30 Карл Томэ Гмбх (Фирма) Способ получени карбостириловыхили ОКСиНдОлОВыХ пРОизВОдНыХ
JPS56122356A (en) * 1980-02-29 1981-09-25 Otsuka Pharmaceut Co Ltd Carbostyril derivative
AT383594B (de) * 1980-02-29 1987-07-27 Otsuka Pharma Co Ltd Verfahren zum herstellen von neuen carbostyrilderivaten und ihren salzen
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
US4578381A (en) * 1982-07-05 1986-03-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
US4663320A (en) * 1983-02-16 1987-05-05 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
FI81578C (fi) * 1984-02-15 1990-11-12 Syntex Inc Foerfarande foer framstaellning av nya fosfodiesterasinhibierande 1,2,3,5-tetrahydroimidazo/2,1-b/ kinazolinderivat.
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
US5227381A (en) * 1988-05-02 1993-07-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative
JP2753622B2 (ja) 1988-05-02 1998-05-20 大塚製薬株式会社 カルボスチリル誘導体
TW201305B (fi) * 1991-04-03 1993-03-01 Otsuka Pharma Co Ltd
AU653060B2 (en) * 1991-08-23 1994-09-15 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelet agglutination inhibitor
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CN101355876B (zh) 2005-11-09 2012-09-05 康宾纳特克斯公司 一种适用于眼部给药的组合物
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
AU2008261102B2 (en) 2007-06-04 2013-11-28 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
CA2930674A1 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
EP2196453A1 (en) * 2008-12-10 2010-06-16 Cellvir Novel substituted aryl derivatives, their process of preparation and their therapeutical uses as anti-HIV agents
WO2011021676A1 (ja) 2009-08-21 2011-02-24 大塚製薬株式会社 ベンゾ［ｂ］［１，４］ジアゼピン－２，４－ジオン化合物の製造方法
TWI481601B (zh) * 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
US8541404B2 (en) 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (zh) 2011-03-01 2018-10-19 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
EP3718557A3 (en) 2013-02-25 2020-10-21 Bausch Health Ireland Limited Guanylate cyclase receptor agonist sp-333 for use in colonic cleansing
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
NZ717739A (en) 2013-08-09 2023-12-22 Ardelyx Inc Compounds and methods for inhibiting phosphate transport
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207554A1 (es) * 1972-12-02 1976-10-15 Otsuka Pharma Co Ltd Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2)
JPS5239035B2 (fi) * 1972-12-14 1977-10-03
JPS5234629B2 (fi) * 1973-02-03 1977-09-05
NL179275C (nl) * 1973-10-24 1986-08-18 Otsuka Pharma Co Ltd Werkwijze voor de bereiding van farmacologisch werkzame glycerol-derivaten en werkwijze voor de bereiding van preparaten die ze bevatten.
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
FI59246C (fi) * 1974-06-24 1981-07-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin
JPS54119478A (en) * 1978-03-06 1979-09-17 Otsuka Pharmaceut Co Ltd Carbostyril derivative

Also Published As

Publication number Publication date
IT7868355A0 (it) 1978-06-09
FI69300B (fi) 1985-09-30
GB2002745A (en) 1979-02-28
FI781811A (fi) 1978-12-11
MX5527E (es) 1983-09-23
NZ187452A (en) 1980-05-27
US4298739A (en) 1981-11-03
NO148813C (no) 1983-12-21
IE46852B1 (en) 1983-10-05
AT367038B (de) 1982-05-25
ATA421378A (de) 1981-10-15
ES470690A1 (es) 1979-10-16
DK149449B (da) 1986-06-16
ES479138A1 (es) 1979-07-01
NO782022L (no) 1978-12-12
DK149449C (da) 1986-11-24
PT68157A (en) 1978-07-01
GB2002745B (en) 1982-02-17
DK254878A (da) 1979-02-09
AR224345A1 (es) 1981-11-30
NL7806245A (nl) 1978-12-12
CH636087A5 (de) 1983-05-13
PH14670A (en) 1981-10-30
FR2393795A1 (fr) 1979-01-05
AU510138B2 (en) 1980-06-12
DE2825048A1 (de) 1978-12-14
NO148813B (no) 1983-09-12
FR2393795B1 (fr) 1986-07-25
AU3686678A (en) 1979-12-13
SE7806710L (sv) 1978-12-11
IE781104L (en) 1978-12-10
CA1098907A (en) 1981-04-07
IT1108326B (it) 1985-12-09
DE2825048C2 (fi) 1991-05-08
FI69300C (fi) 1986-01-10
AR225755A1 (es) 1982-04-30
NL178074C (nl) 1986-01-16

Similar Documents

Publication Publication Date Title
SE444562B (sv) Nya karbostyrilderivat
TW199153B (fi)
BR112012013457A2 (pt) derivados de sulfonamida como agentes indutores de apoptose bcl-2-seletivos para o tratamento do câncer e doenças imunes
JPS5872575A (ja) 新規カルボン酸誘導体、その製法及びこれを含有する血中脂質低下剤
EP3112361A1 (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US4886809A (en) Carbostyril derivatives and salts thereof
EP3666758A1 (en) Process for the preparation of a sulfonamide derivative
JPS5933250A (ja) アシルアニリド、その製法及び抗アンドロゲン作用を有する医薬又は獣医薬組成物
JPH03130281A (ja) 複素環式誘導体、その製造方法および前記誘導体を含有するロイコトリエン誘因性疾患または症状の治療に用いる薬理学的組成物
NL8600596A (nl) Geneeskrachtige verbindingen, werkwijzen ter bereiding daarvan alsmede deze verbindingen als actieve component bevattende preparaten.
DE1913119A1 (de) Alpha-Carboline und Verfahren zu ihrer Herstellung
WO1989009213A1 (en) 6-substituted acyclicpyrimidine nucleoside derivatives and antiviral agents containing same as active ingredients
SE450894B (sv) Karboximidderivat, forfarande for framstellning derav och farmaceutisk komposition
MXPA04002519A (es) Proceso para preparar aripiprazol.
NO121893B (fi)
US4845100A (en) Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same
EP0292023A2 (de) Pyrimidinderivate
NO781556L (no) Benzimidazol-derivater.
EP0256400A2 (de) Pyrimidinderivate, ihre Herstellung und Medikamente die diese Derivate enthalten
JPS62158253A (ja) ４−アミノピリジンアミド誘導体
EP0003771B1 (de) Neue Carbostyrilderivate, ihre Herstellung und diese Verbindungen enthaltende Arzneimittel
GB2069492A (en) Novel sulphur compounds
JPS6117826B2 (fi)
EP0124630B1 (de) Pyrimidin-Thioalkylpyridin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindung enthaltende Arzneimittel
US2759942A (en) Substituted piperidinecarboxylates and methods of preparing same

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 7806710-5

Effective date: 19940110

Format of ref document f/p: F