FR2393795A1 - Derives de carbostyryle, leur procede de preparation et leurs applications en therapeutique - Google Patents

Derives de carbostyryle, leur procede de preparation et leurs applications en therapeutique

Info

Publication number
FR2393795A1
FR2393795A1 FR7817167A FR7817167A FR2393795A1 FR 2393795 A1 FR2393795 A1 FR 2393795A1 FR 7817167 A FR7817167 A FR 7817167A FR 7817167 A FR7817167 A FR 7817167A FR 2393795 A1 FR2393795 A1 FR 2393795A1
Authority
FR
France
Prior art keywords
preparation process
therapeutic applications
carbostyryl derivatives
inflammatory
carbostyryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7817167A
Other languages
English (en)
Other versions
FR2393795B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6931977A external-priority patent/JPS545981A/ja
Priority claimed from JP7586377A external-priority patent/JPS5412385A/ja
Priority claimed from JP53023012A external-priority patent/JPS6059912B2/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of FR2393795A1 publication Critical patent/FR2393795A1/fr
Application granted granted Critical
Publication of FR2393795B1 publication Critical patent/FR2393795B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

L'invention a pour objet de nouveaux dérivés de carbostyryle ayant notamment des propriétés inhibitrices de l'agrégation plaquettaire, anti-inflammatoires, anti-ulcère, vasodilatatrices et inhibitrices de la phosphodiestérase, utilisables pour la prévention ou le traitement des thromboses, de l'artériosclérose, de l'hypertension, de l'asthme, etc, et également utilisables comme agents anti-inflammatoires et anti-ulcère, répondant la la formule générale :
FR7817167A 1977-06-10 1978-06-08 Derives de carbostyryle, leur procede de preparation et leurs applications en therapeutique Expired FR2393795B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP6931977A JPS545981A (en) 1977-06-10 1977-06-10 Carbostyryl derivatives
JP7586377A JPS5412385A (en) 1977-06-24 1977-06-24 Carbostyril derivative
JP53023012A JPS6059912B2 (ja) 1978-02-28 1978-02-28 カルボスチリル誘導体

Publications (2)

Publication Number Publication Date
FR2393795A1 true FR2393795A1 (fr) 1979-01-05
FR2393795B1 FR2393795B1 (fr) 1986-07-25

Family

ID=27284068

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7817167A Expired FR2393795B1 (fr) 1977-06-10 1978-06-08 Derives de carbostyryle, leur procede de preparation et leurs applications en therapeutique

Country Status (21)

Country Link
US (1) US4298739A (fr)
AR (2) AR224345A1 (fr)
AT (1) AT367038B (fr)
AU (1) AU510138B2 (fr)
CA (1) CA1098907A (fr)
CH (1) CH636087A5 (fr)
DE (1) DE2825048A1 (fr)
DK (1) DK149449C (fr)
ES (2) ES470690A1 (fr)
FI (1) FI69300C (fr)
FR (1) FR2393795B1 (fr)
GB (1) GB2002745B (fr)
IE (1) IE46852B1 (fr)
IT (1) IT1108326B (fr)
MX (1) MX5527E (fr)
NL (1) NL178074C (fr)
NO (1) NO148813C (fr)
NZ (1) NZ187452A (fr)
PH (1) PH14670A (fr)
PT (1) PT68157A (fr)
SE (1) SE444562B (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2477149A1 (fr) * 1980-02-29 1981-09-04 Otsuka Pharma Co Ltd Nouveaux derives de carbostyrile, leur procede de preparation et leur application en therapeutique
FR2530626A1 (fr) * 1982-07-05 1984-01-27 Otsuka Pharma Co Ltd Composes de carbostyryle
EP0116948A2 (fr) * 1983-02-16 1984-08-29 Syntex (U.S.A.) Inc. Amides(2-oxo-1,2,3,5-tétrahydroimidazo-(2,1-b)quinazolinyl)-oxyalkyliques
US4663320A (en) * 1983-02-16 1987-05-05 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
US4690925A (en) * 1984-02-15 1987-09-01 Syntex (U.S.A.) Inc. (2-Oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl) oxyalkylamides properties having phosphodiosterase inhibiting

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU843739A3 (ru) * 1978-02-17 1981-06-30 Карл Томэ Гмбх (Фирма) Способ получени карбостириловыхили ОКСиНдОлОВыХ пРОизВОдНыХ
AT383594B (de) * 1980-02-29 1987-07-27 Otsuka Pharma Co Ltd Verfahren zum herstellen von neuen carbostyrilderivaten und ihren salzen
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
JP2753622B2 (ja) 1988-05-02 1998-05-20 大塚製薬株式会社 カルボスチリル誘導体
US5227381A (en) * 1988-05-02 1993-07-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative
TW201305B (fr) * 1991-04-03 1993-03-01 Otsuka Pharma Co Ltd
KR930702307A (ko) * 1991-08-23 1993-09-08 오오쓰까 아끼히꼬 카르보스티릴 유도체 및 혈소판 응집 억제제
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CA2628570A1 (fr) 2005-11-09 2007-05-18 Combinatorx, Incorporated Procedes, compositions et kits pour le traitement de pathologies
ES2393885T7 (es) 2007-06-04 2014-01-30 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
EP2196453A1 (fr) * 2008-12-10 2010-06-16 Cellvir Nouveaux dérivés aryle substitués, leur procédé de préparation et leurs utilisations thérapeutiques en tant qu'agents anti-VIH
CN102639512B (zh) 2009-08-21 2015-12-09 大塚制药株式会社 苯并[b][1,4]二氮杂*-2,4-二酮化合物的制备方法
TWI481601B (zh) 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
US8541404B2 (en) 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
JP6251038B2 (ja) 2011-03-01 2017-12-20 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃアゴニストの調製方法
WO2013106547A1 (fr) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation
AU2014218599C1 (en) 2013-02-25 2018-09-06 Bausch Health Ireland Limited Guanylate cyclase receptor agonists for use in colonic cleansing
CA2905435A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions utiles pour le traitement de troubles gastro-intestinaux
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
US10011637B2 (en) 2013-06-05 2018-07-03 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase C, method of making and using same
JP6694385B2 (ja) 2013-08-09 2020-05-13 アーデリクス，インコーポレーテッド リン酸塩輸送阻害のための化合物及び方法
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207554A1 (es) * 1972-12-02 1976-10-15 Otsuka Pharma Co Ltd Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2)
JPS5239035B2 (fr) * 1972-12-14 1977-10-03
JPS5234629B2 (fr) * 1973-02-03 1977-09-05
SE431451B (sv) * 1973-10-24 1984-02-06 Otsuka Pharma Co Ltd Forfarande for framstellning av 2,3-dihydroxipropoxikinoliner eller -isokinoliner
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
FI59246C (fi) * 1974-06-24 1981-07-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin
JPS54119478A (en) * 1978-03-06 1979-09-17 Otsuka Pharmaceut Co Ltd Carbostyril derivative

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2477149A1 (fr) * 1980-02-29 1981-09-04 Otsuka Pharma Co Ltd Nouveaux derives de carbostyrile, leur procede de preparation et leur application en therapeutique
FR2530626A1 (fr) * 1982-07-05 1984-01-27 Otsuka Pharma Co Ltd Composes de carbostyryle
EP0116948A2 (fr) * 1983-02-16 1984-08-29 Syntex (U.S.A.) Inc. Amides(2-oxo-1,2,3,5-tétrahydroimidazo-(2,1-b)quinazolinyl)-oxyalkyliques
EP0116948A3 (en) * 1983-02-16 1984-12-19 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo-(2,1-b)quinazolinyl)-oxyalkyl-amides
US4663320A (en) * 1983-02-16 1987-05-05 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
US4690925A (en) * 1984-02-15 1987-09-01 Syntex (U.S.A.) Inc. (2-Oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl) oxyalkylamides properties having phosphodiosterase inhibiting
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors

Also Published As

Publication number Publication date
IT1108326B (it) 1985-12-09
PH14670A (en) 1981-10-30
ATA421378A (de) 1981-10-15
IE46852B1 (en) 1983-10-05
NO148813B (no) 1983-09-12
GB2002745B (en) 1982-02-17
AR224345A1 (es) 1981-11-30
AU510138B2 (en) 1980-06-12
PT68157A (en) 1978-07-01
AU3686678A (en) 1979-12-13
GB2002745A (en) 1979-02-28
SE7806710L (sv) 1978-12-11
DE2825048C2 (fr) 1991-05-08
ES479138A1 (es) 1979-07-01
NL178074C (nl) 1986-01-16
DK254878A (da) 1979-02-09
NO148813C (no) 1983-12-21
SE444562B (sv) 1986-04-21
AT367038B (de) 1982-05-25
IT7868355A0 (it) 1978-06-09
US4298739A (en) 1981-11-03
DK149449B (da) 1986-06-16
FR2393795B1 (fr) 1986-07-25
FI69300B (fi) 1985-09-30
IE781104L (en) 1978-12-10
NO782022L (no) 1978-12-12
NZ187452A (en) 1980-05-27
FI69300C (fi) 1986-01-10
CH636087A5 (de) 1983-05-13
FI781811A (fi) 1978-12-11
NL7806245A (nl) 1978-12-12
MX5527E (es) 1983-09-23
CA1098907A (fr) 1981-04-07
DK149449C (da) 1986-11-24
DE2825048A1 (de) 1978-12-14
AR225755A1 (es) 1982-04-30
ES470690A1 (es) 1979-10-16

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Legal Events

Date Code Title Description
ST Notification of lapse