FI69300C - Foerfarande foer framstaellning av terapeutiskt anvaendbara ny karbostyrilderivat - Google Patents
Foerfarande foer framstaellning av terapeutiskt anvaendbara ny karbostyrilderivat Download PDFInfo
- Publication number
- FI69300C FI69300C FI781811A FI781811A FI69300C FI 69300 C FI69300 C FI 69300C FI 781811 A FI781811 A FI 781811A FI 781811 A FI781811 A FI 781811A FI 69300 C FI69300 C FI 69300C
- Authority
- FI
- Finland
- Prior art keywords
- group
- carbostyril
- propoxy
- methyl
- carbon atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6931977A JPS545981A (en) | 1977-06-10 | 1977-06-10 | Carbostyryl derivatives |
| JP6931977 | 1977-06-10 | ||
| JP7586377A JPS5412385A (en) | 1977-06-24 | 1977-06-24 | Carbostyril derivative |
| JP7586377 | 1977-06-24 | ||
| JP53023012A JPS6059912B2 (ja) | 1978-02-28 | 1978-02-28 | カルボスチリル誘導体 |
| JP2301278 | 1978-02-28 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI781811A FI781811A (fi) | 1978-12-11 |
| FI69300B FI69300B (fi) | 1985-09-30 |
| FI69300C true FI69300C (fi) | 1986-01-10 |
Family
ID=27284068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI781811A FI69300C (fi) | 1977-06-10 | 1978-06-07 | Foerfarande foer framstaellning av terapeutiskt anvaendbara ny karbostyrilderivat |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4298739A (fr) |
| AR (2) | AR224345A1 (fr) |
| AT (1) | AT367038B (fr) |
| AU (1) | AU510138B2 (fr) |
| CA (1) | CA1098907A (fr) |
| CH (1) | CH636087A5 (fr) |
| DE (1) | DE2825048A1 (fr) |
| DK (1) | DK149449C (fr) |
| ES (2) | ES470690A1 (fr) |
| FI (1) | FI69300C (fr) |
| FR (1) | FR2393795B1 (fr) |
| GB (1) | GB2002745B (fr) |
| IE (1) | IE46852B1 (fr) |
| IT (1) | IT1108326B (fr) |
| MX (1) | MX5527E (fr) |
| NL (1) | NL178074C (fr) |
| NO (1) | NO148813C (fr) |
| NZ (1) | NZ187452A (fr) |
| PH (1) | PH14670A (fr) |
| PT (1) | PT68157A (fr) |
| SE (1) | SE444562B (fr) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU843739A3 (ru) * | 1978-02-17 | 1981-06-30 | Карл Томэ Гмбх (Фирма) | Способ получени карбостириловыхили ОКСиНдОлОВыХ пРОизВОдНыХ |
| AT383594B (de) * | 1980-02-29 | 1987-07-27 | Otsuka Pharma Co Ltd | Verfahren zum herstellen von neuen carbostyrilderivaten und ihren salzen |
| JPS56122356A (en) | 1980-02-29 | 1981-09-25 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
| FI77852C (fi) * | 1981-02-17 | 1989-05-10 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat. |
| US4442111A (en) * | 1981-07-25 | 1984-04-10 | Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung | Antithrombotic sulfimino and sulfoximino indolinones-2 |
| US4578381A (en) * | 1982-07-05 | 1986-03-25 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
| CH655110A5 (de) * | 1982-09-03 | 1986-03-27 | Otsuka Pharma Co Ltd | Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten. |
| US4663320A (en) * | 1983-02-16 | 1987-05-05 | Syntex (U.S.A.) Inc. | (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof |
| US4490371A (en) * | 1983-02-16 | 1984-12-25 | Syntex (U.S.A.) Inc. | N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides |
| HU193409B (en) * | 1984-02-15 | 1987-10-28 | Syntex Inc | Process for producing 2-square bracket -n-cyclohexyl-4-bracket-oxo-1,2,3,5-tetrahydro-imidazo-square bracket-2,1-b-square bracket closed-quinazolin-7-yl-bracket closed-oxy-alkqne-carboxamidyl-square bracket closed-alkan-acides |
| US4670434A (en) * | 1985-11-14 | 1987-06-02 | Syntex (U.S.A.) Inc. | (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors |
| JP2753622B2 (ja) | 1988-05-02 | 1998-05-20 | 大塚製薬株式会社 | カルボスチリル誘導体 |
| US5227381A (en) * | 1988-05-02 | 1993-07-13 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivative |
| TW201305B (fr) * | 1991-04-03 | 1993-03-01 | Otsuka Pharma Co Ltd | |
| WO1993004042A1 (fr) * | 1991-08-23 | 1993-03-04 | Otsuka Pharmaceutical Co., Ltd. | Derive de carbostyrile et antiagregant plaquettaire |
| US5958926A (en) * | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| EP2218442A1 (fr) | 2005-11-09 | 2010-08-18 | CombinatoRx, Inc. | Procédés, compositions et kits pour le traitement des maladies ophthalmiques |
| MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| DE102008022221A1 (de) | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| CA2726917C (fr) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles |
| WO2010009319A2 (fr) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres |
| EP2196453A1 (fr) * | 2008-12-10 | 2010-06-16 | Cellvir | Nouveaux dérivés aryle substitués, leur procédé de préparation et leurs utilisations thérapeutiques en tant qu'agents anti-VIH |
| TWI481601B (zh) | 2009-08-21 | 2015-04-21 | Otsuka Pharma Co Ltd | 含氮化合物及藥學組成物 |
| EP2468733A4 (fr) | 2009-08-21 | 2013-02-06 | Otsuka Pharma Co Ltd | Procédé de fabrication du composé benzo[b][1,4]diazépine-2,4-dione |
| US8541404B2 (en) | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| US9580471B2 (en) | 2011-03-01 | 2017-02-28 | Synergy Pharmaceuticals, Inc. | Process of preparing guanylate cyclase C agonists |
| WO2013106547A1 (fr) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation |
| US9545446B2 (en) | 2013-02-25 | 2017-01-17 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| WO2014151200A2 (fr) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions utiles pour le traitement de troubles gastro-intestinaux |
| EP2970384A1 (fr) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonistes de la guanylate cyclase et leurs utilisations |
| JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法 |
| JP6694385B2 (ja) | 2013-08-09 | 2020-05-13 | アーデリクス，インコーポレーテッド | リン酸塩輸送阻害のための化合物及び方法 |
| WO2020237096A1 (fr) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combinaison pour baisser le phosphate sérique chez un patient |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR207554A1 (es) * | 1972-12-02 | 1976-10-15 | Otsuka Pharma Co Ltd | Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2) |
| JPS5239035B2 (fr) * | 1972-12-14 | 1977-10-03 | ||
| JPS5234629B2 (fr) * | 1973-02-03 | 1977-09-05 | ||
| NL179275C (nl) * | 1973-10-24 | 1986-08-18 | Otsuka Pharma Co Ltd | Werkwijze voor de bereiding van farmacologisch werkzame glycerol-derivaten en werkwijze voor de bereiding van preparaten die ze bevatten. |
| US4022784A (en) * | 1974-01-31 | 1977-05-10 | Otsuka Pharmaceutical Company Limited | 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives |
| FI59246C (fi) * | 1974-06-24 | 1981-07-10 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin |
| JPS54119478A (en) * | 1978-03-06 | 1979-09-17 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
-
1978
- 1978-06-01 NZ NZ187452A patent/NZ187452A/xx unknown
- 1978-06-01 IE IE1104/78A patent/IE46852B1/en unknown
- 1978-06-06 AU AU36866/78A patent/AU510138B2/en not_active Expired
- 1978-06-07 DE DE19782825048 patent/DE2825048A1/de active Granted
- 1978-06-07 FI FI781811A patent/FI69300C/fi not_active IP Right Cessation
- 1978-06-08 NL NLAANVRAGE7806245,A patent/NL178074C/xx not_active IP Right Cessation
- 1978-06-08 DK DK254878A patent/DK149449C/da not_active IP Right Cessation
- 1978-06-08 FR FR7817167A patent/FR2393795B1/fr not_active Expired
- 1978-06-09 AT AT0421378A patent/AT367038B/de not_active IP Right Cessation
- 1978-06-09 MX MX787136U patent/MX5527E/es unknown
- 1978-06-09 AR AR272511A patent/AR224345A1/es active
- 1978-06-09 SE SE7806710A patent/SE444562B/sv not_active IP Right Cessation
- 1978-06-09 GB GB7826613A patent/GB2002745B/en not_active Expired
- 1978-06-09 NO NO782022A patent/NO148813C/no unknown
- 1978-06-09 PT PT68157A patent/PT68157A/pt unknown
- 1978-06-09 CA CA305,102A patent/CA1098907A/fr not_active Expired
- 1978-06-09 ES ES470690A patent/ES470690A1/es not_active Expired
- 1978-06-09 IT IT68355/78A patent/IT1108326B/it active
- 1978-06-09 CH CH632578A patent/CH636087A5/de not_active IP Right Cessation
- 1978-06-09 PH PH21245A patent/PH14670A/en unknown
-
1979
- 1979-03-30 ES ES479138A patent/ES479138A1/es not_active Expired
-
1980
- 1980-02-05 AR AR279858A patent/AR225755A1/es active
- 1980-04-21 US US06/142,057 patent/US4298739A/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI69300C (fi) | Foerfarande foer framstaellning av terapeutiskt anvaendbara ny karbostyrilderivat | |
| CA1107732A (fr) | Derives des acides phtalazine-4-ylacetiques | |
| AU2004255854B2 (en) | Specific glucocorticosteroid compound having anti- inflammatory activity | |
| US20220081404A1 (en) | Phenothiazine analogues as mitochondrial therapeutic agents | |
| US5281620A (en) | Compounds having antitumor and antibacterial properties | |
| ES2383604T3 (es) | Derivados de purina | |
| WO2021244323A1 (fr) | Forme cristalline d'upadacitinib, son procédé de préparation et son utilisation | |
| WO2022170864A1 (fr) | Forme cristalline du mésylate de beumosul, son procédé de préparation et son utilisation | |
| EP0532530B1 (fr) | Derives de 6-amino-octahydro-indolizinetriol | |
| PT89120B (pt) | Processo para a preparacao de novos derivados flavonoides 2-piperazinil-2-oxo-etileno substituidos | |
| NO159591B (no) | Analogifremgangsmaate for fremstilling av et terapeutisk aktivt karbostyrilderivat. | |
| Narurkar et al. | Synthesis, physicochemical properties, and cytotoxicity of a series of 5′-ester prodrugs of 5-iodo-2′-deoxyuridine | |
| Holmes et al. | The chemistry of heterocyclic quinones. I. the direct oxidation of 6-hydroxycarbostyrils to carbostyril-5, 6-quinones | |
| FI66347C (fi) | Foerfarande foer framstaellning av tetracyklo(4,3,0,02,4,03,7)nonanaminoderivat anvaendbara saosom antivirusmedel | |
| JP2640953B2 (ja) | 芳香族複素環化合物 | |
| WO1994029308A1 (fr) | Analogues de lavendamycine, leur utilisation et leur preparation | |
| KR810000819B1 (ko) | 신규 카르보스티릴 유도체의 제조 방법 | |
| EP0004270B1 (fr) | Dérivés de la streptovaricine C, procédé pour leur préparation et compositions antiviraux les contenant | |
| US4792570A (en) | 3- and 4-biphenyloxyaminoalkanes and related compounds as anti-inflammatory and analgetic agents | |
| JPS6059912B2 (ja) | カルボスチリル誘導体 | |
| US6242425B1 (en) | Quinolinone glycoside, production process, and anti-allergic agent | |
| EP0408714B1 (fr) | Sulfonylnitromethanes heterocycliques, procede servant a leur preparation et compositions pharmaceutiques | |
| CA2132722A1 (fr) | Derives de substitution benzothiazolique d'alcools benzyliques, antagonistes de la leucotriene | |
| US4138566A (en) | Piperazinyl cyclobutenones | |
| Campaigne et al. | Benzo [b] thiophene derivatives. V. Mannich bases with antimicrobial Activity1 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: OTSUKA PHARMACEUTICAL CO. LTD. |