AR224345A1 - Procedimiento para obtener compuestos de 3-(n,n-disustituido amino)-carbonil-alcoxicarboestirilo y 3,4-dihidrocarboestirilo - Google Patents

Procedimiento para obtener compuestos de 3-(n,n-disustituido amino)-carbonil-alcoxicarboestirilo y 3,4-dihidrocarboestirilo

Info

Publication number
AR224345A1
AR224345A1 AR272511A AR27251178A AR224345A1 AR 224345 A1 AR224345 A1 AR 224345A1 AR 272511 A AR272511 A AR 272511A AR 27251178 A AR27251178 A AR 27251178A AR 224345 A1 AR224345 A1 AR 224345A1
Authority
AR
Argentina
Prior art keywords
dihydrocarbonsyrile
alcoxycarbostyrile
disstituted
carbonyl
amino
Prior art date
Application number
AR272511A
Other languages
English (en)
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6931977A external-priority patent/JPS545981A/ja
Priority claimed from JP7586377A external-priority patent/JPS5412385A/ja
Priority claimed from JP53023012A external-priority patent/JPS6059912B2/ja
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Application granted granted Critical
Publication of AR224345A1 publication Critical patent/AR224345A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
AR272511A 1977-06-10 1978-06-09 Procedimiento para obtener compuestos de 3-(n,n-disustituido amino)-carbonil-alcoxicarboestirilo y 3,4-dihidrocarboestirilo AR224345A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP6931977A JPS545981A (en) 1977-06-10 1977-06-10 Carbostyryl derivatives
JP7586377A JPS5412385A (en) 1977-06-24 1977-06-24 Carbostyril derivative
JP53023012A JPS6059912B2 (ja) 1978-02-28 1978-02-28 カルボスチリル誘導体

Publications (1)

Publication Number Publication Date
AR224345A1 true AR224345A1 (es) 1981-11-30

Family

ID=27284068

Family Applications (2)

Application Number Title Priority Date Filing Date
AR272511A AR224345A1 (es) 1977-06-10 1978-06-09 Procedimiento para obtener compuestos de 3-(n,n-disustituido amino)-carbonil-alcoxicarboestirilo y 3,4-dihidrocarboestirilo
AR279858A AR225755A1 (es) 1977-06-10 1980-02-05 Procedimiento para obtener derivados de aminocarbonilalcoxi-carboestirilo o de 3,4-dihidro-carboestirilo

Family Applications After (1)

Application Number Title Priority Date Filing Date
AR279858A AR225755A1 (es) 1977-06-10 1980-02-05 Procedimiento para obtener derivados de aminocarbonilalcoxi-carboestirilo o de 3,4-dihidro-carboestirilo

Country Status (21)

Country Link
US (1) US4298739A (es)
AR (2) AR224345A1 (es)
AT (1) AT367038B (es)
AU (1) AU510138B2 (es)
CA (1) CA1098907A (es)
CH (1) CH636087A5 (es)
DE (1) DE2825048A1 (es)
DK (1) DK149449C (es)
ES (2) ES470690A1 (es)
FI (1) FI69300C (es)
FR (1) FR2393795B1 (es)
GB (1) GB2002745B (es)
IE (1) IE46852B1 (es)
IT (1) IT1108326B (es)
MX (1) MX5527E (es)
NL (1) NL178074C (es)
NO (1) NO148813C (es)
NZ (1) NZ187452A (es)
PH (1) PH14670A (es)
PT (1) PT68157A (es)
SE (1) SE444562B (es)

Families Citing this family (36)

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Publication number Priority date Publication date Assignee Title
SU843739A3 (ru) * 1978-02-17 1981-06-30 Карл Томэ Гмбх (Фирма) Способ получени карбостириловыхили ОКСиНдОлОВыХ пРОизВОдНыХ
AT383594B (de) * 1980-02-29 1987-07-27 Otsuka Pharma Co Ltd Verfahren zum herstellen von neuen carbostyrilderivaten und ihren salzen
JPS56122356A (en) * 1980-02-29 1981-09-25 Otsuka Pharmaceut Co Ltd Carbostyril derivative
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
US4578381A (en) * 1982-07-05 1986-03-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
US4663320A (en) * 1983-02-16 1987-05-05 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
JPS60193991A (ja) * 1984-02-15 1985-10-02 シンテツクス（ユー・エス・エイ）インコーポレイテツド イミダゾキナゾリニルオキシアルキルアミド誘導体
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
JP2753622B2 (ja) 1988-05-02 1998-05-20 大塚製薬株式会社 カルボスチリル誘導体
US5227381A (en) * 1988-05-02 1993-07-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative
TW201305B (es) * 1991-04-03 1993-03-01 Otsuka Pharma Co Ltd
US5506239A (en) * 1991-08-23 1996-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelets aggregation inhibitory agent
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
NZ568694A (en) 2005-11-09 2011-09-30 Zalicus Inc Method, compositions, and kits for the treatment of medical conditions
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
EP2196453A1 (en) * 2008-12-10 2010-06-16 Cellvir Novel substituted aryl derivatives, their process of preparation and their therapeutical uses as anti-HIV agents
TWI481601B (zh) 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
KR20120065360A (ko) 2009-08-21 2012-06-20 오츠카 세이야쿠 가부시키가이샤 벤조［ｂ］［1,4］디아제핀-2,4-디온 화합물의 제조 방법
US8541404B2 (en) 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EA201391254A1 (ru) 2011-03-01 2014-02-28 Синерджи Фармасьютикалз Инк. Способ получения агонистов гуанилатциклазы c
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
CA2902348C (en) 2013-02-25 2021-11-30 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
WO2014197720A2 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
US20160184387A1 (en) 2013-08-09 2016-06-30 Dominique Charmot Compounds and methods for inhibiting phosphate transport
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207554A1 (es) * 1972-12-02 1976-10-15 Otsuka Pharma Co Ltd Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2)
JPS5239035B2 (es) * 1972-12-14 1977-10-03
JPS5234629B2 (es) * 1973-02-03 1977-09-05
NL179275C (nl) * 1973-10-24 1986-08-18 Otsuka Pharma Co Ltd Werkwijze voor de bereiding van farmacologisch werkzame glycerol-derivaten en werkwijze voor de bereiding van preparaten die ze bevatten.
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
FI59246C (fi) * 1974-06-24 1981-07-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin
JPS54119478A (en) * 1978-03-06 1979-09-17 Otsuka Pharmaceut Co Ltd Carbostyril derivative

Also Published As

Publication number Publication date
AU3686678A (en) 1979-12-13
NZ187452A (en) 1980-05-27
GB2002745A (en) 1979-02-28
NL7806245A (nl) 1978-12-12
AR225755A1 (es) 1982-04-30
PT68157A (en) 1978-07-01
DK254878A (da) 1979-02-09
CA1098907A (en) 1981-04-07
PH14670A (en) 1981-10-30
NO782022L (no) 1978-12-12
FR2393795A1 (fr) 1979-01-05
IE46852B1 (en) 1983-10-05
CH636087A5 (de) 1983-05-13
IT7868355A0 (it) 1978-06-09
IE781104L (en) 1978-12-10
NO148813C (no) 1983-12-21
SE7806710L (sv) 1978-12-11
DE2825048C2 (es) 1991-05-08
AU510138B2 (en) 1980-06-12
ATA421378A (de) 1981-10-15
ES479138A1 (es) 1979-07-01
DE2825048A1 (de) 1978-12-14
DK149449B (da) 1986-06-16
IT1108326B (it) 1985-12-09
NL178074C (nl) 1986-01-16
FR2393795B1 (fr) 1986-07-25
DK149449C (da) 1986-11-24
NO148813B (no) 1983-09-12
GB2002745B (en) 1982-02-17
FI69300B (fi) 1985-09-30
SE444562B (sv) 1986-04-21
FI781811A (fi) 1978-12-11
FI69300C (fi) 1986-01-10
US4298739A (en) 1981-11-03
AT367038B (de) 1982-05-25
ES470690A1 (es) 1979-10-16
MX5527E (es) 1983-09-23

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