SA517381665B1 - مستقبلات مولد ضد خيمري تستهدف مستقبل مقترن ببروتين واستخداماتها g - Google Patents

مستقبلات مولد ضد خيمري تستهدف مستقبل مقترن ببروتين واستخداماتها g

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Publication number
SA517381665B1
SA517381665B1 SA517381665A SA517381665A SA517381665B1 SA 517381665 B1 SA517381665 B1 SA 517381665B1 SA 517381665 A SA517381665 A SA 517381665A SA 517381665 A SA517381665 A SA 517381665A SA 517381665 B1 SA517381665 B1 SA 517381665B1
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SA
Saudi Arabia
Prior art keywords
coupled receptor
protein coupled
chimeric antigen
antigen receptors
cars
Prior art date
Application number
SA517381665A
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Arabic (ar)
English (en)
Inventor
ال سميث إيريك
ليو تشينج
جيه برينت جينس رينـير
Original Assignee
.إوريكا ثيرابيوتكس، إنك
ميموريال سلوان - كيترينج كانسر سنتر
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Publication date
Application filed by .إوريكا ثيرابيوتكس، إنك, ميموريال سلوان - كيترينج كانسر سنتر filed Critical .إوريكا ثيرابيوتكس، إنك
Publication of SA517381665B1 publication Critical patent/SA517381665B1/ar

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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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    • A61K35/14—Blood; Artificial blood
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    • C07K—PEPTIDES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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SA517381665A 2014-12-05 2017-06-05 مستقبلات مولد ضد خيمري تستهدف مستقبل مقترن ببروتين واستخداماتها g SA517381665B1 (ar)

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