HRP20211978T1 - Kimerični antigenski receptori koji ciljaju receptor spojen na g-protein i njihove uporabe - Google Patents

Kimerični antigenski receptori koji ciljaju receptor spojen na g-protein i njihove uporabe Download PDF

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Publication number
HRP20211978T1
HRP20211978T1 HRP20211978TT HRP20211978T HRP20211978T1 HR P20211978 T1 HRP20211978 T1 HR P20211978T1 HR P20211978T T HRP20211978T T HR P20211978TT HR P20211978 T HRP20211978 T HR P20211978T HR P20211978 T1 HRP20211978 T1 HR P20211978T1
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Croatia
Prior art keywords
seq
amino acid
acid sequence
set forth
sequence set
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HRP20211978TT
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English (en)
Croatian (hr)
Inventor
Renier J. Brentjens
Eric L. Smith
Cheng Liu
Hong Liu
Original Assignee
Memorial Sloan-Kettering Cancer Center
Eureka Therapeutics, Inc.
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Application filed by Memorial Sloan-Kettering Cancer Center, Eureka Therapeutics, Inc. filed Critical Memorial Sloan-Kettering Cancer Center
Publication of HRP20211978T1 publication Critical patent/HRP20211978T1/hr

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C12N15/09—Recombinant DNA-technology
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HRP20211978TT 2014-12-05 2015-12-04 Kimerični antigenski receptori koji ciljaju receptor spojen na g-protein i njihove uporabe HRP20211978T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462088286P 2014-12-05 2014-12-05
PCT/US2015/064102 WO2016090312A1 (en) 2014-12-05 2015-12-04 Chimeric antigen receptors targeting g-protein coupled receptor and uses thereof
EP15865633.0A EP3227339B1 (en) 2014-12-05 2015-12-04 Chimeric antigen receptors targeting g-protein coupled receptor and uses thereof

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