JP2016520074A5 - - Google Patents
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- JP2016520074A5 JP2016520074A5 JP2016513321A JP2016513321A JP2016520074A5 JP 2016520074 A5 JP2016520074 A5 JP 2016520074A5 JP 2016513321 A JP2016513321 A JP 2016513321A JP 2016513321 A JP2016513321 A JP 2016513321A JP 2016520074 A5 JP2016520074 A5 JP 2016520074A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen receptor
- chimeric antigen
- specific
- cell
- specific chimeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000002865 immune cell Anatomy 0.000 claims description 34
- 108010005327 CD19-specific chimeric antigen receptor Proteins 0.000 claims description 28
- 210000004027 cell Anatomy 0.000 claims description 23
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 13
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 13
- 108091033319 polynucleotide Proteins 0.000 claims description 10
- 102000040430 polynucleotide Human genes 0.000 claims description 10
- 239000002157 polynucleotide Substances 0.000 claims description 10
- 230000004068 intracellular signaling Effects 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 7
- 108020001756 ligand binding domains Proteins 0.000 claims description 7
- 150000007523 nucleic acids Chemical group 0.000 claims description 7
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 6
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- 208000004736 B-Cell Leukemia Diseases 0.000 claims description 3
- 208000003950 B-cell lymphoma Diseases 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 230000011664 signaling Effects 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 2
- 239000013604 expression vector Substances 0.000 claims description 2
- 210000002443 helper t lymphocyte Anatomy 0.000 claims description 2
- 230000002757 inflammatory effect Effects 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 230000004913 activation Effects 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 210000004986 primary T-cell Anatomy 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| USPCT/US2013/040766 | 2013-05-13 | ||
| USPCT/US2013/040755 | 2013-05-13 | ||
| US13/892,805 | 2013-05-13 | ||
| PCT/US2013/040766 WO2013176916A1 (en) | 2012-05-25 | 2013-05-13 | Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells |
| PCT/US2013/040755 WO2013176915A1 (en) | 2012-05-25 | 2013-05-13 | Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy |
| US13/892,805 US11603539B2 (en) | 2012-05-25 | 2013-05-13 | Methods for engineering allogeneic and immunosuppressive resistant T cell for immunotherapy |
| US201361888259P | 2013-10-08 | 2013-10-08 | |
| US61/888,259 | 2013-10-08 | ||
| PCT/EP2014/059662 WO2014184143A1 (en) | 2013-05-13 | 2014-05-12 | Cd19 specific chimeric antigen receptor and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019037174A Division JP6854307B2 (ja) | 2013-05-13 | 2019-03-01 | Ｃｄ１９特異的キメラ抗原受容体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520074A JP2016520074A (ja) | 2016-07-11 |
| JP2016520074A5 true JP2016520074A5 (OSRAM) | 2017-06-08 |
| JP6491643B2 JP6491643B2 (ja) | 2019-04-03 |
Family
ID=51897790
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513321A Active JP6491643B2 (ja) | 2013-05-13 | 2014-05-12 | Ｃｄ１９特異的キメラ抗原受容体およびその使用 |
| JP2019037174A Active JP6854307B2 (ja) | 2013-05-13 | 2019-03-01 | Ｃｄ１９特異的キメラ抗原受容体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019037174A Active JP6854307B2 (ja) | 2013-05-13 | 2019-03-01 | Ｃｄ１９特異的キメラ抗原受容体およびその使用 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US20210000869A9 (OSRAM) |
| EP (3) | EP3546572B9 (OSRAM) |
| JP (2) | JP6491643B2 (OSRAM) |
| KR (1) | KR102248157B1 (OSRAM) |
| CN (2) | CN105431532B (OSRAM) |
| AU (2) | AU2014267436B2 (OSRAM) |
| BR (1) | BR112015028387B1 (OSRAM) |
| CA (1) | CA2911292C (OSRAM) |
| DK (1) | DK3546572T3 (OSRAM) |
| EA (2) | EA036200B1 (OSRAM) |
| ES (2) | ES2930431T3 (OSRAM) |
| FI (2) | FI3546572T3 (OSRAM) |
| HR (2) | HRP20221393T1 (OSRAM) |
| HU (2) | HUE067258T2 (OSRAM) |
| LT (2) | LT3546572T (OSRAM) |
| MA (1) | MA38630B2 (OSRAM) |
| MX (1) | MX374681B (OSRAM) |
| MY (1) | MY172897A (OSRAM) |
| PH (1) | PH12015502479B1 (OSRAM) |
| PL (2) | PL2997141T3 (OSRAM) |
| PT (2) | PT3546572T (OSRAM) |
| RS (2) | RS65484B1 (OSRAM) |
| RU (1) | RU2727447C2 (OSRAM) |
| SA (1) | SA515370135B1 (OSRAM) |
| SG (2) | SG11201508805UA (OSRAM) |
| SI (2) | SI2997141T1 (OSRAM) |
| TW (1) | TWI636992B (OSRAM) |
| UA (1) | UA118106C2 (OSRAM) |
| WO (1) | WO2014184143A1 (OSRAM) |
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