JP2017509342A5 - - Google Patents
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- JP2017509342A5 JP2017509342A5 JP2016558087A JP2016558087A JP2017509342A5 JP 2017509342 A5 JP2017509342 A5 JP 2017509342A5 JP 2016558087 A JP2016558087 A JP 2016558087A JP 2016558087 A JP2016558087 A JP 2016558087A JP 2017509342 A5 JP2017509342 A5 JP 2017509342A5
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- JP
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- Prior art keywords
- car
- antigen receptor
- chimeric antigen
- domain
- engineered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims description 35
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 25
- 210000002865 immune cell Anatomy 0.000 claims description 24
- 108020001756 ligand binding domains Proteins 0.000 claims description 13
- 230000003211 malignant effect Effects 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 201000011510 cancer Diseases 0.000 claims description 7
- 102000040430 polynucleotide Human genes 0.000 claims description 7
- 108091033319 polynucleotide Proteins 0.000 claims description 7
- 239000002157 polynucleotide Substances 0.000 claims description 7
- 210000004896 polypeptide structure Anatomy 0.000 claims description 7
- 239000002246 antineoplastic agent Substances 0.000 claims description 6
- 208000032839 leukemia Diseases 0.000 claims description 6
- 208000030289 Lymphoproliferative disease Diseases 0.000 claims description 5
- 230000000139 costimulatory effect Effects 0.000 claims description 5
- 230000001086 cytosolic effect Effects 0.000 claims description 5
- 230000011664 signaling Effects 0.000 claims description 5
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 4
- 206010025323 Lymphomas Diseases 0.000 claims description 4
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 4
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 4
- 229940041181 antineoplastic drug Drugs 0.000 claims description 4
- 201000001268 lymphoproliferative syndrome Diseases 0.000 claims description 4
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims description 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims description 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 2
- 208000011691 Burkitt lymphomas Diseases 0.000 claims description 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims description 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 2
- 208000034578 Multiple myelomas Diseases 0.000 claims description 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims description 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
- 229940044683 chemotherapy drug Drugs 0.000 claims description 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims description 2
- 238000012217 deletion Methods 0.000 claims description 2
- 230000037430 deletion Effects 0.000 claims description 2
- 239000013604 expression vector Substances 0.000 claims description 2
- 201000003444 follicular lymphoma Diseases 0.000 claims description 2
- 239000003018 immunosuppressive agent Substances 0.000 claims description 2
- 229940124589 immunosuppressive drug Drugs 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000002489 hematologic effect Effects 0.000 description 3
- 201000005787 hematologic cancer Diseases 0.000 description 2
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 2
- 208000004736 B-Cell Leukemia Diseases 0.000 description 1
- 208000003950 B-cell lymphoma Diseases 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020068935A JP6942217B2 (ja) | 2014-03-19 | 2020-04-07 | 癌免疫治療のためのｃｄ１２３特異的キメラ抗原受容体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201470137 | 2014-03-19 | ||
| DKPA201470137 | 2014-03-19 | ||
| PCT/EP2015/055848 WO2015140268A1 (en) | 2014-03-19 | 2015-03-19 | Cd123 specific chimeric antigen receptors for cancer immunotherapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020068935A Division JP6942217B2 (ja) | 2014-03-19 | 2020-04-07 | 癌免疫治療のためのｃｄ１２３特異的キメラ抗原受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017509342A JP2017509342A (ja) | 2017-04-06 |
| JP2017509342A5 true JP2017509342A5 (OSRAM) | 2018-04-19 |
| JP6689202B2 JP6689202B2 (ja) | 2020-04-28 |
Family
ID=58702463
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016558087A Active JP6689202B2 (ja) | 2014-03-19 | 2015-03-19 | 癌免疫治療のためのｃｄ１２３特異的キメラ抗原受容体 |
| JP2020068935A Active JP6942217B2 (ja) | 2014-03-19 | 2020-04-07 | 癌免疫治療のためのｃｄ１２３特異的キメラ抗原受容体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020068935A Active JP6942217B2 (ja) | 2014-03-19 | 2020-04-07 | 癌免疫治療のためのｃｄ１２３特異的キメラ抗原受容体 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US9944709B2 (OSRAM) |
| EP (2) | EP3119807B1 (OSRAM) |
| JP (2) | JP6689202B2 (OSRAM) |
| KR (1) | KR102157411B1 (OSRAM) |
| CN (1) | CN106103490B (OSRAM) |
| AU (1) | AU2015233461B2 (OSRAM) |
| CA (1) | CA2943008C (OSRAM) |
| DK (2) | DK3569619T3 (OSRAM) |
| ES (2) | ES2740903T3 (OSRAM) |
| HU (1) | HUE045480T2 (OSRAM) |
| IL (1) | IL247172B (OSRAM) |
| MX (2) | MX370272B (OSRAM) |
| PL (1) | PL3119807T3 (OSRAM) |
| PT (1) | PT3119807T (OSRAM) |
| RU (1) | RU2727290C2 (OSRAM) |
| TR (1) | TR201910814T4 (OSRAM) |
| WO (1) | WO2015140268A1 (OSRAM) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9745548B2 (en) | 2012-03-15 | 2017-08-29 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US9752113B2 (en) | 2012-03-15 | 2017-09-05 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
| US10689609B2 (en) | 2012-03-15 | 2020-06-23 | Flodesign Sonics, Inc. | Acoustic bioreactor processes |
| US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
| US10322949B2 (en) | 2012-03-15 | 2019-06-18 | Flodesign Sonics, Inc. | Transducer and reflector configurations for an acoustophoretic device |
| US9950282B2 (en) | 2012-03-15 | 2018-04-24 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
| US10737953B2 (en) | 2012-04-20 | 2020-08-11 | Flodesign Sonics, Inc. | Acoustophoretic method for use in bioreactors |
| EP3744736A1 (en) | 2013-02-20 | 2020-12-02 | Novartis AG | Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells |
| US9745569B2 (en) | 2013-09-13 | 2017-08-29 | Flodesign Sonics, Inc. | System for generating high concentration factors for low cell density suspensions |
| US9725710B2 (en) | 2014-01-08 | 2017-08-08 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
| DK3569619T3 (da) | 2014-03-19 | 2021-06-14 | Cellectis | Fremgangsmåde til fremstilling af CD123-specifikke CAR T-celler til cancerimmunterapi |
| US9744483B2 (en) | 2014-07-02 | 2017-08-29 | Flodesign Sonics, Inc. | Large scale acoustic separation device |
| EP3183268B1 (en) | 2014-08-19 | 2020-02-12 | Novartis AG | Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment |
| ES2688035T3 (es) | 2014-08-29 | 2018-10-30 | Gemoab Monoclonals Gmbh | Receptor de antígeno universal que expresa células inmunes para direccionamiento de antígenos múltiples diversos, procedimiento para fabricación del mismo y utilización del mismo para tratamiento de cáncer, infecciones y enfermedades autoinmunes |
| RU2732925C2 (ru) * | 2015-01-26 | 2020-09-24 | Селлектис | МАт-НАПРАВЛЯЕМЫЕ ХИМЕРНЫЕ АНТИГЕННЫЕ РЕЦЕПТОРНЫЕ СИСТЕМЫ ДЛЯ СОРТИРОВКИ/ИСТОЩЕНИЯ СКОНСТРУИРОВАННЫХ ИММУННЫХ КЛЕТОК |
| JP2018509148A (ja) | 2015-03-11 | 2018-04-05 | セレクティスＣｅｌｌｅｃｔｉｓ | 患者における持続性および／または生着を増加させるために同種ｔ細胞を改変する方法 |
| US9777064B2 (en) | 2015-03-17 | 2017-10-03 | Chimera Bioengineering, Inc. | Smart CAR devices, DE CAR polypeptides, side CARs and uses thereof |
| US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| KR20180041152A (ko) * | 2015-08-11 | 2018-04-23 | 셀렉티스 | Cd38 항원 타겟팅 및 cd38 유전자 불활성화를 위하여 조작된 면역치료용 세포들 |
| GB201518136D0 (en) * | 2015-10-14 | 2015-11-25 | Glaxosmithkline Ip Dev Ltd | Novel chimeric antigen receptors |
| FI3368571T3 (fi) * | 2015-10-30 | 2023-02-28 | Transformoivia kasvutekijä-beeta-vasteellisia polypeptidejä ja niiden käyttömenetelmiä | |
| US11052111B2 (en) * | 2015-12-08 | 2021-07-06 | Chimera Bioengineering, Inc. | Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses |
| WO2017178586A1 (en) | 2016-04-15 | 2017-10-19 | Cellectis | A method of engineering prodrug-specific hypersensitive t-cells for immunotherapy by gene expression |
| EP3429633B1 (en) | 2016-04-15 | 2021-02-24 | Cellectis | A method of engineering drug-specific hypersensitive t-cells for immunotherapy by gene inactivation |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
| US10222369B2 (en) | 2016-05-17 | 2019-03-05 | Chimera Bioengineering, Inc. | Methods for making novel antigen binding domains |
| CN107793481A (zh) * | 2016-08-31 | 2018-03-13 | 南京传奇生物科技有限公司 | 一种靶向人cd123的嵌合受体配体及其应用 |
| CN112481217A (zh) | 2016-09-01 | 2021-03-12 | 嵌合体生物工程公司 | Gold优化的car t-细胞 |
| CN107840889A (zh) * | 2016-09-19 | 2018-03-27 | 上海吉倍生物技术有限公司 | 高亲和力的抗cd123抗体及其应用 |
| KR20190127655A (ko) | 2016-10-19 | 2019-11-13 | 프로디자인 소닉스, 인크. | 음향학에 의한 친화성 세포 추출 |
| EP3545082A4 (en) | 2016-11-22 | 2020-07-01 | National University of Singapore | BLOCKING OF CD7 EXPRESSION AND CHIMERIC ANTIGEN RECEPTORS FOR THE IMMUNOTHERAPY OF T-CELL MALIGNANCIES |
| WO2018136606A1 (en) * | 2017-01-18 | 2018-07-26 | Thalia Papayannopoulou | Compositions and methods for transplant recipient conditioning |
| MX2019010196A (es) | 2017-02-28 | 2019-12-19 | Vor Biopharma Inc | Composiciones y métodos para la inhibición de proteínas específicas del linaje. |
| PT3592379T (pt) * | 2017-03-31 | 2024-05-31 | Cellectis Sa | Células imunitárias manipuladas universais dotadas de recetor antigénico quimérico anti-cd22 |
| AU2018251150B2 (en) | 2017-04-13 | 2024-05-09 | Albert-Ludwigs-Universität Freiburg | New sequence specific reagents targeting CCR5 in primary hematopoietic cells |
| AU2018256436B2 (en) | 2017-04-19 | 2024-12-05 | Board Of Regents, The University Of Texas System | Immune cells expressing engineered antigen receptors |
| EP4302768A3 (en) * | 2017-06-22 | 2024-05-01 | Board Of Regents, The University Of Texas System | Methods for producing regulatory immune cells and uses thereof |
| US12144825B2 (en) | 2017-06-30 | 2024-11-19 | Cellectis | Cellular immunotherapy for repetitive administration |
| CN111315872A (zh) | 2017-06-30 | 2020-06-19 | 纪念斯隆-凯特林癌症中心 | 用于癌症的过继性细胞疗法的组合物和方法 |
| EP3645019A4 (en) * | 2017-06-30 | 2021-08-25 | Memorial Sloan-Kettering Cancer Center | COMPOSITIONS AND PROCEDURES FOR ADOPTIVE CELL THERAPY |
| US12241097B2 (en) | 2017-06-30 | 2025-03-04 | Memorial Sloan Kettering Cancer Center | Compositions and methods for adoptive cell therapy for cancer |
| US20210071139A1 (en) * | 2017-10-27 | 2021-03-11 | The Trustees Of The University Of Pennsylvania | Identifying Epigenetic And Transcriptional Targets To Prevent And Reverse T Cell Exhaustion |
| GB201719169D0 (en) | 2017-11-20 | 2018-01-03 | Univ College Cardiff Consultants Ltd | Novel T-cell receptor and ligand |
| CN120098930A (zh) * | 2017-11-22 | 2025-06-06 | 拉霍拉敏感及免疫学研究所 | 工程化的免疫细胞的应用和生产 |
| AU2018385759B2 (en) | 2017-12-14 | 2021-10-21 | Flodesign Sonics, Inc. | Acoustic transducer driver and controller |
| WO2019129851A1 (en) | 2017-12-29 | 2019-07-04 | Cellectis | Method for improving production of car t cells |
| EP3757133A4 (en) | 2018-02-11 | 2021-12-01 | Jiangsu Hengrui Medicine Co., Ltd. | ISOLATED ANTIGENIC CHEMICAL RECEPTOR, MODIFIED T LYMPHOCYTE INCLUDING IT AND ASSOCIATED USE |
| CN111989108B (zh) | 2018-02-13 | 2024-07-16 | 嵌合体生物工程公司 | 利用rna去稳定元件协调基因表达 |
| JP7273421B2 (ja) | 2018-02-21 | 2023-05-15 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用 |
| US20190284288A1 (en) * | 2018-03-19 | 2019-09-19 | The Regents Of The University Of Michigan | Compositions and methods for t-cell and cytokine activation |
| KR20190141511A (ko) * | 2018-06-14 | 2019-12-24 | 주식회사 녹십자랩셀 | 신규 펩티드, 이를 포함하는 키메라 항원 수용체 및 이를 발현하는 면역 세포 |
| EP3844187A1 (en) | 2018-08-28 | 2021-07-07 | Vor Biopharma, Inc. | Genetically engineered hematopoietic stem cells and uses thereof |
| AU2019343184A1 (en) * | 2018-09-20 | 2021-04-15 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with anti-CD123 immunotherapy |
| CN109266618B (zh) * | 2018-10-18 | 2021-04-23 | 赛元生物科技(杭州)有限公司 | 能够靶向肿瘤细胞的巨噬细胞及其制备方法 |
| EP3873606A4 (en) * | 2018-10-30 | 2022-10-26 | MacroGenics, Inc. | Bispecific cd123 x cd3 diabodies for the treatment of hematologic malignancies |
| CA3124444A1 (en) * | 2019-01-23 | 2020-07-30 | Miltenyi Biotec B.V. & Co. KG | A combination of compositions for elimination and enhanced engraftment of hematopoietic stem cells in the bone marrow of a subject |
| US20220160771A1 (en) | 2019-04-10 | 2022-05-26 | Iulia Diaconu | Flt3-specific chimeric antigen receptors and methods of using the same |
| JP2022526843A (ja) | 2019-04-12 | 2022-05-26 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 制御性ｂ細胞の産生方法およびその使用 |
| AU2020334884A1 (en) | 2019-08-18 | 2022-02-17 | Chimera Bioengineering, Inc. | Combination therapy with gold controlled transgenes |
| AU2020336211A1 (en) | 2019-08-28 | 2022-03-10 | Vor Biopharma Inc. | Compositions and methods for CD123 modification |
| WO2022047165A1 (en) | 2020-08-28 | 2022-03-03 | Vor Biopharma Inc. | Compositions and methods for cd123 modification |
| CN112079927B (zh) * | 2020-09-18 | 2021-12-28 | 西安桑尼赛尔生物医药有限公司 | 一种cd123结合蛋白、含其的car及其应用 |
| JP2023545099A (ja) | 2020-10-08 | 2023-10-26 | アフィメド ゲーエムベーハー | 三重特異性バインダー |
| CN112646033B (zh) * | 2020-12-16 | 2022-04-12 | 北京艺妙神州医药科技有限公司 | 靶向cd123的嵌合抗原受体及其用途 |
| CA3202218A1 (en) | 2020-12-18 | 2022-06-23 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| KR20250152662A (ko) | 2020-12-31 | 2025-10-23 | 사노피 | NKp46 및 CD123에 결합하는 다기능성 자연살해(NK) 세포 관여자 |
| WO2022266075A1 (en) | 2021-06-14 | 2022-12-22 | Caribou Biosciences, Inc. | Methods and materials for treating cancer using car constructs with an intracellular domain comprising a stap domain and a kinase domain or a stap domain and a phosphatase domain |
| EP4376877A2 (en) | 2021-07-29 | 2024-06-05 | Vor Biopharma Inc. | Chimeric antigen receptors for treatment of cancer |
| JP2024529381A (ja) | 2021-07-30 | 2024-08-06 | アフィメド ゲーエムベーハー | デュプレックスボディ |
| WO2023020471A1 (en) * | 2021-08-16 | 2023-02-23 | Utc Therapeutics (Shanghai) Co., Ltd. | Cd123-targetting antibodies and uses thereof in cancer therapies |
| AR127568A1 (es) | 2021-11-03 | 2024-02-07 | Affimed Gmbh | Ligandos biespecíficos de cd16a |
| US20250064933A1 (en) * | 2021-12-30 | 2025-02-27 | St. Jude Children's Research Hospital, Inc. | Chimeric antigen receptors comprising a pdz binding motif |
| CN118574646A (zh) * | 2022-01-19 | 2024-08-30 | 上海优替济生生物医药有限公司 | 环状rna及其用途 |
| US11590169B1 (en) | 2022-03-02 | 2023-02-28 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with anti-CD123 immunotherapy |
| CN119365495A (zh) | 2022-05-27 | 2025-01-24 | 赛诺菲 | 与NKp46和BCMA变体结合的具有Fc工程化的自然杀伤（NK）细胞接合物 |
| CN117511882A (zh) * | 2022-08-03 | 2024-02-06 | 浙江大学医学院附属第一医院 | 一种通用型免疫效应细胞及其制备方法和应用 |
| WO2024094004A1 (zh) * | 2022-11-03 | 2024-05-10 | 重庆精准生物技术有限公司 | 靶向cd123的全人源抗体及其应用 |
| AU2024240255A1 (en) * | 2023-03-17 | 2025-10-02 | Cartesian Therapeutics, Inc. | Intracellular signaling and costimulatory domains adapted for prolonged expression of chimeric antigen receptors |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| GB8611832D0 (en) | 1986-05-15 | 1986-06-25 | Holland I B | Polypeptide |
| US5037743A (en) | 1988-08-05 | 1991-08-06 | Zymogenetics, Inc. | BAR1 secretion signal |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| AU6704794A (en) | 1993-04-13 | 1994-11-08 | Sloan-Kettering Institute For Cancer Research | Protection of human bone marrow from high dose antifolate therapy using mutated human dihydrofolate reductase dna |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US6010613A (en) | 1995-12-08 | 2000-01-04 | Cyto Pulse Sciences, Inc. | Method of treating materials with pulsed electrical fields |
| WO1997033988A1 (en) | 1996-03-12 | 1997-09-18 | Sloan-Kettering Institute For Cancer Research | Double mutants of dihydrofolate reductase and methods of using same |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| AU2001243288B2 (en) | 2000-02-24 | 2005-11-24 | Life Technologies Corporation | Simultaneous stimulation and concentration of cells |
| US9982251B2 (en) | 2003-03-14 | 2018-05-29 | Cellectis S.A. | Large volume ex vivo electroporation method |
| US20070036773A1 (en) * | 2005-08-09 | 2007-02-15 | City Of Hope | Generation and application of universal T cells for B-ALL |
| EP2332994A1 (en) * | 2009-12-09 | 2011-06-15 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Trispecific therapeutics against acute myeloid leukaemia |
| GB2481983A (en) | 2010-07-12 | 2012-01-18 | Hart Fenton & Co Ltd | A ship including a gas tank room |
| CA2993567C (en) * | 2010-07-21 | 2022-06-28 | Sangamo Biosciences, Inc. | Methods and compositions for modification of a t-cell receptor gene |
| CA2815512A1 (en) | 2010-10-27 | 2012-05-03 | Philippe Duchateau | Method for increasing the efficiency of double-strand break-induced mutagenesis |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| EP2694089B1 (en) | 2011-04-05 | 2024-06-05 | Cellectis | New tale-protein scaffolds and uses thereof |
| ES2774160T3 (es) * | 2012-02-13 | 2020-07-17 | Seattle Childrens Hospital D/B/A Seattle Childrens Res Institute | Receptores de antígenos quiméricos biespecíficos y usos terapéuticos de los mismos |
| JP6359520B2 (ja) * | 2012-04-11 | 2018-07-18 | アメリカ合衆国 | Ｂ細胞成熟抗原を標的指向するキメラ抗原受容体 |
| GB201206559D0 (en) | 2012-04-13 | 2012-05-30 | Ucl Business Plc | Polypeptide |
| CA2874611C (en) | 2012-05-25 | 2023-01-24 | Cellectis | Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells |
| US20150017136A1 (en) | 2013-07-15 | 2015-01-15 | Cellectis | Methods for engineering allogeneic and highly active t cell for immunotherapy |
| EP3744736A1 (en) | 2013-02-20 | 2020-12-02 | Novartis AG | Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells |
| US9657105B2 (en) * | 2013-03-15 | 2017-05-23 | City Of Hope | CD123-specific chimeric antigen receptor redirected T cells and methods of their use |
| TWI654206B (zh) * | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗－ｃｄ１９嵌合抗原受體治療癌症 |
| JP2017504601A (ja) * | 2013-12-20 | 2017-02-09 | セレクティスＣｅｌｌｅｃｔｉｓ | 免疫療法のためにマルチインプットシグナル感受性ｔ細胞を操作する方法 |
| DK3569619T3 (da) * | 2014-03-19 | 2021-06-14 | Cellectis | Fremgangsmåde til fremstilling af CD123-specifikke CAR T-celler til cancerimmunterapi |
| JP2017519502A (ja) * | 2014-06-17 | 2017-07-20 | セレクティスＣｅｌｌｅｃｔｉｓ | Ｃｄ１２３特異的多重鎖キメラ抗原受容体 |
| JP2018504104A (ja) * | 2014-12-17 | 2018-02-15 | セレクティスＣｅｌｌｅｃｔｉｓ | 非Ｔ細胞伝達ドメインを発現する阻害性キメラ抗原受容体（ｉＣＡＲまたはＮ−ＣＡＲ） |
| RU2732925C2 (ru) * | 2015-01-26 | 2020-09-24 | Селлектис | МАт-НАПРАВЛЯЕМЫЕ ХИМЕРНЫЕ АНТИГЕННЫЕ РЕЦЕПТОРНЫЕ СИСТЕМЫ ДЛЯ СОРТИРОВКИ/ИСТОЩЕНИЯ СКОНСТРУИРОВАННЫХ ИММУННЫХ КЛЕТОК |
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