RU2727290C2 - Cd123-специфические химерные антигенные рецепторы для иммунотерапии рака - Google Patents
Cd123-специфические химерные антигенные рецепторы для иммунотерапии рака Download PDFInfo
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- RU2727290C2 RU2727290C2 RU2016140855A RU2016140855A RU2727290C2 RU 2727290 C2 RU2727290 C2 RU 2727290C2 RU 2016140855 A RU2016140855 A RU 2016140855A RU 2016140855 A RU2016140855 A RU 2016140855A RU 2727290 C2 RU2727290 C2 RU 2727290C2
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
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- A61K39/44—Antibodies bound to carriers
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2510/00—Genetically modified cells
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201470137 | 2014-03-19 | ||
| DKPA201470137 | 2014-03-19 | ||
| PCT/EP2015/055848 WO2015140268A1 (en) | 2014-03-19 | 2015-03-19 | Cd123 specific chimeric antigen receptors for cancer immunotherapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2016140855A RU2016140855A (ru) | 2018-04-20 |
| RU2016140855A3 RU2016140855A3 (OSRAM) | 2018-11-16 |
| RU2727290C2 true RU2727290C2 (ru) | 2020-07-21 |
Family
ID=58702463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016140855A RU2727290C2 (ru) | 2014-03-19 | 2015-03-19 | Cd123-специфические химерные антигенные рецепторы для иммунотерапии рака |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US9944709B2 (OSRAM) |
| EP (2) | EP3119807B1 (OSRAM) |
| JP (2) | JP6689202B2 (OSRAM) |
| KR (1) | KR102157411B1 (OSRAM) |
| CN (1) | CN106103490B (OSRAM) |
| AU (1) | AU2015233461B2 (OSRAM) |
| CA (1) | CA2943008C (OSRAM) |
| DK (2) | DK3119807T3 (OSRAM) |
| ES (2) | ES2740903T3 (OSRAM) |
| HU (1) | HUE045480T2 (OSRAM) |
| IL (1) | IL247172B (OSRAM) |
| MX (2) | MX370272B (OSRAM) |
| PL (1) | PL3119807T3 (OSRAM) |
| PT (1) | PT3119807T (OSRAM) |
| RU (1) | RU2727290C2 (OSRAM) |
| TR (1) | TR201910814T4 (OSRAM) |
| WO (1) | WO2015140268A1 (OSRAM) |
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| US9752113B2 (en) | 2012-03-15 | 2017-09-05 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US10737953B2 (en) | 2012-04-20 | 2020-08-11 | Flodesign Sonics, Inc. | Acoustophoretic method for use in bioreactors |
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