JP2017507917A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017507917A5 JP2017507917A5 JP2016546437A JP2016546437A JP2017507917A5 JP 2017507917 A5 JP2017507917 A5 JP 2017507917A5 JP 2016546437 A JP2016546437 A JP 2016546437A JP 2016546437 A JP2016546437 A JP 2016546437A JP 2017507917 A5 JP2017507917 A5 JP 2017507917A5
- Authority
- JP
- Japan
- Prior art keywords
- chimeric antigen
- antigen receptor
- medicament
- car
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 46
- 210000002865 immune cell Anatomy 0.000 claims description 27
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 14
- 239000000427 antigen Substances 0.000 claims description 13
- 108091007433 antigens Proteins 0.000 claims description 13
- 102000036639 antigens Human genes 0.000 claims description 13
- 239000003814 drug Substances 0.000 claims description 12
- 229920001184 polypeptide Polymers 0.000 claims description 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 11
- 210000004027 cell Anatomy 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- 108091033319 polynucleotide Proteins 0.000 claims description 8
- 102000040430 polynucleotide Human genes 0.000 claims description 8
- 239000002157 polynucleotide Substances 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 4
- 230000011664 signaling Effects 0.000 claims description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 3
- 230000000139 costimulatory effect Effects 0.000 claims description 3
- 150000007523 nucleic acids Chemical group 0.000 claims description 3
- 208000023275 Autoimmune disease Diseases 0.000 claims description 2
- 108010087819 Fc receptors Proteins 0.000 claims description 2
- 102000009109 Fc receptors Human genes 0.000 claims description 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 2
- -1 ICOS Proteins 0.000 claims description 2
- 102000004310 Ion Channels Human genes 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 2
- 230000004913 activation Effects 0.000 claims description 2
- 235000001014 amino acid Nutrition 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 2
- 238000002512 chemotherapy Methods 0.000 claims description 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 210000002443 helper t lymphocyte Anatomy 0.000 claims description 2
- 230000002757 inflammatory effect Effects 0.000 claims description 2
- 230000036210 malignancy Effects 0.000 claims description 2
- 210000003289 regulatory T cell Anatomy 0.000 claims description 2
- 230000019491 signal transduction Effects 0.000 claims description 2
- 230000008685 targeting Effects 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 108010065816 zeta chain antigen T cell receptor Proteins 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 102100038006 High affinity immunoglobulin epsilon receptor subunit alpha Human genes 0.000 description 1
- 101710128966 High affinity immunoglobulin epsilon receptor subunit alpha Proteins 0.000 description 1
- 102100022132 High affinity immunoglobulin epsilon receptor subunit gamma Human genes 0.000 description 1
- 108091010847 High affinity immunoglobulin epsilon receptor subunit gamma Proteins 0.000 description 1
- 102000009438 IgE Receptors Human genes 0.000 description 1
- 108010073816 IgE Receptors Proteins 0.000 description 1
- 108091008874 T cell receptors Proteins 0.000 description 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 230000020411 cell activation Effects 0.000 description 1
- 230000008614 cellular interaction Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201470016 | 2014-01-14 | ||
| DKPA201470016 | 2014-01-14 | ||
| PCT/EP2015/050581 WO2015107075A1 (en) | 2014-01-14 | 2015-01-14 | Chimeric antigen receptor using antigen recognition domains derived from cartilaginous fish |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017507917A JP2017507917A (ja) | 2017-03-23 |
| JP2017507917A5 true JP2017507917A5 (OSRAM) | 2018-02-08 |
Family
ID=49958148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016546437A Pending JP2017507917A (ja) | 2014-01-14 | 2015-01-14 | 軟骨魚類由来の抗原認識ドメインを使用したキメラ抗原受容体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10526406B2 (OSRAM) |
| EP (1) | EP3094354B1 (OSRAM) |
| JP (1) | JP2017507917A (OSRAM) |
| AU (1) | AU2015206040B2 (OSRAM) |
| CA (1) | CA2936693C (OSRAM) |
| ES (1) | ES2701846T3 (OSRAM) |
| WO (1) | WO2015107075A1 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2949648T3 (es) | 2012-12-20 | 2023-10-02 | Purdue Research Foundation | Células T que expresan un receptor antigénico quimérico como terapia contra el cáncer |
| IL303905A (en) | 2015-05-18 | 2023-08-01 | Tcr2 Therapeutics Inc | Compositions and methods for TCR programming using fusion proteins |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Ｃａｒ ｔ細胞療法のための方法および組成物 |
| CN107298715B (zh) * | 2016-04-15 | 2021-05-04 | 阿思科力(苏州)生物科技有限公司 | Slit2D2-嵌合抗原受体及其应用 |
| JP7109789B2 (ja) | 2016-08-02 | 2022-08-01 | ティーシーアール２ セラピューティクス インク． | 融合タンパク質を使用したｔｃｒの再プログラム化のための組成物及び方法 |
| ES2875959T3 (es) | 2016-10-07 | 2021-11-11 | Tcr2 Therapeutics Inc | Composiciones y métodos para reprogramación de receptores de linfocitos T mediante el uso de proteínas de fusión |
| AU2017363311A1 (en) | 2016-11-22 | 2019-06-13 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
| US11850262B2 (en) | 2017-02-28 | 2023-12-26 | Purdue Research Foundation | Compositions and methods for CAR T cell therapy |
| WO2018232020A1 (en) * | 2017-06-13 | 2018-12-20 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| EP3415527B1 (de) | 2017-06-14 | 2025-12-10 | Kymab Ltd. | Verwendung der extrazellulären domäne des transferrinrezeptor 2 zur diagnostik und behandlung von primär und sekundär sklerosierenden erkrankungen |
| GB201721802D0 (en) * | 2017-12-22 | 2018-02-07 | Almac Discovery Ltd | Ror1-specific antigen binding molecules |
| WO2019129851A1 (en) | 2017-12-29 | 2019-07-04 | Cellectis | Method for improving production of car t cells |
| BR112020014913A2 (pt) | 2018-01-22 | 2020-12-08 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Métodos para uso de células t car |
| CA3091674A1 (en) | 2018-02-23 | 2019-08-29 | Endocyte, Inc. | Sequencing method for car t cell therapy |
| CN112236166A (zh) | 2018-06-13 | 2021-01-15 | 科马布有限公司 | 用于治疗骨疾病的转铁蛋白受体-2的拮抗剂和激动剂 |
| GB202020152D0 (en) * | 2020-12-18 | 2021-02-03 | Elasmogen Ltd | Fast-track humanisation of specific binding molecules |
| WO2022133169A1 (en) | 2020-12-18 | 2022-06-23 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| EP4141028A1 (en) * | 2021-08-31 | 2023-03-01 | Johann-Wolfgang-Goethe-Universität Frankfurt am Main | Personalized vnar-based chimeric antigen receptors (vnar-car) for the treatment of clonal b-and t cell malignancies, and methods for producing vnar-cars |
| CN115975010A (zh) * | 2022-08-31 | 2023-04-18 | 闽江学院 | 一种十足目虹彩病毒1的单域抗体及其制备方法和应用 |
| CN116041490A (zh) * | 2022-10-10 | 2023-05-02 | 闽江学院 | 一种针对虾虹彩病毒div1中和抗体的制备方法及其应用 |
| CN120098132B (zh) * | 2025-01-23 | 2025-12-09 | 浙江理工大学 | 一种Cre特异性的鲨鱼单域抗体及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7572631B2 (en) * | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| GB201115911D0 (en) * | 2011-09-14 | 2011-10-26 | Health Prot Agency | Thermostable assay reagents |
| SG11201404285VA (en) | 2012-02-22 | 2014-10-30 | Univ Pennsylvania | Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer |
| WO2013167883A1 (en) * | 2012-05-07 | 2013-11-14 | The University Court Of The University Of Aberdeen | Single domain binding molecule |
| HUE064187T2 (hu) * | 2012-05-25 | 2024-02-28 | Cellectis | Eljárás immunterápiára alkalmas allogén és immunszupresszív-rezisztens T-sejt módosítására |
| KR102064230B1 (ko) * | 2013-02-15 | 2020-01-13 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 키메라 항원 수용체 및 이의 이용 방법 |
-
2015
- 2015-01-14 ES ES15701312T patent/ES2701846T3/es active Active
- 2015-01-14 JP JP2016546437A patent/JP2017507917A/ja active Pending
- 2015-01-14 CA CA2936693A patent/CA2936693C/en not_active Expired - Fee Related
- 2015-01-14 US US15/111,441 patent/US10526406B2/en not_active Expired - Fee Related
- 2015-01-14 AU AU2015206040A patent/AU2015206040B2/en not_active Ceased
- 2015-01-14 WO PCT/EP2015/050581 patent/WO2015107075A1/en not_active Ceased
- 2015-01-14 EP EP15701312.9A patent/EP3094354B1/en not_active Not-in-force
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017507917A5 (OSRAM) | ||
| CN113286879B (zh) | 用于细胞疗法之多样化抗原结合域、新颖平台及其他增强子 | |
| JP7184866B2 (ja) | Ｐｄ１および／またはｌａｇ３結合性物質 | |
| JP7578938B2 (ja) | Ｂ７－ｈ３に対するモノクローナル抗体および細胞治療におけるその使用 | |
| JP2022137054A (ja) | ＮＫｐ４６結合タンパク質の可変領域 | |
| TWI675845B (zh) | 能夠結合ｇｐＡ３３和ＣＤ３的雙特異性單價雙抗體及其用途 | |
| CN114072427B (zh) | 抗dll3嵌合抗原受体及其用途 | |
| TWI693232B (zh) | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 | |
| Klener et al. | Immunotherapy approaches in cancer treatment | |
| US20190048085A1 (en) | Modified cells for immunotherapy | |
| CN118546959A (zh) | Cd19定向性嵌合抗原受体及其在免疫疗法中的用途 | |
| CN109195994A (zh) | 针对cd137的新型双特异性多肽 | |
| AU2015357463A1 (en) | Identification of VSIG8 as the putative vista receptor and its use thereof to produce vista/VSIG8 modulators | |
| CA3169601A1 (en) | Bispecific antigen binding molecules targeting ox40 and fap | |
| ES2717308T3 (es) | Células madre pluri- o multi-potentes genéticamente modificadas y sus usos | |
| AU2022246048A1 (en) | Multispecific proteins comprising an nkp46-binding site, a cancer antgienge binding site fused to a cytokine for nk cell engaging | |
| BR112021007334A2 (pt) | anticorpo anti-l1cam ou fragmento de ligação ao antígeno do mesmo, e receptor de antígeno quimérico compreendendo o mesmo | |
| JP2024519335A (ja) | がん免疫療法のための投薬レジメン | |
| CN110662760A (zh) | 人甲胎蛋白特异性t细胞受体及其用途 | |
| KR20230109651A (ko) | Nkg2a를 표적으로 하는 항체 및 이의 용도 | |
| JP2023087005A (ja) | Ｓｔｒｅｐ－タグ特異的結合タンパク質およびその使用 | |
| JP7354306B2 (ja) | 新規ｉｃｏｓ抗体及びそれらを含む腫瘍標的化抗原結合分子 | |
| CN109897114A (zh) | 具有自杀基因开关的靶向cd47的工程化免疫细胞 | |
| CN118525029A (zh) | 假型病毒颗粒、包含其的组合物和其用途 | |
| HK40065826A (zh) | 抗dll3嵌合抗原受体及其用途 |