JP2018535701A5 - - Google Patents
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- JP2018535701A5 JP2018535701A5 JP2018546725A JP2018546725A JP2018535701A5 JP 2018535701 A5 JP2018535701 A5 JP 2018535701A5 JP 2018546725 A JP2018546725 A JP 2018546725A JP 2018546725 A JP2018546725 A JP 2018546725A JP 2018535701 A5 JP2018535701 A5 JP 2018535701A5
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- 210000001744 T-lymphocyte Anatomy 0.000 claims description 100
- 239000000427 antigen Substances 0.000 claims description 54
- 102000036639 antigens Human genes 0.000 claims description 54
- 108091007433 antigens Proteins 0.000 claims description 54
- 230000000890 antigenic effect Effects 0.000 claims description 46
- 210000004027 cell Anatomy 0.000 claims description 32
- 108091008874 T cell receptors Proteins 0.000 claims description 31
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 31
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 28
- 150000007523 nucleic acids Chemical class 0.000 claims description 27
- 108020004707 nucleic acids Proteins 0.000 claims description 26
- 102000039446 nucleic acids Human genes 0.000 claims description 26
- 210000000130 stem cell Anatomy 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 23
- 108020003175 receptors Proteins 0.000 claims description 23
- 102000005962 receptors Human genes 0.000 claims description 23
- 230000003213 activating effect Effects 0.000 claims description 15
- 230000011664 signaling Effects 0.000 claims description 14
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 12
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims description 12
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 11
- -1 for example Proteins 0.000 claims description 11
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims description 8
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims description 8
- 102000054766 genetic haplotypes Human genes 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 241000124008 Mammalia Species 0.000 claims description 5
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims description 4
- 238000006471 dimerization reaction Methods 0.000 claims description 4
- 230000000813 microbial effect Effects 0.000 claims description 4
- 101150047061 tag-72 gene Proteins 0.000 claims description 4
- 230000006044 T cell activation Effects 0.000 claims description 3
- 235000018417 cysteine Nutrition 0.000 claims description 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 3
- 230000001613 neoplastic effect Effects 0.000 claims description 3
- 241000894006 Bacteria Species 0.000 claims description 2
- 230000001363 autoimmune Effects 0.000 claims description 2
- 230000003115 biocidal effect Effects 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 description 13
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 description 7
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 7
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 5
- 102100038080 B-cell receptor CD22 Human genes 0.000 description 4
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 description 4
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 description 4
- 108700010039 chimeric receptor Proteins 0.000 description 4
- 230000004068 intracellular signaling Effects 0.000 description 4
- 102100023990 60S ribosomal protein L17 Human genes 0.000 description 2
- 101710145634 Antigen 1 Proteins 0.000 description 2
- 102000006306 Antigen Receptors Human genes 0.000 description 2
- 108010083359 Antigen Receptors Proteins 0.000 description 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 2
- 102100027207 CD27 antigen Human genes 0.000 description 2
- 102100038078 CD276 antigen Human genes 0.000 description 2
- 101710185679 CD276 antigen Proteins 0.000 description 2
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 description 2
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 description 2
- 101150013553 CD40 gene Proteins 0.000 description 2
- 102100035793 CD83 antigen Human genes 0.000 description 2
- 102100037904 CD9 antigen Human genes 0.000 description 2
- 102100025466 Carcinoembryonic antigen-related cell adhesion molecule 3 Human genes 0.000 description 2
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 description 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 description 2
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 description 2
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 description 2
- 101000914337 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 3 Proteins 0.000 description 2
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 description 2
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 description 2
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 description 2
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 description 2
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 description 2
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 description 2
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 2
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 description 2
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 description 2
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 description 2
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 description 2
- 102000000440 Melanoma-associated antigen Human genes 0.000 description 2
- 108050008953 Melanoma-associated antigen Proteins 0.000 description 2
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 description 2
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 description 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 description 2
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 2
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 description 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 description 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 description 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 2
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 230000000139 costimulatory effect Effects 0.000 description 2
- 210000002865 immune cell Anatomy 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 238000012737 microarray-based gene expression Methods 0.000 description 2
- 238000012243 multiplex automated genomic engineering Methods 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 description 1
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 description 1
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 description 1
- 210000003995 blood forming stem cell Anatomy 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021183110A JP2022027762A (ja) | 2015-11-27 | 2021-11-10 | 遺伝子改変された細胞およびその使用 |
| JP2024010098A JP2024028648A (ja) | 2015-11-27 | 2024-01-26 | 遺伝子改変された細胞およびその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2015904933A AU2015904933A0 (en) | 2015-11-27 | Genetically modified cells and uses thereof | |
| AU2015904933 | 2015-11-27 | ||
| AU2016901328A AU2016901328A0 (en) | 2016-04-11 | Genetically modified cells and uses thereof - III | |
| AU2016901328 | 2016-04-11 | ||
| PCT/AU2016/051141 WO2017088012A1 (en) | 2015-11-27 | 2016-11-23 | Genetically modified cells and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021183110A Division JP2022027762A (ja) | 2015-11-27 | 2021-11-10 | 遺伝子改変された細胞およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018535701A JP2018535701A (ja) | 2018-12-06 |
| JP2018535701A5 true JP2018535701A5 (OSRAM) | 2019-12-26 |
| JP6976960B2 JP6976960B2 (ja) | 2021-12-08 |
Family
ID=58762790
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018546725A Active JP6976960B2 (ja) | 2015-11-27 | 2016-11-23 | 遺伝子改変された細胞およびその使用 |
| JP2021183110A Pending JP2022027762A (ja) | 2015-11-27 | 2021-11-10 | 遺伝子改変された細胞およびその使用 |
| JP2024010098A Pending JP2024028648A (ja) | 2015-11-27 | 2024-01-26 | 遺伝子改変された細胞およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021183110A Pending JP2022027762A (ja) | 2015-11-27 | 2021-11-10 | 遺伝子改変された細胞およびその使用 |
| JP2024010098A Pending JP2024028648A (ja) | 2015-11-27 | 2024-01-26 | 遺伝子改変された細胞およびその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11400145B2 (OSRAM) |
| EP (3) | EP3380117B1 (OSRAM) |
| JP (3) | JP6976960B2 (OSRAM) |
| CN (2) | CN116121281A (OSRAM) |
| AU (2) | AU2016361451B2 (OSRAM) |
| CA (1) | CA3004120A1 (OSRAM) |
| ES (2) | ES2988976T3 (OSRAM) |
| IL (2) | IL296410A (OSRAM) |
| MY (1) | MY189819A (OSRAM) |
| SG (2) | SG10201912825XA (OSRAM) |
| WO (1) | WO2017088012A1 (OSRAM) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180044404A1 (en) | 2015-03-05 | 2018-02-15 | Fred Hutchinson Cancer Research Center | Immunomodulatory fusion proteins and uses thereof |
| JP7114490B2 (ja) * | 2016-06-24 | 2022-08-08 | アイセル・ジーン・セラピューティクス・エルエルシー | キメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法 |
| JP7193862B2 (ja) | 2016-08-03 | 2022-12-21 | ワシントン・ユニバーシティ | キメラ抗原受容体でのｔ細胞性悪性腫瘍の治療のためのｃａｒ－ｔ細胞の遺伝子編集 |
| JP7215994B2 (ja) | 2016-09-06 | 2023-01-31 | ザ チルドレンズ メディカル センター コーポレーション | 人工多能性幹細胞由来の免疫細胞 |
| AU2018236461B2 (en) | 2017-03-17 | 2025-03-27 | Fred Hutchinson Cancer Center | Immunomodulatory fusion proteins and uses thereof |
| WO2018187356A2 (en) | 2017-04-03 | 2018-10-11 | Neon Therapeutics, Inc. | Protein antigens and uses thereof |
| IL269716B2 (en) * | 2017-04-18 | 2025-07-01 | Fujifilm Cellular Dynamics Inc | Antigen-specific immune effector cells |
| CA3079264A1 (en) * | 2017-10-18 | 2019-04-25 | Intrexon Corporation | Polypeptide compositions comprising spacers |
| TW201930340A (zh) | 2017-12-18 | 2019-08-01 | 美商尼恩醫療公司 | 新抗原及其用途 |
| CN109971721B (zh) * | 2017-12-28 | 2023-10-31 | 上海细胞治疗研究院 | 自表达cd47抗体的间皮素特异性car-t细胞及其用途 |
| CN109971716B (zh) * | 2017-12-28 | 2023-08-01 | 上海细胞治疗研究院 | 自分泌cd47抗体的egfr特异性car-t细胞及其用途 |
| AU2019216982B2 (en) * | 2018-02-11 | 2024-07-04 | Memorial Sloan-Kettering Cancer Center | Non-HLA restricted T cell receptors and uses thereof |
| AU2019225393A1 (en) * | 2018-02-23 | 2020-08-20 | Cartherics Pty. Ltd. | T cell disease treatment targeting TAG-72 |
| GB201804701D0 (en) * | 2018-03-23 | 2018-05-09 | Gammadelta Therapeutics Ltd | Lymphocytes expressing heterologous targeting constructs |
| GB201807945D0 (en) * | 2018-05-16 | 2018-06-27 | Ospedale San Raffaele Srl | Vector production |
| JP2022516389A (ja) * | 2018-05-31 | 2022-02-28 | ワシントン・ユニバーシティ | 血液悪性腫瘍を治療するためのゲノム編集インバリアントナチュラルキラーＴ（ｉＮＫＴ）細胞 |
| MX2020014243A (es) | 2018-06-19 | 2021-05-12 | Biontech Us Inc | Neoantigenos y usos de los mismos. |
| US12281152B2 (en) | 2018-08-01 | 2025-04-22 | City Of Hope | TAG72 targeted chimeric antigen receptor modified T cells for treatment of TAG72-positive tumors |
| CN114929864A (zh) * | 2019-06-12 | 2022-08-19 | 加利福尼亚大学董事会 | 工程化的现成免疫细胞及其使用方法 |
| MX2022006288A (es) | 2019-11-25 | 2022-06-08 | Univ Kyoto | Banco de celulas maestras de celulas t. |
| EP4151660A4 (en) * | 2020-05-22 | 2024-01-17 | Chongqing Precision Biotech Company Limited | Fusion protein for reversing tumor microenvironment and use thereof |
| CN115867294A (zh) | 2020-06-04 | 2023-03-28 | 凯瑞斯马治疗公司 | 嵌合抗原受体的新型构建体 |
| WO2022061837A1 (en) * | 2020-09-27 | 2022-03-31 | Jiangsu Cell Tech Medical Research Institute Co., Ltd. | Fibronectin extra domain b (edb) -specific car-t for cancer |
| US11591381B2 (en) | 2020-11-30 | 2023-02-28 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| WO2022144632A1 (en) | 2020-12-30 | 2022-07-07 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into nk cells |
| US12144827B2 (en) | 2021-02-25 | 2024-11-19 | Lyell Immunopharma, Inc. | ROR1 targeting chimeric antigen receptor |
| US20220333074A1 (en) * | 2021-04-07 | 2022-10-20 | Century Therapeutics, Inc. | Compositions and Methods for Generating Alpha-Beta T Cells from Induced Pluripotent Stem Cells |
| WO2023110824A1 (en) * | 2021-12-15 | 2023-06-22 | Novo Nordisk A/S | Novel integrin associated protein (iap) |
| CN114573710A (zh) * | 2022-02-16 | 2022-06-03 | 南方医科大学珠江医院 | 一种靶向抗原同时外泌cd47抗体的免疫细胞及其应用 |
| WO2024036214A2 (en) * | 2022-08-10 | 2024-02-15 | Jasper Therapeutics, Inc. | Modified stem cell compositions and methods for use |
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| US10093736B2 (en) * | 2012-11-13 | 2018-10-09 | Biontech Ag | Agents for treatment of claudin expressing cancer diseases |
| US9221908B2 (en) | 2012-12-12 | 2015-12-29 | Vasculox, Inc. | Therapeutic CD47 antibodies |
| BR112015013431A2 (pt) | 2012-12-12 | 2017-11-14 | Vasculox Inc | anticorpos monoclonais ou respectivos fragmentos ligantes de antígenos, composição farmacêutica, e usos de anticorpo monoclonal ou respectivo fragmento ligante de antígenos |
| WO2014165707A2 (en) * | 2013-04-03 | 2014-10-09 | Memorial Sloan-Kettering Cancer Center | Effective generation of tumor-targeted t-cells derived from pluripotent stem cells |
| NZ758715A (en) * | 2013-10-31 | 2023-01-27 | Seattle Children’S Hospital Dba Seattle Children’S Res Institute | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| WO2015120363A1 (en) * | 2014-02-10 | 2015-08-13 | Emory University | Expression of chimeric polypeptide with variable lymphocyte receptors on immune cells and uses for treating cancer |
| WO2016154628A1 (en) | 2015-03-26 | 2016-09-29 | Xiuli Wang | Bi-specific targeted chimeric antigen receptor t cells |
| ES2953925T3 (es) * | 2015-11-04 | 2023-11-17 | Fate Therapeutics Inc | Ingeniería genómica de células pluripotentes |
| CN105331586B (zh) | 2015-11-20 | 2020-09-15 | 上海细胞治疗研究院 | 一种包含高效杀伤启动机制的肿瘤精准t细胞及其用途 |
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2016
- 2016-11-23 CN CN202211541314.3A patent/CN116121281A/zh active Pending
- 2016-11-23 US US15/778,836 patent/US11400145B2/en active Active
- 2016-11-23 WO PCT/AU2016/051141 patent/WO2017088012A1/en not_active Ceased
- 2016-11-23 ES ES20169645T patent/ES2988976T3/es active Active
- 2016-11-23 SG SG10201912825XA patent/SG10201912825XA/en unknown
- 2016-11-23 SG SG11201803493UA patent/SG11201803493UA/en unknown
- 2016-11-23 IL IL296410A patent/IL296410A/en unknown
- 2016-11-23 CN CN201680069543.6A patent/CN109152824B/zh active Active
- 2016-11-23 JP JP2018546725A patent/JP6976960B2/ja active Active
- 2016-11-23 AU AU2016361451A patent/AU2016361451B2/en active Active
- 2016-11-23 EP EP16867445.5A patent/EP3380117B1/en active Active
- 2016-11-23 EP EP20169648.1A patent/EP3708588A1/en active Pending
- 2016-11-23 MY MYPI2018701648A patent/MY189819A/en unknown
- 2016-11-23 EP EP20169645.7A patent/EP3708587B1/en active Active
- 2016-11-23 CA CA3004120A patent/CA3004120A1/en active Pending
- 2016-11-23 ES ES16867445T patent/ES2862907T3/es active Active
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2018
- 2018-05-24 IL IL259586A patent/IL259586B2/en unknown
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2021
- 2021-11-10 JP JP2021183110A patent/JP2022027762A/ja active Pending
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2022
- 2022-06-09 US US17/836,052 patent/US20220305106A1/en not_active Abandoned
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2024
- 2024-01-08 AU AU2024200108A patent/AU2024200108A1/en active Pending
- 2024-01-26 JP JP2024010098A patent/JP2024028648A/ja active Pending
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2025
- 2025-07-17 US US19/271,861 patent/US20250340612A1/en active Pending
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