RU2599785C3 - Кристаллические формы 5-хлор-n2-(2-изопропокси-5-метил-4-пиперидин-4-ил-фенил)-n4-[2-(пропан-2-сульфонил)-фенил]-пиримидин-2,4-диамина - Google Patents

Кристаллические формы 5-хлор-n2-(2-изопропокси-5-метил-4-пиперидин-4-ил-фенил)-n4-[2-(пропан-2-сульфонил)-фенил]-пиримидин-2,4-диамина

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Publication number
RU2599785C3
RU2599785C3 RU2013132947A RU2013132947A RU2599785C3 RU 2599785 C3 RU2599785 C3 RU 2599785C3 RU 2013132947 A RU2013132947 A RU 2013132947A RU 2013132947 A RU2013132947 A RU 2013132947A RU 2599785 C3 RU2599785 C3 RU 2599785C3
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crystalline form
phenyl
weight
less
total impurities
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RU2013132947A
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English (en)
Russian (ru)
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RU2013132947A (ru
RU2599785C2 (ru
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Новартис Аг
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Hydrogenated Pyridines (AREA)
RU2013132947A 2010-12-17 2011-12-15 Кристаллические формы 5-хлор-n2-(2-изопропокси-5-метил-4-пиперидин-4-ил-фенил)-n4-[2-(пропан-2-сульфонил)-фенил]-пиримидин-2,4-диамина RU2599785C3 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201061424194P 2010-12-17 2010-12-17
US61/424,194 2010-12-17
PCT/US2011/065030 WO2012082972A1 (en) 2010-12-17 2011-12-15 Crystalline forms of 5-chloro-n2-(2-isopropoxy-5-methyl-4-piperidin-4-yl-phenyl)-n4[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2016136823A Division RU2746159C2 (ru) 2010-12-17 2011-12-15 Кристаллические формы 5-хлор-n2-(2-изопропокси-5-метил-4-пиперидин-4-ил-фенил)-n4-[2-(пропан-2-сульфонил)-фенил]-пиримидин-2,4-диамина

Publications (3)

Publication Number Publication Date
RU2013132947A RU2013132947A (ru) 2015-01-27
RU2599785C2 RU2599785C2 (ru) 2016-10-20
RU2599785C3 true RU2599785C3 (ru) 2019-04-24

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RU2013132947A RU2599785C3 (ru) 2010-12-17 2011-12-15 Кристаллические формы 5-хлор-n2-(2-изопропокси-5-метил-4-пиперидин-4-ил-фенил)-n4-[2-(пропан-2-сульфонил)-фенил]-пиримидин-2,4-диамина
RU2016136823A RU2746159C2 (ru) 2010-12-17 2011-12-15 Кристаллические формы 5-хлор-n2-(2-изопропокси-5-метил-4-пиперидин-4-ил-фенил)-n4-[2-(пропан-2-сульфонил)-фенил]-пиримидин-2,4-диамина

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PL (2) PL2651918T3 (enExample)
PT (2) PT2651918T (enExample)
RS (1) RS57771B1 (enExample)
RU (2) RU2599785C3 (enExample)
SG (2) SG10201510082XA (enExample)
SI (2) SI2651918T1 (enExample)
TN (1) TN2013000216A1 (enExample)
TW (2) TWI576344B (enExample)
WO (1) WO2012082972A1 (enExample)
ZA (1) ZA201303599B (enExample)

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ZA201303599B (en) 2014-02-26
KR20180032680A (ko) 2018-03-30
JP5916752B2 (ja) 2016-05-11
CN106008462A (zh) 2016-10-12
CN106831716A (zh) 2017-06-13
SI3121171T1 (sl) 2018-11-30
SG10201510082XA (en) 2016-01-28
TW201629021A (zh) 2016-08-16
CY1121017T1 (el) 2019-12-11
ES2905973T3 (es) 2022-04-12
HUE041845T2 (hu) 2019-05-28
TN2013000216A1 (en) 2014-11-10
AU2011343775A1 (en) 2013-07-18
CN103282359A (zh) 2013-09-04
EP3453708B1 (en) 2021-10-27
CY1119474T1 (el) 2018-04-04
DK3121171T3 (en) 2018-12-10
PE20140698A1 (es) 2014-06-11
CL2013001723A1 (es) 2013-12-27
CO6801792A2 (es) 2013-11-29
EP3121171A1 (en) 2017-01-25
RS57771B1 (sr) 2018-12-31
EP3121171B1 (en) 2018-08-15
RU2016136823A3 (enExample) 2020-02-06
MY164810A (en) 2018-01-30
RU2013132947A (ru) 2015-01-27
NZ610713A (en) 2014-10-31
SG190856A1 (en) 2013-07-31
PT2651918T (pt) 2017-10-17
CN104262324A (zh) 2015-01-07
WO2012082972A1 (en) 2012-06-21
MX338210B (es) 2016-04-07
KR102325775B1 (ko) 2021-11-12
CN114989139A (zh) 2022-09-02
IL226474A (en) 2016-03-31
CN107056751A (zh) 2017-08-18
RU2746159C2 (ru) 2021-04-08
EP3453708A1 (en) 2019-03-13
CN112125884A (zh) 2020-12-25
KR20190022903A (ko) 2019-03-06
ES2696526T3 (es) 2019-01-16
TW201307299A (zh) 2013-02-16
MX2013006952A (es) 2013-07-15
RU2599785C2 (ru) 2016-10-20
KR20130130022A (ko) 2013-11-29
LT2651918T (lt) 2017-10-10
PL2651918T3 (pl) 2017-12-29
EP3453708B8 (en) 2022-03-16
DK2651918T3 (en) 2017-10-23
EP2651918A1 (en) 2013-10-23
HRP20181737T1 (hr) 2018-12-28
LT3121171T (lt) 2018-11-12
AU2011343775B2 (en) 2015-12-03
US20160175305A1 (en) 2016-06-23
PT3121171T (pt) 2018-11-27
CA2821102A1 (en) 2012-06-21
US9309229B2 (en) 2016-04-12
JP2013545812A (ja) 2013-12-26
GT201300153A (es) 2014-06-09
HRP20171477T1 (hr) 2017-11-17
SI2651918T1 (sl) 2017-10-30
IL226474A0 (en) 2013-07-31
MY177742A (en) 2020-09-23
ES2643016T3 (es) 2017-11-21
PH12013501254A1 (en) 2016-07-29
ECSP13012770A (es) 2013-10-31
AR084309A1 (es) 2013-05-08
BR112013015000A2 (pt) 2016-08-09
MA34771B1 (fr) 2013-12-03
TWI576343B (zh) 2017-04-01
CA2821102C (en) 2019-06-11
KR20200039021A (ko) 2020-04-14
RU2016136823A (ru) 2018-12-11
AR122395A2 (es) 2022-09-07
PL3121171T3 (pl) 2019-01-31
TWI576344B (zh) 2017-04-01
EP2651918B1 (en) 2017-07-12
US20130274279A1 (en) 2013-10-17

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