RU2599785C3 - Кристаллические формы 5-хлор-n2-(2-изопропокси-5-метил-4-пиперидин-4-ил-фенил)-n4-[2-(пропан-2-сульфонил)-фенил]-пиримидин-2,4-диамина - Google Patents

Кристаллические формы 5-хлор-n2-(2-изопропокси-5-метил-4-пиперидин-4-ил-фенил)-n4-[2-(пропан-2-сульфонил)-фенил]-пиримидин-2,4-диамина

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Publication number
RU2599785C3
RU2599785C3 RU2013132947A RU2013132947A RU2599785C3 RU 2599785 C3 RU2599785 C3 RU 2599785C3 RU 2013132947 A RU2013132947 A RU 2013132947A RU 2013132947 A RU2013132947 A RU 2013132947A RU 2599785 C3 RU2599785 C3 RU 2599785C3
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RU
Russia
Prior art keywords
crystalline form
phenyl
weight
less
total impurities
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RU2013132947A
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English (en)
Russian (ru)
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RU2013132947A (ru
RU2599785C2 (ru
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Новартис Аг
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45464892&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2599785(C3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
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Publication of RU2599785C2 publication Critical patent/RU2599785C2/ru
Application granted granted Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Hydrogenated Pyridines (AREA)
RU2013132947A 2010-12-17 2011-12-15 Кристаллические формы 5-хлор-n2-(2-изопропокси-5-метил-4-пиперидин-4-ил-фенил)-n4-[2-(пропан-2-сульфонил)-фенил]-пиримидин-2,4-диамина RU2599785C3 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201061424194P 2010-12-17 2010-12-17
US61/424,194 2010-12-17
PCT/US2011/065030 WO2012082972A1 (en) 2010-12-17 2011-12-15 Crystalline forms of 5-chloro-n2-(2-isopropoxy-5-methyl-4-piperidin-4-yl-phenyl)-n4[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2016136823A Division RU2746159C2 (ru) 2010-12-17 2011-12-15 Кристаллические формы 5-хлор-n2-(2-изопропокси-5-метил-4-пиперидин-4-ил-фенил)-n4-[2-(пропан-2-сульфонил)-фенил]-пиримидин-2,4-диамина

Publications (3)

Publication Number Publication Date
RU2013132947A RU2013132947A (ru) 2015-01-27
RU2599785C2 RU2599785C2 (ru) 2016-10-20
RU2599785C3 true RU2599785C3 (ru) 2019-04-24

Family

ID=45464892

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2016136823A RU2746159C2 (ru) 2010-12-17 2011-12-15 Кристаллические формы 5-хлор-n2-(2-изопропокси-5-метил-4-пиперидин-4-ил-фенил)-n4-[2-(пропан-2-сульфонил)-фенил]-пиримидин-2,4-диамина
RU2013132947A RU2599785C3 (ru) 2010-12-17 2011-12-15 Кристаллические формы 5-хлор-n2-(2-изопропокси-5-метил-4-пиперидин-4-ил-фенил)-n4-[2-(пропан-2-сульфонил)-фенил]-пиримидин-2,4-диамина

Family Applications Before (1)

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RU2016136823A RU2746159C2 (ru) 2010-12-17 2011-12-15 Кристаллические формы 5-хлор-n2-(2-изопропокси-5-метил-4-пиперидин-4-ил-фенил)-n4-[2-(пропан-2-сульфонил)-фенил]-пиримидин-2,4-диамина

Country Status (36)

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EP (3) EP3453708B8 (enExample)
JP (1) JP5916752B2 (enExample)
KR (4) KR20190022903A (enExample)
CN (7) CN112125884A (enExample)
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BR (1) BR112013015000A2 (enExample)
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CY (2) CY1119474T1 (enExample)
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RU (2) RU2746159C2 (enExample)
SG (2) SG10201510082XA (enExample)
SI (2) SI3121171T1 (enExample)
TN (1) TN2013000216A1 (enExample)
TW (2) TWI576343B (enExample)
WO (1) WO2012082972A1 (enExample)
ZA (1) ZA201303599B (enExample)

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WO2017152858A1 (zh) * 2016-03-11 2017-09-14 苏州晶云药物科技有限公司 色瑞替尼的晶型及其制备方法
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CN105061397B (zh) 2015-08-07 2018-01-02 武汉英普瑞医药科技有限公司 一种色瑞替尼的c型晶型及其制备方法与应用

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KR102325775B1 (ko) 2021-11-12
PH12013501254A1 (en) 2016-07-29
CL2013001723A1 (es) 2013-12-27
AR122395A2 (es) 2022-09-07
RS57771B1 (sr) 2018-12-31
TN2013000216A1 (en) 2014-11-10
DK3121171T3 (en) 2018-12-10
MY164810A (en) 2018-01-30
CN112125884A (zh) 2020-12-25
TWI576344B (zh) 2017-04-01
US9309229B2 (en) 2016-04-12
JP5916752B2 (ja) 2016-05-11
CN106008462A (zh) 2016-10-12
LT3121171T (lt) 2018-11-12
CA2821102A1 (en) 2012-06-21
PT3121171T (pt) 2018-11-27
TW201307299A (zh) 2013-02-16
IL226474A (en) 2016-03-31
RU2016136823A (ru) 2018-12-11
DK2651918T3 (en) 2017-10-23
WO2012082972A1 (en) 2012-06-21
GT201300153A (es) 2014-06-09
MY177742A (en) 2020-09-23
PL2651918T3 (pl) 2017-12-29
HRP20181737T1 (hr) 2018-12-28
JP2013545812A (ja) 2013-12-26
ES2696526T3 (es) 2019-01-16
CN107056751A (zh) 2017-08-18
CY1119474T1 (el) 2018-04-04
EP2651918B1 (en) 2017-07-12
SG10201510082XA (en) 2016-01-28
EP2651918A1 (en) 2013-10-23
CA2821102C (en) 2019-06-11
MA34771B1 (fr) 2013-12-03
CN114989139A (zh) 2022-09-02
MX2013006952A (es) 2013-07-15
ES2643016T3 (es) 2017-11-21
BR112013015000A2 (pt) 2016-08-09
TWI576343B (zh) 2017-04-01
EP3453708B8 (en) 2022-03-16
SG190856A1 (en) 2013-07-31
RU2016136823A3 (enExample) 2020-02-06
CY1121017T1 (el) 2019-12-11
RU2746159C2 (ru) 2021-04-08
KR20180032680A (ko) 2018-03-30
PE20140698A1 (es) 2014-06-11
KR20190022903A (ko) 2019-03-06
US20130274279A1 (en) 2013-10-17
ZA201303599B (en) 2014-02-26
EP3453708A1 (en) 2019-03-13
US20160175305A1 (en) 2016-06-23
PL3121171T3 (pl) 2019-01-31
CN106831716A (zh) 2017-06-13
SI3121171T1 (sl) 2018-11-30
IL226474A0 (en) 2013-07-31
CO6801792A2 (es) 2013-11-29
ECSP13012770A (es) 2013-10-31
HUE041845T2 (hu) 2019-05-28
LT2651918T (lt) 2017-10-10
PT2651918T (pt) 2017-10-17
EP3121171A1 (en) 2017-01-25
KR20130130022A (ko) 2013-11-29
KR20200039021A (ko) 2020-04-14
ES2905973T3 (es) 2022-04-12
EP3121171B1 (en) 2018-08-15
SI2651918T1 (sl) 2017-10-30
RU2013132947A (ru) 2015-01-27
EP3453708B1 (en) 2021-10-27
MX338210B (es) 2016-04-07
CN104262324A (zh) 2015-01-07
RU2599785C2 (ru) 2016-10-20
AU2011343775A1 (en) 2013-07-18
HRP20171477T1 (hr) 2017-11-17
AR084309A1 (es) 2013-05-08
AU2011343775B2 (en) 2015-12-03
TW201629021A (zh) 2016-08-16
CN103282359A (zh) 2013-09-04
NZ610713A (en) 2014-10-31

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