JP2012176975A5 - - Google Patents

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Publication number
JP2012176975A5
JP2012176975A5 JP2012127232A JP2012127232A JP2012176975A5 JP 2012176975 A5 JP2012176975 A5 JP 2012176975A5 JP 2012127232 A JP2012127232 A JP 2012127232A JP 2012127232 A JP2012127232 A JP 2012127232A JP 2012176975 A5 JP2012176975 A5 JP 2012176975A5
Authority
JP
Japan
Prior art keywords
tiotropium bromide
crystal
crystals
pharmaceutical formulation
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012127232A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012176975A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2012176975A publication Critical patent/JP2012176975A/ja
Publication of JP2012176975A5 publication Critical patent/JP2012176975A5/ja
Pending legal-status Critical Current

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JP2012127232A 2005-12-19 2012-06-04 臭化チオトロピウムの新規な形態およびそれを製造する方法 Pending JP2012176975A (ja)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US75267205P 2005-12-19 2005-12-19
US60/752,672 2005-12-19
US75453005P 2005-12-27 2005-12-27
US60/754,530 2005-12-27
US76143706P 2006-01-23 2006-01-23
US60/761,437 2006-01-23
US77405106P 2006-02-15 2006-02-15
US60/774,051 2006-02-15
US78031006P 2006-03-07 2006-03-07
US60/780,310 2006-03-07
US83218906P 2006-07-20 2006-07-20
US60/832,189 2006-07-20
US85122306P 2006-10-12 2006-10-12
US60/851,223 2006-10-12
US85274006P 2006-10-18 2006-10-18
US60/852,740 2006-10-18

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2008538130A Division JP5086267B2 (ja) 2005-12-19 2006-12-19 臭化チオトロピウムの新規な形態およびそれを製造する方法

Publications (2)

Publication Number Publication Date
JP2012176975A JP2012176975A (ja) 2012-09-13
JP2012176975A5 true JP2012176975A5 (enExample) 2012-10-25

Family

ID=38115166

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2008538130A Active JP5086267B2 (ja) 2005-12-19 2006-12-19 臭化チオトロピウムの新規な形態およびそれを製造する方法
JP2012037796A Active JP5567610B2 (ja) 2005-12-19 2012-02-23 臭化チオトロピウムの新規な形態およびそれを製造する方法
JP2012127232A Pending JP2012176975A (ja) 2005-12-19 2012-06-04 臭化チオトロピウムの新規な形態およびそれを製造する方法

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2008538130A Active JP5086267B2 (ja) 2005-12-19 2006-12-19 臭化チオトロピウムの新規な形態およびそれを製造する方法
JP2012037796A Active JP5567610B2 (ja) 2005-12-19 2012-02-23 臭化チオトロピウムの新規な形態およびそれを製造する方法

Country Status (17)

Country Link
US (4) US8163913B2 (enExample)
EP (2) EP2123650B1 (enExample)
JP (3) JP5086267B2 (enExample)
KR (1) KR101395881B1 (enExample)
CN (1) CN102731494A (enExample)
AT (1) ATE552256T1 (enExample)
BR (1) BRPI0608427A2 (enExample)
CA (1) CA2627729A1 (enExample)
DK (1) DK1869035T4 (enExample)
ES (2) ES2396978T5 (enExample)
IL (1) IL187947A0 (enExample)
MX (1) MX2007009988A (enExample)
PL (2) PL1869035T5 (enExample)
PT (1) PT1869035E (enExample)
RS (1) RS52663B2 (enExample)
TW (1) TW200732340A (enExample)
WO (1) WO2007075858A2 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
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BRPI0608427A2 (pt) * 2005-12-19 2009-12-29 Sicor Inc novas formas de brometo de tiotrópio e processos para seu preparo
US9108962B2 (en) * 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
SI2240477T1 (sl) * 2008-01-10 2015-02-27 Generics (Uk) Limited Nov postopek za pripravo estrov skopina
EP2172190A1 (en) * 2008-10-02 2010-04-07 Laboratorios Liconsa, S.A. Inhalable particles comprising tiotropium
KR101557633B1 (ko) * 2008-11-04 2015-10-06 시플라 리미티드 낮은 결정화도를 갖는 티오트로피움 브로마이드
BRPI0916047A2 (pt) * 2008-11-04 2015-11-10 Cipla Ltd composição farmacêutica em aerossol, uso de uma composição farmacêutica em aerossol, método para tratamento de sintomas crônicos ou agudos severos, moderados ou leves, ou para tratamento profilático de um distúrbio respiratório, dispensador farmacêutico em aerossol, processo para fabricação de um dispensador farmacêutico em aerossol e processo para fabricação de um complexo de um agente ativo e um adjuvante
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
US8697719B2 (en) * 2009-08-07 2014-04-15 Generics [Uk] Limited Anhydrate of tiotropium bromide
TR201111589A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (pt) 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
EP2897955B1 (en) * 2012-09-11 2019-11-06 Bilgic, Mahmut New tiotropium bromide crystalline form
JP6158939B2 (ja) 2012-11-05 2017-07-05 ゼンティーバ，カー．エス． チオトロピウム溶媒和物の安定化
JP6473738B2 (ja) 2013-04-01 2019-02-20 パルマトリックス，インコーポレイテッド チオトロピウム乾燥粉末
EP2789611A1 (en) * 2013-04-08 2014-10-15 Cerbios-Pharma S.A. A crystalline form of tiotropium bromide
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
RU2567539C1 (ru) * 2015-02-04 2015-11-10 Индивидуальный предприниматель Михайлов Олег Ростиславович КРИСТАЛЛИЧЕСКАЯ γ-МОДИФИКАЦИЯ (1α,2β,4β,5α,7β-7)-[(ГИДРОКСИДИ-2-ТИЕНИЛАЦЕТИЛ)ОКСИ]-9,9-ДИМЕТИЛ-3-ОКСА-9-АЗОНИАТРИЦИКЛО[3.3.1.02,4]НОНАН БРОМИДА МОНОГИДРАТА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЁ ОСНОВЕ
EP3414243A1 (en) * 2016-02-11 2018-12-19 Sima Patent Ve Lisanslama Hizmetleri Ltd. STI Crystalline form of tiotropium bromide anhydrate
EP3822249A4 (en) * 2018-07-13 2022-04-13 Kyowa Hakko Bio Co., Ltd. EUCOMIC ACID NON-SOLVATE CRYSTAL AND METHOD FOR PRODUCTION
PT115583B (pt) 2019-06-17 2022-05-02 Hovione Farm S A Processo contínuo para a preparação de medicamentos anticolinérgicos
EP4108230A1 (en) 2021-06-24 2022-12-28 Laboratoires SMB New dry powder composition of tiotropium for inhalation

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DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US6736830B2 (en) 2000-08-22 2004-05-18 Deborah M. Roust Baby pacifier
ES2227268T3 (es) * 2000-10-12 2005-04-01 BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG Nuevos polvos para inhalacion con contenido en tiotropio.
US6908928B2 (en) * 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
MEP40008A (en) * 2000-10-12 2011-02-10 Boehringer Ingelheim Pharma Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
ME00412B (me) * 2001-06-22 2011-10-10 Boehringer Ingelheim Pharma Kristalni antiholinergik , postupak za njegovo pripremanje i njegova primjena u proizvodnji lijeka
US6608055B2 (en) * 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
US6890291B2 (en) 2001-06-25 2005-05-10 Mission Medical, Inc. Integrated automatic blood collection and processing unit
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MXPA05006383A (es) * 2002-12-16 2005-08-29 Boehringer Ingelheim Pharma Formulaciones de soluciones de hidrofluorocarburo que contienen tiotropio.
UA83813C2 (ru) * 2002-12-20 2008-08-26 Бёрингер Ингельхайм Фарма Гмбх & Ко. Кг Порошковое лекарственное средство, которое содержит соль тиотропия и ксинафоат салметерола
DE10351196B4 (de) 2003-10-28 2016-08-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verwendung einer anodisch mit Silizium bondbaren Glas-Keramik (LTCC)
UA82909C2 (en) 2003-11-03 2008-05-26 Boehringer Ingelheim Int Novel crystalline anhydride with anticholinergic effect
UA82414C2 (uk) * 2003-11-03 2008-04-10 Бёрингер Ингельхайм Интернациональ Гмбх Солі тіотропію, спосіб їх одержання, а також лікарські композиції, які їх містять
US7968717B2 (en) * 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
SI1682541T1 (sl) * 2003-11-03 2010-06-30 Boehringer Ingelheim Int Postopek za pripravo tiotropijevih soli
CN1271073C (zh) 2004-10-26 2006-08-23 江苏正大天晴药业股份有限公司 结晶性抗胆碱能药噻托溴铵晶体
EP2085396A3 (en) * 2005-05-02 2009-11-25 Boehringer Ingelheim International Gmbh Novel crystalline forms of tiotropium bromide
CA2606552A1 (en) * 2005-05-02 2006-11-09 Boehringer Ingelheim International Gmbh Crystalline forms of tiotropium bromide
SI1869035T2 (sl) * 2005-12-19 2015-12-31 Sicor, Inc. Nove kristalne oblike tiotropij bromida in postopek njihove priprave
BRPI0608427A2 (pt) * 2005-12-19 2009-12-29 Sicor Inc novas formas de brometo de tiotrópio e processos para seu preparo
EP1923393A1 (en) 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Crystalline form of tiotropium bromide and urea
EP2020403A1 (en) * 2007-08-02 2009-02-04 Esteve Quimica, S.A. Process for the resolution of zopiclone and intermediate compounds
US8697719B2 (en) * 2009-08-07 2014-04-15 Generics [Uk] Limited Anhydrate of tiotropium bromide
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use

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