PL2123650T3 - Nowa postać bromku tiotropium i sposób jej wytwarzania - Google Patents

Nowa postać bromku tiotropium i sposób jej wytwarzania

Info

Publication number
PL2123650T3
PL2123650T3 PL09010563T PL09010563T PL2123650T3 PL 2123650 T3 PL2123650 T3 PL 2123650T3 PL 09010563 T PL09010563 T PL 09010563T PL 09010563 T PL09010563 T PL 09010563T PL 2123650 T3 PL2123650 T3 PL 2123650T3
Authority
PL
Poland
Prior art keywords
preparation
tiotropium bromide
novel form
novel
tiotropium
Prior art date
Application number
PL09010563T
Other languages
English (en)
Polish (pl)
Inventor
Nicola Diulgheroff
Francesca Scarpitta
Alessandro Pontiroli
Adrienne Kovacsne-Mezei
Judith Aronhime
Alexandr Jegorov
Original Assignee
Sicor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38115166&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2123650(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sicor Inc filed Critical Sicor Inc
Publication of PL2123650T3 publication Critical patent/PL2123650T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL09010563T 2005-12-19 2006-12-19 Nowa postać bromku tiotropium i sposób jej wytwarzania PL2123650T3 (pl)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US75267205P 2005-12-19 2005-12-19
US75453005P 2005-12-27 2005-12-27
US76143706P 2006-01-23 2006-01-23
US77405106P 2006-02-15 2006-02-15
US78031006P 2006-03-07 2006-03-07
US83218906P 2006-07-20 2006-07-20
US85122306P 2006-10-12 2006-10-12
US85274006P 2006-10-18 2006-10-18
EP09010563A EP2123650B1 (en) 2005-12-19 2006-12-19 Novel form of tiotropium bromide and process for preparation thereof
EP06847887.4A EP1869035B2 (en) 2005-12-19 2006-12-19 Novel crystalline form of tiotropium bromide and process for preparation thereof

Publications (1)

Publication Number Publication Date
PL2123650T3 true PL2123650T3 (pl) 2012-09-28

Family

ID=38115166

Family Applications (2)

Application Number Title Priority Date Filing Date
PL09010563T PL2123650T3 (pl) 2005-12-19 2006-12-19 Nowa postać bromku tiotropium i sposób jej wytwarzania
PL06847887T PL1869035T5 (pl) 2005-12-19 2006-12-19 Nowa postać krystaliczna bromku tiotropium i proces jej wytwarzania

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL06847887T PL1869035T5 (pl) 2005-12-19 2006-12-19 Nowa postać krystaliczna bromku tiotropium i proces jej wytwarzania

Country Status (17)

Country Link
US (4) US8163913B2 (enExample)
EP (2) EP1869035B2 (enExample)
JP (3) JP5086267B2 (enExample)
KR (1) KR101395881B1 (enExample)
CN (1) CN102731494A (enExample)
AT (1) ATE552256T1 (enExample)
BR (1) BRPI0608427A2 (enExample)
CA (1) CA2627729A1 (enExample)
DK (1) DK1869035T4 (enExample)
ES (2) ES2384486T3 (enExample)
IL (1) IL187947A0 (enExample)
MX (1) MX2007009988A (enExample)
PL (2) PL2123650T3 (enExample)
PT (1) PT1869035E (enExample)
RS (1) RS52663B2 (enExample)
TW (1) TW200732340A (enExample)
WO (1) WO2007075858A2 (enExample)

Families Citing this family (24)

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US9108962B2 (en) * 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
PT1869035E (pt) * 2005-12-19 2013-01-10 Sicor Inc Novas formas de brometo de tiotrópio e processos para sua preparação
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
WO2009087419A1 (en) * 2008-01-10 2009-07-16 Generics [Uk] Limited Novel process for the preparation of scopine esters
EP2172190A1 (en) * 2008-10-02 2010-04-07 Laboratorios Liconsa, S.A. Inhalable particles comprising tiotropium
AU2009312582B2 (en) * 2008-11-04 2014-03-27 Cipla Limited Tiotropium bromide having a low degree of crystallinity
BRPI0916047A2 (pt) * 2008-11-04 2015-11-10 Cipla Ltd composição farmacêutica em aerossol, uso de uma composição farmacêutica em aerossol, método para tratamento de sintomas crônicos ou agudos severos, moderados ou leves, ou para tratamento profilático de um distúrbio respiratório, dispensador farmacêutico em aerossol, processo para fabricação de um dispensador farmacêutico em aerossol e processo para fabricação de um complexo de um agente ativo e um adjuvante
CA2768553C (en) 2009-08-07 2016-08-02 Generics [Uk] Limited Anhydrate of tiotropium bromide
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
TR201111589A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (pt) 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
EP2897955B1 (en) * 2012-09-11 2019-11-06 Bilgic, Mahmut New tiotropium bromide crystalline form
ES2620758T3 (es) 2012-11-05 2017-06-29 Zentiva K.S. Estabilización de solvatos de tiotropio
KR20150135328A (ko) 2013-04-01 2015-12-02 풀매트릭스 인코퍼레이티드 티오트로피움 건조 분말
EP2789611A1 (en) * 2013-04-08 2014-10-15 Cerbios-Pharma S.A. A crystalline form of tiotropium bromide
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
RU2567539C1 (ru) * 2015-02-04 2015-11-10 Индивидуальный предприниматель Михайлов Олег Ростиславович КРИСТАЛЛИЧЕСКАЯ γ-МОДИФИКАЦИЯ (1α,2β,4β,5α,7β-7)-[(ГИДРОКСИДИ-2-ТИЕНИЛАЦЕТИЛ)ОКСИ]-9,9-ДИМЕТИЛ-3-ОКСА-9-АЗОНИАТРИЦИКЛО[3.3.1.02,4]НОНАН БРОМИДА МОНОГИДРАТА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЁ ОСНОВЕ
WO2017138896A1 (en) * 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate
US11365170B2 (en) 2018-07-13 2022-06-21 Kyowa Hakko Bio Co., Ltd. Non-solvate crystal of eucomic acid and method for producing same
PT115583B (pt) 2019-06-17 2022-05-02 Hovione Farm S A Processo contínuo para a preparação de medicamentos anticolinérgicos
EP4108230A1 (en) 2021-06-24 2022-12-28 Laboratoires SMB New dry powder composition of tiotropium for inhalation

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US5610163A (en) 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
US6736830B2 (en) 2000-08-22 2004-05-18 Deborah M. Roust Baby pacifier
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AU2002214996B2 (en) 2000-10-12 2007-03-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
AP1712A (en) * 2000-10-12 2007-01-24 Boehringer Ingelheim Pharma Novel tiotropium-containing inhalation powder
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
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CN1271073C (zh) 2004-10-26 2006-08-23 江苏正大天晴药业股份有限公司 结晶性抗胆碱能药噻托溴铵晶体
EP1879888A2 (en) * 2005-05-02 2008-01-23 Boehringer Ingelheim International GmbH Crystalline forms of tiotropium bromide
KR20080012932A (ko) 2005-05-02 2008-02-12 베링거 인겔하임 인터내셔날 게엠베하 티오트로퓸 브로마이드의 신규한 결정형
CN101331128B (zh) * 2005-12-19 2013-05-29 西科尔公司 噻托溴铵的形式及其制备方法
PT1869035E (pt) * 2005-12-19 2013-01-10 Sicor Inc Novas formas de brometo de tiotrópio e processos para sua preparação
EP1923393A1 (en) 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Crystalline form of tiotropium bromide and urea
EP2020403A1 (en) * 2007-08-02 2009-02-04 Esteve Quimica, S.A. Process for the resolution of zopiclone and intermediate compounds
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
CA2768553C (en) 2009-08-07 2016-08-02 Generics [Uk] Limited Anhydrate of tiotropium bromide

Also Published As

Publication number Publication date
ES2384486T3 (es) 2012-07-05
JP2012136538A (ja) 2012-07-19
JP5567610B2 (ja) 2014-08-06
JP5086267B2 (ja) 2012-11-28
CN102731494A (zh) 2012-10-17
DK1869035T3 (da) 2013-01-14
US8163913B2 (en) 2012-04-24
US8846926B2 (en) 2014-09-30
US20140057935A1 (en) 2014-02-27
EP1869035B2 (en) 2015-08-12
US20120165364A1 (en) 2012-06-28
CA2627729A1 (en) 2007-07-05
EP2123650B1 (en) 2012-04-04
ES2396978T3 (es) 2013-03-01
US20070225314A1 (en) 2007-09-27
PL1869035T3 (pl) 2013-04-30
RS52663B2 (sr) 2018-05-31
EP2123650A1 (en) 2009-11-25
PT1869035E (pt) 2013-01-10
WO2007075858A2 (en) 2007-07-05
DK1869035T4 (en) 2015-11-16
MX2007009988A (es) 2008-02-22
KR20080078779A (ko) 2008-08-28
ES2396978T5 (es) 2015-12-04
RS52663B (sr) 2013-06-28
PL1869035T5 (pl) 2016-01-29
JP2009513675A (ja) 2009-04-02
KR101395881B1 (ko) 2014-05-21
JP2012176975A (ja) 2012-09-13
BRPI0608427A2 (pt) 2009-12-29
US20120108625A1 (en) 2012-05-03
ATE552256T1 (de) 2012-04-15
IL187947A0 (en) 2008-03-20
EP1869035B1 (en) 2012-10-03
TW200732340A (en) 2007-09-01
EP1869035A2 (en) 2007-12-26
WO2007075858A3 (en) 2007-11-01

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