BRPI0415636A - anidrato cristalino com efeito anticolinérgico - Google Patents
anidrato cristalino com efeito anticolinérgicoInfo
- Publication number
- BRPI0415636A BRPI0415636A BRPI0415636-6A BRPI0415636A BRPI0415636A BR PI0415636 A BRPI0415636 A BR PI0415636A BR PI0415636 A BRPI0415636 A BR PI0415636A BR PI0415636 A BRPI0415636 A BR PI0415636A
- Authority
- BR
- Brazil
- Prior art keywords
- anticholinergic effect
- crystalline anhydrate
- anhydrate
- preparation
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"ANIDRATO CRISTALINO COM EFEITO ANTICOLINéRGICO". A presente invenção refere-se a um novo anidrato cristalino do brometo de tiotrópio, processo para sua preparação bem como seu uso para preparação de um medicamento para o tratamento de doenças do trato respiratório, particularmente para o tratamento de COPD ('chronic obstructive pulmonary disease' = doença pulmonar obstrutiva crónica) e asma.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03025077 | 2003-11-03 | ||
PCT/EP2004/012269 WO2005042527A1 (de) | 2003-11-03 | 2004-10-29 | Neues kristallines anhydrat mit anticholinerger wirksamkeit |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0415636A true BRPI0415636A (pt) | 2006-12-12 |
Family
ID=34530662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0415636-6A BRPI0415636A (pt) | 2003-11-03 | 2004-10-29 | anidrato cristalino com efeito anticolinérgico |
Country Status (34)
Country | Link |
---|---|
EP (1) | EP1682542B1 (pt) |
JP (1) | JP4553902B2 (pt) |
KR (2) | KR101285571B1 (pt) |
CN (1) | CN100509809C (pt) |
AR (1) | AR046319A1 (pt) |
AT (1) | ATE453641T1 (pt) |
AU (1) | AU2004285684B2 (pt) |
BR (1) | BRPI0415636A (pt) |
CA (1) | CA2544352C (pt) |
CO (1) | CO5690641A2 (pt) |
CY (1) | CY1110339T1 (pt) |
DE (1) | DE502004010602D1 (pt) |
DK (1) | DK1682542T3 (pt) |
EA (1) | EA008587B1 (pt) |
EC (1) | ECSP066543A (pt) |
ES (1) | ES2338563T3 (pt) |
HK (1) | HK1099752A1 (pt) |
HR (1) | HRP20100029T1 (pt) |
IL (1) | IL175126A (pt) |
ME (1) | ME00349B (pt) |
MX (1) | MX272045B (pt) |
MY (1) | MY146628A (pt) |
NO (1) | NO20062569L (pt) |
NZ (1) | NZ547581A (pt) |
PE (1) | PE20050996A1 (pt) |
PL (1) | PL1682542T3 (pt) |
PT (1) | PT1682542E (pt) |
RS (2) | RS20060291A (pt) |
SI (1) | SI1682542T1 (pt) |
TW (1) | TWI336330B (pt) |
UA (1) | UA82909C2 (pt) |
UY (1) | UY28596A1 (pt) |
WO (1) | WO2005042527A1 (pt) |
ZA (1) | ZA200602344B (pt) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2007144531A (ru) * | 2005-05-02 | 2009-06-10 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | Новые кристаллические формы тиотропийбромида |
US9108962B2 (en) | 2005-12-19 | 2015-08-18 | Sicor, Inc. | Forms of tiotropium bromide and processes for preparation thereof |
RU2453547C2 (ru) * | 2005-12-19 | 2012-06-20 | Сикор Инк. | Новые формы тиотропия бромида и способы их получения |
RS52663B2 (sr) | 2005-12-19 | 2018-05-31 | Sicor Inc | Nova kristalna forma tiotropijum bromida i proces njene pripreme |
DE602006020620D1 (de) * | 2006-01-04 | 2011-04-21 | Boehringer Ingelheim Pharma | Verwendung von tiotropium-salzen bei der behandlung von mässigem persistierendem asthma |
CN100999521B (zh) * | 2006-01-13 | 2010-12-08 | 江苏正大天晴药业股份有限公司 | 结晶性抗胆碱药噻托溴铵 |
US20080051582A1 (en) | 2006-07-10 | 2008-02-28 | Sicor Inc. | Process for the preparation of tiotropium bromide |
CN101032484B (zh) * | 2007-04-02 | 2010-05-26 | 南京卡文迪许生物工程技术有限公司 | 一种噻托溴铵胶囊型吸入粉雾剂 |
GB0716026D0 (en) | 2007-08-16 | 2007-09-26 | Norton Healthcare Ltd | An inhalable medicament |
KR20110096538A (ko) * | 2008-11-04 | 2011-08-30 | 씨아이피엘에이 엘티디. | 약제학적 에어로졸 조성물 |
JP5650120B2 (ja) * | 2008-11-04 | 2015-01-07 | シプラ・リミテッド | 低い結晶化度を有する臭化チオトロピウム |
CN102639531B (zh) | 2009-08-07 | 2016-01-20 | 基因里克斯(英国)有限公司 | 噻托溴铵的无水合物 |
TR201111589A2 (tr) * | 2011-03-03 | 2012-09-21 | Bi̇lgi̇ç Mahmut | Tiotropyum bromür susuz kristal formu. |
CZ304368B6 (cs) | 2011-11-28 | 2014-04-02 | Zentiva, K.S. | Směsný solvát tiotropium bromidu a způsob jeho přípravy |
GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
EP2897955B1 (en) * | 2012-09-11 | 2019-11-06 | Bilgic, Mahmut | New tiotropium bromide crystalline form |
HUE032455T2 (en) | 2012-11-05 | 2017-09-28 | Zentiva Ks | Stabilization of thiotropium solvates |
EP2913332A1 (en) | 2014-02-27 | 2015-09-02 | Euticals S.P.A. | Crystalline form of tiotropium bromide with lactose |
US10034866B2 (en) | 2014-06-19 | 2018-07-31 | Teva Branded Pharmaceutical Products R&D, Inc. | Inhalable medicament comprising tiotropium |
EP3414243A1 (en) | 2016-02-11 | 2018-12-19 | Sima Patent Ve Lisanslama Hizmetleri Ltd. STI | Crystalline form of tiotropium bromide anhydrate |
EP4108230A1 (en) | 2021-06-24 | 2022-12-28 | Laboratoires SMB | New dry powder composition of tiotropium for inhalation |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3931041C2 (de) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
MXPA03003221A (es) * | 2000-10-12 | 2004-12-03 | Boehringer Ingelheim Pharma | Monohidrato cristalino, procedmiento para su preparacion y su uso para la preparacion de un medicamento. |
DE10111843A1 (de) * | 2001-03-13 | 2002-09-19 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von inflammatorischen Erkrankungen |
SI1401445T1 (sl) * | 2001-06-22 | 2007-02-28 | Boehringer Ingelheim Pharma | Kristalinicen antiholinergik, postopek za njegovo pripravo in njegova uporaba za pripravo zdravila |
-
2004
- 2004-10-29 PT PT04791029T patent/PT1682542E/pt unknown
- 2004-10-29 DE DE502004010602T patent/DE502004010602D1/de not_active Expired - Lifetime
- 2004-10-29 PL PL04791029T patent/PL1682542T3/pl unknown
- 2004-10-29 EA EA200600853A patent/EA008587B1/ru unknown
- 2004-10-29 RS YUP-2006/0291A patent/RS20060291A/sr unknown
- 2004-10-29 UA UAA200605766A patent/UA82909C2/uk unknown
- 2004-10-29 DK DK04791029.4T patent/DK1682542T3/da active
- 2004-10-29 PE PE2004001047A patent/PE20050996A1/es active IP Right Grant
- 2004-10-29 ES ES04791029T patent/ES2338563T3/es not_active Expired - Lifetime
- 2004-10-29 AU AU2004285684A patent/AU2004285684B2/en not_active Ceased
- 2004-10-29 KR KR1020067010918A patent/KR101285571B1/ko active IP Right Grant
- 2004-10-29 WO PCT/EP2004/012269 patent/WO2005042527A1/de active Application Filing
- 2004-10-29 JP JP2006537208A patent/JP4553902B2/ja not_active Expired - Lifetime
- 2004-10-29 KR KR1020127007695A patent/KR101313904B1/ko active IP Right Grant
- 2004-10-29 RS RS20060291A patent/RS51599B/en unknown
- 2004-10-29 EP EP04791029A patent/EP1682542B1/de not_active Expired - Lifetime
- 2004-10-29 SI SI200431356T patent/SI1682542T1/sl unknown
- 2004-10-29 CA CA2544352A patent/CA2544352C/en not_active Expired - Fee Related
- 2004-10-29 CN CNB200480032521XA patent/CN100509809C/zh not_active Expired - Lifetime
- 2004-10-29 BR BRPI0415636-6A patent/BRPI0415636A/pt not_active IP Right Cessation
- 2004-10-29 NZ NZ547581A patent/NZ547581A/en not_active IP Right Cessation
- 2004-10-29 AT AT04791029T patent/ATE453641T1/de active
- 2004-10-29 ME MEP-2008-517A patent/ME00349B/me unknown
- 2004-11-01 MY MYPI20044518A patent/MY146628A/en unknown
- 2004-11-02 TW TW093133282A patent/TWI336330B/zh not_active IP Right Cessation
- 2004-11-03 UY UY28596A patent/UY28596A1/es not_active Application Discontinuation
- 2004-11-03 AR ARP040104040A patent/AR046319A1/es unknown
-
2006
- 2006-03-22 ZA ZA200602344A patent/ZA200602344B/en unknown
- 2006-04-24 IL IL175126A patent/IL175126A/en active IP Right Grant
- 2006-05-02 CO CO06041173A patent/CO5690641A2/es not_active Application Discontinuation
- 2006-05-03 MX MXPA06004940 patent/MX272045B/es active IP Right Grant
- 2006-05-03 EC EC2006006543A patent/ECSP066543A/es unknown
- 2006-06-02 NO NO20062569A patent/NO20062569L/no not_active Application Discontinuation
-
2007
- 2007-05-29 HK HK07105629.1A patent/HK1099752A1/xx not_active IP Right Cessation
-
2010
- 2010-01-15 HR HR20100029T patent/HRP20100029T1/hr unknown
- 2010-02-09 CY CY20101100120T patent/CY1110339T1/el unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 12A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2386 DE 27-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |