RS52663B2 - Nova kristalna forma tiotropijum bromida i proces njene pripreme - Google Patents

Nova kristalna forma tiotropijum bromida i proces njene pripreme

Info

Publication number
RS52663B2
RS52663B2 RS20120583A RSP20120583A RS52663B2 RS 52663 B2 RS52663 B2 RS 52663B2 RS 20120583 A RS20120583 A RS 20120583A RS P20120583 A RSP20120583 A RS P20120583A RS 52663 B2 RS52663 B2 RS 52663B2
Authority
RS
Serbia
Prior art keywords
tiotropium bromide
crystalline
contain
preparation
crystalline form
Prior art date
Application number
RS20120583A
Other languages
English (en)
Serbian (sr)
Inventor
Nicola Diulgheroff
Francesca Scarpitta
Alessandro Pontiroli
Adrienne Kovacsne-Mezei
Judith Aronhime
Alexandr Jegorov
Original Assignee
Sicor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38115166&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS52663(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sicor Inc filed Critical Sicor Inc
Publication of RS52663B publication Critical patent/RS52663B/en
Publication of RS52663B2 publication Critical patent/RS52663B2/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RS20120583A 2005-12-19 2006-12-19 Nova kristalna forma tiotropijum bromida i proces njene pripreme RS52663B2 (sr)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US75267205P 2005-12-19 2005-12-19
US75453005P 2005-12-27 2005-12-27
US76143706P 2006-01-23 2006-01-23
US77405106P 2006-02-15 2006-02-15
US78031006P 2006-03-07 2006-03-07
US83218906P 2006-07-20 2006-07-20
US85122306P 2006-10-12 2006-10-12
US85274006P 2006-10-18 2006-10-18
EP06847887.4A EP1869035B2 (en) 2005-12-19 2006-12-19 Novel crystalline form of tiotropium bromide and process for preparation thereof
PCT/US2006/048734 WO2007075858A2 (en) 2005-12-19 2006-12-19 Novel forms of tiotropium bromide and processes for preparation thereof

Publications (2)

Publication Number Publication Date
RS52663B RS52663B (en) 2013-06-28
RS52663B2 true RS52663B2 (sr) 2018-05-31

Family

ID=38115166

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20120583A RS52663B2 (sr) 2005-12-19 2006-12-19 Nova kristalna forma tiotropijum bromida i proces njene pripreme

Country Status (17)

Country Link
US (4) US8163913B2 (enExample)
EP (2) EP2123650B1 (enExample)
JP (3) JP5086267B2 (enExample)
KR (1) KR101395881B1 (enExample)
CN (1) CN102731494A (enExample)
AT (1) ATE552256T1 (enExample)
BR (1) BRPI0608427A2 (enExample)
CA (1) CA2627729A1 (enExample)
DK (1) DK1869035T4 (enExample)
ES (2) ES2384486T3 (enExample)
IL (1) IL187947A0 (enExample)
MX (1) MX2007009988A (enExample)
PL (2) PL2123650T3 (enExample)
PT (1) PT1869035E (enExample)
RS (1) RS52663B2 (enExample)
TW (1) TW200732340A (enExample)
WO (1) WO2007075858A2 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9108962B2 (en) * 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
TW200732340A (en) * 2005-12-19 2007-09-01 Sicor Inc Novel forms of tiotropium bromide and processes for preparation thereof
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
PL2240477T3 (pl) * 2008-01-10 2015-03-31 Generics Uk Ltd Nowy sposób wytwarzania estrów skopiny
EP2172190A1 (en) * 2008-10-02 2010-04-07 Laboratorios Liconsa, S.A. Inhalable particles comprising tiotropium
NZ592549A (en) * 2008-11-04 2012-09-28 Cipla Ltd A compex of tiotropium bromide and polyvinylpyrrolidone having a low degree of crystallinity
NZ592861A (en) * 2008-11-04 2013-01-25 Cipla Ltd Pharmaceutical aerosol composition
NZ624602A (en) 2009-08-07 2015-11-27 Generics Uk Ltd Anhydrate of tiotropium bromide
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
TR201111589A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (pt) 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
EP2897955B1 (en) * 2012-09-11 2019-11-06 Bilgic, Mahmut New tiotropium bromide crystalline form
EA025960B1 (ru) 2012-11-05 2017-02-28 Зентива, К.С. Стабилизация сольватов тиотропия
WO2014165303A1 (en) 2013-04-01 2014-10-09 Pulmatrix, Inc. Tiotropium dry powders
EP2789611A1 (en) * 2013-04-08 2014-10-15 Cerbios-Pharma S.A. A crystalline form of tiotropium bromide
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
RU2567539C1 (ru) * 2015-02-04 2015-11-10 Индивидуальный предприниматель Михайлов Олег Ростиславович КРИСТАЛЛИЧЕСКАЯ γ-МОДИФИКАЦИЯ (1α,2β,4β,5α,7β-7)-[(ГИДРОКСИДИ-2-ТИЕНИЛАЦЕТИЛ)ОКСИ]-9,9-ДИМЕТИЛ-3-ОКСА-9-АЗОНИАТРИЦИКЛО[3.3.1.02,4]НОНАН БРОМИДА МОНОГИДРАТА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЁ ОСНОВЕ
WO2017138896A1 (en) 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate
US11365170B2 (en) 2018-07-13 2022-06-21 Kyowa Hakko Bio Co., Ltd. Non-solvate crystal of eucomic acid and method for producing same
PT115583B (pt) 2019-06-17 2022-05-02 Hovione Farm S A Processo contínuo para a preparação de medicamentos anticolinérgicos
EP4108230A1 (en) 2021-06-24 2022-12-28 Laboratoires SMB New dry powder composition of tiotropium for inhalation

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US5610163A (en) 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
US6736830B2 (en) 2000-08-22 2004-05-18 Deborah M. Roust Baby pacifier
CA2425539C (en) 2000-10-12 2007-04-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline monohydrate, processes for the preparation thereof and the use thereof for preparing a pharmaceutical composition
SK285389B6 (sk) * 2000-10-12 2006-12-07 Boehringer Ingelheim Pharma Kg Inhalačný prášok s obsahom tiotrópia, kapsula s jeho obsahom a ich použitie
US6908928B2 (en) 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
ES2271280T3 (es) * 2001-06-22 2007-04-16 BOEHRINGER INGELHEIM PHARMA GMBH &amp; CO.KG Anticolinergico cristalino, procedimiento para su preparacion y su uso para la produccion de un medicamento.
US6608055B2 (en) * 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
US6890291B2 (en) 2001-06-25 2005-05-10 Mission Medical, Inc. Integrated automatic blood collection and processing unit
US6627646B2 (en) * 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
RU2005122444A (ru) * 2002-12-16 2007-01-27 Берингер Ингельхайм Фарма Гмбх Унд Ко.Кг (De) Композиции в виде содержащих тиотропий растворов с гидрофторуглеродом
UA83813C2 (ru) * 2002-12-20 2008-08-26 Бёрингер Ингельхайм Фарма Гмбх & Ко. Кг Порошковое лекарственное средство, которое содержит соль тиотропия и ксинафоат салметерола
DE10351196B4 (de) 2003-10-28 2016-08-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verwendung einer anodisch mit Silizium bondbaren Glas-Keramik (LTCC)
PL2083007T3 (pl) * 2003-11-03 2013-09-30 Boehringer Ingelheim Int Sole tiotropium, sposoby ich wytwarzania oraz zawierające je kompozycje farmaceutyczne
US7968717B2 (en) * 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
PE20050996A1 (es) 2003-11-03 2005-12-20 Boehringer Ingelheim Int Nuevo anhidrato cristalino con accion anticolinergica
RS20060292A (sr) * 2003-11-03 2008-08-07 Boehringer Ingelheim International Gmbh., Postupak za dobijanje novih soli tiotropijuma, nove soli tiotropijuma kao takve, kao i farmaceutske formulacije koje ih sadrže
CN1271073C (zh) 2004-10-26 2006-08-23 江苏正大天晴药业股份有限公司 结晶性抗胆碱能药噻托溴铵晶体
CA2606549A1 (en) * 2005-05-02 2006-11-09 Boehringer Ingelheim International Gmbh Crystalline forms of tiotropium bromide
CA2606552A1 (en) * 2005-05-02 2006-11-09 Boehringer Ingelheim International Gmbh Crystalline forms of tiotropium bromide
SI1869035T2 (sl) * 2005-12-19 2015-12-31 Sicor, Inc. Nove kristalne oblike tiotropij bromida in postopek njihove priprave
TW200732340A (en) * 2005-12-19 2007-09-01 Sicor Inc Novel forms of tiotropium bromide and processes for preparation thereof
EP1923393A1 (en) 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Crystalline form of tiotropium bromide and urea
EP2020403A1 (en) * 2007-08-02 2009-02-04 Esteve Quimica, S.A. Process for the resolution of zopiclone and intermediate compounds
NZ624602A (en) * 2009-08-07 2015-11-27 Generics Uk Ltd Anhydrate of tiotropium bromide
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use

Also Published As

Publication number Publication date
EP2123650B1 (en) 2012-04-04
ES2384486T3 (es) 2012-07-05
CA2627729A1 (en) 2007-07-05
KR101395881B1 (ko) 2014-05-21
PL1869035T3 (pl) 2013-04-30
ES2396978T3 (es) 2013-03-01
US20120165364A1 (en) 2012-06-28
PL2123650T3 (pl) 2012-09-28
PT1869035E (pt) 2013-01-10
WO2007075858A2 (en) 2007-07-05
ES2396978T5 (es) 2015-12-04
EP2123650A1 (en) 2009-11-25
BRPI0608427A2 (pt) 2009-12-29
DK1869035T3 (da) 2013-01-14
US20120108625A1 (en) 2012-05-03
CN102731494A (zh) 2012-10-17
ATE552256T1 (de) 2012-04-15
RS52663B (en) 2013-06-28
US8846926B2 (en) 2014-09-30
KR20080078779A (ko) 2008-08-28
PL1869035T5 (pl) 2016-01-29
JP2009513675A (ja) 2009-04-02
JP2012176975A (ja) 2012-09-13
MX2007009988A (es) 2008-02-22
IL187947A0 (en) 2008-03-20
JP2012136538A (ja) 2012-07-19
US8163913B2 (en) 2012-04-24
EP1869035A2 (en) 2007-12-26
JP5567610B2 (ja) 2014-08-06
JP5086267B2 (ja) 2012-11-28
DK1869035T4 (en) 2015-11-16
TW200732340A (en) 2007-09-01
US20140057935A1 (en) 2014-02-27
WO2007075858A3 (en) 2007-11-01
EP1869035B1 (en) 2012-10-03
US20070225314A1 (en) 2007-09-27
EP1869035B2 (en) 2015-08-12

Similar Documents

Publication Publication Date Title
RS52663B2 (sr) Nova kristalna forma tiotropijum bromida i proces njene pripreme
JP2006526031A5 (enExample)
WO2011048604A3 (en) Processes for the preparation of darunavir and the amorphous form thereof
EP1802588A1 (en) Substituted amino-pyrimidones and uses thereof
HRP20250159T1 (hr) Kruti oblici tafamidisa i njegovih soli
HRP20120573T1 (hr) Kristalni oblici 4-metil-n-[3-(4-metil-imidazol-1-il)-5-trifluorometil-fenil]-3-(4-piridin-3-il-pirimidin-2-ilamino) benzamida
MX2008013782A (es) Nueva forma cristalina vi de la agomelatina, su procedimiento de preparacion y las composiciones farmaceuticas que la contienen.
RU2007110026A (ru) ПОЛИМОРФНЫЕ И АМОРФНАЯ ФОРМЫ ФОСФАТНОЙ СОЛИ 8-ФТОР-2-{4-[(МЕТИЛАМИНО)МЕТИЛ]ФЕНИЛ}-1,3,4,5-ТЕТРАГИДРО-6Н-АЗЕПИНО[5.4.3-cd]ИНДОЛ-6-ОНА
JO2793B1 (en) The new crystalline form 5 of agomelatine, its preparation process and the pharmaceutical ingredients it contains
JP2005526011A5 (enExample)
IL217446A (en) Pharmaceutical preparation containing a highly purified active ingredient of 7 - chloro - 5 - hydroxy - 1 - [2 - methyl - 4 - (2 - methylbenzoyl - amino) benzoyl] - 2, 3, 4, 5 - tetrahydro - h - 1 - Benzazepine has a purity of more than 99.5% or its salt, or a drug of its salt
WO2005082892A3 (en) Triazole compounds as antibacterial agents and pharmaceutical compositions containing them
JP2014500861A5 (enExample)
PL2018379T3 (pl) Sole skopiny oraz ich zastosowanie w sposobach wytwarzania N-demetylo-tiotropium i bromku tiotropium
IL181298A0 (en) Solid and crystalline ibandronate sodium and processes for preparation thereof
JP2010132668A5 (enExample)
JP2011527333A5 (enExample)
RU2009133262A (ru) Нападизилатная соль антагониста мускаринового мз-рецептора
MX2013009709A (es) Derivados de heteroarilo como moduladores de nachr alfa 7.
HRP20241789T1 (hr) Čvrsti oblici belumosudila i soli belumosudila
JP2013514980A5 (enExample)
UA83719C2 (ru) Кристаллическая форма iii агомелатина, способ ее получения и фармацевтическая композиция, которая ее содержит
JP2015522037A5 (enExample)
JP2020502224A5 (enExample)
JP2008513510A5 (enExample)