JP2014513712A5 - - Google Patents
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- Publication number
- JP2014513712A5 JP2014513712A5 JP2014510872A JP2014510872A JP2014513712A5 JP 2014513712 A5 JP2014513712 A5 JP 2014513712A5 JP 2014510872 A JP2014510872 A JP 2014510872A JP 2014510872 A JP2014510872 A JP 2014510872A JP 2014513712 A5 JP2014513712 A5 JP 2014513712A5
- Authority
- JP
- Japan
- Prior art keywords
- asenapine maleate
- monoclinic
- stable
- less
- finely divided
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- GMDCDXMAFMEDAG-CHHFXETESA-N (S,S)-asenapine maleate Chemical compound OC(=O)\C=C/C(O)=O.O1C2=CC=CC=C2[C@H]2CN(C)C[C@@H]2C2=CC(Cl)=CC=C21 GMDCDXMAFMEDAG-CHHFXETESA-N 0.000 claims 24
- 229960001615 asenapine maleate Drugs 0.000 claims 24
- 238000000034 method Methods 0.000 claims 9
- 238000010298 pulverizing process Methods 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000013078 crystal Substances 0.000 claims 4
- 208000020016 psychiatric disease Diseases 0.000 claims 4
- 238000001816 cooling Methods 0.000 claims 3
- 238000009826 distribution Methods 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 208000020925 Bipolar disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 238000010992 reflux Methods 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 238000003860 storage Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 1
- 238000010899 nucleation Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161487495P | 2011-05-18 | 2011-05-18 | |
| US61/487,495 | 2011-05-18 | ||
| PCT/GB2012/000450 WO2012156677A1 (en) | 2011-05-18 | 2012-05-18 | A stable micronised monoclinic form of asenapine maleate and its synthesis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014513712A JP2014513712A (ja) | 2014-06-05 |
| JP2014513712A5 true JP2014513712A5 (enExample) | 2015-07-02 |
| JP6014656B2 JP6014656B2 (ja) | 2016-10-25 |
Family
ID=46168537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510872A Active JP6014656B2 (ja) | 2011-05-18 | 2012-05-18 | 化合物の多形体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9505771B2 (enExample) |
| EP (1) | EP2709616B1 (enExample) |
| JP (1) | JP6014656B2 (enExample) |
| ES (1) | ES2665843T3 (enExample) |
| WO (1) | WO2012156677A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2582704A4 (en) * | 2010-06-18 | 2014-04-02 | Reddys Lab Ltd Dr | Asenapine MALEATE |
| US10085971B2 (en) * | 2016-08-22 | 2018-10-02 | Navinta Iii Inc | Pharmaceutical solution of asenapine for sublingual or buccal use |
| CN110087641B (zh) | 2016-12-20 | 2024-03-12 | 罗曼治疗系统股份公司 | 含有阿塞那平和聚硅氧烷或聚异丁烯的透皮治疗系统 |
| PL3338768T3 (pl) | 2016-12-20 | 2020-05-18 | Lts Lohmann Therapie-Systeme Ag | Transdermalny system terapeutyczny zawierający asenapinę |
| JP2020525545A (ja) | 2017-06-26 | 2020-08-27 | エルテーエス ローマン テラピー−ジステーメ アーゲー | アセナピンおよびシリコーンアクリルハイブリッドポリマーを含有する経皮治療システム |
| BR112020026099A2 (pt) | 2018-06-20 | 2021-03-23 | Lts Lohmann Therapie-Systeme Ag | sistema terapêutico transdérmico que contém asenapina |
| CN118806732A (zh) | 2018-06-20 | 2024-10-22 | 罗曼治疗系统股份公司 | 含有阿塞那平的透皮治疗系统 |
| US20250032451A1 (en) * | 2021-11-24 | 2025-01-30 | Oakwood Laboratories, Llc | Microsphere formulations comprising asenapine and methods for making and using the same |
| WO2026095022A1 (ja) * | 2024-11-01 | 2026-05-07 | 大鵬薬品工業株式会社 | キノリン置換化合物の結晶 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7605526A (nl) | 1976-05-24 | 1977-11-28 | Akzo Nv | Nieuwe tetracyclische derivaten. |
| ATE167057T1 (de) | 1994-03-02 | 1998-06-15 | Akzo Nobel Nv | Sublinguales oder bukkales arzneimittel |
| ES2290095T3 (es) * | 2000-12-27 | 2008-02-16 | Ares Trading S.A. | Microparticulas lipidicas por micronizacion criogenica. |
| US7872147B2 (en) | 2005-04-07 | 2011-01-18 | N. V. Organon | Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole |
| KR101422843B1 (ko) | 2005-04-07 | 2014-07-24 | 머크 샤프 앤 도메 비.브이. | 아세나핀 말레에이트의 결정형 |
| US7741358B2 (en) * | 2005-04-14 | 2010-06-22 | N.V. Organon | Crystal form of asenapine maleate |
| US7750167B2 (en) | 2006-07-05 | 2010-07-06 | N.V. Organon | Process for the preparation of asenapine and intermediate products used in said process |
| WO2008148515A1 (en) * | 2007-06-05 | 2008-12-11 | Synthon B.V. | Intranasal administration of asenapine and pharmaceutical compositions therefor |
| EP2582704A4 (en) * | 2010-06-18 | 2014-04-02 | Reddys Lab Ltd Dr | Asenapine MALEATE |
| EP2598496B1 (en) * | 2010-07-29 | 2014-03-19 | Laboratorios Lesvi, S.L. | Novel process for the preparation of asenapine |
| WO2012038975A2 (en) | 2010-09-22 | 2012-03-29 | Msn Laboratories Limited | Process for the preparation of (3ars,12brs)-5-chloro-2-methyl-2,3,3a12b-tetrahydro-1hdibenzo[2,3:6,7] oxepino [4,5-c]pyrrole maleate and it's pharmaceutical composition thereof |
| WO2012066565A2 (en) * | 2010-11-16 | 2012-05-24 | Cadila Healthcare Limited | Asenapine maleate amorphous and crystalline form and process for preparation thereof |
| EP2468750A1 (en) * | 2010-12-13 | 2012-06-27 | Chemo Ibérica, S.A. | Polymorphic forms of asenapine maleate and processes for their preparation |
| ITMI20110734A1 (it) * | 2011-05-02 | 2012-11-03 | Olon Spa | Sali cristallini di asenapina |
| WO2012156676A1 (en) * | 2011-05-18 | 2012-11-22 | Laboratorios Lesvi S.L. | Monoclinic crystalline form of asenapine maleate with a specific particle size distribution |
-
2012
- 2012-05-18 US US14/118,476 patent/US9505771B2/en active Active
- 2012-05-18 ES ES12723725.3T patent/ES2665843T3/es active Active
- 2012-05-18 WO PCT/GB2012/000450 patent/WO2012156677A1/en not_active Ceased
- 2012-05-18 EP EP12723725.3A patent/EP2709616B1/en active Active
- 2012-05-18 JP JP2014510872A patent/JP6014656B2/ja active Active
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