IL226474A - Crystalline forms of 5-chloro-n2- (2-isopropoxy-5-methyl-4-piperidene-4-aryl-phenyl) - n4 [2- (propane-2-sulfonyl) -phenyl] pyrimidine-4,2-diamine - Google Patents

Crystalline forms of 5-chloro-n2- (2-isopropoxy-5-methyl-4-piperidene-4-aryl-phenyl) - n4 [2- (propane-2-sulfonyl) -phenyl] pyrimidine-4,2-diamine

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Publication number
IL226474A
IL226474A IL226474A IL22647413A IL226474A IL 226474 A IL226474 A IL 226474A IL 226474 A IL226474 A IL 226474A IL 22647413 A IL22647413 A IL 22647413A IL 226474 A IL226474 A IL 226474A
Authority
IL
Israel
Prior art keywords
phenyl
piperidin
isopropoxy
pyrimidine
sulfonyl
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IL226474A
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English (en)
Hebrew (he)
Other versions
IL226474A0 (en
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Novartis Ag
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45464892&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL226474(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL226474A0 publication Critical patent/IL226474A0/en
Publication of IL226474A publication Critical patent/IL226474A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL226474A 2010-12-17 2013-05-20 Crystalline forms of 5-chloro-n2- (2-isopropoxy-5-methyl-4-piperidene-4-aryl-phenyl) - n4 [2- (propane-2-sulfonyl) -phenyl] pyrimidine-4,2-diamine IL226474A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201061424194P 2010-12-17 2010-12-17
PCT/US2011/065030 WO2012082972A1 (en) 2010-12-17 2011-12-15 Crystalline forms of 5-chloro-n2-(2-isopropoxy-5-methyl-4-piperidin-4-yl-phenyl)-n4[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine

Publications (2)

Publication Number Publication Date
IL226474A0 IL226474A0 (en) 2013-07-31
IL226474A true IL226474A (en) 2016-03-31

Family

ID=45464892

Family Applications (1)

Application Number Title Priority Date Filing Date
IL226474A IL226474A (en) 2010-12-17 2013-05-20 Crystalline forms of 5-chloro-n2- (2-isopropoxy-5-methyl-4-piperidene-4-aryl-phenyl) - n4 [2- (propane-2-sulfonyl) -phenyl] pyrimidine-4,2-diamine

Country Status (36)

Country Link
US (2) US9309229B2 (enExample)
EP (3) EP2651918B1 (enExample)
JP (1) JP5916752B2 (enExample)
KR (4) KR20180032680A (enExample)
CN (7) CN106831716A (enExample)
AR (2) AR084309A1 (enExample)
AU (1) AU2011343775B2 (enExample)
BR (1) BR112013015000A2 (enExample)
CA (1) CA2821102C (enExample)
CL (1) CL2013001723A1 (enExample)
CO (1) CO6801792A2 (enExample)
CY (2) CY1119474T1 (enExample)
DK (2) DK3121171T3 (enExample)
EC (1) ECSP13012770A (enExample)
ES (3) ES2696526T3 (enExample)
GT (1) GT201300153A (enExample)
HR (2) HRP20171477T1 (enExample)
HU (1) HUE041845T2 (enExample)
IL (1) IL226474A (enExample)
LT (2) LT3121171T (enExample)
MA (1) MA34771B1 (enExample)
MX (1) MX338210B (enExample)
MY (2) MY177742A (enExample)
NZ (1) NZ610713A (enExample)
PE (1) PE20140698A1 (enExample)
PH (1) PH12013501254A1 (enExample)
PL (2) PL3121171T3 (enExample)
PT (2) PT2651918T (enExample)
RS (1) RS57771B1 (enExample)
RU (2) RU2599785C3 (enExample)
SG (2) SG190856A1 (enExample)
SI (2) SI2651918T1 (enExample)
TN (1) TN2013000216A1 (enExample)
TW (2) TWI576344B (enExample)
WO (1) WO2012082972A1 (enExample)
ZA (1) ZA201303599B (enExample)

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CN105272921A (zh) * 2014-06-09 2016-01-27 江苏奥赛康药业股份有限公司 一种制备Ceritinib的方法及其中间体化合物
CN105294649B (zh) * 2014-07-30 2019-05-14 江苏奥赛康药业股份有限公司 一种Ceritinib化合物及其药物组合物
CN105294650A (zh) * 2014-08-01 2016-02-03 江苏奥赛康药业股份有限公司 一种Ceritinib化合物及其药物组合物
HRP20201343T1 (hr) 2014-10-21 2020-11-27 Ariad Pharmaceuticals, Inc. Kristalni oblici 5-kloro-n4-[-2-(dimetilfosforil)fenil]-n2-{2-metoksi-4-[4-(4-metilpiperazin-1-il)piperidin-1-il]pirimidin-2,4-diamina
WO2016081538A1 (en) 2014-11-18 2016-05-26 Teva Pharmaceuticals International Gmbh Solid state forms of ceritinib and salts thereof
CN105601614A (zh) * 2014-11-21 2016-05-25 奥浦顿（上海）医药科技有限公司 一种色瑞替尼晶型及其制备方法
WO2016082795A1 (zh) * 2014-11-28 2016-06-02 苏州晶云药物科技有限公司 色瑞替尼的晶型i及其制备方法
CN105622577A (zh) * 2014-11-29 2016-06-01 江苏先声药业有限公司 一种色瑞替尼的新晶型及其制备方法
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CN105061397B (zh) * 2015-08-07 2018-01-02 武汉英普瑞医药科技有限公司 一种色瑞替尼的c型晶型及其制备方法与应用
CN106699743B (zh) 2015-11-05 2020-06-12 湖北生物医药产业技术研究院有限公司 嘧啶类衍生物及其用途
WO2017152858A1 (zh) * 2016-03-11 2017-09-14 苏州晶云药物科技有限公司 色瑞替尼的晶型及其制备方法
WO2017158619A1 (en) 2016-03-15 2017-09-21 Natco Pharma Limited A modified process for the preparation of ceritinib and amorphous form of ceritinib
JP2019196359A (ja) * 2019-06-17 2019-11-14 ノバルティス アーゲー ピリミジン誘導体およびそれらの中間体を調製する化学的方法
GB201915618D0 (en) 2019-10-28 2019-12-11 Univ Oslo ALK inhibitors for treatment of ALK-negative cancer and antibody-mediated diseases
JP7494435B2 (ja) * 2020-01-17 2024-06-04 シュエンジュウ バイオファーマシューティカル カンパニー リミテッド 未分化リンパ腫キナーゼの多環状阻害剤の結晶形態
TW202144329A (zh) * 2020-03-30 2021-12-01 大陸商江蘇亞虹醫藥科技股份有限公司 硝羥喹啉前藥的晶型、含其的醫藥組成物及其製備方法和應用
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US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
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WO2016098070A1 (en) 2014-12-19 2016-06-23 Novartis Ag Crystalline form of 5-chloro-n2-(2-isopropoxy-5-methyl-4-piperidin-4-yl-phenyl)-n4-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2, 4-diamine
WO2017016529A1 (en) 2015-07-28 2017-02-02 Zentiva, K.S. Solid forms of ceritinib free base
CN105061397B (zh) 2015-08-07 2018-01-02 武汉英普瑞医药科技有限公司 一种色瑞替尼的c型晶型及其制备方法与应用

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ES2643016T3 (es) 2017-11-21
EP3453708B1 (en) 2021-10-27
CO6801792A2 (es) 2013-11-29
TW201629021A (zh) 2016-08-16
LT2651918T (lt) 2017-10-10
TN2013000216A1 (en) 2014-11-10
ES2696526T3 (es) 2019-01-16
US9309229B2 (en) 2016-04-12
BR112013015000A2 (pt) 2016-08-09
EP3121171A1 (en) 2017-01-25
TWI576343B (zh) 2017-04-01
JP5916752B2 (ja) 2016-05-11
ZA201303599B (en) 2014-02-26
DK3121171T3 (en) 2018-12-10
EP2651918A1 (en) 2013-10-23
CA2821102A1 (en) 2012-06-21
CN104262324A (zh) 2015-01-07
PE20140698A1 (es) 2014-06-11
CY1119474T1 (el) 2018-04-04
KR102325775B1 (ko) 2021-11-12
PL2651918T3 (pl) 2017-12-29
CL2013001723A1 (es) 2013-12-27
PL3121171T3 (pl) 2019-01-31
RU2746159C2 (ru) 2021-04-08
US20160175305A1 (en) 2016-06-23
TWI576344B (zh) 2017-04-01
PT3121171T (pt) 2018-11-27
EP3453708B8 (en) 2022-03-16
MX2013006952A (es) 2013-07-15
SG10201510082XA (en) 2016-01-28
AR084309A1 (es) 2013-05-08
WO2012082972A1 (en) 2012-06-21
MA34771B1 (fr) 2013-12-03
GT201300153A (es) 2014-06-09
KR20130130022A (ko) 2013-11-29
CN114989139A (zh) 2022-09-02
MY177742A (en) 2020-09-23
CN106831716A (zh) 2017-06-13
HRP20181737T1 (hr) 2018-12-28
DK2651918T3 (en) 2017-10-23
TW201307299A (zh) 2013-02-16
RU2016136823A (ru) 2018-12-11
SI3121171T1 (sl) 2018-11-30
AU2011343775B2 (en) 2015-12-03
CY1121017T1 (el) 2019-12-11
SG190856A1 (en) 2013-07-31
KR20190022903A (ko) 2019-03-06
SI2651918T1 (sl) 2017-10-30
JP2013545812A (ja) 2013-12-26
ES2905973T3 (es) 2022-04-12
NZ610713A (en) 2014-10-31
PT2651918T (pt) 2017-10-17
EP3121171B1 (en) 2018-08-15
CA2821102C (en) 2019-06-11
CN112125884A (zh) 2020-12-25
KR20200039021A (ko) 2020-04-14
RU2016136823A3 (enExample) 2020-02-06
HRP20171477T1 (hr) 2017-11-17
RS57771B1 (sr) 2018-12-31
CN103282359A (zh) 2013-09-04
IL226474A0 (en) 2013-07-31
AR122395A2 (es) 2022-09-07
EP2651918B1 (en) 2017-07-12
ECSP13012770A (es) 2013-10-31
LT3121171T (lt) 2018-11-12
KR20180032680A (ko) 2018-03-30
US20130274279A1 (en) 2013-10-17
MX338210B (es) 2016-04-07
AU2011343775A1 (en) 2013-07-18
MY164810A (en) 2018-01-30
CN106008462A (zh) 2016-10-12
RU2599785C2 (ru) 2016-10-20
PH12013501254A1 (en) 2016-07-29
CN107056751A (zh) 2017-08-18
EP3453708A1 (en) 2019-03-13
RU2599785C3 (ru) 2019-04-24
HUE041845T2 (hu) 2019-05-28
RU2013132947A (ru) 2015-01-27

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