RU2502799C2 - Способ перепрограммирования соматических клеток - Google Patents
Способ перепрограммирования соматических клеток Download PDFInfo
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- RU2502799C2 RU2502799C2 RU2009140903/10A RU2009140903A RU2502799C2 RU 2502799 C2 RU2502799 C2 RU 2502799C2 RU 2009140903/10 A RU2009140903/10 A RU 2009140903/10A RU 2009140903 A RU2009140903 A RU 2009140903A RU 2502799 C2 RU2502799 C2 RU 2502799C2
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- 238000000034 method Methods 0.000 title claims abstract 19
- 210000001082 somatic cell Anatomy 0.000 title claims abstract 11
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- 108090000623 proteins and genes Proteins 0.000 claims 18
- 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 claims 9
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- RTKIYFITIVXBLE-QEQCGCAPSA-N trichostatin A Chemical compound ONC(=O)/C=C/C(/C)=C/[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 claims 1
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Families Citing this family (158)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20030376A1 (it) | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| US8137907B2 (en) | 2005-01-03 | 2012-03-20 | Cold Spring Harbor Laboratory | Orthotopic and genetically tractable non-human animal model for liver cancer and the uses thereof |
| EP1896587A2 (en) | 2005-05-31 | 2008-03-12 | Cold Spring Harbor Laboratory | METHODS FOR PRODUCING MICRORNAs |
| KR101004634B1 (ko) | 2005-08-01 | 2011-01-04 | 뉴포텐셜, 인크. | 잠재력이 복원된 리프로그래밍된 세포의 제조 |
| WO2007069666A1 (ja) | 2005-12-13 | 2007-06-21 | Kyoto University | 核初期化因子 |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| EP3878949B1 (en) | 2007-04-07 | 2025-06-04 | Whitehead Institute for Biomedical Research | Reprogramming of somatic cells |
| US9213999B2 (en) | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| EP3078738B1 (en) * | 2007-08-31 | 2020-05-20 | Whitehead Institute for Biomedical Research | Wnt pathway stimulation in reprogramming somatic cells |
| AU2008329563A1 (en) * | 2007-11-30 | 2009-06-04 | Cytomatrix Pty Ltd | Methods of inducing pluripotency involving Oct4 protein |
| US20110190729A1 (en) * | 2007-11-30 | 2011-08-04 | Cytomatrix Pty Ltd | Methods of inducing pluripotency involving sox2 protein |
| US9683232B2 (en) | 2007-12-10 | 2017-06-20 | Kyoto University | Efficient method for nuclear reprogramming |
| JP5558097B2 (ja) * | 2007-12-10 | 2014-07-23 | 国立大学法人京都大学 | 効率的な核初期化方法 |
| JP5626619B2 (ja) * | 2008-12-08 | 2014-11-19 | 国立大学法人京都大学 | 効率的な核初期化方法 |
| KR20110006672A (ko) * | 2008-04-07 | 2011-01-20 | 뉴포텐셜, 인크. | Hdac 조절제의 사용을 통한 다능 유전자의 유도에 의한 세포 재프로그래밍 |
| CA2695522C (en) | 2008-05-02 | 2019-01-15 | Kyoto University | Method of nuclear reprogramming |
| BRPI0915146A2 (pt) | 2008-06-13 | 2017-12-05 | Whitehead Inst Biomedical Res | programação e reprodução de células |
| DK2295538T3 (en) * | 2008-07-07 | 2015-12-21 | Takara Bio Inc | Process for producing a pluripotent stem cell |
| JPWO2010027062A1 (ja) * | 2008-09-04 | 2012-02-02 | 独立行政法人理化学研究所 | B細胞由来iPS細胞およびその用途 |
| US20100062534A1 (en) * | 2008-09-09 | 2010-03-11 | The General Hospital Corporation | Inducible lentiviral vectors for reprogramming somatic cells |
| US20110318830A1 (en) * | 2008-11-12 | 2011-12-29 | The Regents Of The University Of California | Compositions and methods for re-programming and re-differentiating cells |
| BRPI0922127A2 (pt) | 2008-12-23 | 2016-09-06 | Segetis Inc | composto, formulação, artigo, polímero e método para fabricar poliamida. |
| JP5553289B2 (ja) * | 2009-02-27 | 2014-07-16 | 国立大学法人京都大学 | 新規核初期化物質 |
| CN102405280B (zh) * | 2009-03-20 | 2015-03-04 | 中胚层公司 | 重新设定的多能干细胞的制备 |
| CN101580816B (zh) * | 2009-04-23 | 2012-02-29 | 中国科学院广州生物医药与健康研究院 | 诱导多能性干细胞快速高效产生的新型无血清培养基以及使用其的方法 |
| EP2421956A4 (en) * | 2009-04-24 | 2013-10-02 | Whitehead Biomedical Inst | COMPOSITIONS AND METHODS FOR OBTAINING OR CULTURING PLURIPOTENTER CELLS |
| AU2010271249B2 (en) | 2009-07-09 | 2016-01-28 | Whitehead Institute For Biomedical Research | Compositions and methods for mammalian genetics and uses thereof |
| EP2468312A4 (en) | 2009-08-19 | 2014-05-14 | Univ Tohoku | FOIL FOR CORNEAL TRANSPLANTS |
| JP2013503198A (ja) | 2009-08-27 | 2013-01-31 | シナプティック リサーチ,リミテッド ライアビリティ カンパニー | 人工多能性幹(iPS)細胞または組織特異的細胞を誘導するための新規タンパク質送達系 |
| WO2011050470A1 (en) * | 2009-10-29 | 2011-05-05 | Mcmaster University | Generating induced pluripotent stem cells and progenitor cells from fibroblasts |
| WO2011079307A2 (en) * | 2009-12-23 | 2011-06-30 | The Salk Institute For Biological Studies | Methods and compositions for treating neurological disorders |
| US9845457B2 (en) | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
| US9249392B2 (en) | 2010-04-30 | 2016-02-02 | Cedars-Sinai Medical Center | Methods and compositions for maintaining genomic stability in cultured stem cells |
| US9089520B2 (en) * | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
| US8765470B2 (en) | 2010-08-04 | 2014-07-01 | Cellular Dynamics International, Inc. | Reprogramming immortalized B-cells to induced pluripotent stem cells |
| WO2012037456A1 (en) | 2010-09-17 | 2012-03-22 | President And Fellows Of Harvard College | Functional genomics assay for characterizing pluripotent stem cell utility and safety |
| US9637732B2 (en) | 2010-11-04 | 2017-05-02 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| US9506039B2 (en) | 2010-12-03 | 2016-11-29 | Kyoto University | Efficient method for establishing induced pluripotent stem cells |
| WO2012115270A1 (ja) * | 2011-02-25 | 2012-08-30 | 学校法人慶應義塾 | iPS細胞クローンの選択方法、及びその選択方法に用いる遺伝子の選択方法 |
| CN102731653B (zh) * | 2011-04-06 | 2013-12-11 | 李凌松 | 一种抗磷酸化Oct4蛋白的抗体及其应用 |
| GB2496375A (en) | 2011-10-28 | 2013-05-15 | Kymab Ltd | A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof |
| GB201122047D0 (en) | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
| KR20250035015A (ko) | 2011-12-05 | 2025-03-11 | 팩터 바이오사이언스 인크. | 세포를 형질감염시키는 방법들 및 생성물들 |
| US8497124B2 (en) | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
| CN104781396A (zh) * | 2012-01-17 | 2015-07-15 | 小利兰·斯坦福大学托管委员会 | 用于体细胞核重编程的先天免疫激活 |
| CN104718283A (zh) * | 2012-04-24 | 2015-06-17 | 布里格姆及妇女医院股份有限公司 | 从头生成多能细胞 |
| EP2861238A4 (en) | 2012-06-05 | 2016-03-16 | Capricor Inc | OPTIMIZED METHODS FOR GENERATING CARDIAC STEM CELLS FROM CARDIAC TISSUE AND THEIR USE IN CARDIAC THERAPY |
| JP6433896B2 (ja) | 2012-08-13 | 2018-12-05 | シーダーズ−サイナイ・メディカル・センターCedars−Sinai Medical Center | 組織再生のためのエキソソームおよびマイクロリボ核酸 |
| JPWO2014057997A1 (ja) | 2012-10-09 | 2016-09-05 | 仲信 林 | 初期化ペプチド及びその用途 |
| WO2014066848A1 (en) | 2012-10-25 | 2014-05-01 | Whitehead Institute For Biomedical Research | Super-enhancers and methods of use thereof |
| WO2014071219A1 (en) | 2012-11-01 | 2014-05-08 | Factor Bioscience Inc. | Methods and products for expressing proteins in cells |
| WO2014117021A2 (en) | 2013-01-25 | 2014-07-31 | Xcell Biosciences, Inc. | Methods, compositions, kits, and systems for selective enrichment of target cells |
| US9434935B2 (en) | 2013-03-10 | 2016-09-06 | Bellicum Pharmaceuticals, Inc. | Modified caspase polypeptides and uses thereof |
| KR102309653B1 (ko) * | 2013-03-11 | 2021-10-08 | 리제너론 파아마슈티컬스, 인크. | 키메라 주요 조직적합성 복합체 (mhc) 제ii부류 분자를 발현하는 유전자전이 마우스 |
| HK1220233A1 (zh) | 2013-03-15 | 2017-04-28 | 怀特黑德生物医学研究院 | 用於神经变性疾病的细胞性发现平台 |
| JP2016521971A (ja) | 2013-04-23 | 2016-07-28 | イェダ リサーチ アンド ディベロップメント カンパニー リミテッド | 単離ナイーブ型多能性幹細胞およびそれを発生させる方法関連出願本出願は、米国特許法119条第(e)項に基づき、2014年1月29日出願の米国特許仮出願第61/932,935号、2013年9月17日出願の米国特許仮出願第61/878,769号、および2013年4月23日出願の米国特許仮出願第61/814,920号の優先権を主張する。また、本出願は、同時に提出された同出願人による同時係属出願である、YaqubHANNA、NoaNOVERSHTERN、およびYoachRAISによる米国特許出願(発明の名称「単離ナイーブ型多能性幹細胞およびそれを発生させる方法(ISOLATEDNAIVEPLURIPOTENTSTEMCELLSANDMETHODSOFGENERATINGSAME)」)(代理人事件記録簿第58870号)にも関する。上記出願の内容はその全体を参考として本明細書に組み込む。 |
| WO2014197638A2 (en) | 2013-06-05 | 2014-12-11 | Bellicum Pharmaceuticals, Inc. | Methods for inducing partial apoptosis using caspase polypeptides |
| EP3008229B1 (en) | 2013-06-10 | 2020-05-27 | President and Fellows of Harvard College | Early developmental genomic assay for characterizing pluripotent stem cell utility and safety |
| WO2015037535A1 (ja) | 2013-09-12 | 2015-03-19 | 株式会社カネカ | 人工多能性幹細胞の分化誘導方法及び選別方法 |
| US11767507B2 (en) | 2013-11-08 | 2023-09-26 | The Mclean Hospital Corporation | Methods for efficient generation of GABAergic interneurons from pluripotent stem cells |
| AU2015210769B2 (en) | 2014-01-31 | 2019-02-07 | Factor Bioscience Inc. | Methods and products for nucleic acid production and delivery |
| US9738873B2 (en) * | 2014-02-10 | 2017-08-22 | The Board Of Trustees Of The Leland Stanford Junior University | Activation of innate immunity for enhanced nuclear reprogramming of somatic cells with mRNA |
| KR102327986B1 (ko) | 2014-03-19 | 2021-11-18 | 브이셀 세라퓨틱스 인코포레이티드 | 다능성 세포에 관한 방법 |
| US11920164B2 (en) | 2014-07-30 | 2024-03-05 | Yeda Research And Development Co. Ltd. | Media for culturing naive human pluripotent stem cells |
| EP3191578B1 (en) | 2014-09-12 | 2020-11-04 | Whitehead Institute for Biomedical Research | Cells expressing apolipoprotein e and uses thereof |
| CA2962444C (en) | 2014-10-03 | 2023-09-05 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| CN107429232B (zh) | 2015-01-26 | 2023-01-03 | 菲特治疗公司 | 免疫调节性提高的细胞及其使用和生产方法 |
| EP4406585A3 (en) | 2015-02-13 | 2024-10-23 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| EP3283502A4 (en) | 2015-04-07 | 2019-04-03 | The General Hospital Corporation | METHOD FOR REACTIVATING GENES ON THE INACTIVE X-CHROMOSOME |
| ES2794628T3 (es) | 2015-04-15 | 2020-11-18 | Univ Massachusetts | Composiciones y métodos para la reactivación de cromosomas XI |
| US20170044609A1 (en) * | 2015-04-24 | 2017-02-16 | California Institute Of Technology | Reactivation of x chromosome genes |
| EP3286310A4 (en) | 2015-04-24 | 2019-01-09 | California Institute of Technology | REACTIVATION OF X-CHROMOSOME GENES |
| CN108135935A (zh) | 2015-07-21 | 2018-06-08 | 儿童医疗中心有限公司 | 表达pd-l1的造血干细胞及其用途 |
| WO2017044853A1 (en) * | 2015-09-09 | 2017-03-16 | Trustees Of Tufts College | Methods of generating neural stem cells |
| US11253551B2 (en) | 2016-01-11 | 2022-02-22 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| CN105624117A (zh) * | 2016-01-18 | 2016-06-01 | 哈尔滨医科大学 | 一种低氧促进小鼠成纤维细胞重编程为心肌细胞的方法 |
| US11351200B2 (en) | 2016-06-03 | 2022-06-07 | Cedars-Sinai Medical Center | CDC-derived exosomes for treatment of ventricular tachyarrythmias |
| WO2017223199A1 (en) * | 2016-06-22 | 2017-12-28 | Xcell Biosciences, Inc. | Methods for increasing cell culture transfection efficiency and cellular reprogramming |
| WO2018035377A1 (en) | 2016-08-17 | 2018-02-22 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| US11434476B2 (en) | 2016-08-19 | 2022-09-06 | Whitehead Institute For Biomedical Research | Methods of editing DNA methylation |
| WO2018057542A1 (en) | 2016-09-20 | 2018-03-29 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
| CN106544315A (zh) * | 2016-10-12 | 2017-03-29 | 广东艾时代生物科技有限责任公司 | 一种脂肪间充质干细胞诱导成多能干细胞的方法 |
| EP3532044A4 (en) | 2016-10-27 | 2020-07-29 | California Institute of Technology | HDAC INHIBITOR COMPOSITIONS FOR CHROMOSOME X REACTIVATION |
| CN110402284B (zh) | 2016-12-16 | 2024-03-08 | 伊维瓦医疗有限公司 | 用于基底膜支架的薄膜插入 |
| DK3565891T3 (da) | 2017-01-09 | 2023-07-24 | Whitehead Inst Biomedical Res | Fremgangsmåder til ændring af genekspression ved forstyrrelse af transkriptionsfaktor-multimere, der strukturerer regulatoriske sløjfer |
| JPWO2018159805A1 (ja) | 2017-03-03 | 2020-01-09 | 国立大学法人京都大学 | 膵前駆細胞の製造方法 |
| JP7303743B2 (ja) * | 2017-04-05 | 2023-07-05 | アスガード セラピューティクス エービー | 細胞を樹状細胞または抗原提示細胞にリプログラムするための組成物、その方法および使用 |
| EP3612191A4 (en) | 2017-04-19 | 2020-12-30 | Cedars-Sinai Medical Center | METHODS AND COMPOSITIONS FOR TREATING SKELETAL MUSCLE DYSTROPHY |
| US20200208093A1 (en) | 2017-06-14 | 2020-07-02 | Takeda Pharmaceutical Company Limited | Cell-sealing device |
| US11879137B2 (en) | 2017-09-22 | 2024-01-23 | The Children's Medical Center Corporation | Treatment of type 1 diabetes and autoimmune diseases or disorders |
| PL241125B1 (pl) | 2017-11-30 | 2022-08-08 | Gdanski Univ Medyczny | Kompozycja farmaceutyczna do zastosowania jako środek do pobudzania regeneracji lub gojenia ran |
| JP7330466B2 (ja) | 2017-11-30 | 2023-08-22 | 国立大学法人京都大学 | 細胞の培養方法 |
| EP3727351A4 (en) | 2017-12-20 | 2021-10-06 | Cedars-Sinai Medical Center | MANIPULATED EXTRACELLULAR VESICLES FOR ENHANCED RELEASE INTO TISSUE |
| CN111868224A (zh) | 2017-12-22 | 2020-10-30 | 国立大学法人京都大学 | 细胞培养装置,培养液抽吸器及细胞培养方法 |
| CN108624621B (zh) * | 2018-01-17 | 2019-04-12 | 中国科学院上海生命科学研究院 | 非人灵长类的体细胞克隆动物的制备方法 |
| CN108103027B (zh) * | 2018-02-02 | 2021-12-24 | 中国医学科学院血液病医院(血液学研究所) | 高效率血细胞重编程同时实现基因编辑的方法 |
| WO2019152549A1 (en) | 2018-02-05 | 2019-08-08 | Cedars-Sinai Medical Center | Methods for therapeutic use of exosomes and y-rnas |
| EP3770253A4 (en) | 2018-03-19 | 2021-12-29 | Kyoto University | Hydrogel capsule |
| US20210054406A1 (en) | 2018-03-30 | 2021-02-25 | Kyoto University | Cell production method |
| WO2019189553A1 (ja) | 2018-03-30 | 2019-10-03 | 国立大学法人京都大学 | 複素環化合物 |
| JP7344486B2 (ja) | 2018-03-30 | 2023-09-14 | 国立大学法人京都大学 | 心筋細胞成熟促進剤 |
| KR102848466B1 (ko) | 2018-04-23 | 2025-08-20 | 오리즈루 세라퓨틱스 가부시키가이샤 | 증식 억제제 |
| CA3108679A1 (en) | 2018-08-03 | 2020-02-06 | Kyoto University | Cell production method |
| US20210301260A1 (en) | 2018-08-10 | 2021-09-30 | Kyoto University | Method for producing cd3-positive cell |
| JP7436990B2 (ja) | 2018-08-10 | 2024-02-22 | 国立大学法人京都大学 | カチオン性脂質を用いた心筋細胞へのトランスフェクション方法 |
| MX2021002018A (es) | 2018-08-22 | 2021-07-15 | Univ Kyoto | Metodo para producir precursores neurales entericos. |
| EP3845654A4 (en) | 2018-08-31 | 2022-05-11 | Noile-Immune Biotech, Inc. | Car-expressing t cells and car expression vector |
| TWI862513B (zh) | 2018-09-19 | 2024-11-21 | 日商千紙鶴治療公司 | 包含胰島素產生細胞之細胞集團、包含該細胞集團之醫藥、其用途及製造方法 |
| JP2022501374A (ja) | 2018-09-21 | 2022-01-06 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 糖尿病を治療するための方法及び組成物、ならびに分泌タンパク質をコードするmRNAを濃縮する方法 |
| US20220135938A1 (en) | 2018-10-15 | 2022-05-05 | Public University Corporation Yokohama City University | Nutrition composition |
| EP3904374A4 (en) | 2018-12-27 | 2022-09-21 | Kyoto University | OBJECT MODIFIED BY A T LYMPHOCYTE RECEPTOR |
| WO2020150391A1 (en) * | 2019-01-15 | 2020-07-23 | Falcon Therapeutics, Inc. | Engineered stem cell constructs and uses thereof |
| EP3919124A4 (en) | 2019-02-01 | 2022-11-23 | Kyoto University | CELL DETECTION METHOD |
| WO2020204149A1 (ja) | 2019-03-29 | 2020-10-08 | 公立大学法人横浜市立大学 | スクリーニング方法および毒性評価法 |
| CA3136401A1 (en) | 2019-04-10 | 2020-10-15 | Orizuru Therapeutics, Inc. | Method for producing biological tissue-like structure |
| AU2020273728A1 (en) | 2019-05-14 | 2021-11-18 | Aleph Farms Ltd. | Pluripotent cell aggregates and use thereof |
| US20220313733A1 (en) | 2019-06-11 | 2022-10-06 | Kyoto University | Method for producing renal interstitial cell |
| AU2020301036A1 (en) | 2019-07-03 | 2022-02-17 | Factor Bioscience Inc. | Cationic lipids and uses thereof |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| JP7541748B2 (ja) | 2019-08-20 | 2024-08-29 | オリヅルセラピューティクス株式会社 | 心筋細胞の富化方法 |
| CA3158631A1 (en) | 2019-10-21 | 2021-04-29 | Orizuru Therapeutics, Inc. | Growth inhibitor |
| JP7723935B2 (ja) | 2019-11-01 | 2025-08-15 | 国立大学法人京都大学 | T細胞の製造方法 |
| KR20220106975A (ko) | 2019-11-25 | 2022-08-01 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | T-세포 마스터 세포 은행 |
| CN115427552A (zh) | 2020-03-19 | 2022-12-02 | 千纸鹤治疗公司 | 心肌细胞的精制方法 |
| WO2021187601A1 (ja) | 2020-03-19 | 2021-09-23 | 国立大学法人京都大学 | 心筋細胞の精製方法 |
| WO2021200901A1 (ja) | 2020-03-31 | 2021-10-07 | 国立大学法人京都大学 | T前駆細胞の製造方法 |
| JPWO2021241668A1 (enExample) | 2020-05-28 | 2021-12-02 | ||
| CN112201307B (zh) * | 2020-09-23 | 2024-09-17 | 温州医科大学 | 一种转录本注释方法以及筛选长非编码rna和内源逆转录病毒来源长非编码rna的方法 |
| TW202237818A (zh) | 2020-11-20 | 2022-10-01 | 日商千紙鶴治療公司 | 成熟化劑 |
| WO2022172960A1 (ja) | 2021-02-09 | 2022-08-18 | オリヅルセラピューティクス株式会社 | 成熟化剤 |
| JPWO2022191171A1 (enExample) | 2021-03-09 | 2022-09-15 | ||
| JPWO2022215718A1 (enExample) | 2021-04-08 | 2022-10-13 | ||
| CN113424794B (zh) * | 2021-04-16 | 2022-07-26 | 安徽农业大学 | 一种优质抗病型地方鸡新品系选育方法 |
| JPWO2022230919A1 (enExample) | 2021-04-28 | 2022-11-03 | ||
| CN113278686A (zh) * | 2021-06-11 | 2021-08-20 | 扬州大学 | 一种研究dna甲基化调控重编程过程的方法 |
| AR127141A1 (es) | 2021-09-27 | 2023-12-20 | Univ Kyoto | Método para producir células t |
| CN118946661A (zh) | 2022-02-04 | 2024-11-12 | 国立大学法人京都大学 | T细胞生产方法 |
| TW202345878A (zh) | 2022-03-23 | 2023-12-01 | 國立大學法人京都大學 | 控制性t細胞之製造方法 |
| AU2023262842A1 (en) | 2022-04-25 | 2024-09-12 | Orizuru Therapeutics, Inc. | Maturing agent having both of alk5 inhibitory activity and cdk8/19 inhibitory activity |
| JPWO2023243627A1 (enExample) | 2022-06-17 | 2023-12-21 | ||
| CN119546748A (zh) | 2022-07-14 | 2025-02-28 | 千纸鹤治疗公司 | 细胞移植用纤维蛋白凝胶片 |
| CN119698464A (zh) | 2022-07-25 | 2025-03-25 | 国立大学法人京都大学 | 从灵长类的胚胎卵巢细胞诱导卵泡的体外培养法 |
| EP4563703A4 (en) | 2022-07-26 | 2025-09-24 | Univ Kyoto | ARTIFICIAL RECEIVER HAVING A LOAD-SHEDDING STRUCTURE |
| WO2024029617A1 (ja) | 2022-08-05 | 2024-02-08 | 国立大学法人京都大学 | 心筋の製造方法 |
| JPWO2024034559A1 (enExample) | 2022-08-08 | 2024-02-15 | ||
| WO2024050517A1 (en) * | 2022-09-02 | 2024-03-07 | The University Of North Carolina At Chapel Hill | Methods of making and using anticancer reprogrammed b cells |
| AU2023353929A1 (en) | 2022-09-26 | 2025-05-01 | Kyoto University | T cell production method |
| JPWO2024070494A1 (enExample) | 2022-09-26 | 2024-04-04 | ||
| JPWO2024071280A1 (enExample) | 2022-09-29 | 2024-04-04 | ||
| EP4620480A1 (en) | 2022-11-16 | 2025-09-24 | Kansai Medical University Educational Corporation | Implantation facilitator, and screening system therefor |
| WO2025038494A1 (en) | 2023-08-11 | 2025-02-20 | Tune Therapeutics, Inc. | Compositions, systems, and methods for lymphoid cell differentiation using targeted gene activation |
| WO2025059073A1 (en) | 2023-09-11 | 2025-03-20 | Tune Therapeutics, Inc. | Epigenetic editing methods and systems for differentiating stem cells |
| WO2025106897A1 (en) * | 2023-11-16 | 2025-05-22 | Colossal Biosciences Inc. | Methods and compositions for creating induced pluripotent stem cells |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2249039C2 (ru) * | 1999-02-04 | 2005-03-27 | Текнион Рисерч Энд Дивелопмент Фаундейшн Лтд. | Способ размножения/поддержания недифференцированных гемопоэтических стволовых клеток или клеток-предшественников (варианты), способ приготовления кондиционированной среды стромальных клеток, способ трансплантации недифференцированных гемопоэтических стволовых клеток или клеток-предшественников (варианты) |
| US20070032447A1 (en) * | 2005-08-01 | 2007-02-08 | Eilertsen Kenneth J | Production of reprogrammed cells with restored potential |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL68218A (en) | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
| US5041138A (en) | 1986-11-20 | 1991-08-20 | Massachusetts Institute Of Technology | Neomorphogenesis of cartilage in vivo from cell culture |
| US4846835A (en) | 1987-06-15 | 1989-07-11 | Grande Daniel A | Technique for healing lesions in cartilage |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| WO1993010218A1 (en) | 1991-11-14 | 1993-05-27 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Vectors including foreign genes and negative selective markers |
| US5646008A (en) | 1993-06-22 | 1997-07-08 | The Regent Of The University Of Michigan | Vertebrate apoptosis gene: compositions and methods |
| CA2167580A1 (en) * | 1993-07-22 | 1995-02-02 | Howard Y. Chen | Expression of human interleukin-1.beta. in a transgenic animal |
| US5723331A (en) | 1994-05-05 | 1998-03-03 | Genzyme Corporation | Methods and compositions for the repair of articular cartilage defects in mammals |
| US5698446A (en) | 1994-09-07 | 1997-12-16 | Chiron Corporation | Methods and compositions for inhibiting production of replication competent virus |
| US5843780A (en) * | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| GB9517779D0 (en) * | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| GB9809178D0 (en) * | 1998-04-29 | 1998-07-01 | Univ Edinburgh | Nuclear reprogramming of somatic cells |
| US6875607B1 (en) * | 1998-11-09 | 2005-04-05 | Es Cell International Pte Ltd | Embryonic stem cells |
| US7015037B1 (en) * | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| AU2002242173A1 (en) | 2001-02-15 | 2002-08-28 | Whithead Institute For Biomedical Research | Stem cell identification |
| US20020137460A1 (en) * | 2001-03-08 | 2002-09-26 | Howard Sun | Universal multi-band (5 bands and more) keyless RF remote control unit using bluetooth radio module as the base |
| EP2354227B1 (en) | 2001-05-31 | 2017-04-19 | Shinya Yamanaka | Genes with ES cell-specific expression |
| JP2003033179A (ja) | 2001-07-05 | 2003-02-04 | Asahi Kasei Corp | 可逆的遺伝子導入ベクター |
| EP1437403A4 (en) | 2001-09-21 | 2004-10-27 | Japan Science & Tech Corp | METHOD FOR PATTERNING REPROGRAMMING FACTOR, METHOD OF PATTERNED REPROGRAMMING FACTOR, METHOD FOR USE OF REPROGRAMMING FACTOR, METHOD FOR DIFFERENTIATING AND SIFE-INGENATING FAN |
| DE10162080A1 (de) * | 2001-12-10 | 2003-06-26 | Albrecht Mueller | Verfahren zur Herstellung von Stammzellen mit erhöhtem Entwicklungspotential |
| GB0202149D0 (en) * | 2002-01-30 | 2002-03-20 | Univ Edinburgh | Pluripotency determining factors and uses thereof |
| GB0211904D0 (en) * | 2002-05-23 | 2002-07-03 | Medical Res Council | Nuclear transfer |
| AU2003247135A1 (en) | 2002-07-23 | 2004-02-09 | Nanodiagnostics, Inc. | Embryonic stem cell markers and uses thereof |
| US7510873B2 (en) * | 2003-06-27 | 2009-03-31 | Ethicon, Incorporated | Postpartum cells isolated from umbilical cord tissue, and methods of making and using the same |
| US7682828B2 (en) * | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| WO2005080598A1 (ja) | 2004-02-19 | 2005-09-01 | Dainippon Sumitomo Pharma Co., Ltd. | 体細胞核初期化物質のスクリーニング方法 |
| EP1574499A1 (en) | 2004-03-08 | 2005-09-14 | DKFZ Deutsches Krebsforschungszentrum | Inhibitors of DNA methylation in tumor cells |
| KR101178786B1 (ko) * | 2004-03-23 | 2012-09-07 | 다이이찌 산쿄 가부시키가이샤 | 다능성 줄기세포의 증식 방법 |
| US20060148104A1 (en) | 2004-10-29 | 2006-07-06 | Massachusetts Institute Of Technology | Detection of ion channel or receptor activity |
| JP2008538898A (ja) * | 2005-04-29 | 2008-11-13 | イノベイティブ デイリー プロダクツ ピーティーワイ リミティッド アズ トラスティー フォー ザ パーティシパンツ オブ ザ コーペラティブ リサーチ センター フォー イノベイティブ デイリー プ | 哺乳動物胚から幹細胞または幹細胞様細胞を作製するための方法 |
| WO2007007054A1 (en) | 2005-07-08 | 2007-01-18 | Cancer Research Technology Limited | Phthalamides, succinimides and related compounds and their use as pharmaceuticals |
| US20090227032A1 (en) * | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| WO2007069666A1 (ja) * | 2005-12-13 | 2007-06-21 | Kyoto University | 核初期化因子 |
| US8278104B2 (en) * | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| GB0615327D0 (en) * | 2006-03-30 | 2006-09-13 | Univ Edinburgh | Culture medium containing kinase inhibitors and uses thereof |
| EP2038247A4 (en) | 2006-06-27 | 2011-08-17 | Jncasr Bangalore | Site-specific inhibitors of histone metyltransferase [HMTASE] and method for their preparation |
| SG193652A1 (en) | 2007-03-23 | 2013-10-30 | Wisconsin Alumni Res Found | Somatic cell reprogramming |
| EP3878949B1 (en) | 2007-04-07 | 2025-06-04 | Whitehead Institute for Biomedical Research | Reprogramming of somatic cells |
| WO2009032456A2 (en) * | 2007-08-01 | 2009-03-12 | Primegen Biotech Llc | Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state |
| EP3078738B1 (en) * | 2007-08-31 | 2020-05-20 | Whitehead Institute for Biomedical Research | Wnt pathway stimulation in reprogramming somatic cells |
| US20110151447A1 (en) | 2007-11-06 | 2011-06-23 | Children's Medical Center Corporation | Method to produce induced pluripotent stem (ips) cells from non-embryonic human cells |
| CN102027105B (zh) | 2008-03-17 | 2015-03-11 | 斯克里普斯研究所 | 用于产生诱导的多能干细胞的组合化学遗传方法 |
| EP2268796A1 (en) | 2008-03-17 | 2011-01-05 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Vectors and methods for generating vector-free induced pluripotent stem (ips) cells using site-specific recombination |
| CA2695522C (en) | 2008-05-02 | 2019-01-15 | Kyoto University | Method of nuclear reprogramming |
| BRPI0915146A2 (pt) | 2008-06-13 | 2017-12-05 | Whitehead Inst Biomedical Res | programação e reprodução de células |
| US20120034192A1 (en) * | 2008-09-19 | 2012-02-09 | Young Richard A | Compositions and methods for enhancing cell reprogramming |
| CA2688804A1 (en) | 2008-12-17 | 2010-06-17 | The Uab Research Foundation | Polycistronic vector for human induced pluripotent stem cell production |
-
2008
- 2008-04-07 EP EP21162420.0A patent/EP3878949B1/en active Active
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- 2024-01-04 JP JP2024000151A patent/JP2024024049A/ja active Pending
- 2024-10-15 US US18/916,572 patent/US20250188423A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2249039C2 (ru) * | 1999-02-04 | 2005-03-27 | Текнион Рисерч Энд Дивелопмент Фаундейшн Лтд. | Способ размножения/поддержания недифференцированных гемопоэтических стволовых клеток или клеток-предшественников (варианты), способ приготовления кондиционированной среды стромальных клеток, способ трансплантации недифференцированных гемопоэтических стволовых клеток или клеток-предшественников (варианты) |
| US20070032447A1 (en) * | 2005-08-01 | 2007-02-08 | Eilertsen Kenneth J | Production of reprogrammed cells with restored potential |
Non-Patent Citations (3)
| Title |
|---|
| SAVARESE ЕТ AL.: 'Hematopoietic Precursor Cells Transiently Reestablish Permissiveness for X inactivation' MOLECULAR AND CELLULAR BIOLOGY vol. 26, no. 19, October 2006, pages 7167-7177. * |
| TAKAHASHI K. ЕТ AL.: 'Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors' CELL vol. 126, no. 4, 25 August 2006, pages 663-676. * |
| TAKAHASHI K. ЕТ AL.: 'Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors' CELL vol. 126, no. 4, 25 August 2006, pages 663-676. SAVARESE ЕТ AL.: 'Hematopoietic Precursor Cells Transiently Reestablish Permissiveness for X inactivation' MOLECULAR AND CELLULAR BIOLOGY vol. 26, no. 19, October 2006, pages 7167-7177. * |
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