RU2380368C2 - Деазапурины и их применение - Google Patents
Деазапурины и их применение Download PDFInfo
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- RU2380368C2 RU2380368C2 RU2004124054/04A RU2004124054A RU2380368C2 RU 2380368 C2 RU2380368 C2 RU 2380368C2 RU 2004124054/04 A RU2004124054/04 A RU 2004124054/04A RU 2004124054 A RU2004124054 A RU 2004124054A RU 2380368 C2 RU2380368 C2 RU 2380368C2
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- Russia
- Prior art keywords
- compound
- alkyl
- aryl
- substituted
- solution
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims abstract description 318
- 125000003118 aryl group Chemical group 0.000 claims abstract description 131
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 115
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 94
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 37
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 25
- 150000003839 salts Chemical class 0.000 claims abstract description 23
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 23
- 125000005842 heteroatom Chemical group 0.000 claims abstract description 21
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 21
- 125000003342 alkenyl group Chemical group 0.000 claims abstract description 20
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 18
- 230000014509 gene expression Effects 0.000 claims abstract description 15
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 15
- 150000002367 halogens Chemical class 0.000 claims abstract description 14
- 102000004127 Cytokines Human genes 0.000 claims abstract description 12
- 108090000695 Cytokines Proteins 0.000 claims abstract description 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 12
- 210000002889 endothelial cell Anatomy 0.000 claims abstract description 10
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 10
- 229910052731 fluorine Inorganic materials 0.000 claims abstract description 9
- 125000000392 cycloalkenyl group Chemical group 0.000 claims abstract description 7
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract description 6
- 125000004430 oxygen atom Chemical group O* 0.000 claims abstract description 5
- 125000006168 tricyclic group Chemical group 0.000 claims abstract description 3
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims abstract 9
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 79
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 30
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 18
- 125000000304 alkynyl group Chemical group 0.000 claims description 16
- 239000001257 hydrogen Substances 0.000 claims description 16
- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 16
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
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- 125000004429 atom Chemical group 0.000 claims description 8
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- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 6
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- FGTJJHCZWOVVNH-UHFFFAOYSA-N tert-butyl-[tert-butyl(dimethyl)silyl]oxy-dimethylsilane Chemical compound CC(C)(C)[Si](C)(C)O[Si](C)(C)C(C)(C)C FGTJJHCZWOVVNH-UHFFFAOYSA-N 0.000 claims description 2
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- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 41
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 38
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| US34659802P | 2002-01-07 | 2002-01-07 | |
| US60/346,598 | 2002-01-07 |
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| BR (1) | BR0306785A (https=) |
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| RU2742122C2 (ru) * | 2014-10-06 | 2021-02-02 | Мерк Патент Гмбх | Соединения гетероарила в качестве ингибиторов ткб и их применение |
| RU2764666C2 (ru) * | 2016-12-29 | 2022-01-19 | Селенити Терапьютикс (Бермуда), Лтд. | Соединения, ингибирующие металлоферменты |
| US11919883B2 (en) | 2016-12-29 | 2024-03-05 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| US12358893B2 (en) | 2019-01-08 | 2025-07-15 | Corxel Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
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| PL2201012T3 (pl) | 2007-10-11 | 2014-11-28 | Astrazeneca Ab | Pochodne pirolo[2,3-d]pirymidyny jako inhibitory kinazy białkowej b |
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| BR112013021236B1 (pt) * | 2011-02-25 | 2021-05-25 | Merck Sharp & Dohme Corp | composto derivado de benzimidazol, e, composição |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2742122C2 (ru) * | 2014-10-06 | 2021-02-02 | Мерк Патент Гмбх | Соединения гетероарила в качестве ингибиторов ткб и их применение |
| RU2764666C2 (ru) * | 2016-12-29 | 2022-01-19 | Селенити Терапьютикс (Бермуда), Лтд. | Соединения, ингибирующие металлоферменты |
| US11919883B2 (en) | 2016-12-29 | 2024-03-05 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| US12458642B2 (en) | 2016-12-29 | 2025-11-04 | Corxel Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| US12358893B2 (en) | 2019-01-08 | 2025-07-15 | Corxel Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20150108 |