BR112014001018A2 - derivado de azabenzimidazol tendo atividade de ativação de ampk - Google Patents

derivado de azabenzimidazol tendo atividade de ativação de ampk

Info

Publication number
BR112014001018A2
BR112014001018A2 BR112014001018A BR112014001018A BR112014001018A2 BR 112014001018 A2 BR112014001018 A2 BR 112014001018A2 BR 112014001018 A BR112014001018 A BR 112014001018A BR 112014001018 A BR112014001018 A BR 112014001018A BR 112014001018 A2 BR112014001018 A2 BR 112014001018A2
Authority
BR
Brazil
Prior art keywords
substituted
group
hydrogen atom
unsubstituted
unsubstituted alkyl
Prior art date
Application number
BR112014001018A
Other languages
English (en)
Inventor
Akira Ino
Eiichi Kojima
Keisuke Tonogaki
Manabu Katou
Masafumi Iwatsu
Masahiko Fujioka
Naoki Ohyabu
Nobuyuki Tanaka
Yu Hinata
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of BR112014001018A2 publication Critical patent/BR112014001018A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

resumo patente de invenção: "derivado de azabenzimidazol tendo atividade de ativação de ampk". a presente invenção refere-se a um composto que é útil como um ativador de ampk. um composto representado pela fórmula (em que r4 representa um átomo de hidrogênio, ou um grupo alquila substituído ou não substituídoa, r1, r2 e r3 independentemente representam um átomo de hidrogênio, um átomo de halogênio, um grupo hidróxi, um grupo ciano, um grupo nitro, um grupo carbóxi, um grupo alquila substituído ou não substituído ou similares, em que um caso onde r1, r2 e r3 representam um átomo de hidrogênio simultaneamente é excluído; x representa uma ligação simples, -s-, -o-, -nr5-, -c(=o)- ou similares; r5 representa um átomo de hidrogênio, ou um grupo alquila substituído ou não substituído, e y representa um grupo cicloalquila substituído ou não substituído, um grupo cicloalquenila substituído ou não substituído, um grupo heterociclila substituído ou não substituído ou similares) ou um sal farmaceuticamente aceitável do mesmo.
BR112014001018A 2011-07-15 2012-07-13 derivado de azabenzimidazol tendo atividade de ativação de ampk BR112014001018A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011156297 2011-07-15
JP2012055785 2012-03-13
PCT/JP2012/067889 WO2013011932A1 (ja) 2011-07-15 2012-07-13 Ａｍｐｋ活性化作用を有するアザベンズイミダゾール誘導体

Publications (1)

Publication Number Publication Date
BR112014001018A2 true BR112014001018A2 (pt) 2017-01-10

Family

ID=47558110

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014001018A BR112014001018A2 (pt) 2011-07-15 2012-07-13 derivado de azabenzimidazol tendo atividade de ativação de ampk

Country Status (11)

Country Link
US (2) US9567330B2 (pt)
EP (2) EP2733141B1 (pt)
JP (2) JP6108467B2 (pt)
KR (1) KR20140040801A (pt)
CN (1) CN103781786A (pt)
AU (1) AU2012284955A1 (pt)
BR (1) BR112014001018A2 (pt)
CA (1) CA2841906A1 (pt)
MX (1) MX2014000452A (pt)
RU (1) RU2014105650A (pt)
WO (1) WO2013011932A1 (pt)

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Also Published As

Publication number Publication date
EP3495366A1 (en) 2019-06-12
US20140194420A1 (en) 2014-07-10
EP2733141A1 (en) 2014-05-21
US10093670B2 (en) 2018-10-09
US20170107219A1 (en) 2017-04-20
US9567330B2 (en) 2017-02-14
AU2012284955A1 (en) 2014-02-27
JP6108467B2 (ja) 2017-04-05
EP2733141B1 (en) 2019-01-09
JPWO2013011932A1 (ja) 2015-02-23
JP6292692B2 (ja) 2018-03-14
CA2841906A1 (en) 2013-01-24
RU2014105650A (ru) 2015-08-27
KR20140040801A (ko) 2014-04-03
CN103781786A (zh) 2014-05-07
WO2013011932A1 (ja) 2013-01-24
MX2014000452A (es) 2014-03-21
EP2733141A4 (en) 2015-03-04
JP2017101049A (ja) 2017-06-08

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]