ATE240949T1 - Epoxysuccinamid-derivate oder ihre salze - Google Patents
Epoxysuccinamid-derivate oder ihre salzeInfo
- Publication number
- ATE240949T1 ATE240949T1 AT98914078T AT98914078T ATE240949T1 AT E240949 T1 ATE240949 T1 AT E240949T1 AT 98914078 T AT98914078 T AT 98914078T AT 98914078 T AT98914078 T AT 98914078T AT E240949 T1 ATE240949 T1 AT E240949T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- group
- alkyl
- salt
- hydrogen atom
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 102000004172 Cathepsin L Human genes 0.000 abstract 1
- 108090000624 Cathepsin L Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 208000037147 Hypercalcaemia Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000148 hypercalcaemia Effects 0.000 abstract 1
- 208000030915 hypercalcemia disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10215197 | 1997-04-18 | ||
| PCT/JP1998/001778 WO1998047887A1 (en) | 1997-04-18 | 1998-04-17 | Novel epoxysuccinamide derivatives or salts thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE240949T1 true ATE240949T1 (de) | 2003-06-15 |
Family
ID=14319744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98914078T ATE240949T1 (de) | 1997-04-18 | 1998-04-17 | Epoxysuccinamid-derivate oder ihre salze |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6110967A (de) |
| EP (1) | EP0921122B1 (de) |
| JP (1) | JP3410476B2 (de) |
| AT (1) | ATE240949T1 (de) |
| AU (1) | AU727497B2 (de) |
| CA (1) | CA2258354A1 (de) |
| DE (1) | DE69814800T2 (de) |
| WO (1) | WO1998047887A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITPD980169A1 (it) | 1998-07-06 | 2000-01-06 | Fidia Advanced Biopolymers Srl | Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione. |
| US20040009891A1 (en) * | 2001-02-14 | 2004-01-15 | Newmillennium Pharmaceutical, Inc. | Method and composition for treating obesity by targeting cathepsin |
| US6620844B2 (en) * | 2001-02-14 | 2003-09-16 | Newmillennium Pharmaceutical, Inc. | Method for reducing blood insulin levels by reducing in vivo cathepsin L activity |
| NZ555911A (en) * | 2002-01-07 | 2008-07-31 | Eisai R&D Man Co Ltd | Deazapurines and uses thereof |
| ITPD20050056A1 (it) | 2005-03-02 | 2006-09-03 | Fidia Farmaceutici | Derivati ammidici del'acido ialuronico in osteoartrosi |
| DE602006020052D1 (de) * | 2005-09-28 | 2011-03-24 | Robert Ternansky | Neue arzneimittel gegen demenz |
| KR20090029725A (ko) | 2006-06-13 | 2009-03-23 | 더 보드 오브 트러스티즈 오프 더 리랜드 스탠포드 쥬니어 유니버시티 | 시스테인 프로테아제의 에폭시드 저해물질 |
| US20100216875A1 (en) * | 2006-12-20 | 2010-08-26 | Gregory Hook | Methods of treating alzheimer's disease |
| US20110092484A1 (en) | 2007-06-08 | 2011-04-21 | Nippon Chemiphar Co., Ltd. | Therapeutic or prophylactic agent for cerebral aneurysm |
| JPWO2009054454A1 (ja) | 2007-10-24 | 2011-03-03 | 国立大学法人 東京医科歯科大学 | カテプシン阻害剤を有効成分として含有するＴｏｌｌ様受容体のシグナル伝達の調整剤 |
| CN101967209B (zh) * | 2010-10-20 | 2012-11-07 | 南京大学 | 一种n-乙酰基乙二胺螯合树脂及其制备方法 |
| US9403843B2 (en) | 2012-02-01 | 2016-08-02 | The Trustees Of Columbia University In The City Of New York | Cysteine protease inhibitors and uses thereof |
| CN104211666B (zh) * | 2013-05-31 | 2017-11-14 | 中国人民解放军军事医学科学院毒物药物研究所 | 2,3‑环氧丁二酰胺类化合物、其制备方法和用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08104683A (ja) * | 1993-10-29 | 1996-04-23 | Takeda Chem Ind Ltd | エポキシコハク酸誘導体 |
| US5556853A (en) * | 1993-10-29 | 1996-09-17 | Takeda Chemical Industries, Ltd. | Epoxysuccinic acid derivatives |
| JPH08104684A (ja) * | 1994-05-31 | 1996-04-23 | Takeda Chem Ind Ltd | エポキシコハク酸関連化合物 |
| WO1995032954A1 (en) * | 1994-05-31 | 1995-12-07 | Takeda Chemical Industries, Ltd. | Epoxysuccinic acid derivatives, their production and use |
| WO1997021694A1 (en) * | 1995-12-12 | 1997-06-19 | Taiho Pharmaceutical Co., Ltd. | Epoxysuccinamide derivatives or salts thereof, and drugs containing the same |
-
1998
- 1998-04-17 DE DE69814800T patent/DE69814800T2/de not_active Expired - Fee Related
- 1998-04-17 US US09/202,607 patent/US6110967A/en not_active Expired - Fee Related
- 1998-04-17 EP EP98914078A patent/EP0921122B1/de not_active Expired - Lifetime
- 1998-04-17 WO PCT/JP1998/001778 patent/WO1998047887A1/ja not_active Ceased
- 1998-04-17 AU AU68537/98A patent/AU727497B2/en not_active Ceased
- 1998-04-17 AT AT98914078T patent/ATE240949T1/de not_active IP Right Cessation
- 1998-04-17 CA CA002258354A patent/CA2258354A1/en not_active Abandoned
- 1998-04-17 JP JP53559298A patent/JP3410476B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP3410476B2 (ja) | 2003-05-26 |
| CA2258354A1 (en) | 1998-10-29 |
| AU727497B2 (en) | 2000-12-14 |
| US6110967A (en) | 2000-08-29 |
| DE69814800D1 (de) | 2003-06-26 |
| EP0921122B1 (de) | 2003-05-21 |
| AU6853798A (en) | 1998-11-13 |
| DE69814800T2 (de) | 2003-12-18 |
| EP0921122A1 (de) | 1999-06-09 |
| EP0921122A4 (de) | 2001-06-13 |
| WO1998047887A1 (en) | 1998-10-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20004485D0 (no) | Sykloalkenderivater, deres fremstilling og anvendelse | |
| PT976748E (pt) | Derivados de pirrolidina com actividade inibidora de fosfolipase a2 | |
| HU9603433D0 (en) | Novel 4-6-diaryl-pyrimidine-derivatives and salts thereof | |
| EP0945440A4 (de) | Aminopyrazolderivate | |
| AU7517400A (en) | N-substituted 4-aminopteridines, synthesis and use thereof as pharmaceutical agent | |
| DE69935718D1 (de) | Antidiabetische medikamente | |
| DE69814800D1 (de) | Epoxysuccinamid-derivate oder ihre salze | |
| DE60025616D1 (de) | Isoindolderivate | |
| AU1041497A (en) | Epoxysuccinamide derivative or salt thereof and medicine comprising the same | |
| ATE223411T1 (de) | 1-methylcarbapenem-derivate | |
| ATE239741T1 (de) | Derivate der phosphonsäure zur inhibierung von carboxypeptidase b | |
| ATE320417T1 (de) | Naphthimidobenzamid-derivate | |
| AU2003235359A1 (en) | Biguanide derivative and therapeutic agent for diabetes containing the same | |
| HUT53788A (en) | Compositions against algae, comprising diphenyl ehter and isothiazolone as active ingredient and coating compositions containing same | |
| HUT53487A (en) | Fungicide compositions containing nitrogen-containing heterocyclic compounds as active components and process for producing the active components | |
| MY104164A (en) | Heterocyclic compounds. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |