ATE240949T1 - Epoxysuccinamid-derivate oder ihre salze - Google Patents
Epoxysuccinamid-derivate oder ihre salzeInfo
- Publication number
- ATE240949T1 ATE240949T1 AT98914078T AT98914078T ATE240949T1 AT E240949 T1 ATE240949 T1 AT E240949T1 AT 98914078 T AT98914078 T AT 98914078T AT 98914078 T AT98914078 T AT 98914078T AT E240949 T1 ATE240949 T1 AT E240949T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- group
- alkyl
- salt
- hydrogen atom
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 102000004172 Cathepsin L Human genes 0.000 abstract 1
- 108090000624 Cathepsin L Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 208000037147 Hypercalcaemia Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000148 hypercalcaemia Effects 0.000 abstract 1
- 208000030915 hypercalcemia disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10215197 | 1997-04-18 | ||
| PCT/JP1998/001778 WO1998047887A1 (en) | 1997-04-18 | 1998-04-17 | Novel epoxysuccinamide derivatives or salts thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE240949T1 true ATE240949T1 (de) | 2003-06-15 |
Family
ID=14319744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98914078T ATE240949T1 (de) | 1997-04-18 | 1998-04-17 | Epoxysuccinamid-derivate oder ihre salze |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6110967A (de) |
| EP (1) | EP0921122B1 (de) |
| JP (1) | JP3410476B2 (de) |
| AT (1) | ATE240949T1 (de) |
| AU (1) | AU727497B2 (de) |
| CA (1) | CA2258354A1 (de) |
| DE (1) | DE69814800T2 (de) |
| WO (1) | WO1998047887A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITPD980169A1 (it) * | 1998-07-06 | 2000-01-06 | Fidia Advanced Biopolymers Srl | Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione. |
| US20040009891A1 (en) * | 2001-02-14 | 2004-01-15 | Newmillennium Pharmaceutical, Inc. | Method and composition for treating obesity by targeting cathepsin |
| US6620844B2 (en) * | 2001-02-14 | 2003-09-16 | Newmillennium Pharmaceutical, Inc. | Method for reducing blood insulin levels by reducing in vivo cathepsin L activity |
| ES2262996T3 (es) * | 2002-01-07 | 2006-12-01 | Eisai Co., Ltd. | Deazapurinas y sus usos. |
| ITPD20050056A1 (it) * | 2005-03-02 | 2006-09-03 | Fidia Farmaceutici | Derivati ammidici del'acido ialuronico in osteoartrosi |
| EP1931656B1 (de) * | 2005-09-28 | 2011-02-09 | Robert Ternansky | Neue arzneimittel gegen demenz |
| JP2010500962A (ja) * | 2006-06-13 | 2010-01-14 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | システインプロテアーゼ類のエポキシド阻害剤 |
| US20100216875A1 (en) * | 2006-12-20 | 2010-08-26 | Gregory Hook | Methods of treating alzheimer's disease |
| EP2168600A1 (de) | 2007-06-08 | 2010-03-31 | Nippon Chemiphar Co., Ltd. | Therapeutisches oder prophylaktisches mittel für ein zerebralaneurysma |
| EP2216047A4 (de) | 2007-10-24 | 2011-12-28 | Nat Univ Corp Tokyo Med & Dent | Regulator zur signalisierung des toll-like-rezeptors mit einem cathepsin-inhibitor als wirkstoff |
| CN101967209B (zh) * | 2010-10-20 | 2012-11-07 | 南京大学 | 一种n-乙酰基乙二胺螯合树脂及其制备方法 |
| JP6175078B2 (ja) | 2012-02-01 | 2017-08-02 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | 新規のシステインプロテアーゼ阻害剤及びその使用 |
| CN104211666B (zh) * | 2013-05-31 | 2017-11-14 | 中国人民解放军军事医学科学院毒物药物研究所 | 2,3‑环氧丁二酰胺类化合物、其制备方法和用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08104683A (ja) * | 1993-10-29 | 1996-04-23 | Takeda Chem Ind Ltd | エポキシコハク酸誘導体 |
| US5556853A (en) * | 1993-10-29 | 1996-09-17 | Takeda Chemical Industries, Ltd. | Epoxysuccinic acid derivatives |
| CA2190151A1 (en) * | 1994-05-31 | 1995-12-07 | Shigetoshi Tsubotani | Epoxysuccinic acid derivatives, their production and use |
| JPH08104684A (ja) * | 1994-05-31 | 1996-04-23 | Takeda Chem Ind Ltd | エポキシコハク酸関連化合物 |
| AU697565B2 (en) * | 1995-12-12 | 1998-10-08 | Taiho Pharmaceutical Co., Ltd. | Epoxysuccinamide derivative or salt thereof and medicine comprising the same |
-
1998
- 1998-04-17 US US09/202,607 patent/US6110967A/en not_active Expired - Fee Related
- 1998-04-17 WO PCT/JP1998/001778 patent/WO1998047887A1/ja not_active Ceased
- 1998-04-17 AU AU68537/98A patent/AU727497B2/en not_active Ceased
- 1998-04-17 AT AT98914078T patent/ATE240949T1/de not_active IP Right Cessation
- 1998-04-17 CA CA002258354A patent/CA2258354A1/en not_active Abandoned
- 1998-04-17 DE DE69814800T patent/DE69814800T2/de not_active Expired - Fee Related
- 1998-04-17 EP EP98914078A patent/EP0921122B1/de not_active Expired - Lifetime
- 1998-04-17 JP JP53559298A patent/JP3410476B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6110967A (en) | 2000-08-29 |
| EP0921122B1 (de) | 2003-05-21 |
| WO1998047887A1 (en) | 1998-10-29 |
| CA2258354A1 (en) | 1998-10-29 |
| DE69814800D1 (de) | 2003-06-26 |
| EP0921122A1 (de) | 1999-06-09 |
| AU6853798A (en) | 1998-11-13 |
| AU727497B2 (en) | 2000-12-14 |
| EP0921122A4 (de) | 2001-06-13 |
| JP3410476B2 (ja) | 2003-05-26 |
| DE69814800T2 (de) | 2003-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |