JP4411455B2 - デアザプリンおよびそれらの用途 - Google Patents
デアザプリンおよびそれらの用途 Download PDFInfo
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- JP4411455B2 JP4411455B2 JP2003558011A JP2003558011A JP4411455B2 JP 4411455 B2 JP4411455 B2 JP 4411455B2 JP 2003558011 A JP2003558011 A JP 2003558011A JP 2003558011 A JP2003558011 A JP 2003558011A JP 4411455 B2 JP4411455 B2 JP 4411455B2
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- JP
- Japan
- Prior art keywords
- aliphatic
- compound
- aryl
- substituted
- heteroaliphatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34659802P | 2002-01-07 | 2002-01-07 | |
| PCT/US2003/000366 WO2003057696A1 (en) | 2002-01-07 | 2003-01-07 | Deazapurines and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005524621A JP2005524621A (ja) | 2005-08-18 |
| JP2005524621A5 JP2005524621A5 (https=) | 2006-08-24 |
| JP4411455B2 true JP4411455B2 (ja) | 2010-02-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003558011A Expired - Fee Related JP4411455B2 (ja) | 2002-01-07 | 2003-01-07 | デアザプリンおよびそれらの用途 |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US7314936B2 (https=) |
| EP (2) | EP1474425B9 (https=) |
| JP (1) | JP4411455B2 (https=) |
| KR (2) | KR101108722B1 (https=) |
| CN (1) | CN100503608C (https=) |
| AT (1) | ATE327236T1 (https=) |
| AU (2) | AU2003235741B8 (https=) |
| BR (1) | BR0306785A (https=) |
| CA (1) | CA2472479C (https=) |
| CY (1) | CY1106138T1 (https=) |
| DE (2) | DE60305446D1 (https=) |
| DK (1) | DK1474425T3 (https=) |
| ES (1) | ES2262996T3 (https=) |
| IL (3) | IL162884A0 (https=) |
| MX (1) | MXPA04006614A (https=) |
| NO (1) | NO329994B1 (https=) |
| NZ (2) | NZ533958A (https=) |
| PT (1) | PT1474425E (https=) |
| RU (1) | RU2380368C2 (https=) |
| SI (1) | SI1474425T1 (https=) |
| WO (1) | WO2003057696A1 (https=) |
| ZA (1) | ZA200406272B (https=) |
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| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| UY29177A1 (es) | 2004-10-25 | 2006-05-31 | Astex Therapeutics Ltd | Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos |
| KR20060087386A (ko) * | 2005-01-28 | 2006-08-02 | 주식회사 대웅제약 | 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물 |
| WO2006083908A1 (en) * | 2005-02-02 | 2006-08-10 | Eisai Co., Ltd. | Crystalline 1h-imidazo[4,5-b]pyridin-5-amine,7-[5-[(cyclohexylmethylamino)-methyl]-1h-indol-2-yl]-2-methyl, sulfate (1:1), trihydrate and its pharmaceutical uses |
| UY29825A1 (es) * | 2005-10-03 | 2007-05-31 | Astrazeneca Ab | Derivados sustituidos de 3h-imidazol-(4,5 b (beta))piridina-2-il benzoatos y benzamidas, composiciones farmacéuticas que los contienen y aplicaciones |
| DK3421471T3 (da) | 2006-04-25 | 2021-06-14 | Astex Therapeutics Ltd | Purin- og deazapurinderivater som farmaceutiske forbindelser |
| WO2007125315A2 (en) * | 2006-04-25 | 2007-11-08 | Astex Therapeutics Limited | Pharmaceutical compounds |
| PL2201012T3 (pl) | 2007-10-11 | 2014-11-28 | Astrazeneca Ab | Pochodne pirolo[2,3-d]pirymidyny jako inhibitory kinazy białkowej b |
| US8507473B2 (en) * | 2008-09-11 | 2013-08-13 | Arena Pharmaceuticals, Inc. | 3H-imidazo[4,5-b]pyridin-5-ol derivatives useful in the treatment of GPR81 receptor disorders |
| WO2011021678A1 (ja) * | 2009-08-21 | 2011-02-24 | 武田薬品工業株式会社 | 縮合複素環化合物 |
| US8299070B2 (en) * | 2009-11-25 | 2012-10-30 | Japan Tobacco Inc. | Indole compounds and pharmaceutical use thereof |
| WO2012033149A1 (ja) | 2010-09-10 | 2012-03-15 | 塩野義製薬株式会社 | Ａｍｐｋ活性化作用を有するヘテロ環縮合イミダゾール誘導体 |
| SG192941A1 (en) * | 2011-02-25 | 2013-09-30 | Merck Sharp & Dohme | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| EA027506B1 (ru) | 2011-04-01 | 2017-08-31 | Астразенека Аб | Способ лечения рака молочной железы |
| GB201106814D0 (en) * | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compounds |
| BR112014001018A2 (pt) | 2011-07-15 | 2017-01-10 | Shionogi & Co | derivado de azabenzimidazol tendo atividade de ativação de ampk |
| HRP20191982T4 (hr) | 2011-11-30 | 2023-01-06 | Astrazeneca Ab | Kombinacijsko liječenje raka |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| GB201401198D0 (en) * | 2014-01-24 | 2014-03-12 | Bial Portela & Ca Sa | Process for the syntheis of substituted urea compounds |
| EP2913330A1 (en) | 2014-02-27 | 2015-09-02 | Laboratoire Biodim | Condensed derivatives of imidazole useful as pharmaceuticals |
| CN104974187A (zh) * | 2014-04-10 | 2015-10-14 | 吉林省博创药业有限公司 | 菲罗啉类衍生物及其制备方法和应用 |
| US10253023B2 (en) * | 2014-10-06 | 2019-04-09 | Merck Patent Gmbh | Heteroaryl compounds as BTK inhibitors and uses thereof |
| EP3562306B1 (en) | 2016-12-29 | 2025-02-26 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| JP7227157B2 (ja) | 2016-12-29 | 2023-02-21 | フェーズバイオ ファーマシューティカルズ，インコーポレイテッド | 金属酵素阻害剤化合物 |
| KR20190043437A (ko) * | 2017-10-18 | 2019-04-26 | 씨제이헬스케어 주식회사 | 단백질 키나제 억제제로서의 헤테로고리 화합물 |
| CN111448190B (zh) | 2017-11-14 | 2023-09-26 | 百时美施贵宝公司 | 取代的吲哚化合物 |
| BR112020011668A2 (pt) | 2017-12-15 | 2020-11-17 | Bristol-Myers Squibb Company | compostos de éter de indol substituído |
| JP7313354B2 (ja) * | 2017-12-19 | 2023-07-24 | ブリストル－マイヤーズ スクイブ カンパニー | Ｔｌｒ阻害剤として有用なアミド置換されたインドール化合物 |
| BR112020012084A2 (pt) * | 2017-12-19 | 2020-11-24 | Bristol-Myers Squibb Company | compostos de indol substituído úteis como inibidores de tlr |
| WO2019126082A1 (en) | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | 6-azaindole compounds |
| CA3085942A1 (en) | 2017-12-20 | 2019-06-27 | Bristol-Myers Squibb Company | Aryl and heteroaryl substituted indole compounds |
| BR112020011984A2 (pt) * | 2017-12-20 | 2020-11-17 | Bristol-Myers Squibb Company | compostos de amino indol úteis como inibidores de tlr |
| US11299501B2 (en) | 2017-12-20 | 2022-04-12 | Bristol-Myers Squibb Company | Diazaindole compounds |
| CN112955450A (zh) | 2018-10-24 | 2021-06-11 | 百时美施贵宝公司 | 经取代的吲哚和吲唑化合物 |
| ES2963696T3 (es) | 2018-10-24 | 2024-04-01 | Bristol Myers Squibb Co | Compuestos diméricos de indol sustituidos |
| KR102195348B1 (ko) | 2018-11-15 | 2020-12-24 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물 |
| JP2022516969A (ja) | 2019-01-08 | 2022-03-03 | フェーズバイオ ファーマシューティカルズ，インコーポレイテッド | 金属酵素阻害剤化合物 |
| EP3965888B1 (en) | 2019-05-09 | 2024-08-21 | Bristol-Myers Squibb Company | Substituted benzimidazolone compounds |
| WO2021067326A1 (en) | 2019-10-01 | 2021-04-08 | Bristol-Myers Squibb Company | Substituted bicyclic heteroaryl compounds |
| CN114829350B (zh) | 2019-10-04 | 2024-05-28 | 百时美施贵宝公司 | 经取代的咔唑化合物 |
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-
2003
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- 2003-01-07 KR KR1020107012410A patent/KR101108722B1/ko not_active Expired - Fee Related
- 2003-01-07 MX MXPA04006614A patent/MXPA04006614A/es active IP Right Grant
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- 2003-01-07 DE DE60305446A patent/DE60305446D1/de not_active Expired - Lifetime
- 2003-01-07 US US10/500,840 patent/US7314936B2/en not_active Expired - Fee Related
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- 2003-01-07 SI SI200330396T patent/SI1474425T1/sl unknown
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- 2003-01-07 RU RU2004124054/04A patent/RU2380368C2/ru not_active IP Right Cessation
- 2003-01-07 KR KR1020047010595A patent/KR100980163B1/ko not_active Expired - Fee Related
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- 2003-01-07 AU AU2003235741A patent/AU2003235741B8/en not_active Ceased
- 2003-01-07 EP EP06005483A patent/EP1707566A1/en not_active Withdrawn
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2004
- 2004-01-07 US US10/753,261 patent/US20040186127A1/en not_active Abandoned
- 2004-08-05 ZA ZA2004/06272A patent/ZA200406272B/en unknown
- 2004-08-06 NO NO20043290A patent/NO329994B1/no not_active IP Right Cessation
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2006
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2007
- 2007-09-28 US US11/906,056 patent/US7868002B2/en not_active Expired - Fee Related
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2008
- 2008-05-19 IL IL191543A patent/IL191543A0/en unknown
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2009
- 2009-02-20 AU AU2009200689A patent/AU2009200689A1/en not_active Abandoned
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- 2010-11-02 US US12/917,669 patent/US8691814B2/en not_active Expired - Fee Related
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