RU2358716C2 - Органические соединения - Google Patents

Органические соединения Download PDF

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Publication number
RU2358716C2
RU2358716C2 RU2005134173/15A RU2005134173A RU2358716C2 RU 2358716 C2 RU2358716 C2 RU 2358716C2 RU 2005134173/15 A RU2005134173/15 A RU 2005134173/15A RU 2005134173 A RU2005134173 A RU 2005134173A RU 2358716 C2 RU2358716 C2 RU 2358716C2
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RU
Russia
Prior art keywords
alkyl
composition according
group
halogen
substituted
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RU2005134173/15A
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English (en)
Russian (ru)
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RU2005134173A (ru
Inventor
Томоюки ООМУРА (JP)
Томоюки ООМУРА
Мадхусудхан ПУДИПЕДДИ (US)
Мадхусудхан ПУДИПЕДДИ
Алан Эдуард РОЙС (US)
Алан Эдуард РОЙС
Коллин РЮГГЕР (US)
Коллин РЮГГЕР
Масаки САСАКИ (JP)
Масаки САСАКИ
Токухиро ТАМУРА (JP)
Токухиро ТАМУРА
Original Assignee
Новартис Аг
Митсубиши Фарма Корпорейшн
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Application filed by Новартис Аг, Митсубиши Фарма Корпорейшн filed Critical Новартис Аг
Publication of RU2005134173A publication Critical patent/RU2005134173A/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
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    • A—HUMAN NECESSITIES
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    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Surgery (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
RU2005134173/15A 2003-04-08 2004-04-06 Органические соединения RU2358716C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46121503P 2003-04-08 2003-04-08
US60/461,215 2003-04-08

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2009105403/15A Division RU2009105403A (ru) 2003-04-08 2009-02-17 Твердая фармацевтическая композиция для перорального введения (варианты)

Publications (2)

Publication Number Publication Date
RU2005134173A RU2005134173A (ru) 2006-09-10
RU2358716C2 true RU2358716C2 (ru) 2009-06-20

Family

ID=32326722

Family Applications (5)

Application Number Title Priority Date Filing Date
RU2005134173/15A RU2358716C2 (ru) 2003-04-08 2004-04-06 Органические соединения
RU2009105403/15A RU2009105403A (ru) 2003-04-08 2009-02-17 Твердая фармацевтическая композиция для перорального введения (варианты)
RU2010146697/15A RU2475236C2 (ru) 2003-04-08 2010-11-17 Способ получения фармацевтической композиции
RU2010147000/15A RU2475237C2 (ru) 2003-04-08 2010-11-18 Предназначенная для перорального применения фармацевтическая композиция
RU2012148593/15A RU2012148593A (ru) 2003-04-08 2012-11-15 Предназначенная для перорального применения фармацевтическая композиция

Family Applications After (4)

Application Number Title Priority Date Filing Date
RU2009105403/15A RU2009105403A (ru) 2003-04-08 2009-02-17 Твердая фармацевтическая композиция для перорального введения (варианты)
RU2010146697/15A RU2475236C2 (ru) 2003-04-08 2010-11-17 Способ получения фармацевтической композиции
RU2010147000/15A RU2475237C2 (ru) 2003-04-08 2010-11-18 Предназначенная для перорального применения фармацевтическая композиция
RU2012148593/15A RU2012148593A (ru) 2003-04-08 2012-11-15 Предназначенная для перорального применения фармацевтическая композиция

Country Status (41)

Country Link
US (11) US20060275357A1 (enExample)
EP (5) EP2769713A1 (enExample)
JP (3) JP5495467B2 (enExample)
KR (3) KR20110005320A (enExample)
CN (2) CN101797241B (enExample)
AR (3) AR043987A1 (enExample)
AT (3) AT501681B1 (enExample)
AU (1) AU2004228929B2 (enExample)
BE (2) BE1015972A5 (enExample)
BR (1) BRPI0409250B8 (enExample)
CA (2) CA2521325C (enExample)
CL (2) CL2004000745A1 (enExample)
CY (3) CY1110260T1 (enExample)
DE (4) DE202004021680U1 (enExample)
DK (2) DK2316431T3 (enExample)
EC (1) ECSP056090A (enExample)
ES (3) ES2320767T3 (enExample)
FR (2) FR2854073B1 (enExample)
GB (1) GB2400318B (enExample)
GR (1) GR1005052B (enExample)
HR (3) HRP20050886B1 (enExample)
HU (2) HUE028247T2 (enExample)
IL (3) IL170888A (enExample)
IS (2) IS2682B (enExample)
IT (1) ITMI20040682A1 (enExample)
LU (1) LU91867I2 (enExample)
MA (1) MA27729A1 (enExample)
MX (1) MXPA05010860A (enExample)
MY (1) MY141249A (enExample)
NO (4) NO329332B1 (enExample)
NZ (3) NZ592339A (enExample)
PE (5) PE20150676A1 (enExample)
PL (2) PL1613288T3 (enExample)
PT (1) PT1613288E (enExample)
RU (5) RU2358716C2 (enExample)
SG (1) SG175449A1 (enExample)
SI (2) SI1613288T1 (enExample)
TN (1) TNSN05256A1 (enExample)
TW (1) TWI332847B (enExample)
WO (1) WO2004089341A1 (enExample)
ZA (1) ZA200507394B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013187795A1 (ru) * 2012-06-13 2013-12-19 Открытое акционерное общество "Новосибхимфарм" Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний
WO2014011083A2 (ru) 2012-07-11 2014-01-16 Алла Хем, Ллс Фармацевтическая композиция с улучшенной сыпучестью, лекарственное средство, способ получения и применение

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CN1891212B (zh) * 2005-07-07 2010-10-13 马启明 一种口服制剂及其制备方法
CA2820510A1 (en) * 2005-09-09 2007-03-15 Novartis Ag Treatment of autoimmune diseases
US7687456B2 (en) 2005-11-09 2010-03-30 Proteolix, Inc. Compounds for enzyme inhibition
TWI389683B (zh) 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
EP2484688B1 (en) 2006-06-19 2016-06-08 Onyx Therapeutics, Inc. Peptide epoxyketones for proteasome inhibition
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EP1905434A1 (en) * 2006-09-26 2008-04-02 Novartis AG Organic compounds comprising an S1P receptor agonist and their therapeutic use
EP1923058A1 (en) * 2006-09-26 2008-05-21 Novartis AG Coated pharmaceutical composition comprising an S1P agonist or modulator
AU2011235934A1 (en) * 2006-09-26 2011-11-03 Novartis Ag Pharmaceutical compositions comprising an S1P modulator
EP1923055A1 (en) * 2006-09-26 2008-05-21 Novartis AG Freeze-dried pharmaceutical composition comprising an S1P agonist or modulator
KR20090057399A (ko) * 2006-09-26 2009-06-05 노파르티스 아게 Ｓ１ｐ 조정제를 포함하는 제약 조성물
EP1923054A1 (en) * 2006-09-26 2008-05-21 Novartis AG Fast disintegrating pharmaceutical composition comprising an S1P agonist or modulator
WO2008124210A1 (en) * 2007-02-14 2008-10-16 Emory University Methods and compositions for treating or preventing infection using leukocyte sequestration agents
JP4463875B2 (ja) 2007-03-29 2010-05-19 第一三共株式会社 医薬組成物
MX2010003732A (es) 2007-10-04 2010-08-09 Onyx Therapeutics Inc Inhibidores de peptido cetona epoxi de proteasa cristalina y la sintesis de ceto-epoxidos de aminoacido.
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EP3733161A1 (en) * 2007-10-12 2020-11-04 Novartis AG Compositions comprising sphingosine 1 phosphate (s1p) receptor modulators
JP5534645B2 (ja) * 2008-01-11 2014-07-02 日医工株式会社 無包装状態において安定性に優れた塩酸サルポグレラート含有経口投与製剤
TW200946105A (en) 2008-02-07 2009-11-16 Kyorin Seiyaku Kk Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient
BRPI0909625B1 (pt) 2008-03-17 2021-09-08 Actelion Pharmaceuticals Ltd Agonista seletivo do receptor s1p1 para o uso como um medicamento, uso de um agonista seletivo do receptor s1p1 e kit contendo diferentes unidades de medicação de um agonista seletivo do receptor s1p1
WO2009155475A1 (en) 2008-06-20 2009-12-23 Novartis Ag Paediatric compositions for treating1 multiple sclerosis
RU2519768C2 (ru) * 2008-06-20 2014-06-20 Мерк Патент Гмбх Поддающаяся прямому прессованию и быстро распадающаяся матрица таблетки
ATE543393T1 (de) * 2008-09-04 2012-02-15 Cargill Inc Erythritol-tablettierung
PE20120059A1 (es) 2008-10-21 2012-02-27 Onyx Therapeutics Inc Combinaciones farmaceuticas con epoxicetonas peptidicas
PE20120012A1 (es) 2008-11-11 2012-02-02 Novartis Ag Sales de fingolimod
AU2013100533B4 (en) * 2008-11-11 2013-12-12 Novartis Ag Crystalline forms of fingolimod HCL
CN102209705A (zh) * 2008-11-11 2011-10-05 诺瓦提斯公司 芬戈莫德盐酸盐的结晶形式
JP5305421B2 (ja) 2008-12-17 2013-10-02 第一三共株式会社 ジアミン誘導体の製造方法
EP2383272A4 (en) 2009-01-13 2012-07-25 Daiichi Sankyo Co Ltd ACTIVE BLOOD CREATION FACTOR HEMMER
ES2542236T3 (es) 2009-03-10 2015-08-03 Daiichi Sankyo Company, Limited Procedimiento de producción de un derivado de diamina
WO2010104106A1 (ja) 2009-03-13 2010-09-16 第一三共株式会社 光学活性なジアミン誘導体の製造方法
TWI504598B (zh) 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
CN102481296A (zh) * 2009-06-18 2012-05-30 第一三共株式会社 溶解性改善的药用组合物
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US8853147B2 (en) 2009-11-13 2014-10-07 Onyx Therapeutics, Inc. Use of peptide epoxyketones for metastasis suppression
US9359398B2 (en) 2010-03-01 2016-06-07 Onyx Therapeutics, Inc. Compounds for immunoproteasome inhibition
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