RU2264413C2 - РЕКОМБИНАНТНОЕ АНТИТЕЛО К ЧЕЛОВЕЧЕСКОМУ ИНТЕРЛЕЙКИНУ 1β - Google Patents
РЕКОМБИНАНТНОЕ АНТИТЕЛО К ЧЕЛОВЕЧЕСКОМУ ИНТЕРЛЕЙКИНУ 1β Download PDFInfo
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Cited By (3)
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| RU2582261C2 (ru) * | 2011-02-25 | 2016-04-20 | Редженерон Фармасьютикалс, Инк. | Мыши adam6 |
| US9706759B2 (en) | 2011-12-20 | 2017-07-18 | Regeneron Pharmaceuticals, Inc. | Humanized light chain mice |
| US11666040B2 (en) | 2012-06-12 | 2023-06-06 | Regeneron Pharmaceuticals, Inc. | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
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| JP4955185B2 (ja) | 2000-06-29 | 2012-06-20 | アボット・ラボラトリーズ | 二重特異性抗体ならびに作製方法および使用方法 |
| GB0020685D0 (en) | 2000-08-22 | 2000-10-11 | Novartis Ag | Organic compounds |
| CA2474616A1 (en) * | 2002-01-28 | 2003-08-07 | Medarex, Inc. | Human monoclonal antibodies to prostate specific membrane antigen (psma) |
| GB0303337D0 (en) | 2003-02-13 | 2003-03-19 | Celltech R&D Ltd | Biological products |
| ATE491953T1 (de) * | 2003-09-15 | 2011-01-15 | Oklahoma Med Res Found | Verfahren zur verwendung von cytokintests zur diagnose, behandlung und beurteilung von ankyloider spondylitis |
| JP4588763B2 (ja) | 2004-02-06 | 2010-12-01 | ユニバーシティー オブ マサチューセッツ | クロストリジウム・ディフィシル（Ｃｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅ）毒素に対する抗体およびその使用 |
| EP1851245B1 (en) | 2005-01-26 | 2012-10-10 | Amgen Fremont Inc. | Antibodies against interleukin-1 beta |
| PA8672101A1 (es) * | 2005-04-29 | 2006-12-07 | Centocor Inc | Anticuerpos anti-il-6, composiciones, métodos y usos |
| PT1899378E (pt) | 2005-06-21 | 2010-01-26 | Xoma Technology Ltd | Anticorpos de ligação de il-1β e os seus fragmentos |
| PL1940465T3 (pl) * | 2005-10-26 | 2013-01-31 | Novartis Ag | Nowe zastosowanie przeciwciał anty-IL-1beta |
| EP3219328B1 (en) | 2005-12-29 | 2020-06-17 | Janssen Biotech, Inc. | Human anti-il-23 antibodies, compositions, method and uses |
| US7943328B1 (en) | 2006-03-03 | 2011-05-17 | Prometheus Laboratories Inc. | Method and system for assisting in diagnosing irritable bowel syndrome |
| EP2021026A1 (en) * | 2006-04-14 | 2009-02-11 | Novartis AG | Use of il-i antibodies for treating ophthalmic disorders |
| US20080085524A1 (en) * | 2006-08-15 | 2008-04-10 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
| US7695718B2 (en) | 2006-12-20 | 2010-04-13 | Xoma Technology Ltd. | Methods for the treatment of IL-1β related diseases |
| EP2114443A4 (en) * | 2006-12-29 | 2011-08-10 | Abbott Lab | IL-1A / IL-1B ANTIBODY WITH DOUBLE SPECIFICITY |
| AU2008219681A1 (en) | 2007-02-28 | 2008-09-04 | Merck Sharp & Dohme Corp. | Combination therapy for treatment of immune disorders |
| KR20160017119A (ko) * | 2007-05-29 | 2016-02-15 | 노파르티스 아게 | 항-ｉｌ-1-베타 치료법에 대한 신규 적응증 |
| HRP20141194T1 (hr) * | 2007-12-20 | 2015-04-24 | Xoma (Us) Llc | Postupci lijeäśenja gihta |
| CA2727171A1 (en) * | 2008-06-06 | 2009-12-10 | Xoma Technology Ltd. | Methods for the treatment of rheumatoid arthritis |
| WO2010028275A1 (en) | 2008-09-05 | 2010-03-11 | Xoma Technology Ltd. | METHODS FOR TREATING OR PREVENTING IL-1ß RELATED DISEASES |
| DK2493922T3 (en) | 2009-10-26 | 2017-04-24 | Hoffmann La Roche | Process for preparing a glycosylated immunoglobulin |
| EA201201526A1 (ru) | 2010-05-07 | 2013-06-28 | Ксома Текнолоджи Лтд. | Способы лечения состояний, связанных с il-1b |
| DE102010033565B4 (de) * | 2010-07-27 | 2012-06-21 | Tetec Tissue Engineering Technologies Ag | Marker zur Bestimmung von Chondrozyten |
| IL315833A (en) | 2010-08-02 | 2024-11-01 | Regeneron Pharma | Mice producing binding proteins containing VL regions |
| CN103328511B (zh) | 2010-09-10 | 2016-01-20 | 埃派斯进有限公司 | 抗-IL-1β抗体及其使用方法 |
| IL273982B2 (en) | 2011-08-05 | 2023-03-01 | Regeneron Pharma | Humanized mice possess a universal light chain |
| DE102011083595A1 (de) | 2011-09-28 | 2013-03-28 | Bayer Pharma AG | Inhibition der Wirkung von Interleukin 1 beta zur Behandlung der Endometriose |
| EP2794657B1 (en) | 2011-12-19 | 2017-10-11 | Xoma (Us) Llc | Methods for treating acne |
| WO2013122544A2 (en) | 2012-02-13 | 2013-08-22 | Agency For Science, Technology And Research | IL-1β NEUTRALIZING HUMAN MONOCLONAL ANTIBODIES |
| BR112016021572A2 (pt) | 2014-03-21 | 2017-10-03 | Regeneron Pharma | Métodos para preparar um animal não humano geneticamente modificado e para produzir proteínas de ligação, hibridoma, ácido nucleico, célula, e, proteína de ligação |
| ES2762640T3 (es) | 2014-03-21 | 2020-05-25 | Regeneron Pharma | Proteínas VL de unión a antígeno que exhiben diferentes características de unión |
| EP3271403A1 (en) | 2015-03-19 | 2018-01-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| US20190269757A1 (en) | 2018-03-05 | 2019-09-05 | Janssen Biotech, Inc. | Methods of Treating Crohn's Disease with Anti-IL23 Specific Antibody |
| CN110818793A (zh) * | 2018-08-14 | 2020-02-21 | 中山康方生物医药有限公司 | 抗IL-1β的抗体、其药物组合物及其用途 |
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| KR20220012883A (ko) | 2019-05-23 | 2022-02-04 | 얀센 바이오테크 인코포레이티드 | Il-23 및 tnf 알파에 대한 항체의 병용요법으로 염증성 장질환을 치료하는 방법 |
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| US4772685A (en) | 1985-10-02 | 1988-09-20 | Merck & Co., Inc. | Immunogenic peptides of human interleukin-1 and the corresponding anti-peptide antibodies |
| US4935343A (en) * | 1986-08-08 | 1990-06-19 | Syntex (U.S.A.) Inc. | Monoclonal antibodies for interleukin-1β |
| FR2640146B1 (fr) * | 1988-12-08 | 1993-12-24 | Commissariat A Energie Atomique | Anticorps monoclonaux anti-interleukines 1(alpha) et 1(beta), leur procede de production et applications desdits anticorps a la detection des interleukines 1(alpha) et 1(beta) et en therapeutique |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| JP3714683B2 (ja) * | 1992-07-30 | 2005-11-09 | 生化学工業株式会社 | 抗リウマチ剤 |
| US5429614A (en) | 1993-06-30 | 1995-07-04 | Baxter International Inc. | Drug delivery system |
| WO1995001997A1 (en) * | 1993-07-09 | 1995-01-19 | Smithkline Beecham Corporation | RECOMBINANT AND HUMANIZED IL-1β ANTIBODIES FOR TREATMENT OF IL-1 MEDIATED INFLAMMATORY DISORDERS IN MAN |
| US6051228A (en) | 1998-02-19 | 2000-04-18 | Bristol-Myers Squibb Co. | Antibodies against human CD40 |
| GB0001448D0 (en) * | 2000-01-21 | 2000-03-08 | Novartis Ag | Organic compounds |
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2000
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| US10905109B2 (en) | 2011-02-25 | 2021-02-02 | Regeneren Pharmaceuticals, Inc. | ADAM6 mice |
| US9932408B2 (en) | 2011-02-25 | 2018-04-03 | Regeneron Pharmaceuticals, Inc. | ADAM6 mice |
| US9944716B2 (en) | 2011-02-25 | 2018-04-17 | Regeneron Pharmaceuticals, Inc. | ADAM6 mice |
| US10072095B2 (en) | 2011-02-25 | 2018-09-11 | Regeneron Pharmaceuticals, Inc. | ADAM6 mice |
| US12207628B2 (en) | 2011-02-25 | 2025-01-28 | Regeneron Pharmaceuticals, Inc. | ADAM6 mice |
| US11950578B2 (en) | 2011-02-25 | 2024-04-09 | Regeneron Pharmaceuticals, Inc. | ADAM6 mice |
| US10577430B2 (en) | 2011-02-25 | 2020-03-03 | Regeneron Pharmaceuticals, Inc. | ADAM6 mice |
| RU2582261C2 (ru) * | 2011-02-25 | 2016-04-20 | Редженерон Фармасьютикалс, Инк. | Мыши adam6 |
| US10694725B2 (en) | 2011-02-25 | 2020-06-30 | Regeneron Pharmaceuticals, Inc. | ADAM6 mice |
| US11612151B2 (en) | 2011-12-20 | 2023-03-28 | Regeneron Pharmaceuticals, Inc. | Humanized light chain mice |
| US11617357B2 (en) | 2011-12-20 | 2023-04-04 | Regeneron Pharmaceuticals, Inc. | Humanized light chain mice |
| US9706759B2 (en) | 2011-12-20 | 2017-07-18 | Regeneron Pharmaceuticals, Inc. | Humanized light chain mice |
| US10561124B2 (en) | 2011-12-20 | 2020-02-18 | Regeneron Pharmaceuticals, Inc. | Humanized light chain mice |
| US12433266B2 (en) | 2011-12-20 | 2025-10-07 | Regeneron Pharmaceuticals, Inc. | Humanized light chain mice |
| US11666040B2 (en) | 2012-06-12 | 2023-06-06 | Regeneron Pharmaceuticals, Inc. | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
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