JP3978338B2 - ヒトＩＬ−１βに対する抗体 - Google Patents
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| PCT/EP2001/000591 WO2001053353A2 (en) | 2000-01-21 | 2001-01-19 | Recombinant antibodies to human interkleukin-1 beta |
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| GB0001448D0 (en) * | 2000-01-21 | 2000-03-08 | Novartis Ag | Organic compounds |
| IL153567A0 (en) | 2000-06-29 | 2003-07-06 | Abbott Lab | Dual specificity antibodies and methods of making and using |
| GB0020685D0 (en) | 2000-08-22 | 2000-10-11 | Novartis Ag | Organic compounds |
| MXPA04007262A (es) * | 2002-01-28 | 2004-10-29 | Medarex Inc | Anticuerpos monoclonales humanos para antigeno de membrana especifico de prostata (psma). |
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| WO2005029091A2 (en) * | 2003-09-15 | 2005-03-31 | Oklahoma Medical Research Foundation | Method of using cytokine assays to diagnose, treat, and evaluate inflammatory and autoimmune diseases |
| PL2857418T3 (pl) | 2004-02-06 | 2017-10-31 | Univ Massachusetts | Przeciwciała przeciw toksynom Clostridium difficile i ich zastosowania |
| EP2361933A3 (en) * | 2005-01-26 | 2012-05-02 | Amgen Fremont Inc. | Antibodies against interleukin-1 beta |
| PA8672101A1 (es) * | 2005-04-29 | 2006-12-07 | Centocor Inc | Anticuerpos anti-il-6, composiciones, métodos y usos |
| ES2335232T3 (es) * | 2005-06-21 | 2010-03-23 | Xoma Technology Ltd. | Anticuerpos y fragmentos de los mismos que se unen a la il-1 beta. |
| EP4218815A3 (en) * | 2005-10-26 | 2024-03-27 | Novartis AG | Use of anti il-1beta antibodies |
| JP5193881B2 (ja) | 2005-12-29 | 2013-05-08 | セントカー・インコーポレーテツド | ヒト抗ｉｌ−２３抗体、組成物、方法および用途 |
| US7943328B1 (en) | 2006-03-03 | 2011-05-17 | Prometheus Laboratories Inc. | Method and system for assisting in diagnosing irritable bowel syndrome |
| EP2021026A1 (en) * | 2006-04-14 | 2009-02-11 | Novartis AG | Use of il-i antibodies for treating ophthalmic disorders |
| US20080085524A1 (en) * | 2006-08-15 | 2008-04-10 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
| RU2554747C9 (ru) | 2006-12-20 | 2015-10-20 | Ксома (Сша) Ллс | Способы лечения il-1бета-зависимых заболеваний |
| WO2008082651A2 (en) * | 2006-12-29 | 2008-07-10 | Abbott Laboratories | Dual-specific il-1a/ il-1b antibodies |
| NZ579297A (en) | 2007-02-28 | 2012-03-30 | Schering Corp | Combination therapy comprising an il-23 antagonist and a cytokine antagonist for treatment of immune disorders |
| KR102824865B1 (ko) * | 2007-05-29 | 2025-06-26 | 노파르티스 아게 | 항-ｉｌ-1-베타 치료법에 대한 신규 적응증 |
| SI2391650T1 (sl) * | 2007-12-20 | 2015-03-31 | Xoma (Us) Llc | Postopki za zdravljenje protina |
| PT2293816E (pt) * | 2008-06-06 | 2013-02-13 | Xoma Technology Ltd | Métodos para o tratamento da artrite reumatoide |
| EP2341936A4 (en) | 2008-09-05 | 2012-07-25 | Xoma Technology Ltd | METHOD FOR TREATING OR PREVENTING IL-1ß-CONTAINED ILLNESSES |
| HRP20240920T1 (hr) | 2009-10-26 | 2024-10-11 | F. Hoffmann - La Roche Ag | Postupak za proizvodnju glikoziliranog imunoglobulina |
| SG185473A1 (en) * | 2010-05-07 | 2012-12-28 | Xoma Technology Ltd | METHODS FOR THE TREATMENT OF IL-1ß RELATED CONDITIONS |
| DE102010033565B4 (de) * | 2010-07-27 | 2012-06-21 | Tetec Tissue Engineering Technologies Ag | Marker zur Bestimmung von Chondrozyten |
| CA3250882A1 (en) | 2010-08-02 | 2025-11-29 | Regeneron Pharamaceuticals, Inc. | Mice that Make Binding Proteins Comprising VL Domains |
| JP5866130B2 (ja) | 2010-09-10 | 2016-02-17 | アペクシジェン， インコーポレイテッド | 抗ＩＬ−１β抗体およびその使用方法 |
| SI2738258T2 (sl) | 2011-02-25 | 2023-05-31 | Regeneron Pharmaceuticals, Inc. | Miši ADAM6 |
| MY172718A (en) | 2011-08-05 | 2019-12-11 | Regeneron Pharma | Humanized universal light chain mice |
| DE102011083595A1 (de) | 2011-09-28 | 2013-03-28 | Bayer Pharma AG | Inhibition der Wirkung von Interleukin 1 beta zur Behandlung der Endometriose |
| WO2013096516A1 (en) | 2011-12-19 | 2013-06-27 | Xoma Technology Ltd. | Methods for treating acne |
| KR102081657B1 (ko) | 2011-12-20 | 2020-02-26 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 경쇄 마우스 |
| RS60583B1 (sr) | 2012-02-13 | 2020-08-31 | Agency Science Tech & Res | Ljudska monoklonalna antitela koja vrše neutralizaciju il-ss |
| HUE055617T2 (hu) | 2012-06-12 | 2021-12-28 | Regeneron Pharma | Korlátozott immunglobulin nehézlánc lókuszokkal rendelkezõ, humanizált, nem humán élõlények |
| BR112016021572A2 (pt) | 2014-03-21 | 2017-10-03 | Regeneron Pharma | Métodos para preparar um animal não humano geneticamente modificado e para produzir proteínas de ligação, hibridoma, ácido nucleico, célula, e, proteína de ligação |
| BR112016021679A2 (pt) | 2014-03-21 | 2018-12-04 | Regeneron Pharmaceuticals, Inc. | proteína de ligação ao antígeno, métodos de produção de uma proteína de ligação ao antígeno e de identificação de uma ou mais proteínas de ligação ao antígeno, hibridoma, ácido nucleico, célula, e, animal não humano geneticamente modificado. |
| CA2979702A1 (en) | 2015-03-19 | 2016-09-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| US20190269757A1 (en) | 2018-03-05 | 2019-09-05 | Janssen Biotech, Inc. | Methods of Treating Crohn's Disease with Anti-IL23 Specific Antibody |
| CN110818793A (zh) * | 2018-08-14 | 2020-02-21 | 中山康方生物医药有限公司 | 抗IL-1β的抗体、其药物组合物及其用途 |
| BR112021009287A2 (pt) | 2018-11-20 | 2021-10-26 | Janssen Biotech, Inc. | Método seguro e eficaz para tratar psoríase com anticorpo específico anti-il-23 |
| CN113874073A (zh) | 2019-05-23 | 2021-12-31 | 詹森生物科技公司 | 用针对IL-23和TNFα的抗体的联合疗法治疗炎性肠病的方法 |
| CN115768466A (zh) | 2020-05-21 | 2023-03-07 | 詹森生物科技公司 | 用抗IL-23和TNFα抗体的联合疗法治疗炎性肠病的方法 |
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| US4772685A (en) | 1985-10-02 | 1988-09-20 | Merck & Co., Inc. | Immunogenic peptides of human interleukin-1 and the corresponding anti-peptide antibodies |
| US4935343A (en) * | 1986-08-08 | 1990-06-19 | Syntex (U.S.A.) Inc. | Monoclonal antibodies for interleukin-1β |
| FR2640146B1 (fr) * | 1988-12-08 | 1993-12-24 | Commissariat A Energie Atomique | Anticorps monoclonaux anti-interleukines 1(alpha) et 1(beta), leur procede de production et applications desdits anticorps a la detection des interleukines 1(alpha) et 1(beta) et en therapeutique |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| JP3714683B2 (ja) * | 1992-07-30 | 2005-11-09 | 生化学工業株式会社 | 抗リウマチ剤 |
| US5429614A (en) | 1993-06-30 | 1995-07-04 | Baxter International Inc. | Drug delivery system |
| WO1995001997A1 (en) * | 1993-07-09 | 1995-01-19 | Smithkline Beecham Corporation | RECOMBINANT AND HUMANIZED IL-1β ANTIBODIES FOR TREATMENT OF IL-1 MEDIATED INFLAMMATORY DISORDERS IN MAN |
| US6051228A (en) | 1998-02-19 | 2000-04-18 | Bristol-Myers Squibb Co. | Antibodies against human CD40 |
| GB0001448D0 (en) * | 2000-01-21 | 2000-03-08 | Novartis Ag | Organic compounds |
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