RU2237672C2 - Новые производные эритромицина, способ их получения и применение в качестве медикаментов - Google Patents

Новые производные эритромицина, способ их получения и применение в качестве медикаментов Download PDF

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Publication number
RU2237672C2
RU2237672C2 RU99125547A RU99125547A RU2237672C2 RU 2237672 C2 RU2237672 C2 RU 2237672C2 RU 99125547 A RU99125547 A RU 99125547A RU 99125547 A RU99125547 A RU 99125547A RU 2237672 C2 RU2237672 C2 RU 2237672C2
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RU
Russia
Prior art keywords
formula
erythromycin
derivatives
ppm
methyl
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RU99125547A
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English (en)
Russian (ru)
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RU99125547A (ru
Inventor
Алексис ДЕНИ (FR)
Алексис Дени
Original Assignee
Хехст Марион Руссель
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Publication of RU99125547A publication Critical patent/RU99125547A/ru
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Publication of RU2237672C2 publication Critical patent/RU2237672C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
RU99125547A 1998-11-24 1999-11-23 Новые производные эритромицина, способ их получения и применение в качестве медикаментов RU2237672C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9814782A FR2786188B1 (fr) 1998-11-24 1998-11-24 Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
FR9814782 1998-11-24

Publications (2)

Publication Number Publication Date
RU99125547A RU99125547A (ru) 2001-09-10
RU2237672C2 true RU2237672C2 (ru) 2004-10-10

Family

ID=9533122

Family Applications (1)

Application Number Title Priority Date Filing Date
RU99125547A RU2237672C2 (ru) 1998-11-24 1999-11-23 Новые производные эритромицина, способ их получения и применение в качестве медикаментов

Country Status (24)

Country Link
US (2) US6440941B1 (https=)
EP (1) EP1004592B1 (https=)
JP (1) JP2000159790A (https=)
KR (1) KR100587445B1 (https=)
CN (1) CN1165546C (https=)
AR (1) AR021388A1 (https=)
AT (1) ATE245160T1 (https=)
AU (1) AU772171B2 (https=)
BR (1) BR9905735A (https=)
CA (1) CA2290136C (https=)
DE (1) DE69909577T2 (https=)
DK (1) DK1004592T3 (https=)
ES (1) ES2198867T3 (https=)
FR (1) FR2786188B1 (https=)
HU (1) HUP9904392A3 (https=)
IL (1) IL133101A (https=)
MX (1) MXPA99010813A (https=)
NO (1) NO314729B1 (https=)
PL (1) PL336736A1 (https=)
PT (1) PT1004592E (https=)
RU (1) RU2237672C2 (https=)
TR (1) TR199902888A3 (https=)
TW (1) TWI247747B (https=)
ZA (1) ZA997176B (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
CA2359708C (en) * 1999-01-27 2005-10-25 Pfizer Products Inc. Ketolide antibiotics
EA200100983A1 (ru) 1999-05-24 2002-10-31 Пфайзер Продактс Инк. Производные 13-метилэритромицина
DE60104240T2 (de) 2000-06-30 2005-08-04 Pfizer Products Inc., Groton Makrolid-Antibiotika
ES2552682T3 (es) 2003-03-10 2015-12-01 Merck Sharp & Dohme Corp. Agentes antibacterianos novedosos
FR2862647B1 (fr) * 2003-11-25 2008-07-04 Aventis Pharma Sa Derives de pyrazolyle, procede de preparation et intermediaires de ce procede a titre de medicaments et de compositions pharmaceutiques les renfermant
JP2008508322A (ja) * 2004-07-28 2008-03-21 ランバクシー ラボラトリーズ リミテッド 抗菌剤としてのケトライド誘導体
CN105732745A (zh) 2007-10-25 2016-07-06 森普拉制药公司 大环内酯类抗菌剂的制备方法
WO2009137787A1 (en) * 2008-05-09 2009-11-12 Enanta Pharmaceuticals, Inc. Processes for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives
AU2009308182B2 (en) * 2008-10-24 2016-05-19 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
DK2550286T3 (en) 2010-03-22 2016-02-29 Cempra Pharmaceuticals Inc CRYSTALLINE FORMS OF A MACROLID AND APPLICATIONS THEREOF
CN105198944B (zh) 2010-05-20 2018-06-01 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
EP2613630A4 (en) * 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES
WO2012052412A1 (de) 2010-10-22 2012-04-26 Bayer Cropscience Ag Neue heterocylische verbindungen als schädlingsbekämpfungsmittel
MX2014011537A (es) 2012-03-27 2015-02-10 Cempra Pharmaceuticals Inc Formulaciones parenterales para la administracion de antibioticos macrolidos.
HK1217665A1 (zh) 2013-03-14 2017-01-20 森普拉制药公司 用於治療呼吸道疾病的方法及其製劑
RU2015138797A (ru) 2013-03-15 2017-04-24 Семпра Фармасьютикалс, Инк. Конвергентные способы получения макролидных антибактериальных агентов
CN106432383A (zh) * 2016-09-14 2017-02-22 重庆两江药物研发中心有限公司 索利霉素及其中间体的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0596802A1 (fr) * 1992-11-05 1994-05-11 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation, leur application comme médicaments
GB2288174A (en) * 1994-04-08 1995-10-11 Roussel Uclaf Erythromycin derivatives, processes for preparing them, pharmaceutical compositions containing them, and their use as medicaments
RU2114859C1 (ru) * 1992-11-05 1998-07-10 Руссель Юклаф Производные эритромицина, фармацевтическая композиция, способ получения производных эритромицина

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182895A (en) * 1976-12-20 1980-01-08 Sterling Drug Inc. 1-Amino-lower-alkyl-3,4-diphenyl-1H-pyrazoles
CA1098527A (en) * 1976-12-20 1981-03-31 Denis M. Bailey 1-amino-lower-alkyl-3,4-diphenyl-1h-pyrazoles
JPH04234891A (ja) * 1990-03-05 1992-08-24 Fujisawa Pharmaceut Co Ltd 新規セフェム化合物およびその塩
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2727969B1 (fr) * 1994-12-09 1997-01-17 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
CZ9904388A3 (cs) * 1997-06-11 2002-10-16 Pfizer Products Inc. 9-Oximové deriváty erythromycinu
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0596802A1 (fr) * 1992-11-05 1994-05-11 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation, leur application comme médicaments
RU2114859C1 (ru) * 1992-11-05 1998-07-10 Руссель Юклаф Производные эритромицина, фармацевтическая композиция, способ получения производных эритромицина
GB2288174A (en) * 1994-04-08 1995-10-11 Roussel Uclaf Erythromycin derivatives, processes for preparing them, pharmaceutical compositions containing them, and their use as medicaments

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ferroni R. et al. Arzneimittel-Forshung. 1990, 40(6), 705-9, abstract: Chemical Abstracts, 113: 171942. Асратян Г.В. и др. Журнал прикладной химии. 1986, т. LIX, № 6, с. 1296-1300. *

Also Published As

Publication number Publication date
MXPA99010813A (es) 2005-09-08
AU5952299A (en) 2000-05-25
IL133101A (en) 2007-02-11
FR2786188A1 (fr) 2000-05-26
ZA997176B (en) 2000-11-20
CN1165546C (zh) 2004-09-08
TR199902888A2 (xx) 2000-06-21
ES2198867T3 (es) 2004-02-01
NO995745D0 (no) 1999-11-23
US6664398B2 (en) 2003-12-16
TR199902888A3 (tr) 2000-06-21
JP2000159790A (ja) 2000-06-13
NO314729B1 (no) 2003-05-12
CN1263101A (zh) 2000-08-16
KR100587445B1 (ko) 2006-06-08
FR2786188B1 (fr) 2002-10-31
US6440941B1 (en) 2002-08-27
EP1004592B1 (fr) 2003-07-16
US20030050254A1 (en) 2003-03-13
DE69909577D1 (de) 2003-08-21
TWI247747B (en) 2006-01-21
HUP9904392A3 (en) 2001-08-28
HU9904392D0 (en) 2000-01-28
CA2290136A1 (fr) 2000-05-24
AU772171B2 (en) 2004-04-08
HUP9904392A2 (hu) 2000-05-28
PT1004592E (pt) 2003-12-31
CA2290136C (fr) 2010-07-20
IL133101A0 (en) 2001-03-19
DE69909577T2 (de) 2004-06-03
NO995745L (no) 2000-05-25
EP1004592A1 (fr) 2000-05-31
ATE245160T1 (de) 2003-08-15
KR20000057017A (ko) 2000-09-15
AR021388A1 (es) 2002-07-17
PL336736A1 (en) 2000-06-05
DK1004592T3 (da) 2003-10-27
BR9905735A (pt) 2000-08-08

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20051124