ZA997176B - Derivatives of erythromycin, their preparation process and their use as medicaments. - Google Patents

Derivatives of erythromycin, their preparation process and their use as medicaments.

Info

Publication number
ZA997176B
ZA997176B ZA9907176A ZA997176A ZA997176B ZA 997176 B ZA997176 B ZA 997176B ZA 9907176 A ZA9907176 A ZA 9907176A ZA 997176 A ZA997176 A ZA 997176A ZA 997176 B ZA997176 B ZA 997176B
Authority
ZA
South Africa
Prior art keywords
erythromycin
medicaments
derivatives
preparation process
preparation
Prior art date
Application number
ZA9907176A
Other languages
English (en)
Inventor
Alexis Denis
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of ZA997176B publication Critical patent/ZA997176B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ZA9907176A 1998-11-24 1999-11-18 Derivatives of erythromycin, their preparation process and their use as medicaments. ZA997176B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9814782A FR2786188B1 (fr) 1998-11-24 1998-11-24 Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments

Publications (1)

Publication Number Publication Date
ZA997176B true ZA997176B (en) 2000-11-20

Family

ID=9533122

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9907176A ZA997176B (en) 1998-11-24 1999-11-18 Derivatives of erythromycin, their preparation process and their use as medicaments.

Country Status (24)

Country Link
US (2) US6440941B1 (xx)
EP (1) EP1004592B1 (xx)
JP (1) JP2000159790A (xx)
KR (1) KR100587445B1 (xx)
CN (1) CN1165546C (xx)
AR (1) AR021388A1 (xx)
AT (1) ATE245160T1 (xx)
AU (1) AU772171B2 (xx)
BR (1) BR9905735A (xx)
CA (1) CA2290136C (xx)
DE (1) DE69909577T2 (xx)
DK (1) DK1004592T3 (xx)
ES (1) ES2198867T3 (xx)
FR (1) FR2786188B1 (xx)
HU (1) HUP9904392A3 (xx)
IL (1) IL133101A (xx)
MX (1) MXPA99010813A (xx)
NO (1) NO314729B1 (xx)
PL (1) PL336736A1 (xx)
PT (1) PT1004592E (xx)
RU (1) RU2237672C2 (xx)
TR (1) TR199902888A2 (xx)
TW (1) TWI247747B (xx)
ZA (1) ZA997176B (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
SI1147121T1 (en) 1999-01-27 2004-04-30 Pfizer Products Inc. Ketolide antibiotics
EE200100613A (et) 1999-05-24 2003-02-17 Pfizer Products Inc. 13-metüülerütromütsiini derivaadid
TR200401847T4 (tr) 2000-06-30 2004-09-21 Pfizer Products Inc. Makrolit antibiyotikler.
EP2772254A3 (en) 2003-03-10 2015-03-11 Optimer Pharmaceuticals, Inc. Novel Antibacterial Agents
FR2862647B1 (fr) 2003-11-25 2008-07-04 Aventis Pharma Sa Derives de pyrazolyle, procede de preparation et intermediaires de ce procede a titre de medicaments et de compositions pharmaceutiques les renfermant
US20080287376A1 (en) * 2004-07-28 2008-11-20 Mohammad Salman Ketolide Derivatives as Antibacterial Agents
JP5698979B2 (ja) * 2007-10-25 2015-04-08 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライド系抗菌剤の調製プロセス
US8552162B2 (en) * 2008-05-09 2013-10-08 Enanta Pharmaceuticals, Inc. Processes for the preparation of 2 fluoro 6-11 bicyclic erythromycin derivatives
CN105616437A (zh) * 2008-10-24 2016-06-01 森普拉制药公司 使用含三唑的大环内酯的生物防御
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN108310000A (zh) 2009-09-10 2018-07-24 森普拉制药公司 治疗疟疾、结核病和mac疾病的方法
EP3009442B1 (en) 2010-03-22 2019-06-19 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
DK2571506T3 (en) 2010-05-20 2017-08-28 Cempra Pharmaceuticals Inc PROCEDURES FOR THE MANUFACTURE OF MACROLIDES AND KETOLIDES AND INTERMEDIATES
US9815863B2 (en) * 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
WO2012052412A1 (de) 2010-10-22 2012-04-26 Bayer Cropscience Ag Neue heterocylische verbindungen als schädlingsbekämpfungsmittel
RU2658050C2 (ru) 2012-03-27 2018-06-19 Семпра Фармасьютикалз, Инк. Парентеральные составы для введения макролидных антибиотиков
JP6426696B2 (ja) 2013-03-14 2018-11-21 センプラ ファーマシューティカルズ，インコーポレイテッド 呼吸器疾患の治療のための方法および製剤
CA2907085A1 (en) 2013-03-15 2014-09-18 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CN106432383A (zh) * 2016-09-14 2017-02-22 重庆两江药物研发中心有限公司 索利霉素及其中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182895A (en) * 1976-12-20 1980-01-08 Sterling Drug Inc. 1-Amino-lower-alkyl-3,4-diphenyl-1H-pyrazoles
CA1098527A (en) * 1976-12-20 1981-03-31 Denis M. Bailey 1-amino-lower-alkyl-3,4-diphenyl-1h-pyrazoles
JPH04234891A (ja) * 1990-03-05 1992-08-24 Fujisawa Pharmaceut Co Ltd 新規セフェム化合物およびその塩
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2727969B1 (fr) * 1994-12-09 1997-01-17 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
JP2000513026A (ja) * 1997-06-11 2000-10-03 ファイザー・プロダクツ・インク ９−オキシム エリスロマイシン誘導体
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments

Also Published As

Publication number Publication date
HU9904392D0 (en) 2000-01-28
IL133101A0 (en) 2001-03-19
JP2000159790A (ja) 2000-06-13
RU2237672C2 (ru) 2004-10-10
EP1004592A1 (fr) 2000-05-31
ES2198867T3 (es) 2004-02-01
MXPA99010813A (es) 2005-09-08
FR2786188B1 (fr) 2002-10-31
ATE245160T1 (de) 2003-08-15
FR2786188A1 (fr) 2000-05-26
NO314729B1 (no) 2003-05-12
CN1263101A (zh) 2000-08-16
KR20000057017A (ko) 2000-09-15
AU772171B2 (en) 2004-04-08
PT1004592E (pt) 2003-12-31
PL336736A1 (en) 2000-06-05
KR100587445B1 (ko) 2006-06-08
CA2290136C (fr) 2010-07-20
DE69909577T2 (de) 2004-06-03
TR199902888A3 (tr) 2000-06-21
AU5952299A (en) 2000-05-25
TR199902888A2 (xx) 2000-06-21
CA2290136A1 (fr) 2000-05-24
US20030050254A1 (en) 2003-03-13
DE69909577D1 (de) 2003-08-21
CN1165546C (zh) 2004-09-08
TWI247747B (en) 2006-01-21
IL133101A (en) 2007-02-11
US6664398B2 (en) 2003-12-16
HUP9904392A3 (en) 2001-08-28
AR021388A1 (es) 2002-07-17
HUP9904392A2 (hu) 2000-05-28
US6440941B1 (en) 2002-08-27
NO995745D0 (no) 1999-11-23
BR9905735A (pt) 2000-08-08
EP1004592B1 (fr) 2003-07-16
DK1004592T3 (da) 2003-10-27
NO995745L (no) 2000-05-25

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