DE69909577D1 - Derivate von Erythromycin, ihr Verfahren zur Herstellung, und ihre Verwendung als Arzneimittel - Google Patents

Derivate von Erythromycin, ihr Verfahren zur Herstellung, und ihre Verwendung als Arzneimittel

Info

Publication number
DE69909577D1
DE69909577D1 DE69909577T DE69909577T DE69909577D1 DE 69909577 D1 DE69909577 D1 DE 69909577D1 DE 69909577 T DE69909577 T DE 69909577T DE 69909577 T DE69909577 T DE 69909577T DE 69909577 D1 DE69909577 D1 DE 69909577D1
Authority
DE
Germany
Prior art keywords
erythromycin
medicines
derivatives
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69909577T
Other languages
English (en)
Other versions
DE69909577T2 (de
Inventor
Alexis Denis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of DE69909577D1 publication Critical patent/DE69909577D1/de
Application granted granted Critical
Publication of DE69909577T2 publication Critical patent/DE69909577T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69909577T 1998-11-24 1999-11-23 Derivate von Erythromycin, ihr Verfahren zur Herstellung, und ihre Verwendung als Arzneimittel Expired - Lifetime DE69909577T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9814782A FR2786188B1 (fr) 1998-11-24 1998-11-24 Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
FR9814782 1998-11-24

Publications (2)

Publication Number Publication Date
DE69909577D1 true DE69909577D1 (de) 2003-08-21
DE69909577T2 DE69909577T2 (de) 2004-06-03

Family

ID=9533122

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69909577T Expired - Lifetime DE69909577T2 (de) 1998-11-24 1999-11-23 Derivate von Erythromycin, ihr Verfahren zur Herstellung, und ihre Verwendung als Arzneimittel

Country Status (24)

Country Link
US (2) US6440941B1 (de)
EP (1) EP1004592B1 (de)
JP (1) JP2000159790A (de)
KR (1) KR100587445B1 (de)
CN (1) CN1165546C (de)
AR (1) AR021388A1 (de)
AT (1) ATE245160T1 (de)
AU (1) AU772171B2 (de)
BR (1) BR9905735A (de)
CA (1) CA2290136C (de)
DE (1) DE69909577T2 (de)
DK (1) DK1004592T3 (de)
ES (1) ES2198867T3 (de)
FR (1) FR2786188B1 (de)
HU (1) HUP9904392A3 (de)
IL (1) IL133101A (de)
MX (1) MXPA99010813A (de)
NO (1) NO314729B1 (de)
PL (1) PL336736A1 (de)
PT (1) PT1004592E (de)
RU (1) RU2237672C2 (de)
TR (1) TR199902888A3 (de)
TW (1) TWI247747B (de)
ZA (1) ZA997176B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
BR9916969A (pt) * 1999-01-27 2001-11-06 Pfizer Prod Inc Antibióticos cetólidos
AU3832100A (en) 1999-05-24 2000-12-12 Pfizer Products Inc. 13-methyl-erythromycin derivatives
ATE271062T1 (de) 2000-06-30 2004-07-15 Pfizer Prod Inc Makrolid-antibiotika
CA2801100A1 (en) 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Macrolides and processes for their preparation
FR2862647B1 (fr) * 2003-11-25 2008-07-04 Aventis Pharma Sa Derives de pyrazolyle, procede de preparation et intermediaires de ce procede a titre de medicaments et de compositions pharmaceutiques les renfermant
RU2397987C2 (ru) * 2004-07-28 2010-08-27 Рэнбакси Лабораториз Лимитед Кетолидные производные в качестве антибактериальных агентов
CN105732745A (zh) 2007-10-25 2016-07-06 森普拉制药公司 大环内酯类抗菌剂的制备方法
US8552162B2 (en) 2008-05-09 2013-10-08 Enanta Pharmaceuticals, Inc. Processes for the preparation of 2 fluoro 6-11 bicyclic erythromycin derivatives
CN107854477A (zh) 2008-10-24 2018-03-30 森普拉制药公司 使用含三唑的大环内酯治疗抗性疾病的方法
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
WO2011032052A1 (en) 2009-09-10 2011-03-17 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
EP2550286B1 (de) 2010-03-22 2015-12-09 Cempra Pharmaceuticals, Inc. Kristalline formen eines makrolids und verwendungen dafür
PL2571506T3 (pl) 2010-05-20 2017-10-31 Cempra Pharmaceuticals Inc Sposoby sporządzania makrolidów i ketolidów oraz ich produktów pośrednich
KR20180110181A (ko) * 2010-09-10 2018-10-08 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
JP5953308B2 (ja) 2010-10-22 2016-07-20 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 殺害虫剤としての新規ヘテロ環式化合物
IN2014DN08939A (de) 2012-03-27 2015-05-22 Cempra Pharmaceuticals Inc
AU2014239959A1 (en) 2013-03-14 2015-10-01 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
EP2968384A4 (de) 2013-03-15 2017-02-15 Cempra Pharmaceuticals, Inc. Konvergente verfahren zur herstellung antibakterieller makrolidmittel
CN106432383A (zh) * 2016-09-14 2017-02-22 重庆两江药物研发中心有限公司 索利霉素及其中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1098527A (en) * 1976-12-20 1981-03-31 Denis M. Bailey 1-amino-lower-alkyl-3,4-diphenyl-1h-pyrazoles
US4182895A (en) * 1976-12-20 1980-01-08 Sterling Drug Inc. 1-Amino-lower-alkyl-3,4-diphenyl-1H-pyrazoles
JPH04234891A (ja) * 1990-03-05 1992-08-24 Fujisawa Pharmaceut Co Ltd 新規セフェム化合物およびその塩
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2727969B1 (fr) * 1994-12-09 1997-01-17 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
IL132767A0 (en) * 1997-06-11 2001-03-19 Pfizer Prod Inc 9-Oxime erythromycin derivatives
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments

Also Published As

Publication number Publication date
ES2198867T3 (es) 2004-02-01
MXPA99010813A (es) 2005-09-08
JP2000159790A (ja) 2000-06-13
NO995745L (no) 2000-05-25
AU5952299A (en) 2000-05-25
IL133101A0 (en) 2001-03-19
BR9905735A (pt) 2000-08-08
EP1004592A1 (de) 2000-05-31
TR199902888A2 (xx) 2000-06-21
US6440941B1 (en) 2002-08-27
AU772171B2 (en) 2004-04-08
CA2290136C (fr) 2010-07-20
PL336736A1 (en) 2000-06-05
ZA997176B (en) 2000-11-20
DE69909577T2 (de) 2004-06-03
IL133101A (en) 2007-02-11
CA2290136A1 (fr) 2000-05-24
TWI247747B (en) 2006-01-21
EP1004592B1 (de) 2003-07-16
PT1004592E (pt) 2003-12-31
CN1165546C (zh) 2004-09-08
HUP9904392A2 (hu) 2000-05-28
FR2786188A1 (fr) 2000-05-26
AR021388A1 (es) 2002-07-17
US20030050254A1 (en) 2003-03-13
NO314729B1 (no) 2003-05-12
KR20000057017A (ko) 2000-09-15
FR2786188B1 (fr) 2002-10-31
DK1004592T3 (da) 2003-10-27
RU2237672C2 (ru) 2004-10-10
US6664398B2 (en) 2003-12-16
KR100587445B1 (ko) 2006-06-08
CN1263101A (zh) 2000-08-16
ATE245160T1 (de) 2003-08-15
NO995745D0 (no) 1999-11-23
TR199902888A3 (tr) 2000-06-21
HU9904392D0 (en) 2000-01-28
HUP9904392A3 (en) 2001-08-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC