AR021388A1 - Derivados de la eritromicina, su procedimiento de preparacion y su aplicacion como medicamento - Google Patents
Derivados de la eritromicina, su procedimiento de preparacion y su aplicacion como medicamentoInfo
- Publication number
- AR021388A1 AR021388A1 ARP990105985A ARP990105985A AR021388A1 AR 021388 A1 AR021388 A1 AR 021388A1 AR P990105985 A ARP990105985 A AR P990105985A AR P990105985 A ARP990105985 A AR P990105985A AR 021388 A1 AR021388 A1 AR 021388A1
- Authority
- AR
- Argentina
- Prior art keywords
- radicals
- alkenyl
- alkyl
- alkynyl
- erythromycin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
La presente tiene por objeto los compuestos de formula (1) en la que: Y representa un átomo de hidrogeno o un átomo de fluor; n representa un numero enterocomprendido entre 1 y 8; Z representa un átomo de hidrogeno o el resto de un ácido carboxílico,eventualmente sustituido en el heterociclo con uno o variosradicales alquilo, alquenilo, alquinilo, O-alquilo, O-alquenilo, O-alquinilo, S-alquilo, S-alquenilo, S-alquinilo que contienen hasta 8 átomos de C, uno ovarios radicales OH, NH2, C=N, NO2,CF3 o uno o varios radicales arilo que contienen hasta 14 átomos de C o heteroarilo que contiene uno o varios átomos denitrogeno, oxígeno o azufre, pudiendo los radicales arilo o heteroarilo estar ellos mismo sustituidos así como sus sales de adicioncon ácidos. Los productosde formula (1) que presentan propiedades antibioticas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9814782A FR2786188B1 (fr) | 1998-11-24 | 1998-11-24 | Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021388A1 true AR021388A1 (es) | 2002-07-17 |
Family
ID=9533122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990105985A AR021388A1 (es) | 1998-11-24 | 1999-11-24 | Derivados de la eritromicina, su procedimiento de preparacion y su aplicacion como medicamento |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6440941B1 (es) |
| EP (1) | EP1004592B1 (es) |
| JP (1) | JP2000159790A (es) |
| KR (1) | KR100587445B1 (es) |
| CN (1) | CN1165546C (es) |
| AR (1) | AR021388A1 (es) |
| AT (1) | ATE245160T1 (es) |
| AU (1) | AU772171B2 (es) |
| BR (1) | BR9905735A (es) |
| CA (1) | CA2290136C (es) |
| DE (1) | DE69909577T2 (es) |
| DK (1) | DK1004592T3 (es) |
| ES (1) | ES2198867T3 (es) |
| FR (1) | FR2786188B1 (es) |
| HU (1) | HUP9904392A3 (es) |
| IL (1) | IL133101A (es) |
| MX (1) | MXPA99010813A (es) |
| NO (1) | NO314729B1 (es) |
| PL (1) | PL336736A1 (es) |
| PT (1) | PT1004592E (es) |
| RU (1) | RU2237672C2 (es) |
| TR (1) | TR199902888A2 (es) |
| TW (1) | TWI247747B (es) |
| ZA (1) | ZA997176B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2786188B1 (fr) * | 1998-11-24 | 2002-10-31 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments |
| SI1147121T1 (en) | 1999-01-27 | 2004-04-30 | Pfizer Products Inc. | Ketolide antibiotics |
| EE200100613A (et) | 1999-05-24 | 2003-02-17 | Pfizer Products Inc. | 13-metüülerütromütsiini derivaadid |
| TR200401847T4 (tr) | 2000-06-30 | 2004-09-21 | Pfizer Products Inc. | Makrolit antibiyotikler. |
| EP2772254A3 (en) | 2003-03-10 | 2015-03-11 | Optimer Pharmaceuticals, Inc. | Novel Antibacterial Agents |
| FR2862647B1 (fr) | 2003-11-25 | 2008-07-04 | Aventis Pharma Sa | Derives de pyrazolyle, procede de preparation et intermediaires de ce procede a titre de medicaments et de compositions pharmaceutiques les renfermant |
| US20080287376A1 (en) * | 2004-07-28 | 2008-11-20 | Mohammad Salman | Ketolide Derivatives as Antibacterial Agents |
| JP5698979B2 (ja) * | 2007-10-25 | 2015-04-08 | センプラ ファーマシューティカルズ，インコーポレイテッド | マクロライド系抗菌剤の調製プロセス |
| US8552162B2 (en) * | 2008-05-09 | 2013-10-08 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of 2 fluoro 6-11 bicyclic erythromycin derivatives |
| CN105616437A (zh) * | 2008-10-24 | 2016-06-01 | 森普拉制药公司 | 使用含三唑的大环内酯的生物防御 |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| CN108310000A (zh) | 2009-09-10 | 2018-07-24 | 森普拉制药公司 | 治疗疟疾、结核病和mac疾病的方法 |
| EP3009442B1 (en) | 2010-03-22 | 2019-06-19 | Cempra Pharmaceuticals, Inc. | Crystalline forms of a macrolide, and uses therefor |
| DK2571506T3 (en) | 2010-05-20 | 2017-08-28 | Cempra Pharmaceuticals Inc | PROCEDURES FOR THE MANUFACTURE OF MACROLIDES AND KETOLIDES AND INTERMEDIATES |
| US9815863B2 (en) * | 2010-09-10 | 2017-11-14 | Cempra Pharmaceuticals, Inc. | Hydrogen bond forming fluoro ketolides for treating diseases |
| WO2012052412A1 (de) | 2010-10-22 | 2012-04-26 | Bayer Cropscience Ag | Neue heterocylische verbindungen als schädlingsbekämpfungsmittel |
| RU2658050C2 (ru) | 2012-03-27 | 2018-06-19 | Семпра Фармасьютикалз, Инк. | Парентеральные составы для введения макролидных антибиотиков |
| JP6426696B2 (ja) | 2013-03-14 | 2018-11-21 | センプラ ファーマシューティカルズ，インコーポレイテッド | 呼吸器疾患の治療のための方法および製剤 |
| CA2907085A1 (en) | 2013-03-15 | 2014-09-18 | Cempra Pharmaceuticals, Inc. | Convergent processes for preparing macrolide antibacterial agents |
| CN106432383A (zh) * | 2016-09-14 | 2017-02-22 | 重庆两江药物研发中心有限公司 | 索利霉素及其中间体的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4182895A (en) * | 1976-12-20 | 1980-01-08 | Sterling Drug Inc. | 1-Amino-lower-alkyl-3,4-diphenyl-1H-pyrazoles |
| CA1098527A (en) * | 1976-12-20 | 1981-03-31 | Denis M. Bailey | 1-amino-lower-alkyl-3,4-diphenyl-1h-pyrazoles |
| JPH04234891A (ja) * | 1990-03-05 | 1992-08-24 | Fujisawa Pharmaceut Co Ltd | 新規セフェム化合物およびその塩 |
| US5527780A (en) * | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
| FR2718450B1 (fr) * | 1994-04-08 | 1997-01-10 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2719587B1 (fr) * | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2727969B1 (fr) * | 1994-12-09 | 1997-01-17 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| FR2742757B1 (fr) * | 1995-12-22 | 1998-01-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| JP2000513026A (ja) * | 1997-06-11 | 2000-10-03 | ファイザー・プロダクツ・インク | ９−オキシム エリスロマイシン誘導体 |
| FR2786188B1 (fr) * | 1998-11-24 | 2002-10-31 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments |
-
1998
- 1998-11-24 FR FR9814782A patent/FR2786188B1/fr not_active Expired - Fee Related
-
1999
- 1999-11-16 TW TW088119939A patent/TWI247747B/zh not_active IP Right Cessation
- 1999-11-17 AU AU59522/99A patent/AU772171B2/en not_active Expired
- 1999-11-18 CA CA2290136A patent/CA2290136C/fr not_active Expired - Lifetime
- 1999-11-18 US US09/442,681 patent/US6440941B1/en not_active Expired - Lifetime
- 1999-11-18 ZA ZA9907176A patent/ZA997176B/xx unknown
- 1999-11-22 JP JP11331141A patent/JP2000159790A/ja active Pending
- 1999-11-23 MX MXPA99010813A patent/MXPA99010813A/es active IP Right Grant
- 1999-11-23 AT AT99402907T patent/ATE245160T1/de active
- 1999-11-23 RU RU99125547A patent/RU2237672C2/ru not_active IP Right Cessation
- 1999-11-23 IL IL133101A patent/IL133101A/en not_active IP Right Cessation
- 1999-11-23 EP EP99402907A patent/EP1004592B1/fr not_active Expired - Lifetime
- 1999-11-23 ES ES99402907T patent/ES2198867T3/es not_active Expired - Lifetime
- 1999-11-23 DE DE69909577T patent/DE69909577T2/de not_active Expired - Lifetime
- 1999-11-23 CN CNB99127394XA patent/CN1165546C/zh not_active Expired - Lifetime
- 1999-11-23 PT PT99402907T patent/PT1004592E/pt unknown
- 1999-11-23 HU HU9904392A patent/HUP9904392A3/hu unknown
- 1999-11-23 NO NO19995745A patent/NO314729B1/no unknown
- 1999-11-23 KR KR1019990052014A patent/KR100587445B1/ko active IP Right Grant
- 1999-11-23 DK DK99402907T patent/DK1004592T3/da active
- 1999-11-24 AR ARP990105985A patent/AR021388A1/es not_active Application Discontinuation
- 1999-11-24 TR TR1999/02888A patent/TR199902888A2/xx unknown
- 1999-11-24 BR BR9905735-2A patent/BR9905735A/pt active Search and Examination
- 1999-11-24 PL PL99336736A patent/PL336736A1/xx not_active Application Discontinuation
-
2002
- 2002-07-02 US US10/188,394 patent/US6664398B2/en not_active Expired - Lifetime
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |